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L Carim et al.
Cytogenetics and cell genetics, 88(3-4), 330-332 (2000-06-01)
We have isolated C15orf3, a novel human gene that lacks homology to any known gene family. The C15orf3 gene encodes a transcript of 1676 nt with an ORF of 187 amino acids and a predicted protein product size of 20.8
Valentina Fodale et al.
PloS one, 9(12), e112262-e112262 (2014-12-03)
In Huntington's disease, expansion of a CAG triplet repeat occurs in exon 1 of the huntingtin gene (HTT), resulting in a protein bearing>35 polyglutamine residues whose N-terminal fragments display a high propensity to misfold and aggregate. Recent data demonstrate that
Marilyn G Wiebe et al.
Applied microbiology and biotechnology, 99(22), 9439-9447 (2015-08-13)
An open reading frame CC1225 from the Caulobacter crescentus CB15 genome sequence belongs to the Gfo/Idh/MocA protein family and has 47 % amino acid sequence identity with the glucose-fructose oxidoreductase from Zymomonas mobilis (Zm GFOR). We expressed the ORF CC1225
Nguyen H Tran et al.
Chemical Society reviews, 42(24), 9454-9479 (2013-09-18)
Presently there is a glut of glycerol as the by-product of biofuel production and it will grow as production increases. The conundrum is how we can consume this material and convert it into a more useful product. One potential route
Wen Qin et al.
Chembiochem : a European journal of chemical biology, 15(18), 2747-2753 (2014-10-30)
Macrolactins (MLNs) have unique structural patterns containing a 24-membered ring lactone and diverse bioactivities. The MLN skeleton is biosynthesized via a trans-acyl transferase (AT) type I polyketide synthase (PKS) pathway, but the tailoring steps are still unknown. Herein, we report
Shweta Mishra et al.
PloS one, 10(1), e0116611-e0116611 (2015-01-31)
New Delhi metallo β-lactamases are one of the most significant emerging resistance determinants towards carbapenem drugs. Their persistence and adaptability often depends on their genetic environment and linkage. This study reports a unique and novel arrangement of blaNDM-1 gene within
K O Tokarchuk et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(1), 25-31 (2013-05-30)
We investigated the changes in the forms of plasma iron and participation of aldehydes in the development of oxidative stress under glycerol-induced rhabdomyolysis in rats. Rhabdomyolysis was caused by intramuscular injection of 50% glycerol in the dose 10 ml/kg. We
Nicholas L Bartelli et al.
Protein science : a publication of the Protein Society, 24(11), 1764-1776 (2015-08-11)
Cytoplasmic domains of transmembrane bacterial chemoreceptors are largely extended four-helix coiled coils. Previous observations suggested the domain was structurally dynamic. We probed directly backbone dynamics of this domain of the transmembrane chemoreceptor Tar from Escherichia coli using site-directed spin labeling
Hong-Bo Wang et al.
Nature communications, 6, 6240-6240 (2015-02-12)
Epstein-Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal epithelial cells remain elusive. EBV glycoprotein B (gB) is the critical fusion protein for infection of both
Jinjin Wu et al.
Environmental research, 138, 67-73 (2015-02-24)
Silver nanoparticles (Ag-NPs) are among the most commonly used nanomaterials and may be exposed to human and ecosystem. Prior in vitro study showed that Ag-NPs compromised neurodevelopment of PC12 cells. This study aims to investigate the effect of prenatal exposure
Laura R Kuck et al.
PloS one, 9(10), e109616-e109616 (2014-10-21)
Titer on Chip (Flu-ToC) is a new technique for quantification of influenza hemagglutinin (HA) concentration. In order to evaluate the potential of this new technique, a comparison of Flu-ToC to more conventional methods was conducted using recombinant HA produced in
Keijiro Hara et al.
Cancer letters, 356(2 Pt B), 496-505 (2014-10-11)
The effect of the third member of the Dickkopf family (DKK3) in the Wnt pathway in glioblastoma remains unclear. We first demonstrated the non-specific interaction of Wnt3a and Wnt5a with the receptors LRP6 and ROR2 and the up-regulation of the
A F Hernández-Pérez et al.
Bioresource technology, 200, 1085-1088 (2015-12-01)
Biotechnological production of xylitol is an attractive route to add value to a sugarcane biorefinery, through utilization of the hemicellulosic fraction of sugarcane straw, whose availability is increasing in Brazil. Herein, supplementation of the sugarcane straw hemicellulosic hydrolyzate (xylose 57gL(-1))
Ying Dong et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 957, 30-35 (2014-03-25)
Glycerol has the latent capacity to act as a plasma volume expander and disguise blood doping practices. Therefore, it has been prohibited in sports as a masking agent by the World Anti-Doping Agency (WADA) since January 2010 and a urinary
Sivankutty Indu et al.
Molecular & cellular proteomics : MCP, 14(12), 3185-3195 (2015-10-04)
DYNLT1 is a member of a gene family identified within the t-complex of the mouse, which has been linked with male germ cell development and function in the mouse and the fly. Though defects in the expression of this gene
Carolien E van de Sandt et al.
