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Y Murakami et al.
Cell death and differentiation, 21(11), 1746-1757 (2014-07-19)
The CD300 receptor family members are a group of molecules that modulate a variety of immune cell processes. We show that mouse CD300b (CLM7/LMIR5), expressed on myeloid cells, recognizes outer membrane-exposed phosphatidylserine (PS) and does not, as previously reported, directly
Atsushi Kanda et al.
The British journal of nutrition, 111(12), 2067-2078 (2014-03-07)
We have previously shown that whey protein hydrolysate (WPH) causes a greater increase in muscle protein synthesis than does a mixture of amino acids that is identical in amino acid composition. The present study was conducted to investigate the effect
Adam A Profit et al.
Archives of biochemistry and biophysics, 567, 46-58 (2014-12-20)
A comprehensive investigation of peptides derived from the 22-29 region of human islet amyloid polypeptide (hIAPP) that contain phenylalanine analogs at position 23 with a variety of electron donating and withdrawing groups, along with heteroaromatic surrogates, has been employed to
Daniel Cavanagh et al.
Applied and environmental microbiology, 81(12), 3961-3972 (2015-04-05)
Lactococcus lactis is predominantly associated with dairy fermentations, but evidence suggests that the domesticated organism originated from a plant niche. L. lactis possesses an unusual taxonomic structure whereby strain phenotypes and genotypes often do not correlate, which in turn has
Erin M B McNerny et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(3), 455-464 (2014-09-13)
Collagen cross-linking is altered in many diseases of bone, and enzymatic collagen cross-links are important to bone quality, as evidenced by losses of strength after lysyl oxidase inhibition (lathyrism). We hypothesized that cross-links also contribute directly to bone fracture toughness.
Michel Wagner et al.
Rapid communications in mass spectrometry : RCM, 29(18), 1632-1640 (2015-10-16)
An isotopic labeling strategy based on derivatizing amine-containing metabolites has been developed using light ((12) C6 ) and heavy ((13) C6 ) N-benzoyloxysuccinimide reagents for semi-targeted metabolomic applications. Differentially labeled samples were combined and analyzed simultaneously by liquid chromatography/high-resolution tandem
Kerstin A Heyl et al.
mBio, 5(5), e01492-e01414 (2014-08-28)
The C-type lectin receptor Dectin-1 is expressed mainly on myeloid cells mediating the immune response targeting respiratory pathogens such as Aspergillus fumigatus and Mycobacterium tuberculosis. The pulmonary epithelium serves as an important interface for interactions between these pathogens and the
Michael P Torrens-Spence et al.
Phytochemistry, 106, 37-43 (2014-08-12)
Plant aromatic amino acid decarboxylases (AAADs) catalyze the decarboxylation of aromatic amino acids with either benzene or indole rings. Because the substrate selectivity of AAADs is intimately related to their physiological functions, primary sequence data and their differentiation could provide
Audrey Roy-Lachapelle et al.
Analytical and bioanalytical chemistry, 407(18), 5487-5501 (2015-05-04)
A new analytical method was developed for the detection of alkaloid cyanotoxins in harmful algal blooms. The detection of the nonproteinogenic amino acid β-N-methylamino-L-alanine (BMAA) and two of its conformation isomers, 2,4-diaminobutyric acid (DAB) and N-(2-aminoethyl) glycine (AEG), as well
Devika Subramanian et al.
Gene, 574(1), 149-162 (2015-08-10)
Staphylococcus aureus is a major human pathogen and ramoplanin is an antimicrobial attributed for effective treatment. The goal of this study was to examine the transcriptomic profiles of ramoplanin sensitive and resistant S. aureus to identify putative modules responsible for
Hidetada Matsuoka et al.
American journal of physiology. Cell physiology, 309(4), C251-C263 (2015-06-19)
TWIK-related acid-sensitive K(+) (TASK) channels produce background K(+) currents. We elucidated that TASK1 channels in rat adrenal medullary cells and PC12 cells are internalized in a clathrin-dependent manner in response to nerve growth factor (NGF). Here, the molecular mechanism for
Rima Chattopadhyay et al.
Journal of lipid research, 56(3), 562-577 (2015-01-06)
To understand the mechanisms of 15(S)-HETE-induced endothelial cell (EC) barrier dysfunction, we examined the role of xanthine oxidase (XO). 15(S)-HETE induced junction adhesion molecule A (JamA) phosphorylation on Y164, Y218, and Y280 involving XO-mediated reactive oxygen species production and Src
Toni E Newsome et al.
Journal of chromatography. A, 1364, 261-270 (2014-09-15)
Nanofibrous silica-based stationary phases for electrospun ultra-thin layer chromatography (E-UTLC) are described. Nanofibers were produced by electrospinning a solution of silica nanoparticles dispersed in polyvinylpyrrolidone solutions to create composite silica/polymer nanofibers. Stationary phases were created from as-spun nanofibers, or the
Christina Li-Ping Thio et al.
PloS one, 10(6), e0129033-e0129033 (2015-06-18)
The Chikungunya virus (CHIKV) is an arthropod borne virus. In the last 50 years, it has been the cause of numerous outbreaks in tropical and temperate regions, worldwide. There is limited understanding regarding the underlying molecular mechanisms involved in CHIKV
Gehad G Mohamed et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 60(13), 3141-3154 (2004-10-13)
The ternary piroxicam (Pir; 4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) complexes of Fe(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) with various amino acids (AA) such as glycine (Gly) or DL-phenylalanine (PhA) were prepared and characterized by elemental analyses, molar conductance, IR, UV-Vis, magnetic moment
Libo He et al.
