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Britani Nicole Blackstone et al.
Tissue engineering. Part A, 20(19-20), 2746-2755 (2014-04-10)
Autologous engineered skin (ES) offers promise as a treatment for massive full thickness burns. Unfortunately, ES is orders of magnitude weaker than normal human skin causing it to be difficult to apply surgically and subject to damage by mechanical shear
Jianxia Sun et al.
Food chemistry, 154, 330-336 (2014-02-13)
1,3-Dichloro-2-propanol (1,3-DCP) is a well-known food processing contaminant that has been shown to impede male reproductive function. However, its mechanism of action remains elusive. In this study, the effects of 1,3-DCP on progesterone production were investigated using the R2C Leydig
Ivanesa Pardo et al.
Breast cancer research : BCR, 16(2), R26-R26 (2014-03-19)
Our efforts to prevent and treat breast cancer are significantly impeded by a lack of knowledge of the biology and developmental genetics of the normal mammary gland. In order to provide the specimens that will facilitate such an understanding, The
Cara M Hueston et al.
Endocrinology, 155(9), 3527-3537 (2014-06-14)
Although progesterone is most commonly regarded in terms of its role in the female estrous cycle, reproductive behavior, and pregnancy, progesterone is also a precursor to corticosterone (CORT) and is released from the adrenal glands of both sexes in response
Nelson Fuentes-Martínez et al.
Histology and histopathology, 30(1), 87-93 (2014-07-10)
Our previous studies demonstrated the expression of procollagen11A1 in fibroblasts of pancreatic cancer desmoplasia and the lack of expression in fibroblasts of pancreatitis by means of the polyclonal antibody (anti-proCOL11A1 pAb) we generated. In a similar way, we decided to
Prevention of preterm parturition.
Jonathan P Winickoff et al.
The New England journal of medicine, 370(19), 1860-1860 (2014-05-09)
T Tharmalingam-Jaikaran et al.
Reproduction (Cambridge, England), 148(6), 569-580 (2014-09-13)
Follicular fluid (FF), an important microenvironment for the development of oocytes, contains many proteins that are glycosylated with N-linked glycans. This study aimed i) to present an initial analysis of the N-linked glycan profile of bovine FF using hydrophilic interaction
Jasmina Kercmar et al.
Hormones and behavior, 66(4), 667-673 (2014-09-24)
Sex steroid hormones secreted by gonads influence development and expression of many behaviors including parental behaviors. The capacity to display many behaviors develops under the influence of sex steroid hormones; it begins with gonadal differentiation and lasts through puberty. The
Jia-Ning Xu et al.
The Journal of clinical endocrinology and metabolism, 99(8), 2795-2803 (2014-05-16)
Endometriosis is an estrogen-dependent disease affecting reproductive women. Metformin could have a therapeutic effect on endometriosis through regulation of local estrogen production. The aim of this study was to investigate the molecular and cellular mechanism by which metformin regulates StAR
Julie C McNally et al.
Theriogenology, 82(9), 1263-1272 (2014-09-28)
Progesterone treatments are used to increase submission rates in postpartum dairy cows; however, in many cases the protocol is used as a blanket therapy for all cows without regard for physiological or disease state. The objective of this study was
Naoko Sato et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 24(9), 1549-1557 (2014-09-26)
Corticotropin-releasing hormone (CRH), a major regulator of the stress response, regulates various biological functions through its interaction with CRH receptors 1 (CRHR1) and 2 (CRHR2). CRH, CRHR1, and CRHR2 have recently been reported in several types of carcinoma, but the
Enrico Papaleo et al.
Archives of gynecology and obstetrics, 290(1), 169-176 (2014-02-20)
Modest increases of serum progesterone at human chorionic gonadotrophin (hCG) administration in controlled ovarian hyperstimulation (COH) cycles have been shown to have a negative impact on pregnancy outcomes. The aim of this study was to identify early predictors of progesterone
Javier R Ambrosio et al.
International journal for parasitology, 44(10), 687-696 (2014-06-01)
We examined the effects of oestradiol (E2) and progesterone (P4) on cytoskeletal protein expression in the helminth Taenia crassiceps - specifically actin, tubulin and myosin. These proteins assemble into flame cells, which constitute the parasite excretory system. Total protein extracts
Achraf Adib et al.
Reproduction (Cambridge, England), 148(4), 403-416 (2014-07-27)
The first ovulation induced by male effect in sheep during seasonal anoestrus usually results in the development of a short cycle that can be avoided by progesterone priming before ram introduction. In elucidating the involvement of the hypothalamic-pituitary-gonadal axis in
Progesterone is not the same as 17α-hydroxyprogesterone caproate: implications for obstetrical practice.
Roberto Romero et al.
American journal of obstetrics and gynecology, 208(6), 421-426 (2013-05-07)
Sang Jun Han et al.
