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Charles W Schindler et al.
The Journal of pharmacology and experimental therapeutics, 369(3), 328-336 (2019-03-23)
β-Methylphenethylamine [(BMPEA), 2-phenylpropan-1-amine] is a structural isomer of amphetamine (1-phenylpropan-2-amine) that has been identified in preworkout and weight loss supplements, yet little information is available about its pharmacology. Here, the neurochemical and cardiovascular effects of BMPEA and its analogs, N-methyl-2-phenylpropan-1-amine...
Cory R Weissman et al.
The Journal of clinical psychiatry, 79(3) (2018-04-28)
The purpose of this study was to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on suicidal ideation in patients with treatment-resistant major depression (TRD) (patients who failed to clinically respond to at least 2 medication trials). We pooled...
Richard C Tenpenny et al.
ACS chemical neuroscience, 8(5), 987-995 (2017-04-19)
Although serotonin neurotransmission has been implicated in several neurodevelopmental and psychological disorders, the factors that drive dysfunction of the serotonin system are poorly understood. Current research regarding the serotonin system revolves around its dysfunction in neuropsychiatric disorders, but there is...
Haihui Zheng et al.
Biopharmaceutics & drug disposition, 39(7), 344-353 (2018-07-18)
This study aimed to reveal age-related changes in the expression and activity of seven hepatic drug metabolizing enzymes (DMEs) in male wild-type and breast cancer resistance protein knockout (Bcrp1-/- ) FVB mice. The protein expression of four cytochrome P450 (Cyps)...
Dorina Winter et al.
European archives of psychiatry and clinical neuroscience, 267(1), 51-62 (2016-04-20)
Neural underpinnings of emotion dysregulation in borderline personality disorder (BPD) are characterized by limbic hyperactivity and disturbed prefrontal activity. It is unknown whether neural correlates of emotion regulation change after a psychotherapy which has the goal to improve emotion dysregulation...
Claudia Pedron et al.
Neuropeptides, 85, 102094-102094 (2020-11-11)
Fibromyalgia is characterized by the amplification of central nervous system pain with concomitant fatigue, sleep, mood disorders, depression, and anxiety. It needs extensive pharmacological therapy. In the present study, Swiss mice were treated with reserpine (0.25 mg/kg, s.c.) over three consecutive...
Christy Duan et al.
Current psychiatry reports, 19(10), 70-70 (2017-08-22)
Imaging research has sought to uncover brain structure, function, and metabolism in women with postpartum depression (PPD) as little is known about its underlying pathophysiology. This review discusses the imaging modalities used to date to evaluate postpartum depression and highlights...
James M Brimson et al.
Scientific reports, 10(1), 9251-9251 (2020-06-10)
Sigma-1 and sigma-2 receptors are emerging therapeutic targets. We have identified that simple ammonium salts bind to these receptors and are effective in vivo. Radioligand binding assays were used to obtain structure-activity relationships of these salts. MTS assays were performed...
Yifat Eliezer et al.
Current biology : CB, 29(10), 1573-1583 (2019-05-06)
Organisms' capacity to anticipate future conditions is key for survival. Associative memories are instrumental for learning from past experiences, yet little is known about the processes that follow memory retrieval and their potential advantage in preparing for impending developments. Here, using...
Wu Song et al.
Neurochemical research, 43(7), 1371-1382 (2018-05-24)
Depression is a major social and health problem worldwide. Compound K (CK), an intestinal metabolite of panaxadiol ginsenosides, has been demonstrated to possess significant pharmacological effects on the central nervous system (CNS). Here, we set up this study to investigate...
Kevin Champagne-Jorgensen et al.
Brain, behavior, and immunity, 77, 7-15 (2018-12-26)
The use of antibiotics has recently risen to prominence in neuroscience due to their potential value in studying the microbiota-gut-brain axis. In this context they have been largely employed to illustrate the many influences of the gut microbiota on brain...
Jacopo Pasquini et al.
Parkinsonism & related disorders, 77, 170-175 (2019-04-15)
Serotonergic raphe nuclei dysfunction has been documented in Parkinson's disease, both in pathological and neuroimaging studies, and has been associated with scores of tremor and non-motor symptoms. However, no in vivo longitudinal investigations have been conducted to assess the rate...
Jong Min Choi et al.
Biomedical chromatography : BMC, 30(12), 1963-1974 (2016-05-31)
To evaluate changes in tryptophan metabolism and discover diagnostic biomarkers for gastric cancer, a quantitative method was developed for tryptophan and its seven metabolites (indole-3-lactic acid, anthranilic acid, serotonin, nicotinic acid, kynurenic acid, kynurenine and 3-indoxyl sulfate) in both human...
Yan Zheng et al.
Talanta, 211, 120751-120751 (2020-02-20)
At present, probe electrospray ionization mass spectrometry is widely used in the single cell analysis. As the continuous expansion of requirements for detecting more metabolite species from single cells, the sensitivity and accuracy of the instrument and the enrichment capacity...
C Tabeling et al.
Allergy, 72(7), 1061-1072 (2016-12-03)
Spleen tyrosine kinase (Syk) is an intracellular nonreceptor tyrosine kinase, which has been implicated as central immune modulator promoting allergic airway inflammation. Syk inhibition has been proposed as a new therapeutic approach in asthma. However, the direct effects of Syk...