Vaccine, 32(43), 5614-5623 (2014-08-21)
Vaccines used against seasonal influenza are poorly effective against influenza A viruses of novel subtypes that may have pandemic potential. Furthermore, pre(pandemic) influenza vaccines are poorly immunogenic, which can be overcome by the use of adjuvants. A limited number of
Junwen Zheng et al.
Journal of immunology research, 2015, 738547-738547 (2015-11-12)
Respiratory syncytial virus (RSV) infection upregulates genes of the suppressor of cytokine signaling (SOCS) family, which utilize a feedback loop to inhibit type I interferon dependent antiviral signaling pathway. Here, we reconstituted RSV nonstructural (NS) protein expression plasmids (pNS1, pNS2
Sunita Maharjan et al.
Scientific reports, 4, 5896-5896 (2014-08-01)
Dysfunctions of the mitochondria and the ubiquitin-proteasome system, as well as generation of reactive oxygen species (ROS), are linked to many aging-related neurodegenerative disorders. However, the order of these events remains unclear. Here, we show that the initial impairment occurs
Justyna Zaborowska et al.
PloS one, 9(9), e107654-e107654 (2014-09-19)
The Herpes Simplex Virus 1 (HSV-1)-encoded ICP22 protein plays an important role in viral infection and affects expression of host cell genes. ICP22 is known to reduce the global level of serine (Ser)2 phosphorylation of the Tyr1Ser2Pro3Thr4Ser5Pro6Ser7 heptapeptide repeats comprising
Francesco Ballestriero et al.
PloS one, 9(10), e109201-e109201 (2014-10-09)
The purple pigment violacein is well known for its numerous biological activities including antibacterial, antiviral, antiprotozoan, and antitumor effects. In the current study we identify violacein as the antinematode agent produced by the marine bacterium Microbulbifer sp. D250, thereby extending
Tristan P C van Doormaal et al.
The Journal of surgical research, 192(1), 200-205 (2014-06-04)
We aim to find a storage protocol for vessels that preserves their dimensional, histologic, and mechanical characteristics to facilitate reproducible anastomosis experiments and microsurgical training with constant quality. We compared stored rabbit aortas, harvested in a slaughterhouse, using five different
Ayten Hijazi et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 4968-4977 (2015-08-19)
Developmental exposure to bisphenol A (BPA) is associated with lung dysfunction and diseases. However, it is unknown if this association has a fetal origin. The present study addressed this important question by examining the effects of BPA on fetal lung
Jennifer C Bailey et al.
Immunology, 143(4), 679-691 (2014-07-06)
CD1d-mediated lipid antigen presentation activates a subset of innate immune lymphocytes called invariant natural killer T (NKT) cells that, by virtue of their potent cytokine production, bridge the innate and adaptive immune systems. Transforming growth factor (TGF-β) is a known
Andrew C Schuerger et al.
Astrobiology, 15(6), 478-491 (2015-06-11)
Between April 2009 and July 2011, the NASA Haughton-Mars Project (HMP) led the Northwest Passage Drive Expedition (NWPDX), a multi-staged long-distance crewed rover traverse along the Northwest Passage in the Arctic. In April 2009, the HMP Okarian rover was driven
K V Dmitruk et al.
TSitologiia i genetika, 47(6), 3-21 (2014-01-21)
Until recently, the methylotrophic yeast was not considered as a potential producer of biofuels, particularly of ethanol from lignocellulosic hydrolysates. The first work published 10 years ago reveals the ability of thermotolerant methylotrophic yeast Hansenula polymorpha to ferment xylose--one of
Clara Pereira et al.
Experimental cell research, 333(1), 73-79 (2015-03-03)
Mutations in Parkin, an E3 ubiquitin ligase, are associated to autosomal recessive Parkinson's disease (PD). Parkin has been mainly implicated, along with Pink1, in mitochondrial autophagy in response to stress. In this study, a yeast model was developed to analyse
D Brouard et al.
Vox sanguinis, 108(2), 197-204 (2014-12-04)
The last two decades have seen major developments in genotyping assays to facilitate the procurement of red blood cell units to alloimmunized patients. To make genotyping faster, simpler and less costly, a nanotechnology approach based on metal/silica fluorescent nanoparticles and
Paola Lorena Smaldini et al.
PloS one, 10(10), e0141116-e0141116 (2015-10-31)
The induction of peripheral tolerance may constitute a disease-modifying treatment for allergic patients. We studied how oral immunotherapy (OIT) with milk proteins controlled allergy in sensitized mice (cholera toxin plus milk proteins) upon exposure to the allergen. Symptoms were alleviated
Kyung Min Jeong et al.
Archives of pharmacal research, 38(12), 2143-2152 (2015-11-05)
Deep eutectic solvents (DESs) were investigated as tunable, environmentally benign, yet superior extraction media to enhance the extraction of anthocyanins from grape skin, which is usually discarded as waste. Ten DESs containing choline chloride as hydrogen bond acceptor combined with
Ying Yang et al.
The Plant cell, 27(9), 2455-2468 (2015-08-25)
The photoperiodic response is one of the most important factors determining heading date in rice (Oryza sativa). Although rhythmic expression patterns of flowering time genes have been reported to fine-tune the photoperiodic response, posttranslational regulation of key flowering regulators has
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