Human reproduction update, 20(4), 467-484 (2014-03-19)
Endometriosis is defined as the colonization and growth of endometrial tissue at anatomic sites outside the uterine cavity. Up to 15% of reproductive-aged women in the USA suffer from painful symptoms of endometriosis, such as infertility, pelvic pain, menstrual cycle
David Landry et al.
Endocrine, 48(3), 957-967 (2014-10-23)
Obesity in men is associated with lower testosterone levels, related to reduced sperm concentration and the development of various diseases with aging. Hormones produced by the adipose tissue may have influences on both metabolism and reproductive function. Among them, the
Hyun-Gyo Lee et al.
Reproductive sciences (Thousand Oaks, Calif.), 21(9), 1153-1160 (2014-02-28)
Dysregulated cyclin-dependent kinases (CDKs) are considered a potential target for cancer therapy. Flavopiridol is a potent CDK inhibitor. In this study, the antiproliferative effect of the flavonoid compound flavopiridol and its mechanism in human uterine leiomyoma cells were investigated. The
M L'Hermite
Climacteric : the journal of the International Menopause Society, 16 Suppl 1, 44-53 (2013-07-17)
Hormone replacement therapy (HRT) remains the gold standard for treatment of climacteric symptoms in menopausal women; it is relatively safe in healthy subjects for at least 5 years, provided it had been initiated before the age of 60 years and/or
Maria Campaña-Seoane et al.
International journal of pharmaceutics, 477(1-2), 495-505 (2014-12-03)
The aim of this study is to propose that mucoadhesive vaginal emulsions can be able to resist the clearance effect of vaginal fluid and to have an effective control release of progesterone. With this goal, silicon derivative, cyclomethicone pentamer, was
E Wielogorska et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 69, 260-266 (2014-04-29)
Endocrine disruptors (EDs) are compounds known to interfere with the endocrine system by disturbing the action or pathways of natural hormones which may lead to infertility or cancer. Our diet is considered to be one of the main exposure routes
Clara John et al.
Journal of chromatography. A, 1371, 184-195 (2014-12-03)
Recently, hydroxy sterols and bile acids have gained growing interest as they are important regulators of energy homoeostasis and inflammation. The high number of different hydroxy sterols and bile acid species requires powerful analytical tools to quantify these structurally and
Ga-Young Lee et al.
Archives of pharmacal research, 38(1), 98-107 (2014-07-06)
In this study, we examined the catalytic activity of CYP106A1 from the Bacillus megaterium American Type Culture Collection 14581 strain. The CYP106A1 gene was cloned from B. megaterium, heterologously expressed in Escherichia coli, and purified. Potential electron partners and possible
Joan-Carles Arce et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 30(6), 444-450 (2014-03-01)
The aim was to compare ovarian response and clinical outcome of potential high-responders after stimulation with highly purified menotropin (HP-hMG) or recombinant follicle-stimulating hormone (rFSH) for in vitro fertilisation/intracytoplasmic sperm injection. Retrospective analysis was performed on data collected in two
Marc M Schumacher et al.
eLife, 4 (2015-03-06)
Schnyder corneal dystrophy (SCD) is an autosomal dominant disorder in humans characterized by abnormal accumulation of cholesterol in the cornea. SCD-associated mutations have been identified in the gene encoding UBIAD1, a prenyltransferase that synthesizes vitamin K2. Here, we show that
Vinícius Cestari do Amaral et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 31(2), 148-151 (2014-10-10)
The aim of this study was to evaluate the effects of metoclopramide-induced hyperprolactinemia on the prolactin (PRL) and PRL receptor's expression in the uterus of mice. For this purpose, 49 Swiss mice were divided into the following groups: GrSS (non-ovariectomized
Reza Rezvani et al.
Clinical endocrinology, 81(5), 736-745 (2014-07-22)
Sex steroid hormones play an important regulatory role in fat metabolism and obesity. We hypothesized involvement of interactions between ovarian hormones with acylation stimulating protein (ASP). In 392 women with wide age (18-69 years) and body size (BMI: 17 to 90 kg/m(2)
C M Sosa et al.
Molecular human reproduction, 21(3), 244-254 (2014-12-03)
The acrosome reaction is a unique event in the lifespan of sperm characterized by the exocytosis of the acrosomal content and the release of hybrid vesicles formed by patches of the outer acrosomal membrane and the plasma membrane. This unique
Epidermal growth factor receptor (EGFR) signaling is a key mediator of hormone-induced leukocyte infiltration in the pubertal female mammary gland.
Aupperlee MD, Zhao Y, Tan YS, et al.
Endocrinology, 155(6), 2301-2313 (2014)
M Muz et al.
Environmental technology, 35(9-12), 1055-1063 (2014-04-08)
The fate and removal of six selected endocrine disrupting compounds in a lab-scale anaerobic/aerobic (A/O) sequencing batch reactor (SBR), operating at 5 days, solids retention time (SRT) were investigated. A carbamazepine (CBZ), acetaminophen (ATP), diltiazem (DTZ), butyl benzyl phthalate (BBP)
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