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Robert B Denman et al.
Neuroscience letters, 572, 38-43 (2014-05-06)
Changes in cytoplasmic pH are known to regulate diverse cellular processes and influence neuronal activities. In neurons, the intracellular alkalization is shown to occur after stimulating several channels and receptors. For example, it has previously demonstrated in P19 neurons that
Juliana C Perry et al.
Journal of sleep research, 23(2), 168-175 (2013-11-29)
Chronic short sleep duration has been linked to sympathoexcitation and increased risk of cardiovascular disease. The central nervous system plays an important role in the regulation of sympathetic activity. Thus, the present study evaluates the pre-autonomic neurones in the paraventricular
Poulomee Bose et al.
Peptides, 73, 43-50 (2015-08-25)
Neurotensin (NT) is an endogenous neuropeptide that modulates dopamine and glutamate neurotransmission in several limbic regions innervated by neurons located in the ventral tegmental area (VTA). While several studies showed that NT exerted a direct modulation on VTA dopamine neurons
Wei Xu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(13), 5867-5877 (2013-03-29)
Although the contribution of postsynaptic mechanisms to long-term synaptic plasticity has been studied extensively, understanding the contribution of presynaptic modifications to this process lags behind, primarily because of a lack of techniques with which to directly and quantifiably measure neurotransmitter
Rogier B Poorthuis et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(11), 4843-4853 (2013-03-15)
Adolescence is a period in which the developing prefrontal cortex (PFC) is sensitive to maladaptive changes when exposed to nicotine. Nicotine affects PFC function and repeated exposure to nicotine during adolescence impairs attention performance and impulse control during adulthood. Nicotine
Matthew S Dicken et al.
The European journal of neuroscience, 42(9), 2644-2653 (2015-09-16)
The strength of γ-aminobutyric acid (GABA)-mediated inhibitory synaptic input is a principle determinant of neuronal activity. However, because of differences in the number of GABA afferent inputs and the sites of synapses, it is difficult to directly assay for altered
Lin-Lin Bi et al.
Neuropharmacology, 72, 148-156 (2013-05-07)
The medial prefrontal cortex (mPFC) has been implicated in modulating anxiety. However, it is unknown whether excitatory or inhibitory neurotransmission in the infralimbic (IL) subregion of the mPFC underlies the pathology of anxiety-related behavior. To address this issue, we infused
Kevin W McCairn et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(15), 6581-6593 (2013-04-12)
A neurosurgical intervention that has shown potential for treating basal ganglia (BG) mediated motor tics involves high-frequency deep brain stimulation (HF-DBS) targeted to the output nucleus of the BG: the globus pallidus internus (GPi). This study used a nonhuman primate
Woo Hyeun Kang et al.
Journal of neurotrauma, 32(13), 1011-1019 (2014-12-18)
Traumatic brain injury (TBI) alters function and behavior, which can be characterized by changes in electrophysiological function in vitro. A common cognitive deficit after mild-to-moderate TBI is disruption of persistent working memory, of which the in vitro correlate is long-lasting
Chia Ying Chang et al.
Neurotoxicology, 50, 157-169 (2015-09-08)
The citrus flavonoid hesperidin exerts neuroprotective effects and could cross the blood-brain barrier. Given the involvement of glutamate neurotoxicity in the pathogenesis of neurodegenerative disorders, this study was conducted to evaluate the potential role of hesperidin in glutamate release and
Orang Alem et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(43), 14324-14327 (2014-10-24)
Magnetoencephalography has long held the promise of providing a noninvasive tool for localizing epileptic seizures in humans because of its high spatial resolution compared with the scalp EEG. Yet, this promise has been elusive, not because of a lack of
C M Florez et al.
Neurobiology of disease, 82, 213-225 (2015-06-21)
Seizures are the most common clinical presentation of severe hypoglycemia, usually as a side effect of insulin treatment for juvenile onset type 1 diabetes mellitus and advanced type 2 diabetes. We used the mouse thick hippocampal slice preparation to study
Robert D Sanders et al.
Critical care medicine, 41(7), 1627-1636 (2013-03-13)
Benzodiazepines are used for treating anxiety, epilepsy, muscle spasm, alcohol withdrawal, palliation, insomnia, and sedation as they allosterically modulate γ-amino-butyric acid type A (GABAA) receptors. Despite widespread use, the importance and mechanism of their immune side-effects are poorly understood. Herein
Yuji Kamikubo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(47), 18661-18671 (2013-11-22)
G-protein-coupled receptors (GPCRs) may form heteromeric complexes and cooperatively mediate cellular responses. Although heteromeric GPCR complexes are suggested to occur in many neurons, their contribution to neuronal function remains unclear. We address this question using two GPCRs expressed in cerebellar
G Telegdy et al.
