Showing 1-30 of 836 results for "17933"
Axel Andrés et al.
Journal of chromatography. A, 1385, 42-48 (2015-02-11)
Retention of ionizable analytes under gradient elution depends on the pH of the mobile phase, the pKa of the analyte and their evolution along the programmed gradient. In previous work, a model depending on two fitting parameters was recommended because...
Fabiana D M Siman et al.
Journal of cardiovascular pharmacology, 65(1), 28-38 (2014-08-28)
Ouabain occurs in nanomolar concentrations in myocardial infarction and heart failure (HF). However, the effects of ouabain in vascular function in HF conditions were not investigated yet. Therefore, we analyzed the effects of acute administration of 3 nM ouabain in...
Ulrich Thormann et al.
BioMed research international, 2015, 943603-943603 (2015-02-27)
Screws for ligament reconstruction are nowadays mostly made of poly-L-lactide (PLLA). However, magnesium-based biomaterials are gathering increased interest in this research field because of their good mechanical property and osteoanabolic influence on bone metabolism. The aim of this pilot study...
H Gül Akıllıoğlu et al.
Journal of agricultural and food chemistry, 62(46), 11289-11295 (2014-11-05)
This study aimed to investigate the effects of hydrophobic and ionic interactions on glycation of native and high-shear treated casein during heating. Casein-epicatechin and casein-calcium complexes were formed and glycated with glucose at different temperatures ranging from 70 to 150...
JianJun Yang et al.
Molecular neurobiology, 51(1), 8-18 (2014-04-05)
Maged1 is a member of the type II melanoma antigen (MAGE) family of proteins, which is highly conserved in the brain between mouse and human. Recently, Maged1 has been reported to be involved in depression and impaired sexual behavior. However...
Amalia Papadaki et al.
The Biochemical journal, 467(3), 473-486 (2015-02-20)
Acid ecto-phosphatase activity has been implicated in Leishmania donovani promastigote virulence. In the present study, we report data contributing to the molecular/structural and functional characterization of the L. donovani LdMAcP (L. donovani membrane acid phosphatase), member of the histidine acid...
Aleksandar Lolić et al.
The Science of the total environment, 508, 240-250 (2014-12-08)
The occurrence of seven pharmaceuticals and two metabolites belonging to non-steroidal anti-inflammatory drugs and analgesics therapeutic classes was studied in seawaters. A total of 101 samples covering fourteen beaches and five cities were evaluated in order to assess the spatial...
Meyliana Wulandari et al.
Analytical and bioanalytical chemistry, 407(3), 803-812 (2014-07-25)
This paper describes the synthesis of novel molecularly imprinted polymers (MIPs), prepared by a noncovalent imprinting approach, for cleanup and preconcentration of curcumin (CUR) and bisdemethoxycurcumin (BDMC) from medicinal herbal extracts and further analysis by high-performance liquid chromatography with fluorescence...
Jun Zhe Min et al.
European journal of mass spectrometry (Chichester, England), 20(6), 477-486 (2014-01-01)
A rapid and sensitive ultraperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS) method has been developed and validated for quantitatively determining diacetylpolyamines in the human fingernail. N(1),N(8)-diacetylspermidine (DiAct-Spd), N(1),N(12)- diacetylspermine (DiAct-Spm) and 1,6-diaminohexane (DAH) the [internal standard...
Marzieh Kamankesh et al.
Meat science, 103, 61-67 (2015-01-27)
A simple and rapid analytical tech nique for the simultaneous determination of 16 polycyclic aromatic hydrocarbons (PAHs) in grilled meat was developed using microwave-assisted extraction and dispersive liquid-liquid microextraction (MAE-DLLME) followed by gas chromatography-mass spectrometry (GC-MS). The effective parameters in...
Nam Ah Kim et al.
Drug development and industrial pharmacy, 41(2), 300-306 (2014-02-08)
Correlation of thermodynamic and secondary structural stability of proteins at various buffer pHs was investigated using differential scanning calorimetry (DSC), dynamic light scattering (DLS) and attenuated total reflection Fourier-transform infrared spectroscopy (ATR FT-IR). Recombinant human epithelial growth factor (rhEGF) was...
Heath D Schmidt et al.
Addiction biology, 20(2), 285-296 (2014-02-11)
Emerging evidence indicates that type I metabotropic glutamate receptors (mGluRs) in the nucleus accumbens play a critical role in cocaine seeking. The present study sought to determine the role of accumbens core mGluR1, mGluR5 and protein kinase C (PKC) in...
Franziska Janusch et al.
Environmental toxicology and pharmacology, 38(3), 792-799 (2014-10-13)
The application of antibiotics including fluoroquinolones to farming animals is widespread and may lead to the development of antibiotic resistance and other environmental effects. To calculate environmental loads and for a proper risk assessment it is necessary to determine the...
John R P Knight et al.
The Biochemical journal, 465(2), 227-238 (2014-10-30)
Cells respond to external stress conditions by controlling gene expression, a process which occurs rapidly via post-transcriptional regulation at the level of protein synthesis. Global control of translation is mediated by modification of translation factors to allow reprogramming of the...
Yun Yang et al.
mAbs, 7(2), 440-450 (2015-02-14)
Panitumumab, as a commercially available antibody, is an effective anticancer therapeutic against epidermal growth factor receptor (EGFR), although it exerts weak antibody-dependent cell-mediated cytotoxicity (ADCC) activity owing to its IgG2 nature. Here, we firstly engineered panitumumab by grafting its variable...
Casey McQuade et al.