BMC genomics, 16, 184-184 (2015-04-19)
Compensatory growth is accelerated compared with normal growth and occurs when growth-limiting conditions are overcome. Most animals, especially fish, are capable of compensatory growth, but the mechanisms remain unclear. Further investigation of the mechanism of compensatory growth in fish is
Jinrui Gan et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(7), 1715-1723 (2015-07-15)
We report a novel platform using optimized SiO2@Au core-shell structures as matrices for highly efficient laser desorption/ionization mass spectrometry analysis of small biomolecules (MW<700 Da). Owing to the designer structure, SiO2@Au nanoshells can achieve low detection-of-limits (~pmol-fmol) in mass spectrometry
Raja R Pillai et al.
The Journal of nutrition, 145(5), 954-959 (2015-03-13)
Lysine requirements of well-nourished children from developing regions have been found to be similar to those of children from developed regions (33.5 mg · kg⁻¹ · d⁻¹). However, intestinal parasites have been shown to increase lysine requirements in undernourished adults, and it is not
James A Stapleton et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(31), 9632-9637 (2015-07-23)
Advances in computational design methods have made possible extensive engineering of soluble proteins, but designed β-barrel membrane proteins await improvements in our understanding of the sequence determinants of folding and stability. A subset of the amino acid residues of membrane
Agnes Lau et al.
EMBO molecular medicine, 7(3), 339-356 (2015-02-11)
The cellular prion protein (PrP(C)) comprises a natively unstructured N-terminal domain, including a metal-binding octarepeat region (OR) and a linker, followed by a C-terminal domain that misfolds to form PrP(S) (c) in Creutzfeldt-Jakob disease. PrP(C) β-endoproteolysis to the C2 fragment
Xingfeng Li et al.
Food chemistry, 186, 265-270 (2015-05-16)
Phenyllactic acid, a phenolic acid phytochemical with the antimicrobial activity, was rarely reported in food besides honey and sourdough. This study evidenced a new food source of phenyllactic acid and elucidated its metabolic mechanism. Phenyllactic acid naturally occurred in Chinese
Zhen Zeng et al.
Food chemistry, 188, 591-595 (2015-06-05)
The formation of 2-vinylfuran from the corresponding 4-oxo-2-hexenal (OHE, a lipid oxidation product) under the catalysis of amino acid were studied. The effects of amino acids, reaction temperature, reaction time, water content, pH, metallic ions and some food additives on
Ping Chen et al.
Gene, 567(2), 138-145 (2015-05-11)
In insects, pigment patterns are formed by melanin, ommochromes, and pteridines. Here, the effects of pteridine synthesis on melanin formation were studied using 4th instar larvae of a wild-type silkworm strain, dazao (Bombyx mori), with normal color and markings. Results
F Tamarozzi et al.
Parasite immunology, 36(10), 494-502 (2014-06-10)
The host inflammatory response to the Onchocerca volvulus endosymbiont, Wolbachia, is a major contributing factor in the development of chronic pathology in humans (onchocerciasis/river blindness). Recently, the toll-like pattern recognition receptor motif of the major inflammatory ligands of filarial Wolbachia
Johanne M Lewis et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 187, 177-183 (2015-06-09)
Antarctic icefishes (Family Channichthyidae) within the suborder Notothenioidei lack the oxygen-binding protein hemoglobin (Hb), and six of the 16 species of icefishes lack myoglobin (Mb) in heart ventricle. As iron-centered proteins, Hb and Mb can promote the formation of reactive
Courtney J Sobers et al.
Biomaterials, 52, 385-394 (2015-03-31)
This work uses global gene expression analysis to compare the extent to which model substrates presenting peptide adhesion motifs mimic the use of conventional extracellular matrix protein coated substrates for cell culture. We compared the transcriptional activities of genes in
Sohei Nakayama et al.
Cancer research, 74(20), 5891-5902 (2014-08-29)
The discovery of somatic mutations in EGFR and development of EGFR tyrosine kinase inhibitors (TKI) have revolutionized treatment for lung cancer. However, resistance to TKIs emerges in almost all patients and currently no effective treatment is available. Here, we show
Vinod Kumar et al.
Archives of biochemistry and biophysics, 566, 15-25 (2014-12-21)
Legume Bowman-Birk inhibitors (BBIs) that inhibit mammalian proteases exist as dimers in solution. The structural basis governing dimerization of HGI-III (horsegram seed BBI) was investigated. An intra-monomer salt bridge (D76-K71) stabilizes an atypical hook-like conformation at the C-terminus. We postulate
Equilibrium and kinetic studies of the enantioselective complexation of (dl)-phenylalanine with copper (II) N-decyl-(l)-hydroxyproline.
Pickering PJ and Chaudhuri JB.
Chemical Engineering Science, 52(3), 377-386 (1997)
Wei Huang et al.
Organic letters, 17(21), 5344-5347 (2015-10-17)
The cyclizidine biosynthetic gene cluster was identified from Streptomyces NCIB 11649, which revealed the polyketide biosynthetic machinery for cyclizidine alkaloid biosynthesis. Both in vivo mutagenesis study and in vitro biochemical analysis provided insight into the timing and mechanism of the
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