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Ramon Ocadiz-Ruiz et al.
Oncotarget, 8(55), 94330-94344 (2017-12-08)
ZBP-89 (Zfp148, ZNF148) is a Kruppel-type zinc-finger family transcription factor that binds to GC-rich DNA elements. Earlier studies in cell lines demonstrated that ZBP-89 cooperates with Wnt β-catenin signaling by inducing β-catenin gene expression. Since β-catenin levels are normally highest
Heterogeneous nuclear ribonucleoprotein K is associated with poor prognosis and regulates proliferation and apoptosis in bladder cancer.
Chen, X; Gu, P; Xie, R; Han, J; Liu, H; Wang, B; Xie, W; Xie, W; Zhong, G; Chen, C; Xie et al.
Journal of Cellular and Molecular Medicine null
Wei Guo et al.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 22(4), 705-722 (2019-01-19)
Semaphorin 3B (SEMA3B) is frequently inactivated in several carcinomas. However, as the host gene of miR-6872, the roles of SEMA3B, antisense lncRNA SEMA3B-AS1, and miR-6872 in gastric cardia adenocarcinoma (GCA) tumorigenesis have not been clarified. The expression levels of SEMA3B
Qinbo Cai et al.
Cellular and molecular gastroenterology and hepatology, 11(3), 857-880 (2020-11-09)
The association between cellular senescence and Helicobacter pylori-induced atrophic gastritis is not clear. Here, we explore the role of cellular senescence in H pylori-induced atrophic gastritis and the underlying mechanism. C57BL/6J mice were infected with H pylori for biological and
Hui Sang et al.
Journal of molecular cell biology, 11(6), 474-488 (2018-11-28)
Lin28a is a pluripotent factor that promotes somatic cell reprogramming. Unlike other pluripotent factors, Lin28a expression is transient and accumulated in primed embryonic stem (ES) cells, but its exact function and mechanism in the conversion of ES cells from naïve
Xin He et al.
Nucleic acids research, 43(7), 3712-3725 (2015-03-18)
PIWI-interacting RNA (piRNA) silences the transposons in germlines or induces epigenetic modifications in the invertebrates. However, its function in the mammalian somatic cells remains unknown. Here we demonstrate that a piRNA derived from Growth Arrest Specific 5, a tumor-suppressive long
Yu-Jiao Li et al.
Journal of neuroinflammation, 16(1), 132-132 (2019-07-01)
Liver X receptors (LXRs), including LXRα and LXRβ, are key regulators of transcriptional programs for both cholesterol homeostasis and inflammation in the brain. Here, the modes of action of LXRs and the epigenetic mechanisms regulating LXRβ expression in anterior cingulate
Szilvia Juhász et al.
Molecular cell, 71(1), 11-24 (2018-06-26)
ATRX is a chromatin remodeler that, together with its chaperone DAXX, deposits the histone variant H3.3 in pericentromeric and telomeric regions. Notably, ATRX is frequently mutated in tumors that maintain telomere length by a specific form of homologous recombination (HR).
Yu Xiong et al.
Cell death and differentiation, 26(10), 1929-1941 (2019-01-16)
Necroptosis is a programmed form of necrotic cell death, which is tightly regulated by the necroptotic signaling pathway containing receptor-interacting protein (RIP)1, RIP3, and mixed-lineage kinase domain-like (MLKL) protein. In addition to the RIP1-RIP3-MLKL axis, other factors regulating necroptosis are
Xiao-Ling Ma et al.
Frontiers in cell and developmental biology, 8, 153-153 (2020-04-02)
Trophoblasts as the particular cells of the placenta play an important role in implantation and formation of the maternal-fetal interface. RND3 (also known as RhoE) is a unique member of the Rnd subfamily of small GTP-binding proteins. However, its function
Ziyue Li et al.
Molecular medicine reports, 15(1), 297-304 (2016-12-14)
Amelogenesis, beginning with thickened epithelial aggregation and ending with highly mineralized enamel formation, is a process mediated by a complex signaling network that involves several molecules, including growth and transcription factors. During early tooth development, the transcription factor B‑cell CLL/lymphoma 11B (Bcl11b)
lncRNA Up-Regulated in Nonmuscle Invasive Bladder Cancer Facilitates Tumor Growth and Acts as a Negative Prognostic Factor of Recurrence.
Zhang, S; Zhong, G; He, W; Yu, H; Huang, J; Lin, T
The Journal of urology null
Dopamine inhibits the effector functions of activated NK cells via the upregulation of the D5 receptor.
Mikulak, J; Bozzo, L; Roberto, A; Pontarini, E; Tentorio, P; Hudspeth, K; Lugli, E; Mavilio, D
Journal of immunology (Baltimore, Md. : 1950) null
Camilla Nylund et al.
PloS one, 7(9), e45382-e45382 (2012-10-03)
Cancer-testis (CT) antigens are predominantly expressed in testis or placenta, but absent in most adult tissues. During malignant transformation CT genes are often activated. CT antigen 16 (CT16, PAGE5) is frequently expressed in advanced melanoma but its biological function has
Xu Chen et al.