Small (Weinheim an der Bergstrasse, Germany), 11(7), 834-843 (2014-09-30)
Gold nanoparticles have garnered interest as both radiosensitzers and computed tomography (CT) contrast agents. However, the extremely high concentrations of gold required to generate CT contrast is far beyond that needed for meaningful radiosensitization, which limits their use as combined...
Alison J Scott et al.
Health physics, 106(1), 120-128 (2013-11-28)
Integral to the characterization of radiation-induced tissue damage is the identification of unique biomarkers. Biomarker discovery is a challenging and complex endeavor requiring both sophisticated experimental design and accessible technology. The resources within the National Institute of Allergy and Infectious...
Donato Cosco et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 89, 30-39 (2014-12-03)
Novel PEGylated PLA nanocapsules (PEG-AcPLA nanocapsules), loading high percentage of water soluble drugs have been formulated by using multiple emulsion technique without using conventional stabilizers. In particular, sodium deoxycholate hydrate has been used to obtain nanocapsules having a mean diameter...
Marcela Valdés-Tovar et al.
Chronobiology international, 32(2), 164-177 (2014-09-24)
The light-dark cycle is an environmental factor that influences immune physiology, and so, variations of the photoperiod length result in altered immune responsivity. Macrophage physiology comprises a spectrum of functions that goes from host defense to immune down-regulation, in addition...
Cathy M Rushworth et al.
Lab on a chip, 15(3), 711-717 (2014-12-11)
We have developed a disposable microfluidic chip with integrated cavity mirrors comprised of two pieces of 3M Vikuiti™ enhanced specular reflector II (ESRII) film, for performing cavity-enhanced absorption spectroscopy with a white light-emitting diode (LED). Compared to measurements made with...
Katerina Naumoska et al.
Journal of chromatography. A, 1381, 229-238 (2015-01-20)
Three TLC methods were used for an initial screening of some common plant triterpenoids and phytosterols in cuticular wax extracts of different vegetables (zucchini, eggplant, tomato, red pepper, mangold, spinach, lettuce, white-colored radicchio di Castelfranco, raddichio Leonardo, white cabbage, red...
Smita Jaiswal et al.
Experimental biology and medicine (Maywood, N.J.), 240(1), 67-78 (2014-08-16)
The development of small animal models that elicit human immune responses to dengue virus (DENV) is important since prior immunity is a major risk factor for developing severe dengue disease. This study evaluated anti-DENV human antibody (hAb) responses generated from...
Esther Y Cheah et al.
Biochemical pharmacology, 93(4), 519-526 (2015-01-06)
The airway epithelium is an important source of relaxant mediators, and damage to the epithelium caused by respiratory tract viruses may contribute to airway hyperreactivity. The aim of this study was to determine whether influenza A-induced epithelial damage would modulate...
Wirginia Kukula-Koch et al.
Analytical and bioanalytical chemistry, 407(9), 2581-2589 (2015-01-27)
A rapid hydrostatic counter-current chromatography-thin-layer chromatography-electrospray-ionization time-of-flight mass spectrometry (CCC-TLC-ESI-TOF-MS) technique was established for use in seeking potent anti-Alzheimer's drugs among the acethylcholinesterase inhibitors in Argemone mexicana L. underground parts, with no need to isolate components in pure form. The...
G Kelmer et al.
Journal of veterinary pharmacology and therapeutics, 38(1), 35-40 (2014-07-31)
Regional limb perfusion (RLP) significantly decreases morbidity and mortality associated with distal limb injuries in horses. There is an urgent need for finding additional effective antimicrobial drugs for use in RLP. In this study, we tested the pharmacokinetics (PK) of...
Björn Bauer et al.
Immunology, 145(1), 114-123 (2014-12-17)
Keratinocyte-associated C-type lectin (KACL) is a peculiar C-type lectin-like receptor (CTLR) due to its selective expression by human keratinocytes and cognate interaction with the genetically coupled CTLR NKp65. KACL and NKp65 are members of the CLEC2 and NKRP1 subfamilies of...
Suresh B Lakshminarayana et al.
Antimicrobial agents and chemotherapy, 59(2), 1200-1210 (2014-12-10)
Limited information is available on the pharmacokinetic (PK) and pharmacodynamic (PD) parameters driving the efficacy of antimalarial drugs. Our objective in this study was to determine dose-response relationships of a panel of related spiroindolone analogs and identify the PK-PD index...
Tomoe Kanbara et al.
Journal of pharmacological sciences, 126(3), 264-273 (2014-10-28)
Oxaliplatin is a chemotherapeutic agent that induces chronic refractory neuropathy. To determine whether opioids effectively relieve this chronic neuropathy, we investigated the efficacies of morphine, oxycodone, and fentanyl, and the mechanisms underlying opioid antinociception, in oxaliplatin-induced neuropathy in rats. Rats...
Daniel Marshall et al.
Journal of immunology (Baltimore, Md. : 1950), 193(11), 5525-5533 (2014-10-29)
The developmental pathways of regulatory T cells (T(reg)) generation in the thymus are not fully understood. In this study, we reconstituted thymic development of Zap70-deficient thymocytes with a tetracycline-inducible Zap70 transgene to allow temporal dissection of T(reg) development. We find...
Syed Ghulam Musharraf et al.
Scientific reports, 5, 8607-8607 (2015-02-26)
Lung cancer has been the most common death causing cancer in the world for several decades. This study is focused on the metabolite profiling of plasma from lung cancer (LC) patients with three control groups including healthy non-smoker (NS), smokers...

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