Xiaoshu Sun et al.
Journal of ethnopharmacology, 262, 112998-112998 (2020-06-03)
Natural bear bile powder (NBBP) has been used to treat seizures for thousands of years, but its application is greatly restricted due to ethical reasons. Cultured bear bile powder (CBBP), which is produced by biotransformation, may be an appropriate substitute...
Robert Patejdl et al.
Pflugers Archiv : European journal of physiology, 471(7), 995-1005 (2019-05-03)
Class-I-antiarrhythmics like ajmaline are known to alter smooth muscle function, which may cause alterations in gastrointestinal motility. The effects of ajmaline on isolated gastric and portal vein smooth muscle and the underlying mechanisms are unknown. We studied the effects of...
Zhihua Jia et al.
Molecular pain, 14, 1744806918756466-1744806918756466 (2018-01-23)
Voxel-based morphometry is used to detect structural brain changes in patients with migraine. However, the relevance of migraine and structural changes is not clear. This study investigated structural brain abnormalities based on voxel-based morphometry using a rat model of recurrent...
Debra L Schutte et al.
Research in gerontological nursing, 1-12 (2020-04-15)
The purpose of this study was to examine genetic variability and knee pain in persons with osteoarthritis (OA). Seventy-five participants with medial compartment knee OA were recruited from a large Midwestern tertiary care center. Participants exhibited a mean age of...
Comprehensive Investigation of Metabolic Changes Occurring in the Rat Brain Hippocampus after Fluoxetine Administration Using Two Complementary In Vivo Techniques: Solid Phase Microextraction and Microdialysis.
Boyaci, et al.
ACS Chemical Neuroscience, 11, 3749-3760 (2020)
Panagiotis G Adamopoulos et al.
Gene, 719, 144075-144075 (2019-08-27)
The human L-DOPA decarboxylase (DDC) is a gene that has been in the center of research attention in many laboratories the last decades, due to its major implication in various disorders, including many types of cancer. In the current work...
Thomas Migkos et al.
Planta medica, 86(10), 708-716 (2020-05-15)
The dietary intake of flavonoids seems to be inversely related to cardiovascular mortality. The consumption of isoflavonoids is increasing in the general population, especially due to the use of food supplements and a variety of isoflavonoid-rich foods. However, detailed studies...
Daniel Worms et al.
Protein expression and purification, 164, 105479-105479 (2019-08-24)
The serotonin transporter belongs to the family of sodium-chloride coupled neurotransmitter transporter and is related to depression in humans. It is therefore an important drug target to support treatment of depression. Recently, structures of human serotonin transporter in complex with...
Hirak Chakraborty et al.
Faraday discussions, 207, 409-421 (2018-01-24)
The oligomerization of G protein-coupled receptors (GPCRs) represents an important process in GPCR function and drug discovery. We have addressed cholesterol-dependent oligomerization state of the serotonin1A receptor, a representative GPCR and an important drug target, utilizing photobleaching image correlation spectroscopy...
Pirzada Jamal Ahmed Siddiqui et al.
Bioscience, biotechnology, and biochemistry, 81(7), 1369-1378 (2017-04-14)
Brown seaweeds exhibit several health benefits in treating and managing wide array of ailments. In this study, the antidepressant-like effect of methaolic extracts from Sargassum swartzii (SS), Stoechospermum marginatum (SM), and Nizamuddinia zanardinii (NZ) was examined in forced swimming test...
Yoshihito Shinozaki et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(38), 23970-23981 (2020-09-05)
Fruit set is the process whereby ovaries develop into fruits after pollination and fertilization. The process is induced by the phytohormone gibberellin (GA) in tomatoes, as determined by the constitutive GA response mutant procera However, the role of GA on...
Thangavelu Kokulnathan et al.
Ultrasonics sonochemistry, 44, 231-239 (2018-04-24)
In the modern world, the contamination of ecosystem by human and veterinary pharmaceutical drugs through the metabolic excretion, improper disposal/industrial waste has been subjected to a hot issue. Therefore, exploitation of exclusive structured material and reliable technique is a necessary...
Ross S DeAngelis et al.
The Journal of experimental biology, 223(Pt 17) (2020-09-09)
Female mate choice is a dynamic process that allows individuals to selectively mate with those of the opposite sex that display a preferred set of traits. Because in many species males compete with each other for fertilization opportunities, female mate...
Hina Singh et al.
Journal of neuroinflammation, 17(1), 226-226 (2020-07-31)
HIV-1 infection remains a major public health concern despite effective combination antiretroviral therapy (cART). The virus enters the central nervous system (CNS) early in infection and continues to cause HIV-associated neurocognitive disorders (HAND). The pathogenic mechanisms of HIV-associated brain injury...
Daniel Ojeda-Juárez et al.
Brain, behavior, and immunity, 89, 184-199 (2020-06-15)
People living with HIV (PLWH) continue to develop HIV-associated neurocognitive disorders despite combination anti-retroviral therapy. Lipocalin-2 (LCN2) is an acute phase protein that has been implicated in neurodegeneration and is upregulated in a transgenic mouse model of HIV-associated brain injury....
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