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Carolina Panis et al.
Cancer letters, 357(1), 186-195 (2014-12-02)
Overexpression of human epithelial growth factor receptor 2 (HER2) is a poor prognostic factor in breast cancer. HER2 is a transmembrane receptor comprising an extracellular domain (ECD), a single transmembrane domain, and an intracellular domain (ICD) with tyrosine-kinase activity. Receptor...
Hsun-Ming Chang et al.
The Journal of clinical endocrinology and metabolism, 99(10), E1922-E1932 (2014-07-26)
Exerting a broad range of biological effects in various tissues, activins are homo- or heterodimers of activin/inhibin β-subunits (βA, βB, βC, and βE in humans). Although activins A (βAβA), B (βBβB), AB (βAβB), and AC (βAβC) have been demonstrated in...
Miro Kasum et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 29(8), 744-748 (2013-06-12)
The aim of this review is to analyze the relationship between the preovulatory progesterone (P) rise and the in vitro fertilization (IVF) pregnancy outcome. It also investigates the sources and effects of P level increase, including the underlying mechanisms and...
Progesterone for traumatic brain injury--resisting the sirens' song.
Lee H Schwamm
The New England journal of medicine, 371(26), 2522-2523 (2014-12-11)
Maša Sinreih et al.
PloS one, 10(2), e0117984-e0117984 (2015-02-14)
Progesterone has a number of important functions throughout the human body. While the roles of progesterone are well known, the possible actions and implications of progesterone metabolites in different tissues remain to be determined. There is a growing body of...
V A Nunes et al.
The Journal of endocrinology, 221(2), 273-284 (2014-03-07)
Progesterone has been associated with the development of gestational diabetes (GD) due to the enhancement of insulin resistance. As β-cell apoptosis participates in type 1 and type 2 diabetes pathophysiology, we proposed the hypothesis that progesterone might contribute to the...
Alexandra J White et al.
Environmental health : a global access science source, 13, 108-108 (2014-12-17)
Previous studies suggest that polycyclic aromatic hydrocarbons (PAHs) may adversely affect breast cancer risk. Indoor air pollution from use of indoor stoves and/or fireplaces is an important source of ambient PAH exposure. However, the association between indoor stove/fireplace use and...
Weiming Zheng et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(3), 285-299 (2015-01-08)
Hormonal regulation of pituitary gonadotropin gene expression has been attributed to gonadotropin-releasing hormone (GnRH)-mediated stimulation of immediate early gene expression and gonadal steroid interactions with their respective nuclear receptors. A number of orphan nuclear receptors including steroidogenic factor 1, liver...
Mei Fu et al.
PloS one, 9(12), e113669-e113669 (2014-12-06)
This study aimed to establish yak mammary epithelial cells (YMECs) for an in vitro model of yak mammary gland biology. The primary culture of YMECs was obtained from mammary gland tissues of lactating yak and then characterized using immunocytochemistry, RT-PCR...
Safiya A Wahd et al.
Reproductive biology and endocrinology : RB&E, 12, 120-120 (2014-12-03)
The role of ovarian reserve markers as predictors of the controlled ovarian stimulation (COS) response in intracytoplasmic sperm injection (ICSI) cycles in women with endometriosis has been much debated. The aim of the present study is to assess the predictability...
Rong-Hu Ke et al.
Journal of neuro-oncology, 118(2), 369-376 (2014-04-18)
Homo sapiens longevity assurance homolog 2 of yeast LAG1 (LASS2) has been indicated to have a critical role in various tumors. In the study, we aimed to evaluate the LASS2 expression level in prognostic significance and compare it with commonly...
Yan Yang et al.
Stem cells and development, 24(4), 459-470 (2014-10-24)
The primary function of Leydig cells is to secrete testosterone, which is critical in the regulation of male reproduction and development. Low levels of testosterone will lead to male hypogonadism. Stem cell-derived Leydig cell transplantation may be a promising alternative...
Maureen E Groer et al.
American journal of reproductive immunology (New York, N.Y. : 1989), 73(3), 193-198 (2014-09-18)
Little is known about postpartum immune recovery and relationships of common dysphoric moods, stress, immunology, and endocrinology. Healthy women (n = 72) were followed for six postpartum months with immune and hormone measures and dysphoric moods and stress scales. A panel of...
Khatera Ibrahimi et al.
Neurology, 84(2), 125-131 (2014-12-17)
A case-control study to investigate the effect of the menstrual cycle on trigeminal nerve-induced vasodilation in healthy women and patients with menstrually related migraine (MRM). Using a laser-Doppler imager, we compared the vasodilator effects of capsaicin application and electrical stimulation...
Eddy J Chen et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(6), 1273-1280 (2014-10-17)
The CYP17A1 inhibitor abiraterone markedly reduces androgen precursors and is thereby effective in castration-resistant prostate cancer (CRPC). However, abiraterone increases progesterone, which can activate certain mutant androgen receptors (AR) identified previously in flutamide-resistant tumors. Therefore, we sought to determine if...
