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José Ángel García-Pedraza et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 42(5), 618-627 (2019-01-31)
Sympathetic overdrive is a key player in hypertension, where the mesenteric vasculature plays a relevant role in modulating blood pressure. Although 5-HT inhibits noradrenergic mesenteric neurotransmission in normotensive rats, its effect on the mesenteric sympathetic drive in hypertensive rats has
Ramin Ataee et al.
Archives of Iranian medicine, 13(2), 120-125 (2010-03-02)
Serotonin (5HT) has been shown to be a mitogenic factor in several carcinomas. Its mitogenic effect is elicited through a wide range of 5HT receptor subtypes. In this study, the effects of 5HT, 5HT3 (1-phenylbiguanide hydrochloride) and 5HT4 (cisapride) agonists
Y Tsutsui et al.
Neuroscience, 157(3), 683-696 (2008-10-18)
The aims of the present study were to investigate whether the activation of the 5-HT receptor subtypes (5-HT(4) and 5-HT(3)) acted significantly on the modification of the tetrodotoxin-resistant sodium current (I(NaR)) in small-sized rat trigeminal ganglion (TG) neurons and whether
Sadhana Kanoo et al.
Neuroscience letters, 440(3), 242-245 (2008-06-24)
The present study was conducted to examine the role of phospholipase A(2) and prostaglandins in Indian red scorpion (Mesobuthus tamulus; MBT) venom-induced augmentation of cardiopulmonary reflexes elicited by phenyldiguanide (PDG). Trachea, femoral artery and jugular vein were cannulated in urethane
B Veeresh et al.
Indian journal of pharmacology, 41(5), 221-223 (2010-02-24)
The aim of the present study was to investigate the involvement of nitric oxide in 5-HT(3) receptor agonist-induced fluid accumulation in jejunum and colon of anesthetized rats. Fluid movement in jejunum and colon were determined simultaneously in the same rat
Jayanti Pant et al.
Neuroscience letters, 530(1), 69-74 (2012-10-09)
Bisphenol A (BPA), a toxic chemical released from plastics, produces respiratory arrest and hypotension after a latency. The latency was similar to the reflex apnoea induced by the vagal C fibre stimulation. Therefore, the present study was undertaken to examine
José-Ángel García-Pedraza et al.
Vascular pharmacology, 72, 172-180 (2015-05-25)
Although serotonin has been shown to inhibit peripheral sympathetic outflow, serotonin regulation on renal sympathetic outflow has not yet been elucidated. This study investigated which 5-HT receptor subtypes are involved. Wistar rats were anesthetized (sodium pentobarbital; 60mg/kg, i.p.), and prepared
Abhaya Dutta et al.
Pulmonary pharmacology & therapeutics, 25(5), 383-391 (2012-07-24)
Phenylbiguanide (PBG) and capsaicin evoke cardiorespiratory reflexes utilizing two separate pathways. It is known that Indian Red Scorpion (Mesobuthus tumulus; MBT) venom augments PBG (5-HT(3)) responses but, the effect of MBT venom on capsaicin (TRPV1)-induced response is not known. Therefore
Patrick S Hosford et al.
The Journal of physiology, 593(7), 1715-1729 (2015-02-20)
The nucleus tractus solitarii (NTS) integrates inputs from cardiovascular afferents and thus is crucial for cardiovascular homeostasis. These afferents primarily release glutamate, although 5-HT has also been shown to play a role in their actions. Using fast-cyclic voltammetry, an increase
José Raul Cisternas et al.
Journal of integrative neuroscience, 10(4), 475-487 (2012-01-21)
Many studies have investigated the role of oxidative stress on cardiovascular system in the brainstem of spontaneously hypertensive rats (SHR). However, we do not know yet if catalase inhibition influences cardiopulmonary reflex (Bezol-Jarisch reflex). Thus, we aimed to evaluate the
Tomoko K Ichinose et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 303(5), R539-R550 (2012-07-21)
Previously we have shown that adenosine operating via the A(1) receptor subtype may inhibit glutamatergic transmission in the baroreflex arc within the nucleus of the solitary tract (NTS) and differentially increase renal (RSNA), preganglionic adrenal (pre-ASNA), and lumbar (LSNA) sympathetic
J P Chen et al.
Brain research, 543(2), 354-357 (1991-03-15)
The serotonin-3 (5-HT3) agonist 1-phenylbiguanide (0.1-1.0 mM in perfusate) caused a robust, dose-dependent enhancement of extracellular dopamine content in nucleus accumbens as measured by in vivo microdialysis. This action was antagonized by co-perfusion of the 5-HT3 antagonists zacopride and GR38032F
José Ángel García-Pedraza et al.
Journal of cardiovascular pharmacology, 69(1), 13-22 (2016-09-28)
5-Hydroxytryptamine (5-HT) modulates the cardiac parasympathetic neurotransmission, inhibiting the bradyarrhythmia by 5-HT2 receptor activation. We aimed to determine whether the chronic selective 5-HT2 blockade (sarpogrelate) could modify the serotonergic modulation on vagal cardiac outflow in pithed rat. Bradycardic responses in
S Kanoo et al.
Acta physiologica (Oxford, England), 196(4), 365-373 (2009-01-13)
This study was performed to delineate the kinin (receptor)-dependent pathways in the Indian red scorpion (Mesobuthus tamulus; MBT) venom-induced pulmonary oedema as well as the augmentation of cardio-pulmonary reflexes evoked by phenyldiguanide (PDG). In urethane-anaesthetized adult rats, the effect of
Y L Kuo et al.
Journal of applied physiology (Bethesda, Md. : 1985), 105(2), 611-620 (2008-06-07)
Sensitization of vagal lung C fibers has been postulated to contribute to the development of asthma, but support for this notion is still lacking. We investigated the characteristics and function of pulmonary C fibers (PCFs) in ovalbumin (OVA)-sensitized Brown Norway
Abhaya Dutta et al.
