Showing 1-30 of 86 results for "14510"
Eun Sun Jung et al.
Scientific reports, 5, 8805-8805 (2015-03-06)
Beta-amyloid (Aβ), a major pathological hallmark of Alzheimer's disease (AD), is derived from amyloid precursor protein (APP) through sequential cleavage by β-secretase and γ-secretase enzymes. APP is an integral membrane protein, and plays a key role in the pathogenesis of...
Xiang Peng et al.
Thrombosis research, 134(2), 418-425 (2014-07-06)
Proteinase 3 (PR3) is released from neutrophil azurophilic granules and exerts complex effects on the inflammatory process. PR3 catalyzes the degradation of a number of macromolecules, but the consequences on blood cells are less well defined. In the present study...
Jinbin Tian et al.
Pflugers Archiv : European journal of physiology, 466(7), 1301-1316 (2013-10-15)
In the central nervous system, canonical transient receptor potential (TRPC) channels have been implicated in mediating neuronal excitation induced by stimulating metabotropic receptors, including group 1 metabotropic glutamate receptors (mGluRs). Lateral septal (LS) neurons express high levels of TRPC4 and...
Naadiya Carrim et al.
PloS one, 9(11), e113679-e113679 (2014-11-22)
We have previously shown the presence of a TRAF4/p47phox/Hic5/Pyk2 complex associated with the platelet collagen receptor, GPVI, consistent with a potential role of this complex in GPVI-dependent ROS formation. In other cell systems, NOX-dependent ROS formation is facilitated by Pyk2...
Tauseef M Asmat et al.
PloS one, 9(12), e114474-e114474 (2014-12-03)
The pili and outer membrane proteins of Neisseria meningitidis (meningococci) facilitate bacterial adhesion and invasion into host cells. In this context expression of meningococcal PilC1 protein has been reported to play a crucial role. Intracellular calcium mobilization has been implicated...
Xiaoge Gao et al.
Oncotarget, 5(8), 2077-2084 (2014-05-09)
The presence and level of circulating galectin-3 (Gal-3), a member of the galectin family, is associated with diverse diseases ranging from heart failure, immune disorders to cancer metastasis and serves as a biomarker of diagnosis and treatment response. However, the...
Sylvain Chauvette et al.
Neuron, 75(6), 1105-1113 (2012-09-25)
Long-term plasticity contributes to memory formation and sleep plays a critical role in memory consolidation. However, it is unclear whether sleep slow oscillation by itself induces long-term plasticity that contributes to memory retention. Using in vivo prethalamic electrical stimulation at...
Andrew A Vu et al.
PloS one, 8(1), e54794-e54794 (2013-01-30)
Sound perception requires functional hair cell mechanotransduction (MET) machinery, including the MET channels and tip-link proteins. Prior work showed that uptake of ototoxic aminoglycosides (AG) into hair cells requires functional MET channels. In this study, we examined whether tip-link proteins...
Swati Gupta et al.
Biochimica et biophysica acta, 1840(12), 3423-3433 (2014-09-02)
The diversity of platelet functions implies multiple activation states arising in response to different stimuli. Distinguishing between these states has been challenging. We used fluorescently labelled carbohydrate binding proteins lectins to investigate agonist-induced changes in platelet surface glycosylation. Each of...
Patricia Santofimia-Castaño et al.
Toxicology letters, 229(3), 465-473 (2014-07-30)
Ebselen is a seleno-organic compound that causes cell death in several cancer cell types. The mechanisms underlying its deleterious effects have not been fully elucidated. In this study, the effects of ebselen (1 μM-40 μM) on AR42J tumor cells have...
Jingsheng Xia et al.
The Journal of physiology, 592(16), 3443-3461 (2014-05-27)
Store-operated calcium channels (SOCs) are calcium-selective cation channels that mediate calcium entry in many different cell types. Store-operated calcium entry (SOCE) is involved in various cellular functions. Increasing evidence suggests that impairment of SOCE is responsible for numerous disorders. A...
Tatiana V Vygodina et al.
Biochimica et biophysica acta, 1837(7), 1188-1195 (2014-03-13)
Cytochrome c oxidase from bovine heart binds Ca(2+) reversibly at a specific Cation Binding Site located near the outer face of the mitochondrial membrane. Ca(2+) shifts the absorption spectrum of heme a, which allowed earlier the determination of the kinetic...
Geoffrey E Bray et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(19), 8202-8215 (2013-05-10)
Activation of the nerve growth factor (NGF) receptor trkA and tissue acidosis are critically linked to inflammation-associated nociceptor sensitization. This study explored how increased acidity is linked to sensory neuron sensitization to NGF. Adult Wistar rat primary sensory neurons grown...
Ina Nemet et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(24), 8164-8174 (2014-06-13)
The photoreceptor outer segment (OS) is comprised of two compartments: plasma membrane (PM) and disk membranes. It is unknown how the PM renewal is coordinated with that of the disk membranes. Here we visualized the localization and trafficking process of...
D Mehra et al.
Molecular pharmacology, 86(6), 696-706 (2014-10-03)
Catecholaminergic polymorphic ventricular tachycardia (CPVT) causes sudden cardiac death due to mutations in cardiac ryanodine receptors (RyR2), calsequestrin, or calmodulin. Flecainide, a class I antiarrhythmic drug, inhibits Na(+) and RyR2 channels and prevents CPVT. The purpose of this study is...
