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18-0800

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Erico R Carmona et al.
Mutation research, 724(1-2), 35-40 (2011-06-08)
The in vivo genotoxic activity of two inorganic lead compounds was studied in Drosophila melanogaster by measurement of two different genetic endpoints. We used the wing-spot test and the comet assay. The comet assay was conducted with larval haemocytes. The...
Margarita Topashka-Ancheva et al.
Biological trace element research, 147(1-3), 206-216 (2011-12-07)
The detoxification capacity of the clinoptilolite modification KLS-10-MA used as food additive in small mammals, chronically lead-exposed, was proven for the first time. The modified clinoptilolite was prepared based on natural Bulgarian clinoptilolite deposits. As a powder, it was mechanically...
Misaki Kojima et al.
Biological & pharmaceutical bulletin, 35(2), 246-250 (2012-02-02)
Hepatic 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) and cholesterol 7α-hydroxylase (Cyp7a1) are rate-limiting enzymes for cholesterol biosynthesis and catabolism, respectively. Involvement of inflammatory cytokines, particularly interleukin-1 (IL-1), in alterations of HMGR and Cyp7a1 gene expression during development of lead nitrate (LN)-induced hypercholesterolemia was...
Kilarkaje Narayana et al.
Drug and chemical toxicology, 35(2), 208-217 (2011-10-13)
The aim of the present study was to investigate the coexistence of oxidative DNA damage and apoptosis- and necrosis-related DNA damage, and to correlate with ultrastructural changes in hepatocyte nuclei in the lead-nitrate-exposed liver. Adult male Wistar rats were exposed...
Xiao Shu et al.
Environmental science and pollution research international, 19(3), 893-902 (2011-10-04)
Cuttings and seedlings of Jatropha curcas L. were exposed to different regimes of lead (Pb) stress as Pb(NO₃)₂ at 0 (CK), 0.5, 1, 2, 3, and 4 mM kg⁻¹ soil. The effect of Pb treatment on the root length, tolerance...
Kiyomitsu Nemoto et al.
The Journal of toxicological sciences, 36(3), 357-364 (2011-06-02)
Administration of lead ion (Pb) to rats and mice affects hepatic functions such as the induction of hepatic cell proliferation and upregulation of cholesterol biosynthesis. To identify the genes for which expression changes in response to Pb-administration, we analyzed hepatic...
M M Naik et al.
Letters in applied microbiology, 56(2), 99-104 (2012-11-21)
A lead-resistant bacteria isolated from soil contaminated with car battery waste were identified as Providencia alcalifaciens based on biochemical characteristics, FAME profile and 16S rRNA sequencing and designated as strain 2EA. It resists lead nitrate up to 0·0014 mol l(-1)...
Yanhong Lou et al.
Ecotoxicology (London, England), 22(2), 207-214 (2012-11-15)
Cadmium (Cd) and lead (Pb) are regarded as the most toxic environmental pollutants because they are a threat not only to plants, but also to humans. Better understanding of the growth response, uptake and translocation of Cd and Pb in...
I V Kushkevych et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 83(6), 104-109 (2012-03-01)
Glutathione is the metal stress protector and changes of its level in the sulfate-reducing bacteria cells under the influence of heavy metal salts have not been studied yet. CdCl2, Pb(NO3)2, CuCl2, and ZnCl2 influence on the total glutathione level in...
Andrea Jorissen et al.
Archives of toxicology, 87(2), 249-258 (2012-08-23)
Mercury and lead are widespread in the environment, causing chronic exposure of a large population to low concentrations of these metals. While several studies demonstrated that low levels of both metals affect the immune system, little is known about underlying...
Magdalena Mroczek-Zdyrska et al.
Biological trace element research, 147(1-3), 320-328 (2011-12-14)
The effect of selenium (Se) on Vicia faba L. minor roots subjected to lead (Pb) stress was studied by investigating root growth, root viability, and antioxidant enzyme activity. The experiments were carried out on plants grown for 2 weeks on...
Veena Sharma et al.
Indian journal of biochemistry & biophysics, 49(6), 458-462 (2013-01-29)
The in vivo protective role of hydro-methanolic root extract of Withania somnifera (WS) was evaluated in alleviating lead nitrate (LN)-induced toxicity in male Swiss albino mice by measuring hematoserological profiles. The lead-treated (20 mg/kg body wt, p.o.) albino mice (25-30...
B V S Lakshmi et al.
Environmental toxicology and pharmacology, 35(3), 361-368 (2013-03-08)
From time immemorial Vitis vinifera (Black grapes) have been used both for medicinal and nourishment purposes. The aim of this study is to investigate the protective effect of Black grapes against lead nitrate induced oxidative stress. Exposure to lead significantly...
Yujiao Zhu et al.
Fish & shellfish immunology, 34(2), 617-622 (2013-01-01)
Glucose regulated protein (GRP) located in endoplasmic reticulum (ER) was a member of heat shock protein (Hsp) family. The protective mechanism adapted to ER stimuli was closely related to GRP. GRP78, known as BiP, was one of central regulator responded...
Kiyomitsu Nemoto et al.
The Journal of toxicological sciences, 38(1), 127-129 (2013-01-30)
We previously demonstrated the super-induced expression of the Grin2c gene encoding the N-methyl-D-aspartate receptor 2C subunit during the development of liver enlargement with hepatocellular hypertrophy induced by phenobarbital, clofibrate, or piperonyl butoxide. In the present study, we assessed whether or...
