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Showing 1-30 of 804 results for "17-700" within Papers
Zhiming Dong et al.
Molecular cancer research : MCR, 15(7), 800-810 (2017-05-26)
Maternally expressed gene 3 (MEG3), a long non-coding RNA (lncRNA), has tumor-suppressor properties and its expression is lost in several human tumors. However, its biological role in esophageal squamous cell carcinoma (ESCC) tumorigenesis is poorly defined. The present study determined
Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway.
Li, Z; Zhang, Y; Ramanujan, K; Ma, Y; Kirsch, DG; Glass, DJ
Cancer research null
Fang Shen et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 41(3), 530-545 (2020-04-07)
RNA-binding protein fox-1 homolog 1 (Rbfox-1), an RNA-binding protein in neurons, is thought to be associated with many neurological diseases. To date, the mechanism on which Rbfox-1 worsens secondary cell death in ICH remains poorly understood. In this study, we
Rong Qiu et al.
Journal of immunology (Baltimore, Md. : 1950), 204(12), 3160-3170 (2020-05-18)
It is well known that some pathogenic cells have enhanced glycolysis; the regulatory network leading to increased glycolysis are not well characterized. In this study, we show that CNS-infiltrated pathogenic TH17 cells from diseased mice specifically upregulate glycolytic pathway genes
Xueying Yang et al.
Cell death & disease, 12(5), 462-462 (2021-05-10)
FTO removes the N6-methyladenosine (m6A) modification from genes and plays a critical role in cancer development. However, the mechanisms underlying the regulation of FTO and its subsequent impact on the regulation of the epitranscriptome remain to be further elucidated. Here
Long non-coding RNA LINC00672 contributes to p53 protein-mediated gene suppression and promotes endometrial cancer chemosensitivity.
Li, W; Li, H; Zhang, L; Hu, M; Li, F; Deng, J; An, M; Wu, S; Ma, R; Lu, J; Zhou, Y
The Journal of Biological Chemistry null
Archana D Siddam et al.
PLoS genetics, 14(3), e1007278-e1007278 (2018-03-23)
Opacification of the ocular lens, termed cataract, is a common cause of blindness. To become transparent, lens fiber cells undergo degradation of their organelles, including their nuclei, presenting a fundamental question: does signaling/transcription sufficiently explain differentiation of cells progressing toward
Dietary lipids modulate the expression of miR-107, an miRNA that regulates the circadian system.
Daimiel-Ruiz, L; Klett-Mingo, M; Konstantinidou, V; Mico, V; Aranda, JF; Garcia et al.
Molecular Nutrition And Food Research null
Cunjie Chang et al.
Nature communications, 13(1), 1363-1363 (2022-03-18)
Deregulation of alternative splicing is implicated as a relevant source of molecular heterogeneity in cancer. However, the targets and intrinsic mechanisms of splicing in hepatocarcinogenesis are largely unknown. Here, we report a functional impact of a Splicing Regulatory Glutamine/Lysine-Rich Protein
Guohua Lü et al.
Aging, 12(4), 3218-3237 (2020-02-18)
Chondrocyte apoptosis and extracellular matrix (ECM) degeneration have been implicated in the pathogenesis of osteoarthritis (OA). Based on previously reported microarray analysis, HRAS (Harvey rat sarcoma viral oncogene homolog), a member of the RAS protein family, was chosen as a
TET-Mediated Sequestration of miR-26 Drives EZH2 Expression and Gastric Carcinogenesis.
Deng, M; Zhang, R; He, Z; Qiu, Q; Lu, X; Yin, J; Liu, H; Jia, X; He, Z
Cancer Research null
Deepak Parashar et al.
Cell reports, 29(13), 4389-4406 (2019-12-26)
Genomic amplification of 3q26.2 locus leads to the increased expression of microRNA 551b-3p (miR551b-3p) in triple-negative breast cancer (TNBC). Our results demonstrate that miR551b-3p translocates to the nucleus with the aid of importin-8 (IPO8) and activates STAT3 transcription. As a consequence
PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing.
Liang, X; Chen, W; Shi, H; Gu, X; Li, Y; Qi, Y; Xu, K; Zhao, A; Liu, J
Cell Death & Disease null
Hao Li et al.
Oncotarget, 5(8), 2318-2329 (2014-05-09)
Long non-coding RNAs (lncRNAs) play key roles in the progression and metastasis of some carcinomas. We previously showed that the expression of lncRNA H19 (H19) was higher in gastric cancer (GC) tissues than that in paired noncanerous tissues. However, the
Shufang Jin et al.
Molecular cancer, 21(1), 97-97 (2022-04-10)
N6-methyladenosine (m6A) RNA modification plays a critical role in various physiological and pathological conditions. However, the role of m6A modification in head and neck squamous cell carcinoma (HNSCC) remains elusive. In this study, the expression of m6A demethylases was detected
Huiwen Song et al.
