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Farzaneh Rafie et al.
Current eye research, 35(12), 1081-1089 (2010-10-22)
The purpose of this study was to investigate the in vivo effects of a new smart polymer loaded with dexamethasone on inflamed rabbit eye. Polymeric micelles were prepared using N-isopropylacrylamide (NIPAAM), vinyl pyrrolidone (VP), and methacrylate (MAA) as monomers in
Vadde Sudhakar Reddy et al.
IUBMB life, 67(4), 291-299 (2015-04-23)
αB-Crystallin (αBC) is a member of the small heat shock protein family that responds to a variety of stress and prevents the aggregation of partially unfolded proteins. Chronic hyperglycemia created during diabetes results in skeletal muscle atrophy and leads to
Bradley W Davis et al.
Biophysical journal, 109(10), 2182-2194 (2015-11-21)
Subcellular compartmentalization of biomolecules and their reactions is common in biology and provides a general strategy for improving and/or controlling kinetics in metabolic pathways that contain multiple sequential enzymes. Enzymes can be colocalized in multiprotein complexes, on scaffolds or inside
Takashi Miyata et al.
Journal of molecular recognition : JMR, 25(6), 336-343 (2012-05-30)
Tumor-marker-imprinted hydrogels having lectin and antibody molecules as ligands for a tumor-specific marker glycoprotein were strategically prepared by biomolecular imprinting using minute amounts of low-molecular-weight or high-molecular-weight cross-linkers. The tumor-marker-imprinted hydrogels shrank gradually in response to a target glycoprotein, because
G V Vedamurthy et al.
Parasite immunology, 37(11), 568-578 (2015-09-04)
Haemonchus contortus, an economically important blood-sucking parasite of sheep and goats, survives the harsh host gut environment by secreting a number of proteins referred as excretory/secretory (ES) products. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a glycolytic enzyme, is one of the components of
Guoqiang Liu et al.
Small (Weinheim an der Bergstrasse, Germany), 11(23), 2807-2816 (2015-02-05)
A facile route to fabricate a nanocomposite of Fe3O4@poly[N-isopropylacrylamide (NIPAM)-co-2-(dimethylamino)ethyl methacrylate (DMAEMA)]@Au (Fe3O4@PND@Au) is developed for magnetically recyclable and thermally tunable catalysis. The negatively charged Au nanoparticles with an average diameter of 10 nm are homogeneously loaded onto positively charged
Wei Luo et al.
Nanoscale, 9(27), 9548-9555 (2017-07-01)
The responsive photonic crystal (RPC) balls with adjustable lattice constant and controllable rotation developed to date are all based on Janus particles of three dimensional (3-D) periodical structures, which suffer from color uneveness and asymmetric volume change, limiting the applications
Carl Julien et al.
Methods in molecular biology (Clifton, N.J.), 849, 473-491 (2012-04-25)
Tau is a highly soluble microtubule-associated protein (MAP) that is abundant in the central nervous system and expressed mainly in neuronal axons. Intracellular aggregates of insoluble tau protein are present in a group of neurodegenerative diseases called tauopathies, which include
Mi-Joung Lee et al.
Lymphatic research and biology, 12(4), 282-288 (2014-11-21)
Taxanes can cause fluid accumulation by increasing extracellular fluid (ECF). Taxane-based regimens are standard of care for early breast cancer, but it is unknown whether they increase the risk of lymphedema. The aim of this study was to describe the
Ariel Wang et al.
Cells, 10(5) (2021-05-01)
Pulmonary arterial adventitial fibroblasts (PAAFs) are important regulators of fibrotic vascular remodeling during the progression of pulmonary arterial hypertension (PAH), a disease that currently has no effective anti-fibrotic treatments. We conducted in-vitro experiments in PAAFs cultured on hydrogels attached to
German A Parada et al.
Advanced healthcare materials, 6(19) (2017-07-18)
Hydrogels have been proposed for sensing, drug delivery, and soft robotics applications, yet most of these materials suffer from low mechanical robustness and high permeability to small molecules, limiting their widespread use. This study reports a general strategy and versatile
Dariusz Suchy et al.
Naunyn-Schmiedeberg's archives of pharmacology, 387(8), 733-742 (2014-05-02)
Macrophages are crucial for the development of atherosclerotic plaques. Classically activated macrophages contribute to plaque growth and destabilization, while alternatively activated macrophages increase plaque stability. Here, we assessed the influence of ezetimibe on the activation of monocyte-derived macrophages isolated from
Mingquan Liu et al.
Journal of chromatography. A, 1218(2), 286-292 (2010-12-15)
A temperature-responsive poly(N-isopropylacrylamide-co-N,N'-methylenebisacrylamide) [poly(NIPAAm-co-BIS)] monolith was prepared via a free-radical polymerization technique using an aqueous redox initiator in solution at -12°C. The effect of the % T (total monomer concentration/100 mL) and % C (cross-linker concentration/100 mL) on the visual
Paolo Ferruti et al.
Macromolecular bioscience, 14(3), 390-400 (2014-05-14)
A linear amphoteric poly(amidoamino acid), L-ARGO7, is prepared by Michael-type polyaddition of L-arginine with N,N'-methylenebisacrylamide. Chain-extension of acrylamide end-capped L-ARGO7 oligomers with piperazine leads to high-molecular-weight copolymers in which L-arginine maintains its absolute configuration. Acid/base properties of L-ARGO7 polymers show
Marta Puig et al.
