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Jeff S Bowman et al.
PloS one, 10(8), e0135868-e0135868 (2015-08-19)
Taxonomic marker gene studies, such as the 16S rRNA gene, have been used to successfully explore microbial diversity in a variety of marine, terrestrial, and host environments. For some of these environments long term sampling programs are beginning to build
Melinda L Micallef et al.
BMC genomics, 16, 669-669 (2015-09-04)
Cyanobacteria are well known for the production of a range of secondary metabolites. Whilst recent genome sequencing projects has led to an increase in the number of publically available cyanobacterial genomes, the secondary metabolite potential of many of these organisms
Zian Lin et al.
The Analyst, 140(15), 5287-5294 (2015-06-19)
CuFe2O4 magnetic nanocrystal clusters (CuFe2O4 MNCs) were proposed as a new matrix for small molecule analysis by negative ion matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for the first time. We demonstrated its advantages over conventional organic matrices in
Grete Andersen et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 308(2), R123-R130 (2014-11-21)
In healthy individuals, postexercise protein supplementation increases muscle protein anabolism. In patients with muscular dystrophies, aerobic exercise improves muscle function, but the effect of exercise on muscle protein balance is unknown. Therefore, we investigated 1) muscle protein balance before, during
Adam A Profit et al.
Archives of biochemistry and biophysics, 567, 46-58 (2014-12-20)
A comprehensive investigation of peptides derived from the 22-29 region of human islet amyloid polypeptide (hIAPP) that contain phenylalanine analogs at position 23 with a variety of electron donating and withdrawing groups, along with heteroaromatic surrogates, has been employed to
XRD, thermal and FTIR studies on gel grown DL-Phenylalanine crystals.
Ramachandran E and Natarajan S.
Crystal Research and Technology, 42(6), 617-620 (2007)
Ying Zhou et al.
The Analyst, 139(12), 3122-3126 (2014-05-03)
A new type of rapid, sensitive, and selective fluorescence turn-on assay was developed for detection of histidine using a DNA-scaffolded silver nanocluster/Cu(2+) ensemble (DNA-AgNC/Cu(2+)). Cu(2+) was first bound to nucleic acids of the DNA-AgNCs forming a DNA-AgNC/Cu(2+) ensemble and then
Marina Berditsch et al.
Applied and environmental microbiology, 81(11), 3593-3603 (2015-03-22)
Gramicidin S (GS) is a nonribosomally synthesized decapeptide from Aneurinibacillus migulanus. Its pronounced antibiotic activity is attributed to amphiphilic structure and enables GS interaction with bacterial membranes. Despite its medical use for over 70 years, the peptide-lipid interactions of GS
Chi-Chou Huang et al.
Oncotarget, 6(11), 8698-8708 (2015-04-01)
Stabilization of Bcl-2 protein by paxillin (PXN)-mediated ERK activation was recently reported to cause an unfavorable response to 5-Fluorouracil-based chemotherapy. Here, we present evidence from cell and animal models to demonstrate that stabilization of Bcl-2 protein by phosphorylation at Serine
Jennifer L Anderson et al.
Molecular cancer research : MCR, 12(12), 1740-1754 (2014-08-06)
Members of the Ewing sarcoma family of tumors (ESFT) contain tumor-associated translocations that give rise to oncogenic transcription factors, most commonly EWS/FLI1. EWS/FLI1 plays a dominant role in tumor progression by modulating the expression of hundreds of target genes. Here
Varongsiri Kemsawasd et al.
Applied microbiology and biotechnology, 99(23), 10191-10207 (2015-08-11)
In this study, the influence of twenty different single (i.e. 19 amino acids and ammonium sulphate) and two multiple nitrogen sources (N-sources) on growth and fermentation (i.e. glucose consumption and ethanol production) performance of Saccharomyces cerevisiae and of four wine-related
Weidong Liu et al.
Chembiochem : a European journal of chemical biology, 16(6), 924-929 (2015-03-11)
A meso-diaminopimelate dehydrogenase (DAPDH) from Clostridium tetani E88 (CtDAPDH) was found to have low activity toward the D-amino acids other than its native substrate. Site-directed mutagenesis similar to that carried out on the residues mutated by Vedha-Peters et al. resulted
Shuji Wakatsuki et al.
The Journal of cell biology, 211(4), 881-896 (2015-11-18)
Oxidative stress is a well-known inducer of neuronal apoptosis and axonal degeneration. We previously showed that the E3 ubiquitin ligase ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B activation. We now demonstrate that oxidative stress serves as an
Franca F Kirchberg et al.
The Journal of clinical endocrinology and metabolism, 100(1), 149-158 (2014-11-05)
The protective effect of breast-feeding against later obesity may be explained by the lower protein content compared with formula milk. However, the metabolic mechanisms remain unknown. We studied the metabolic response to a higher or lower protein supply in infancy.
Chunhua Yu et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(3), G146-G161 (2015-06-06)
Metaplastic epithelial cells of Barrett's esophagus transformed by the combination of p53-knockdown and oncogenic Ras expression are known to activate signal transducer and activator of transcription 3 (STAT3). When phosphorylated at tyrosine 705 (Tyr705), STAT3 functions as a nuclear transcription
Avrajit Chakraborty et al.