Autophagy, 15(8), 1419-1437 (2019-03-15)
N6-methyladenosine (m6A) mRNA modifications play critical roles in various biological processes. However, no study addresses the role of m6A in macroautophagy/autophagy. Here, we show that m6A modifications are increased in H/R-treated cardiomyocytes and ischemia/reperfusion (I/R)-treated mice heart. We found that
Yushan Li et al.
Journal of cellular and molecular medicine, 26(2), 385-398 (2021-12-02)
It has been shown that N6-methyladenosine (m6A) modification is involved in the development of complex human diseases, especially in the development of cancer. Our research investigated the role and mechanism of the m6A modification of lncRNA KCNQ1 overlapping transcript 1
Cheng-Lin Wu et al.
The Journal of biological chemistry, 290(50), 30175-30192 (2015-10-23)
Long non-coding RNAs (lncRNAs) have recently emerged as key players in many physiologic and pathologic processes. Although many lncRNAs have been identified, few lncRNAs have been characterized functionally in aging. In this study, we used human fibroblast cells to investigate
Yu Huang et al.
Cancer cell international, 21(1), 636-636 (2021-12-01)
Circular RNAs (circRNAs), which are endogenous non-coding RNAs, are associated with various biological processes including development, homeostatic maintenance, and pathological responses. Accumulating evidence has implicated non-coding RNAs in cancer progression, and the role of circRNAs in particular has drawn wide
Li-Min Xu et al.
Journal of experimental & clinical cancer research : CR, 35(1), 162-162 (2016-10-14)
Gliomas are the most common type of primary brain tumour in the central nervous system of adults. The long non-coding RNA (lncRNA) HOXA transcript at the distal tip (HOTTIP) is transcribed from the 5' tip of the HOXA locus. HOTTIP
Feng Wang et al.
Oncotarget, 6(10), 7899-7917 (2015-03-12)
The long non-coding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) has been recently shown to be dysregulated, which plays an important role in the progression of several cancers. However, the biological role and clinical significance of UCA1 in the carcinogenesis of
Xuexia Zhou et al.
Nature communications, 5, 4581-4581 (2014-08-06)
Bcl-2-associated transcription factor 1 (BCLAF1) is known to be involved in multiple biological processes. Although several splice variants of BCLAF1 have been identified, little is known about how BCLAF1 splicing is regulated or the contribution of alternative splicing to its
Ying Wu et al.
Oncotarget, 6(11), 9160-9172 (2015-04-13)
Long noncoding RNAs (lncRNAs) have emerged as key regulators of tumor development and progression. The lncRNA HNF1A-antisense 1 (HNF1A-AS1) is a 2455-bp transcript on chromosome 12 with a potential oncogenic role in esophageal adenocarcinoma. Nevertheless, current understanding of the involvement
CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer.
Ling, H; Spizzo, R; Atlasi, Y; Nicoloso, M; Shimizu, M; Redis, RS; Nishida, N; Gafa et al.
Genome Research null
Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans.
Yang, F; Zhang, L; Huo, XS; Yuan, JH; Xu, D; Yuan, SX; Zhu, N; Zhou, WP; Yang, GS; Wang et al.
Hepatology null
Jimmy Jacob et al.
Cancer letters, 372(1), 137-146 (2016-01-08)
Lemur tyrosine kinase-3 (LMTK3) plays an important role in cancer progression and is associated with breast, lung, gastric and colorectal cancer. MicroRNAs (miRNAs) are small endogenous non-coding RNAs that typically repress target genes at post-transcriptional level and have an important
Qi Yang et al.
PLoS genetics, 8(12), e1003172-e1003172 (2013-01-10)
Fragile X syndrome (FXS) is a form of inherited mental retardation in humans that results from expansion of a CGG repeat in the Fmr1 gene. Recent studies suggest a role of astrocytes in neuronal development. However, the mechanisms involved in
Jennifer N Dumdie et al.
Developmental cell, 44(3), 392-402 (2018-02-07)
Global transcriptional silencing is a highly conserved mechanism central to the oocyte-to-embryo transition. We report the unexpected discovery that global transcriptional silencing in oocytes depends on an mRNA decay activator. Oocyte-specific loss of ZFP36L2 an RNA-binding protein that promotes AU-rich
The long non-coding RNA HOTAIR promotes thyroid cancer cell growth, invasion and migration through the miR-1-CCND2 axis.
Di, W; Li, Q; Shen, W; Guo, H; Zhao, S
American Journal of Cancer Research null
Kun Chi et al.
Journal of cellular and molecular medicine, 25(17), 8504-8521 (2021-07-24)
Long non-coding RNA (lncRNA) plays an important role in the renal inflammatory response caused by hyperuricaemia. However, the underlying molecular mechanisms through which lncRNA is involved in endothelial injury induced by hyperuricaemia remain unclear. In this study, we investigated the
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