Molecular cancer research : MCR, 13(1), 161-173 (2014-10-05)
The crucial role of tumor-associated fibroblasts (TAF) in cancer progression is now clear in non-small cell lung cancer (NSCLC). However, therapies against TAFs are limited due to a lack of understanding in the subtype-specific mechanisms underlying their accumulation. Here, the
Timothy G Short et al.
Anesthesia and analgesia, 121(2), 357-365 (2015-05-21)
An association between relatively deep anesthesia, as guided by the bispectral index (BIS), and increased postoperative mortality has been demonstrated in 6 of 8 published observational studies, but association does not necessarily mean causality. Small clinical trials of anesthetic depth
Yi-Wei Huang et al.
Journal of cellular physiology, 230(9), 2086-2097 (2015-02-03)
Ca(2+) -mediated formation of cell polarity is essential for directional migration which plays an important role in physiological and pathological processes in organisms. To examine the critical role of store-operated Ca(2+) entry, which is the major form of extracellular Ca(2+)
Christopher A Dieni et al.
PeerJ, 2, e558-e558 (2014-09-12)
The wood frog, Rana sylvatica, survives whole-body freezing and thawing each winter. The extensive adaptations required at the biochemical level are facilitated by alterations to signaling pathways, including the insulin/Akt and AMPK pathways. Past studies investigating changing tissue-specific patterns of
Sang Heon Kim et al.
Analytica chimica acta, 1131, 80-89 (2020-09-16)
Sharp-tipped anisotropic silver (Ag) nanostructures are attracting increasing attention because of their unusual optical properties. However, the sharp tips make such nanostructures thermodynamically unstable; thus, they have been considered unsuitable for use in colorimetric sensing because of their tendency to
Jintian Cheng et al.
Electrophoresis, 34(8), 1189-1196 (2013-02-14)
A polar polymethacrylate-based monolithic column was introduced and evaluated as a hydrophilic interaction CEC stationary phase. The monolithic stationary phase was prepared by in situ copolymerization of a neutral monomer 2-hydroxyethyl methacrylate and a polar cross-linker N,N'-methylene bisacrylamide in a
Chaenyung Cha et al.
Journal of biomaterials science. Polymer edition, 26(13), 828-840 (2015-06-13)
Poly(lactic-co-glycolic acid) (PLGA) microspheres have been widely used as drug carriers for minimally invasive, local, and sustained drug delivery. However, their use is often plagued by limited controllability of encapsulation efficiency, initial burst, and release rate of drug molecules, which
Kıvılcım Çaktü et al.
Artificial cells, nanomedicine, and biotechnology, 42(6), 365-375 (2013-12-07)
Cholesterol-imprinted monosize poly(glycidyl methacrylate-N-methacryloyl-(L)-tyrosine methylester) microspheres were embedded into the poly(hydroxyethyl methacrylate) (PHEMA) cryogels and the resulting composite cryogel was used for the selective removal of cholesterol. Composite cryogels were characterized by swelling tests, multipoint BET apparatus, SEM, FTIR and
Multicolor polymer-dispersed liquid crystal.
Naomi Kumano et al.
Advanced materials (Deerfield Beach, Fla.), 23(7), 884-888 (2010-12-29)
Jens Moeller et al.
PloS one, 13(1), e0189901-e0189901 (2018-01-04)
Polyacrylamide gels functionalized with extracellular matrix proteins are commonly used as cell culture platforms to evaluate the combined effects of extracellular matrix composition, cell geometry and substrate rigidity on cell physiology. For this purpose, protein transfer onto the surface of
Ufuk Kuyrukluyıldız et al.
International journal of clinical and experimental medicine, 8(4), 5691-5698 (2015-07-02)
Backround: Surgical operations are alternative treatments in persons with Obstructive Sleep Apnea Syndrome who cannot tolerate continuous positive airway pressure therapy. Drug-Induced Sleep Endoscopy is a method with which somnolence is pharmacologically induced and collapse is evaluated through nasal endoscopy
C Zeng et al.
Bioorganic & medicinal chemistry, 23(17), 5702-5708 (2015-07-30)
The T box riboswitch is an intriguing potential target for antibacterial drug discovery. Found primarily in Gram-positive bacteria, the riboswitch regulates gene expression by selectively responding to uncharged tRNA to control transcription readthrough. Polyamines and molecular crowding are known to
Tobias Werther et al.
Neonatology, 107(1), 34-41 (2014-10-18)
The lower margin amplitude (LMA) of the amplitude-integrated electroencephalogram (aEEG) is suppressed in neonates during deep sedation, a feature that is attributed to the bispectral index (BIS) in adults. We compare the BIS and the LMA of the aEEG in
Shaoxuan Yu et al.
Nanotechnology, 26(14), 145703-145703 (2015-03-19)
Selenium nanoparticles (Se NPs) possess well-known excellent biological activities and low toxicity, and have been employed for numerous applications except as inhibitors to protein glycation. Herein, the present study is carried out to investigate the inhibitory effect of Se NPs
Yu Liu et al.
PloS one, 10(4), e0123862-e0123862 (2015-04-18)
The CONCERT-CL closed-loop infusion system designed by VERYARK Technology Co., Ltd. (Guangxi, China) is an innovation using TCI combined with closed-loop controlled intravenous anesthesia under the guide of BIS. In this study we performed a randomized, controlled, multicenter study to
Varun Kesherwani et al.
Neuroscience letters, 576, 45-50 (2014-06-07)
Fasudil (HA-1077), a specific Rho kinase II (ROCKII) inhibitor, is in clinical trials for recovery from spinal cord injury (SCI). The primary role of Fasudil is in axonal regeneration, as it inhibits ROCKII, the key signaling molecule involved in collapse
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