Lubomira Rumlova et al.
Environmental toxicology and pharmacology, 33(3), 459-464 (2012-03-13)
This study evaluates the toxic effects of five substances (atropine, fenitrothion, potassium cyanide, mercuric chloride and lead nitrate) on the yeast Saccharomyces cerevisiae. It describes a new biological toxicity test based on inhibition of S. cerevisiae viability and compares it...
Hongmei Wang et al.
Journal of hazardous materials, 244-245, 718-725 (2012-11-28)
Inhibition of bacterial oxidation of ferrous iron (Fe(II)) by Pb(NO(3))(2) was investigated with a mixed culture of Acidithiobacillus ferrooxidans. The culture was incubated at 30 °C in ferrous-sulfate medium amended with 0-24.2 mM Pb(II) added as Pb(NO(3))(2). Anglesite (PbSO(4)) precipitated...
Qiang Wang et al.
Brain research, 1455, 19-27 (2012-04-17)
Lead (Pb) can target the vascular system for both acute injury and disease promotion. Cellular iron (Fe) disruption may be implicated in Pb vascular toxicity. To investigate the potential involvement of iron response element 1 (IRP1) protein in the vascular...
Trivedi Mrugesh et al.
Acta poloniae pharmaceutica, 68(5), 653-656 (2011-09-21)
The present study was an attempt to investigate toxic effects of lead on red blood corpuscle (RBC) under in vitro conditions. Venous blood samples from adult, healthy, well-nourished male donors falling in age group of 25-30 years were collected in...
Rami Alkhatib et al.
Plant cell reports, 30(8), 1427-1434 (2011-03-16)
Effect of various lead (Pb) concentrations on the systemic movement of RNA viruses was examined in tobacco plants. Prior to inoculation, plants were grown hydroponically for 6 days in Hoagland's solution supplemented with five concentrations of lead nitrate [Pb(NO(3))(2)]: 0.0 (control)...
Patrícia Reckziegel et al.
Toxicology letters, 203(1), 74-81 (2011-03-16)
We investigated the antioxidant potential of gallic acid (GA), a natural compound found in vegetal sources, on the motor and oxidative damages induced by lead. Rats exposed to lead (50 mg/kg, i.p., once a day, 5 days) were treated with...
Azra Rabbani-Chadegani Iii et al.
Journal of biochemical and molecular toxicology, 25(3), 127-134 (2011-06-15)
The biological activity of heavy metals is related to their physicochemical interaction with biological receptors. In the present study, the effect of low concentrations of nickel nitrate and lead nitrate (<0.3 mM) on rat liver soluble chromatin and histone proteins...
Pimluck Kijjanapanich et al.
Environmental technology, 35(13-16), 1989-1996 (2014-06-25)
Construction and demolition debris (CDD) is a product of construction, renovation or demolition activities. It has a high gypsum content (52.4% of total gypsum), concentrated in the CDD sand (CDDS) fraction. To comply with the posed limit of the maximum...
Xuemei Li et al.
Journal of hazardous materials, 213-214, 55-61 (2012-02-24)
An endophytic fungus was tested in rice (Oryza sativa L.) exposed to four levels of lead (Pb) stress (0, 50, 100 and 200 μM) to assess effects on plant growth, photosynthesis and antioxidant enzyme activity. Under Pb stress conditions, endophyte-infected...
Salwa A Abduljaleel et al.
Pakistan journal of biological sciences : PJBS, 16(22), 1551-1556 (2014-02-12)
The influence of dietary cadmium on the accumulation and effects of dietary lead, examined in chicken. This experiment was conducted to investigate the toxic effects of dietary Cd and Pb on chick's body weight and organ, content of the tissues...
Merylin Zizza et al.
Aquatic toxicology (Amsterdam, Netherlands), 126, 231-241 (2012-12-19)
The hindering effects of metals and in particular lead (Pb) are representing a growing threat to aquatic organisms such as fish. This observation derives from toxic concentrations of Pb accounting for altered neurophysiological activities of some interesting teleost models like...
Hans J Jakobsen et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 211(2), 195-206 (2011-06-28)
The acquisition and different appearances observed for wide bandwidth solid-state MAS NMR spectra of low-γ nuclei, using (14)N as an illustrative nucleus and employing two different commercial spectrometers (Varian, 14.1T and Bruker, 19.6T), have been compared/evaluated and optimized from an...
Mostafa Lamhamdi et al.
Comptes rendus biologies, 334(2), 118-126 (2011-02-22)
Lead (Pb) is an environmental pollutant extremely toxic to plants and other living organisms including humans. To assess Pb phytotoxicity, experiments focusing on germination of wheat seeds were germinated in a solution containing Pb (NO(3))(2) (0.05; 0.1; 0.5; 1g/L) during...
Brenna R Hill et al.
Peptides, 38(1), 159-162 (2012-09-08)
Peptide YY (PYY) and ghrelin (GHR) may modulate one another's actions within the hypothalamus. Peripheral infusion of PYY in humans acutely suppresses circulating concentrations of GHR. Whether an association between PYY and GHR exists in the peripheral circulation of humans...
Michaela D Wharfe et al.
American journal of physiology. Endocrinology and metabolism, 311(3), E575-E586 (2016-07-14)
Adaptations in maternal carbohydrate metabolism are particularly important in pregnancy because glucose is the principal energy substrate used by the fetus. As metabolic homeostasis is intricately linked to the circadian system via the rhythmic expression of clock genes, it is...
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