Toxicon : official journal of the International Society on Toxinology, 57(2), 193-198 (2010-11-30)
Pulmonary edema is a consistent feature of Mesobuthus tamulus (MBT) envenomation. Kinins, prostaglandins and other inflammatory mediators are implicated in it. Since, histamine also increases capillary permeability, this study was undertaken to evaluate whether MBT venom utilizes histamine to produce
E S Tanigina et al.
Bulletin of experimental biology and medicine, 154(2), 192-195 (2013-01-19)
Administration of 3,5-dicarbomethoxyphenylbiguanide to rats with experimental epinephrine-induced myocarditis was followed by a decrease in activity of marker enzymes for cardiomyocyte cytolysis in the blood serum. This agent also decreased the intensity of free radical processes and had a normalizing
Irena Matulková et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 170, 256-266 (2016-07-29)
Three polymorphic modifications of bis(N-phenylbiguanidium(1+)) oxalate are reported, and their characterization is discussed in this paper. The non-centrosymmetric bis(N-phenylbiguanidium(1+)) oxalate (I), which was obtained from an aqueous solution at 313K, belongs to the monoclinic space group Cc (a=6.2560(2)Å, b=18.6920(3)Å, c=18.2980(5)Å
Bashair M Mussa et al.
European journal of pharmacology, 601(1-3), 198-206 (2008-11-26)
Cholecystokinin and serotonin are released from the gastrointestinal tract in response to the products of digestion and play critical roles in mediating pancreatic secretion via vago-vagal reflex pathways. This study was designed to investigate the effects of activation of cholecystokinin
M R Simões et al.
Clinical and experimental pharmacology & physiology, 43(11), 1038-1045 (2016-10-21)
Mercury is known to cause harmful neural effects affecting the cardiovascular system. Here, we evaluated the chronic effects of low-dose mercury exposure on the autonomic control of the cardiovascular system. Wistar rats were treated for 30 days with HgCl
Debra I Diz et al.
Journal of cardiovascular pharmacology, 51(6), 542-548 (2008-05-14)
Endogenous angiotensin (Ang)-(1-7) enhances, while Ang II attenuates, baroreceptor sensitivity (BRS) for reflex control of heart rate (HR) in Sprague-Dawley (SD) rats. In (mRen2)27 renin transgenic rats [(mRen2)], there is overexpression of the mouse Ren2 gene in brain, leading to
Michelle E Bartman et al.
Respiratory physiology & neurobiology, 172(1-2), 42-52 (2010-04-20)
To determine the role of central serotonin 5-HT(3) receptors in respiratory motor control, respiratory motor bursts were recorded from hypoglossal (XII) nerve rootlets on isolated adult turtle brainstems during bath-application of 5-HT(3) receptor agonists and antagonists. mCPBG and PBG (5-HT(3)
Maylla Ronacher Simões et al.
Cardiovascular toxicology, 17(2), 190-199 (2016-06-09)
Lead (Pb) induces adverse effects when it chronically accumulates in the body, including effects on the nervous and cardiovascular systems. Wistar rats were exposed to lead acetate for 30 days (first dose 4 µg/100 g followed by 0.05 µg/100 g/day, i.m.) to investigate the cardiovascular
Reaction of 2, 3-Dichloro-1, 4-Naphthoquinone with 1-Phenylbiguanide and 2-Guanidinebenzimidazole.
El-Shaieb KM.
J. Chin. Chem. Soc., 54(5), 1353-1358 (2007)
Donatella Mutolo et al.
Neuroscience letters, 448(2), 200-203 (2008-10-29)
We investigated the changes induced by pulmonary C-fibre receptor activation in the cough reflex evoked by mechanical stimulation of the tracheobronchial tree in pentobarbitone anesthetized, spontaneously breathing rabbits. Phrenic nerve and abdominal muscle activities were monitored along with tracheal and
Florence Netzer et al.
The European journal of neuroscience, 29(10), 2017-2028 (2009-05-21)
Stimulation of the dorsolateral periaqueductal gray matter (dlPAG) and the B3 cell group inhibits the cardiovagal component of the baroreflex in rats. Our aim was to determine whether the defence reaction induces similar modulatory effects on the cardiac response of
David J Majewski et al.
Respiratory physiology & neurobiology, 164(3), 338-349 (2008-09-09)
Discrete midline lesions uncouple left and right respiratory motor output in mammals, but not in frogs and lampreys. To address this question in reptiles, isolated adult turtle brainstems were cut along the midline while recording respiratory motor output (bursts of
John Eme et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 181(7), 981-990 (2011-03-30)
Hypoxia is a naturally occurring environmental challenge for embryonic non-avian reptiles, and this study is the first to investigate the impact of chronic hypoxia on a possible chemoreflex loop in a developing non-avian reptile. We measured heart rate and blood
Domitila A Huber et al.
The Journal of physiology, 588(Pt 9), 1515-1525 (2010-03-10)
Adult obese Zucker rats (OZRs) have reduced sympathetic responses to evoked changes in arterial pressure (AP) compared to lean Zucker rats (LZRs). This study examined whether attenuated sympathetic baroreflexes in OZRs may be due to altered sensory or central mechanisms.
Colleen J Thomas et al.
Clinical and experimental pharmacology & physiology, 38(7), 410-415 (2011-04-15)
1. Cardiac natriuretic peptides act on cardiopulmonary chemoreceptor afferents to enhance the von Bezold-Jarisch reflex (BJR). Activity of the natriuretic peptide particulate guanylyl cyclase receptor is essential for full expression of the BJR. Whether natriuretic peptides act directly on cardiac
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