Walter Marcotti et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(16), 5505-5514 (2014-04-18)
Tip links between adjacent stereocilia are believed to gate mechano-electrical transducer (MET) channels and mediate the electrical responses of sensory hair cells. We found that mouse auditory hair cells that lack tip links due to genetic mutations or exposure to...
Lilian Kisiswa et al.
Nature neuroscience, 16(7), 865-873 (2013-06-12)
Reverse signaling via members of the tumor necrosis factor (TNF) superfamily controls multiple aspects of immune function. Here we document TNFα reverse signaling in the nervous system to our knowledge for the first time and show that it has a...
Jay M Bolnick et al.
Alcoholism, clinical and experimental research, 38(6), 1646-1653 (2014-06-04)
Apoptosis is induced by ethanol (EtOH) in human placental trophoblast cells, possibly disrupting placentation and contributing to intrauterine growth restriction in fetal alcohol spectrum disorder (FASD). EtOH induces programmed cell death in several embryonic tissues by raising intracellular Ca(2+) ....
Romain Pigeat et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(1), 64-73 (2015-01-09)
Slow waves of non-REM sleep are suggested to play a role in shaping synaptic connectivity to consolidate recently acquired memories and/or restore synaptic homeostasis. During sleep slow waves, both GABAergic neurons of the nucleus reticularis thalami (NRT) and thalamocortical (TC)...
M Pérez-Domínguez et al.
Neurochemical research, 39(7), 1219-1231 (2014-04-08)
Thrombin effect increasing swelling-induced glutamate efflux was examined in cultured cortical astrocytes, cerebellar granule neurons (CGN), hippocampal and cortical neurons. Hypotonic glutamate efflux (monitored by D-[(3)H]aspartate) from cortical astrocytes was increased by thrombin (5 U/mL) to reach 16% of the...
M E Volkov
Bulletin of experimental biology and medicine, 154(1), 100-103 (2013-01-19)
Experiments with fluorescent dyes showed that high concentrations of K(+) ions in the medium depolarize the membrane and enhance exo-endocytosis in nerve structures, which is accompanied by an increase in acetylcholine concentration in the somatic muscle of earthworm. In the...
Jennifer A Boylston et al.
Cell cycle (Georgetown, Tex.), 13(18), 2913-2930 (2014-12-09)
Fragile histidine triad (FHIT) gene deletions are among the earliest and most frequent events in carcinogenesis, particularly in carcinogen-exposed tissues. Though FHIT has been established as an authentic tumor suppressor, the mechanism underlying tumor suppression remains opaque. Most experiments designed...
Pinar Batat et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 11(11), 1666-1674 (2012-12-18)
Efficient Ca(2+)-switched fluorescent sensors, where fluorescence output is governed by a light-activated ion-gated electron transfer pathway, can be obtained on combining BODIPY chromophores with a readily oxidized biocompatible and selective BAPTA receptor. Herein we report the synthesis and studies of...
Kwang-Youn Kim et al.
Journal of cellular biochemistry, 114(5), 1124-1134 (2012-11-30)
The limited treatment option for recurrent prostate cancer and the eventual resistance to conventional chemotherapy drugs has fueled continued interest in finding new anti-neoplastic agents of natural product origin. We previously reported anti-proliferative activity of deoxypodophyllotoxin (DPT) on human prostate...
Zhihong Lu et al.
Rejuvenation research, 22(6), 513-520 (2019-02-26)
Although learning and memory decline are associated with aging, some older individuals show high cognitive function. The mechanism underlying successful aging is not clear, although augmented N-methyl-D-aspartate receptor-independent long-term depression (LTD) has been found in successfully aged rats. We hypothesized...
Benjamin K Stafford et al.
The Journal of physiology, 592(22), 4877-4889 (2014-09-14)
Postsynaptic AMPA- and NMDA-type glutamate receptors (AMPARs, NMDARs) are commonly expressed at the same synapses. AMPARs are thought to mediate the majority of fast excitatory neurotransmission whereas NMDARs, with their relatively slower kinetics and higher Ca(2+) permeability, are thought to...
Caroline Cros et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(12), R1493-R1501 (2014-11-08)
Cardiomyocyte contraction depends on rapid changes in intracellular Ca(2+). In mammals, Ca(2+) influx as L-type Ca(2+) current (ICa) triggers the release of Ca(2+) from sarcoplasmic reticulum (SR) and Ca(2+)-induced Ca(2+) release (CICR) is critical for excitation-contraction coupling. In fish, the...
Naiyan Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(41), E2832-E2841 (2012-09-27)
Although cholinergic innervation of the cortex by the nucleus basalis (NB) is known to modulate cortical neuronal responses and instruct cortical plasticity, little is known about the underlying cellular mechanisms. Using cell-attached recordings in vivo, we demonstrate that electrical stimulation...
Asheebo Rojas et al.
Neurobiology of disease, 70, 74-89 (2014-06-22)
Prostaglandin E2 (PGE2) regulates membrane excitability, synaptic transmission, plasticity, and neuronal survival. The consequences of PGE2 release following seizures has been the subject of much study. Here we demonstrate that the prostaglandin E2 receptor 1 (EP1, or Ptger1) modulates native...
Nicholas A Courtney et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(22), 7645-7656 (2014-05-30)
Metabotropic transmission typically occurs through the spillover activation of extrasynaptic receptors. This study examined the mechanisms underlying somatodendritic dopamine and noradrenaline transmission and found that the extent of spillover and pooling varied dramatically between these two transmitters. In the mouse...

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