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14668

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Tomoaki Haraguchi et al.
Journal of agricultural and food chemistry, 62(24), 5589-5594 (2014-05-27)
This study demonstrated that 0.5% dietary rutin, ellagic acid, or curcumin markedly increased cecal succinate levels in rats fed a high-fat diet, whereas catechin, caffeic acid, and quercetin did not. Other organic acids were modestly or hardly affected by polyphenols.
Shuang Zhang et al.
Molecules (Basel, Switzerland), 17(12), 13917-13922 (2012-11-28)
Four phenolic compounds were isolated from the roots of Sanguisorba officinalis L. by silica gel column chromatography and preparative HPLC. On the basis of chemical and spectroscopic methods, their structures were identified as methyl 4-O-β-D-glucopyranosy-5-hydroxy-3-methoxylbenzoate (1), 3,3′,4′-tri-O-methylellagic acid (2), fisetinidol-(4α-8)-catechin
Jung-Heun Ha et al.
The Journal of nutrition, 144(6), 799-806 (2014-04-05)
Inflammation and endoplasmic reticulum (ER) stress are common denominators for vision-threatening diseases such as diabetic retinopathy and age-related macular degeneration. Based on our previous study, supplementation with muscadine grape polyphenols (MGPs) alleviated systemic insulin resistance and proinflammatory responses. In this
Bing Tang et al.
International journal of cardiology, 180, 134-141 (2014-12-02)
Pulmonary artery hypertension (PAH) is characterized by vascular remodeling, high pulmonary blood pressure, and right ventricular hypertrophy. Oxidative stress, inflammation and pulmonary artery remodeling are important components in PAH. Ellagic acid (EA) is a phenolic compound with anti-oxidative, anti-inflammatory, and
Yoshiyuki Morishima et al.
American journal of clinical pathology, 143(2), 241-247 (2015-01-18)
Edoxaban, an oral direct factor Xa inhibitor, does not require routine monitoring. However, assessment of the anticoagulant effects may be required in certain situations. We investigated the effects of edoxaban on prothrombin time (PT), activated partial thromboplastin time (aPTT), and
Tony K McGhie et al.
Food & function, 3(11), 1170-1175 (2012-08-18)
We report the detection of JAK2 inhibitory activity in a Boysenberry (Rubus loganbaccus x R. baileyanus Britt.) drink using a combination of analytical-scale high performance liquid chromatography (HPLC) with a high-sensitivity time-resolved fluorescence coupled with fluorescence resonance energy transfer (TR-FRET)
V Arulmozhi et al.
Colloids and surfaces. B, Biointerfaces, 110, 313-320 (2013-06-05)
Ellagic acid (EA), a naturally occurring polyphenolic compound is well documented for its anticancer property in numerous pre-clinical models. The properties like poor water solubility and limited oral bio-availability of ellagic acid has hampered its clinical applications. The present study
Ellagic acid protects against cisplatin-induced nephrotoxicity in rats: a dose-dependent study.
H Nasri
European review for medical and pharmacological sciences, 17(6), 849-850 (2013-04-24)
Sonia Trombino et al.
Anticancer research, 33(11), 4847-4854 (2013-11-14)
The aim of the present study was to prepare a hydrogel, based on ellagic acid and glycine, embedded with folic acid, as a subcutaneous implant for the treatment of breast cancer. The function of folic acid is to selectively and
Marjan Van Blerk et al.
Thrombosis and haemostasis, 113(1), 154-164 (2014-09-19)
The Belgian national External Quality Assessment Scheme performed a nationwide survey using lyophilised plasma samples spiked with dabigatran or rivaroxaban to demonstrate to the Belgian clinical laboratories how these drugs affect their routine coagulation assays prothrombin time (PT), activated partial
Jatinder Rana et al.
Journal of cosmetic science, 64(6), 445-453 (2014-01-09)
Current efforts to develop effective skin lightening products through the inhibition of melanin production have focused on compounds that inhibit the function and activity of tyrosinase, the rate-limiting enzyme in the melanin biosynthesis pathway. Synthetic tyrosinase inhibitors, such as hydroquinone
Bin Li et al.
Carbohydrate polymers, 92(2), 1443-1450 (2013-02-13)
Structurally varied, carboxyl-containing cellulose derivatives were evaluated for their ability to form amorphous solid dispersions (ASD) with ellagic acid (EA), in order to improve the solubility of this high-melting, poorly bioavailable, but highly bioactive natural flavonoid compound. ASDs of EA
Saar Aharoni et al.
BioFactors (Oxford, England), 41(1), 44-51 (2015-02-05)
It was documented that pomegranate has anti-inflammatory effects. In this study, we investigated a direct effect of pomegranate juice (PJ) and its polyphenols on macrophage inflammatory phenotype. In vitro, PJ and its major polyphenols dose-dependently attenuated macrophage response to M1
Yaghoob Farbood et al.
Life sciences, 124, 120-127 (2015-02-01)
Traumatic brain injury (TBI) remains one of the main clinical problems globally and is a common cause of death among youth. Cognitive defects such as thinking, memory and behavior or mental health disorders are considered as the most frequent effects
Andreia R H da Silva et al.
Journal of ethnopharmacology, 153(3), 908-916 (2014-04-08)
Scutia buxifolia is a native tree of Southern Brazil, Uruguay, and Argentina, which is popularly known as "coronilha" and it is used as a cardiotonic, antihypertensive and diuretic substance. The aim of this study was to assess the acute and
Ana Oliveira et al.
