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158127

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Luke Grundy et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(17), 3900-3916 (2021-03-18)
Understanding the sensory mechanisms innervating the bladder is paramount to developing efficacious treatments for chronic bladder hypersensitivity conditions. The contribution of Mas-gene-related G protein-coupled receptors (Mrgpr) to bladder signaling is currently unknown. Using male and female mice, we show with
Soram Idiyasan Chanu et al.
Biochimica et biophysica acta, 1863(9), 2111-2119 (2017-05-23)
Formation of Neurofibrillary Tangles (NFTs) in neuronal tissues has been implicated as the hallmark of disease pathogenesis and tau mediated toxicity in human and mammalian models. However, previous studies had failed to correlate NFT formation with pathogenesis of human neuronal
Alessandro Luciani et al.
Nature communications, 11(1), 970-970 (2020-02-23)
Deregulation of mitochondrial network in terminally differentiated cells contributes to a broad spectrum of disorders. Methylmalonic acidemia (MMA) is one of the most common inherited metabolic disorders, due to deficiency of the mitochondrial methylmalonyl-coenzyme A mutase (MMUT). How MMUT deficiency
Pingwei Xu et al.
Cancer immunology research, 8(9), 1193-1205 (2020-07-15)
Malignant pleural effusion (MPE) is a frequent complication of various cancers and often leads to a poor quality of life, prognosis, and life expectancy, and its management remains palliative. New approaches that can effectively treat MPE are highly desirable. Here
Pushpanathan Muthuirulan et al.
Nature communications, 12(1), 4161-4161 (2021-07-08)
Given the pleiotropic nature of coding sequences and that many loci exhibit multiple disease associations, it is within non-coding sequence that disease-specificity likely exists. Here, we focus on joint disorders, finding among replicated loci, that GDF5 exhibits over twenty distinct
Yann Roussel et al.
eNeuro, 7(1) (2020-02-02)
Significant maturation of swimming in zebrafish (Danio rerio) occurs within the first few days of life when fish transition from coiling movements to burst swimming and then to beat-and-glide swimming. This maturation occurs against a backdrop of numerous developmental changes
Ting Bei et al.
Molecules (Basel, Switzerland), 26(11) (2021-07-03)
Total body irradiation is a standard procedure of bone marrow transplantation (BMT) which causes a rapid increase in reactive oxygen species (ROS) in the bone marrow microenvironment during BMT. The increase in ROS reduces the engraftment ability of donor cells
Inmaculada Bravo-Caparrós et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(4), 5951-5966 (2020-03-12)
Neuron-immune interaction in the dorsal root ganglia (DRG) plays a pivotal role in the neuropathic pain development after nerve injury. Sigma-1 receptor (Sig-1R) is expressed by DRG neurons but its role in neuropathic pain is not fully understood. We investigated
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Honglei Jin et al.
Autophagy, 17(4), 840-854 (2020-03-03)
Although MIR516A has been reported to be downregulated and act as a tumor suppressor in multiple cancers, its expression and potential contribution to human bladder cancer (BC) remain unexplored. Unexpectedly, we showed here that MIR516A was markedly upregulated in human
Margherita Peron et al.
Development (Cambridge, England), 148(17) (2021-09-03)
The STAT3 transcription factor, acting both in the nucleus and mitochondria, maintains embryonic stem cell pluripotency and promotes their proliferation. In this work, using zebrafish, we determined in vivo that mitochondrial STAT3 regulates mtDNA transcription in embryonic and larval stem
Lei Jiang et al.
Cancer biology & therapy, 16(3), 466-476 (2015-03-18)
Glucocorticoid (GC) resistance remains a major obstacle to successful treatment of lymphoid malignancies. Till now, the precise mechanism of GC resistance remains unclear. In the present study, dexamethasone (Dex) inhibited cell proliferation, arrested cell cycle in G0/G1-phase, and induced apoptosis
Yanjiao Ou et al.
Frontiers in medicine, 8, 649279-649279 (2021-05-01)
Objective: Increasing evidence highlights antisense long non-coding RNAs (lncRNAs) as promising therapeutic targets for cancers. Herein, this study focused on the clinical implications and functions of a novel antisense lncRNA PRKAG2-AS1 in hepatocellular carcinoma (HCC). Methods: PRKAG2-AS1 expression was examined
Yan-Yan Wu et al.
Journal of economic entomology, 108(4), 1486-1494 (2015-10-16)
Honey bees are at an unavoidable risk of exposure to neonicotinoid pesticides, which are used worldwide. Compared with the well-studied roles of these pesticides in nontarget site (including midgut, ovary, or salivary glands), little has been reported in the target
Patrizia Pellegatti et al.