Scientific reports, 5, 8293-8293 (2015-02-07)
WD repeat domain 5 (WDR5) plays an important role in various biological functions through the epigenetic regulation of gene transcription; however, its role in bladder cancer remains largely unknown. Our study investigated the role of WDR5 in bladder cancer and
Dan Dai et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 42(10), 2064-2071 (2017-04-28)
Oxytocin (OXT), synthesized in the hypothalamic paraventricular nucleus (PVN) and then released into different brain areas, may play a crucial role in various behaviors and neuropsychiatric disorders, including depression. Testosterone has been proposed by clinical studies to have the opposite
Laurie E Risner et al.
The Journal of biological chemistry, 288(41), 29901-29910 (2013-08-31)
The MLL CXXC domain binds nonmethylated CpG-containing DNA and is essential for the oncogenic properties of MLL fusion proteins. To determine potential functional promiscuity of similar DNA binding domains, we replaced the MLL CXXC domain in the context of the
Bhavna Malik et al.
FEBS letters, 587(18), 3038-3044 (2013-07-31)
AF9 is known to interact with multiple proteins including activators and repressors of transcription. Our data indicate that other AF9 binding proteins compete with the histone methyltransferase DOT1L for AF9 binding thus diminishing its ability to methylate lysine 79 of
Tao Huang et al.
Carcinogenesis, 41(5), 571-581 (2020-07-11)
Cripto-1 (CR1), an oncofetal protein, had been implied to reactivate in some cancers. However, the relationship between CR1 expression and patient outcomes and the tumor biological function of CR1 contributing to invasion and metastasis in hepatocellular carcinoma (HCC) is poorly
Cheng Wang et al.
Cell death & disease, 9(11), 1047-1047 (2018-10-17)
Autophagy is a key regulatory process in maintaining cellular homoeostasis via lysosome degradation. Growing evidence reveals that poly(ADP-ribose) polymerase-1 (PARP1) is involved in the progression of many cardiovascular diseases. This study was undertaken to discuss the role of PARP1 in
Decreased c-rel activation contributes to aberrant interleukin-2 expression in CD4(+)T cells of aged rats.
Gong, Z; Liu, T; Wan, Y; Hang, Z; Tong, X; Zhang, B; Yang, H; Zhang, X; Zhang, L; Jin, G
Molecular Immunology null
Long noncoding RNA ZEB1-AS1 acts as an oncogene in osteosarcoma by epigenetically activating ZEB1.
Liu, C; Lin, J
American Journal of Translational Research null
Long non-coding RNA HNF1A-AS1 promotes hepatocellular carcinoma cell proliferation by repressing NKD1 and P21 expression.
Wang, C; Mou, L; Chai, HX; Wang, F; Yin, YZ; Zhang, XY
Biomedicine and Pharmacotherapy null
Ling Pan et al.
The Journal of clinical investigation, 131(22) (2021-11-16)
The tumorigenic mechanism for pancreatic ductal adenocarcinoma (PDAC) is not clear, although chronic inflammation is implicated. Here, we identified an inflammatory cytokine-regulated transfer RNA-derived (tRNA-derived) fragment, tRF-21-VBY9PYKHD (tRF-21), as a tumor suppressor in PDAC progression. We found that the biogenesis
Rui Gao et al.
Stem cells (Dayton, Ohio), 33(3), 925-938 (2014-11-12)
While Polycomb group protein Bmi1 is important for stem cell maintenance, its role in lineage commitment is largely unknown. We have identified Bmi1 as a novel regulator of erythroid development. Bmi1 is highly expressed in mouse erythroid progenitor cells and
Toni R Bartling et al.
Free radical biology & medicine, 74, 99-107 (2014-06-29)
Aberrant matrix metalloproteinase-1 (MMP-1) expression contributes to the pathogenesis of many degenerative disease processes that are associated with increased oxidative damage or stress. We and others have established that shifts in steady-state H2O2 production resulting from enforced antioxidant gene expression
LncRNA FIRRE/NF-kB feedback loop contributes to OGD/R injury of cerebral microglial cells.
Zang, Y; Zhou, X; Wang, Q; Li, X; Huang, H
Biochemical and biophysical research communications null
Changhao Chen et al.
Cell death & disease, 8(10), e3060-e3060 (2017-10-06)
The transition from androgen-dependent to metastatic castration-resistant prostate cancer (PCa) is a lethal event of uncertain molecular aetiology. Our previous studies demonstrated that L-plastin is involved in PCa invasion and metastasis and is upregulated by androgen and oestrogen in the
Chuan-Yang Fu et al.
Nucleic acids research, 45(5), 2423-2437 (2016-12-04)
Vascular endothelial growth factor (VEGF) plays a pivotal role in angiogenesis. Previous studies focused on transcriptional regulation modulated by proximal upstream cis-regulatory elements (CREs) of the human vegfa promoter. However, we hypothesized that distal upstream CREs may also be involved
Megan L Linscott et al.
PloS one, 14(7), e0220530-e0220530 (2019-07-31)
Fibroblast growth factor 8 (FGF8) is a potent morphogen that regulates the ontogenesis of gonadotropin-releasing hormone (GnRH) neurons, which control the hypothalamus-pituitary-gonadal (HPG) axis, and therefore reproductive success. Indeed, FGF8 and FGFR1 deficiency severely compromises vertebrate reproduction in mice and
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