Food chemistry, 171, 370-378 (2014-10-14)
An immediate decrease in the total antioxidant activity (23%) and total phenolic content (14%) was observed after addition of strawberry preparations to yoghurt. The total anthocyanin content did not change immediately, but decreased 24% throughout the yoghurt shelf-life. The individual
Ephraim Philip Lansky
Journal of medicinal food, 9(1), 119-122 (2006-04-04)
A recent profusion of pomegranate nutraceutical products, "standardized to 40% ellagic acid," has appeared in the marketplace. This Perspective reviews the chemical and functional studies of pomegranate as well as the virtues and dangers of ellagic acid, and concludes that
B Kaiser et al.
Thrombosis research, 65(2), 157-164 (1992-01-15)
Using biochemically defined conditions on a fast kinetic centrifugal analyzer the effect of recombinant hirudin (rH) and unfractionated heparin (UH) on thrombin and factor Xa generation was investigated. Diluted fibrinogen deficient human plasma was incubated with increasing concentrations of the
Ting-Yu Kao et al.
Anticancer research, 32(10), 4413-4418 (2012-10-13)
Ellagic acid has been demonstrated to inhibit the growth of several types of cancer cells. However, whether it sensitizes human colorectal carcinoma cells to 5-fluorouracil, has not yet been investigated. Colorectal carcinoma HT-29, Colo 320DM, SW480 and LoVo cells were
Valentina Furlanetto et al.
Journal of agricultural and food chemistry, 60(36), 9162-9170 (2012-08-29)
Ellagic acid (EA), a natural polyphenol abundant in fruits and common in our diet, is under intense investigation for its chemopreventive activity resulting from multiple effects. EA inhibits topoisomerase II, but the effects on the human enzyme of urolithins, its
Aleksandra Owczarek et al.
Acta poloniae pharmaceutica, 70(1), 111-114 (2013-04-25)
Aerial and underground parts of Geum rivale (Rosaceae) were investigated. Tiliroside, gallic acid, ellagic acid and a sterol fraction were isolated from aerial parts of the plant. The sterol fraction was analyzed using GC-MS. Eleven phenolic acids were identified in
Rocío González-Barrio et al.
Journal of agricultural and food chemistry, 58(7), 3933-3939 (2010-03-12)
The fate of anthocyanins, ellagic acid, and ellagitannins was studied following the consumption of 300 g of raspberries by healthy human volunteers and subjects with an ileostomy. Postingestion plasma and urine from the former and ileal fluid and urine from
Irwin R A Menezes et al.
Pharmaceutical biology, 53(2), 185-191 (2014-09-27)
Murraya paniculata (Linn) JACK (Rutaceae) is used in traditional medicine in the treatment of diabetes, inflammation, and microbial disorders. This study determined the polyphenol composition and antimicrobial and acute toxicological activity of the hydroethanolic extract of M. paniculata leaves (EEMp).
Antonio Aguilera-Carbo et al.
Applied microbiology and biotechnology, 78(2), 189-199 (2007-12-25)
In the last years, tannin biodegradation has been the subject of a lot of studies due to its commercial importance and scientific relevance. Tannins are molecules of low biodegradation and represent the main chemical group of natural anti-microbials occurring in
Rocío García-Villalba et al.
Journal of agricultural and food chemistry, 61(37), 8797-8806 (2013-08-30)
Ellagic acid (EA) is converted to urolithins by gut microbiota. Urolithins have beneficial biological effects in humans, but differences in urolithin production capacity among individuals have been shown. Therefore, the identification of the urolithin production pathways and the microorganisms implicated
Patrice Njomnang Soh et al.
PloS one, 7(9), e45906-e45906 (2012-10-03)
The search for new antimalarial chemotherapy has become increasingly urgent due to parasite resistance to current drugs. Ellagic acid (EA) is a polyphenol, recently found in various plant products, that has effective antimalarial activity in vitro and in vivo without
Carolyn Bell et al.
The Journal of pharmacy and pharmacology, 60(2), 139-144 (2008-02-02)
There is currently a shifting focus towards finding natural compounds that may prevent or treat cancer, due to the problems that exist with current chemotherapeutic regimens. The fruit of the Punica granatum (pomegranate) contains hundreds of phytochemicals and pomegranate extracts
Amanda Dahl et al.
Journal of drugs in dermatology : JDD, 12(1), 52-58 (2013-02-05)
Hydroquinone (HQ) is the benchmark prescription agent for skin lightening. However, HQ use is recently banned in Europe and in parts of Asia because of potential long-term consequences, including carcinogenesis when orally consumed. This has resulted in development of alternative
Min Zhao et al.
Cancer letters, 337(2), 210-217 (2013-05-21)
Ellagic acid (EA) is a polyphenol found in several plants and fruits. The objectives of this study were to examine the molecular mechanisms by which EA inhibits pancreatic cancer growth in Balb C nude mice. PANC-1 cells were injected subcutaneously
Coskun Usta et al.
International journal of food sciences and nutrition, 64(7), 907-913 (2013-05-25)
In recent years, the therapeutic use of non-drug substances such as herbal and medicinal foods is increasing progressively. Of these substances, Punica granatum L., which is an ancient and highly distinctive fruit, has been proposed for treatment of several different
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