PloS one, 3(7), e2599-e2599 (2008-07-10)
There is growing awareness that tumour cells build up a "self-advantageous" microenvironment that reduces effectiveness of anti-tumour immune response. While many different immunosuppressive mechanisms are likely to come into play, recent evidence suggests that extracellular adenosine acting at A2A receptors
Andrew Tsz Hang Choy et al.
PloS one, 10(6), e0131827-e0131827 (2015-06-27)
Tissue engineering offers high hopes for the treatment of intervertebral disc (IVD) degeneration. Whereas scaffolds of the disc nucleus and annulus have been extensively studied, a truly biomimetic and mechanically functional biphasic scaffold using naturally occurring extracellular matrix is yet
Andrej Ondracka et al.
Current biology : CB, 28(12), 1964-1969 (2018-06-12)
Coordination of the cell division cycle with the growth of the cell is critical to achieve cell size homeostasis [1]. Mechanisms coupling the cell division cycle with cell growth have been described across diverse eukaryotic taxa [2-4], but little is
Apolinar Maya-Mendoza et al.
Methods (San Diego, Calif.), 57(2), 140-148 (2012-06-12)
The precise regulation of DNA replication is fundamental to the preservation of intact genomes during cell proliferation. Our understanding of this process has been based traditionally on a combination of techniques including biochemistry, molecular biology and cell biology. In this
Isabel Pablos et al.
Cell reports, 37(4), 109892-109892 (2021-10-22)
The main viral protease (3CLpro) is indispensable for SARS-CoV-2 replication. We delineate the human protein substrate landscape of 3CLpro by TAILS substrate-targeted N-terminomics. We identify more than 100 substrates in human lung and kidney cells supported by analyses of SARS-CoV-2-infected
Rosa M Suárez et al.
Molecules (Basel, Switzerland), 17(8), 8735-8741 (2012-07-27)
The synthesis of 9,9'-[1,2-ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6H-purin-6-one, a minor impurity of acyclovir, is described. Starting with commercial N-(9-acetyl-6-oxo-1H-purin-2-yl)acetamide, the process uses an acid catalysed phase transfer catalysis (PTC) process to produce the selective alkylation at the 9 position of the guanine ring.
Thankiah Sudhaharan et al.
PloS one, 6(2), e16603-e16603 (2011-02-12)
Adenomatous Polyposis Coli (APC) is a tumor suppressor gene product involved in colon cancer. APC is a large multidomain molecule of 2843 amino acid residues and connects cell-cell adhesion, the F-actin/microtubule cytoskeleton and the nucleus. Here we show that Cdc42
Caroline E von Allmen et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(28), 11673-11678 (2009-07-01)
Suppression by natural CD4(+)CD25(+) regulatory T cells (Tregs) is one mechanism by which tolerance is maintained. However, the way in which Tregs mediate suppression is not well understood. Here, we show that secreted phospholipase A2 (sPLA2)-IID is selectively produced by
Luca Giordano et al.
Gene therapy (2021-03-06)
Plants and other organisms, but not insects or vertebrates, express the auxiliary respiratory enzyme alternative oxidase (AOX) that bypasses mitochondrial respiratory complexes III and/or IV when impaired. Persistent expression of AOX from Ciona intestinalis in mammalian models has previously been
Geometric effect of cell adhesive polygonal micropatterns on neuritogenesis and axon guidance
Jang Min Jee and Nam Yoonkey
Journal of Neural Engineering, 9(4), 046019-046019 (2012)
Xiang-Chuan Wang et al.
Organic & biomolecular chemistry, 10(18), 3636-3641 (2012-04-13)
A new and efficient synthesis of substituted indene has been achieved via copper(I)-catalyzed domino three-component coupling and cyclization reaction in moderate to good yield.
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Hailong Han et al.
EMBO reports, 21(8), e48686-e48686 (2020-06-03)
Impairment of PINK1/parkin-mediated mitophagy is currently proposed to be the molecular basis of mitochondrial abnormality in Parkinson's disease (PD). We here demonstrate that PINK1 directly phosphorylates Drp1 on S616. Drp1S616 phosphorylation is significantly reduced in cells and mouse tissues deficient
Helen M McRae et al.
Development (Cambridge, England), 147(21) (2020-10-01)
Börjeson-Forssman-Lehmann syndrome (BFLS) is an intellectual disability and endocrine disorder caused by plant homeodomain finger 6 (PHF6) mutations. Individuals with BFLS present with short stature. We report a mouse model of BFLS, in which deletion of Phf6 causes a proportional
Narelle E McGregor et al.
Bio-protocol, 10(6), e3560-e3560 (2021-03-05)
Bone formation occurs during embryogenesis, skeletal growth and during the process of skeletal renewal throughout life. In the process of bone formation, osteoblasts lay down a collagen-containing matrix, termed osteoid, which is gradually hardened by incorporation of mineral crystals. Although
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