H Pothmann et al.
Theriogenology, 83(8), 1249-1253 (2015-02-12)
The objectives of this study were to assess the prevalence of subclinical endometritis and the presence of common uterine pathogens in repeat breeder cows. A total of 121 cows with three or more consecutive artificial inseminations without conception and no...
Jianfeng Zhang et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 65, 15-20 (2014-09-10)
We assessed the efficacy of biodegradable microspheres (MSs) containing nomegestrol acetate (NOMAC) for treatment of endometriosis in a rat model and investigated its preliminary mechanism of action. Sprague-Dawley rats with surgically implanted endometrial autografts were divided randomly into four groups...
Ana Cristina S Herrera et al.
Clinical breast cancer, 14(6), 451-459 (2014-08-01)
Recent studies have suggested a regulatory role for some of the metabolites derived from oxidative stress in breast cancer. In this way, cancer-induced oxidative changes could modify the breast environment and potentially trigger systemic responses that may affect disease prognosis and...
Michael Cho et al.
Contraception, 90(1), 94-96 (2014-03-07)
The objective was to investigate changes in luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2) and progesterone (P) during the hormone-free interval (HFI) of 6 combined oral contraceptives (COCs). Blood samples were obtained from 62 women. When COCs were grouped...
Juanjuan Wu et al.
Experimental cell research, 328(2), 351-360 (2014-08-31)
The actions of the transcription factor Nuclear factor erythroid 2-related factor (Nrf2) in breast cancer have been shown to include both pro-oncogenic and anti-oncogenic activities which is influenced, at least in part, by the hormonal environment. However, direct regulation of...
Francesco Massari et al.
Histology and histopathology, 29(10), 1295-1303 (2014-03-08)
Adenocarcinoma of the paraurethral glands represents a very rare neoplasm of the urinary tract. Due to the rarity of this disease, there is no standard therapeutic approach. We report a case of adenocarcinoma of the paraurethral glands in a 56-year-old...
Naoyuki Maeda et al.
PloS one, 10(2), e0117795-e0117795 (2015-02-24)
Corticosterone is synthesized in the adrenal glands and is circulated throughout the body to perform regulatory functions in various tissues. The testis is known to synthesize and secrete testosterone and other androgens. We developed an accurate method to measure steroid...
Imran A Khan et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 15(4), 566-571 (2013-11-06)
Gestational diabetes mellitus (GDM) is defined as glucose intolerance first recognized during pregnancy. Insertion/deletion (I/D) polymorphism of a 287 bp Alu repetitive sequence in intron 16 of the angiotensin-converting enzyme (ACE) gene has been widely investigated in Asian Indian populations...
Kenichiro Kumasaka et al.
American journal of surgery, 208(6), 961-968 (2014-10-13)
Mannitol, hypertonic saline, and progesterone may blunt leukocyte recruitment after traumatic brain injury (TBI). We hypothesized that progesterone reduces pericontusional recruitment of leukocytes to a greater extent than either osmotherapy a day after TBI. CD1 mice underwent controlled cortical impact...
Sadik Sahin et al.
Archives of gynecology and obstetrics, 291(1), 185-191 (2014-08-01)
The aim of this study was to compare the incidence of ectopic pregnancy in GnRH agonist triggered IVF cycles with intensive luteal support versus hCG triggered IVF cycles. This study was conducted as a retrospective cohort analysis of women who...
Hideyuki Ohzawa et al.
Breast cancer (Tokyo, Japan), 21(5), 563-570 (2012-10-31)
The effectiveness of neoadjuvant chemotherapy is evaluated on the basis of pathological responses and survival outcome, because achievement of a pathological complete response (pCR) is a good predictor of long-term survival. However, few studies have assessed the survival of breast...
Xiao-Huan Liang et al.
The Journal of biological chemistry, 289(34), 23534-23545 (2014-07-12)
Embryo implantation is a highly synchronized process between an activated blastocyst and a receptive uterus. Successful implantation relies on the dynamic interplay of estrogen and progesterone, but the key mediators underlying embryo implantation are not fully understood. Here we show...
Prevention of preterm parturition.
Jay D Iams
The New England journal of medicine, 370(19), 1861-1861 (2014-05-09)
Jee Hyun Kim et al.
Journal of Korean medical science, 29(9), 1266-1270 (2014-09-24)
This prospective study investigated the relationship between anti-Müllerian hormone (AMH) level in the follicular fluid (FF) and the quality of the oocyte and embryo. A total of 65 FF samples from 54 women were included in this study. FF was...
Matthew L Turner et al.
Endocrinology, 155(4), 1453-1465 (2014-01-21)
Bacteria often infect the endometrium of cattle to cause endometritis, uterine disease, and infertility. Lipopeptides are commonly found among bacteria and are detected by the Toll-like receptor (TLR) cell surface receptor TLR2 on immune cells. Heterodimers of TLR2 with TLR1...
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