Molecular genetics and genomics : MGG, 290(4), 1523-1542 (2015-03-01)
We generated the bast transcriptomes of a deficient lignified phloem fibre mutant and its wild-type jute (Corchorus capsularis) using Illumina paired-end sequencing. A total of 34,163 wild-type and 29,463 mutant unigenes, with average lengths of 1442 and 1136 bp, respectively
Rachel Schwartz-Narbonne et al.
Scientific reports, 5, 9791-9791 (2015-06-10)
Understanding woolly mammoth ecology is key to understanding Pleistocene community dynamics and evaluating the roles of human hunting and climate change in late Quaternary megafaunal extinctions. Previous isotopic studies of mammoths' diet and physiology have been hampered by the 'mammoth
Yunjun Liu et al.
Transgenic research, 24(4), 753-763 (2015-03-31)
5-Enolpyruvylshikimate-3-phosphate synthase (EPSPS) and glyphosate N-acetyltransferase (GAT) can detoxify glyphosate by alleviating the suppression of shikimate pathway. In this study, we obtained transgenic tobacco plants overexpressing AM79 aroA, GAT, and both of them, respectively, to evaluate whether overexpression of both
Xuan Zhuang et al.
Scientific reports, 5, 7922-7922 (2015-01-30)
The aim of this study was to identify mRNA targets of dysregulated miRNAs through the integrated analysis of miRNA and mRNA expression profiling in men with normal versus impaired spermatogenesis. The expression of mRNAs and miRNAs in testicular tissues obtained
Jun Yuan et al.
Scientific reports, 5, 13438-13438 (2015-08-25)
The successful colonization of plant growth promoting rhizobacteria (PGPR) in the rhizosphere is an initial and compulsory step in the protection of plants from soil-borne pathogens. Therefore, it is necessary to evaluate the role of root exudates in the colonization
Ayome Abibi et al.
The Journal of biological chemistry, 289(31), 21651-21662 (2014-06-18)
The antimicrobial activity of phenyl-thiazolylurea-sulfonamides against Staphylococcus aureus PheRS are dependent upon phenylalanine levels in the extracellular fluids. Inhibitor efficacy in animal models of infection is substantially diminished by dietary phenylalanine intake, thereby reducing the perceived clinical utility of this
Lai Kuan Tan et al.
PloS one, 9(8), e106329-e106329 (2014-08-30)
Y. enterocolitica and Y. pseudotuberculosis are important food borne pathogens. However, the presence of competitive microbiota makes the isolation of Y. enterocolitica and Y. pseudotuberculosis from naturally contaminated foods difficult. We attempted to evaluate the performance of a modified Cefsulodin-Irgasan-Novobiocin
Ourania N Kostopoulou et al.
PloS one, 10(8), e0134526-e0134526 (2015-08-13)
As fight against antibiotic resistance must be strengthened, improving old drugs that have fallen in reduced clinical use because of toxic side effects and/or frequently reported resistance, like chloramphenicol (CAM), is of special interest. Chloramphenicol (CAM), a prototypical wide-spectrum antibiotic
Vinod Kumar et al.
Archives of biochemistry and biophysics, 566, 15-25 (2014-12-21)
Legume Bowman-Birk inhibitors (BBIs) that inhibit mammalian proteases exist as dimers in solution. The structural basis governing dimerization of HGI-III (horsegram seed BBI) was investigated. An intra-monomer salt bridge (D76-K71) stabilizes an atypical hook-like conformation at the C-terminus. We postulate
Devika Subramanian et al.
Gene, 574(1), 149-162 (2015-08-10)
Staphylococcus aureus is a major human pathogen and ramoplanin is an antimicrobial attributed for effective treatment. The goal of this study was to examine the transcriptomic profiles of ramoplanin sensitive and resistant S. aureus to identify putative modules responsible for
Ping Chen et al.
Gene, 567(2), 138-145 (2015-05-11)
In insects, pigment patterns are formed by melanin, ommochromes, and pteridines. Here, the effects of pteridine synthesis on melanin formation were studied using 4th instar larvae of a wild-type silkworm strain, dazao (Bombyx mori), with normal color and markings. Results
Johanne M Lewis et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 187, 177-183 (2015-06-09)
Antarctic icefishes (Family Channichthyidae) within the suborder Notothenioidei lack the oxygen-binding protein hemoglobin (Hb), and six of the 16 species of icefishes lack myoglobin (Mb) in heart ventricle. As iron-centered proteins, Hb and Mb can promote the formation of reactive
James A Stapleton et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(31), 9632-9637 (2015-07-23)
Advances in computational design methods have made possible extensive engineering of soluble proteins, but designed β-barrel membrane proteins await improvements in our understanding of the sequence determinants of folding and stability. A subset of the amino acid residues of membrane
Jinrui Gan et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(7), 1715-1723 (2015-07-15)
We report a novel platform using optimized SiO2@Au core-shell structures as matrices for highly efficient laser desorption/ionization mass spectrometry analysis of small biomolecules (MW<700 Da). Owing to the designer structure, SiO2@Au nanoshells can achieve low detection-of-limits (~pmol-fmol) in mass spectrometry
Rima Chattopadhyay et al.
Journal of lipid research, 56(3), 562-577 (2015-01-06)
To understand the mechanisms of 15(S)-HETE-induced endothelial cell (EC) barrier dysfunction, we examined the role of xanthine oxidase (XO). 15(S)-HETE induced junction adhesion molecule A (JamA) phosphorylation on Y164, Y218, and Y280 involving XO-mediated reactive oxygen species production and Src
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