Behavioural brain research, 252, 88-91 (2013-06-08)
Urocortin 3 (Ucn 3) was tested for anxiolytic action in mice an elevated plus maze. For detection of the possible involvement of neurotransmitters, the mice were pretreated with receptor blockers: haloperidol, phenoxybenzamine, propranolol, atropine, methysergide, bicuculline or naloxone. The peptide
Diasynou Fioravante et al.
eLife, 3, e03011-e03011 (2014-08-07)
In presynaptic boutons, calcium (Ca(2+)) triggers both neurotransmitter release and short-term synaptic plasticity. Whereas synaptotagmins are known to mediate vesicle fusion through binding of high local Ca(2+) to their C2 domains, the proteins that sense smaller global Ca(2+) increases to
Bo Shi et al.
Scientific reports, 5, 17751-17751 (2015-12-10)
One paradigm of oysters as the hyper-accumulators of many toxic metals is the inter-individual variation of metals, but the molecular mechanisms remain very elusive. A comprehensive analysis of the transcriptome of Crassostrea angulata was conducted to reveal the relationship between
Daniel Reyes-Haro et al.
Journal of neuroscience research, 91(4), 527-534 (2013-01-30)
The ependymal glial cells (EGCs) from the periventricular zone of the cerebellum were studied to determine their distribution and the functional properties of their γ-aminobutyric acid type A (GABA(A) ) receptors. EGCs were identified by the presence of ciliated structures
Sampsa T Sipilä et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(30), 10003-10009 (2014-07-25)
Although functional glycinergic synapses have not been identified in the hippocampus, neurons in this area express Cl(-) permeable extrasynaptic glycine receptors (GlyRs). In experiments on CA3 pyramidal neurons on postnatal day 0-6 rat hippocampal slices, we detected robust GlyR activity
Benjamin Owen et al.
Journal of neurophysiology, 113(10), 3646-3662 (2015-04-10)
Axon conduction fidelity is important for signal transmission and has been studied in various axons, including the Schaffer collateral axons of the hippocampus. Previously, we reported that high-frequency stimulation (HFS) depresses Schaffer collateral excitability when assessed by whole-cell recordings from
Camille Liautard et al.
Epilepsia, 54(7), 1251-1261 (2013-05-15)
Dravet syndrome (DS) is caused by dominant mutations of the SCN1A gene, encoding the NaV 1.1 sodium channel α subunit. Gene targeted mouse models of DS mutations replicate patients' phenotype and show reduced γ-aminobutyric acid (GABA)ergic inhibition. However, little is
Kenji Matsuura et al.
Neuroscience letters, 555, 18-23 (2013-08-13)
Protein synthesis is required for long-lasting synaptic plasticity. We examined the time-dependent changes in protein expression that occurred in the hippocampus during synaptic plasticity using two-dimensional gel electrophoresis followed by mass spectrometry. The levels of 15 proteins were significantly changed
Anne M J Verstegen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(21), 7266-7280 (2014-05-23)
Cyclin-dependent kinase-5 (Cdk5) was reported to downscale neurotransmission by sequestering synaptic vesicles (SVs) in the release-reluctant resting pool, but the molecular targets mediating this activity remain unknown. Synapsin I (SynI), a major SV phosphoprotein involved in the regulation of SV
Deivid C Rodrigues et al.
Cell reports, 30(12), 4179-4196 (2020-03-27)
Regulation of translation during human development is poorly understood, and its dysregulation is associated with Rett syndrome (RTT). To discover shifts in mRNA ribosomal engagement (RE) during human neurodevelopment, we use parallel translating ribosome affinity purification sequencing (TRAP-seq) and RNA
Somnogenic effect of exogenous heat shock protein 70 kDa is mediated by GABA(A) receptors in the preoptic area of the hypothalamus.
I V Ekimova
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 449, 89-92 (2013-05-09)
Gláucia Melo Reis et al.
Pharmacology, biochemistry, and behavior, 131, 112-118 (2015-02-18)
The stimulation of the retrosplenial cortex (RSC) is antinociceptive in the rat tail-flick and formalin tests. The rat RSC is caudal to and send projections to the ipsilateral anterior cingulate cortex (ACC), which is also involved in pain processing. This
Tsutomu Kamiyama et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(3), 1181-1191 (2015-01-23)
The corticospinal (CS) tract is essential for voluntary movement, but what we know about the organization and development of the CS tract remains limited. To determine the total cortical area innervating the seventh cervical spinal cord segment (C7), which controls
Torben J Hausrat et al.
Nature communications, 6, 6872-6872 (2015-04-22)
Neurotransmitter receptor density is a major variable in regulating synaptic strength. Receptors rapidly exchange between synapses and intracellular storage pools through endocytic recycling. In addition, lateral diffusion and confinement exchanges surface membrane receptors between synaptic and extrasynaptic sites. However, the
Xiangdong Chen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(3), 600-609 (2009-01-23)
Ketamine has important anesthetic, analgesic, and psychotropic actions. It is widely believed that NMDA receptor inhibition accounts for ketamine actions, but there remains a dearth of behavioral evidence to support this hypothesis. Here, we present an alternative, behaviorally relevant molecular
Herbal products and GABA receptors
Johnston GAR, et al.
Encyclopedia of Neuroscience, 169(2), 1095-1101 (2009)
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