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194301

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S L Gisbert-González et al.
Pharmaceutical research, 13(8), 1154-1161 (1996-08-01)
The uptake of zinc as acexamic acid salt in the rat gastrointestinal tract, using an in situ static technique, was studied. Our aim was to investigate an absorption window for zinc and the uptake kinetics in the colon. To detect
Gastroprotective effect of zinc.
D Lapenna et al.
Digestive diseases and sciences, 39(9), 1882-1884 (1994-09-01)
Masayoshi Yamaguchi et al.
International journal of molecular medicine, 12(5), 755-761 (2003-10-09)
The preventive effect of zinc compounds on bone loss in streptozotocin (STZ)-diabetic rats was investigated. Rats received a single subcutaneous administration of STZ (6.0 mg/100 g body weight), and 7, 14 or 21 days later the animals were sacrificed by
A Igarashi et al.
International journal of molecular medicine, 4(6), 615-620 (1999-11-24)
The alteration in bone components in the femoral-diaphyseal tissues with fracture healing was investigated. Rats were sacrificed 7 and 14 days after the femoral fracture. Protein content in the femoral-diaphyseal tissues was markedly elevated by fracture healing. Analysis with sodium
M Yamaguchi et al.
General pharmacology, 30(3), 423-427 (1998-03-24)
1. The effect of zinc compounds on bone components in the femoral-metaphyseal tissues from elderly female rats (50 weeks old) was investigated in vitro. Bone tissues were cultured for 24 hr in Dulbecco's modified Eagle medium containing either vehicle or
C A Tagliati et al.
General pharmacology, 33(1), 67-71 (1999-07-31)
Complexation of piroxicam with zinc extends its absorption time in rats. The time of peak concentration value for complexed piroxicam was 5.27 hr compared to only 2.56 hr for the uncomplexed agent. Piroxicam and zinc-piroxicam show similar inhibitory effects on
C T Yu et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 35(12), 913-915 (2003-02-06)
To study the effect of solution pH value on the chelation structure of zinc acexamate. A series of samples at different solution pH values were prepared by 10% HCl or 1 mol.L-1 NH3.H2O. Then API/TOFMS with electrospray ion source was
U Lee et al.
Xenobiotica; the fate of foreign compounds in biological systems, 42(3), 310-315 (2011-10-14)
The pharmacokinetics of ϵ-acetamidocaproic acid (AACA) were evaluated after the intravenous and oral administration of an antiulcer agent, zinc acexamate (ZAC) at a dose of 20 mg kg⁻¹ (ion pairing between zinc and AACA) in rats with indomethacin-induced acute gastric ulcer
J Guilarte López-Mañas et al.
Gastroenterologia y hepatologia, 21(5), 212-217 (1998-06-30)
Zinc acexamate (ZAM) is an antiulcer agent with antisecretory and gastroprotective properties. The aim of this study was to evaluate endoscopically and morphometrically the efficacy of ZAM in the prophylaxis of gastroduodenal lesions induced by pyroxicam. Thirty nine patients from
Seung Yon Han et al.
The Journal of pharmacy and pharmacology, 64(10), 1452-1460 (2012-09-05)
Anti-ulcer drugs are frequently used in patients with acute renal failure (ARF). Zinc acexamate is ionized to zinc and ε-acetamidocaproic acid and free EACA exerts a potent therapeutic effect in treating gastric or duodenal ulcers with few side effects. Thus
A Igarashi et al.
International journal of molecular medicine, 8(4), 433-438 (2001-09-20)
The effect of zinc, a stimulator of bone formation, on bone protein components in the femoral-diaphyseal tissues with fracture healing was investigated. Rats were sacrificed between 1 and 7 days after the femoral fracture, and the diaphyseal tissues were cultured
Zinc acexamate allergy.
P A Galindo et al.
Contact dermatitis, 38(5), 301-302 (1998-07-17)
C Navarro et al.
Prostaglandins, leukotrienes, and essential fatty acids, 50(6), 305-310 (1994-06-01)
Gastrotoxic activities of different non-steroidal anti-inflammatory drugs (NSAIDs) (diclofenac, indomethacin, ketoprofen, naproxen and piroxicam) administered per os were compared with their ability to inhibit gastric prostaglandin E2 (PGE2) synthesis in the rat. In a parallel study, effects of pretreatment with
H Y Li et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 30(1), 17-20 (1995-01-01)
Zinc acexamate (ZAC) is a new antiulcer drug. This paper reports the pharmacokinetics of ZAC in rats after single oral administration. The concentrations in biological samples were detected by spectrophotometry. This study shows that the concentration-time curve of ZAC in
Seth Chitayat et al.
Biochemistry, 46(7), 1732-1742 (2007-02-01)
The plasma lipoprotein lipoprotein(a) [Lp(a)] comprises a low-density lipoprotein (LDL)-like particle covalently attached to the glycoprotein apolipoprotein(a) [apo(a)]. Apo(a) consists of multiple tandem repeating kringle modules, similar to plasminogen kringle IV (designated KIV1-KIV10), followed by modules homologous to the kringle
A García-Plaza et al.
Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva, 88(11), 757-762 (1996-11-01)
A multicentric double-blind trial comparing 600 mg/d of Zinc Acexamate (ACZ) and 40 mg/d of Famotidine (FMT) in the short term treatment of acute duodenal ulcer included 199 patients, diagnosed by endoscopy. One-hundred and five patients received ACZ and 94
Y Tsutsui et al.
Pharmacology, 58(4), 209-219 (1999-03-17)
Zinc acexamate (NAS-501), an anti-ulcer agent, has been reported to prevent various acute experimental gastric mucosal lesions and duodenal ulcers in rats. In order to clarify the mechanisms by which NAS-501 exhibits the anti-ulcer effects, we investigated the anti-oxidative effects
A Rodríguez de la Serna et al.
The Journal of rheumatology, 21(5), 927-933 (1994-05-01)
To assess in a multicenter double blind clinical trial the gastroenteroprotective effect of zinc acexamate (ZAC). 276 patients with rheumatic disease and history of peptic ulcer or intolerance to nonsteroidal antiinflammatory drugs (NSAID), and requiring treatment with these drugs were
Topical treatment of peritoneal catheter-related exit-site granuloma with acetamidohexanoic acid combined with gentamicin.
Carlos G Musso et al.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 26(4), 505-506 (2006-08-03)
J F Wu et al.
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 17(4), 375-378 (1996-07-01)
beta = 11.6 h. The bioavailability was about 52.8%. After ig [3H]ZA (4.44 MBq.kg-1), higher radioactivities were observed in kidney, liver, and gastrointestinal tract but lower in brain, fat, and femur. ZA given i.g. in rats was absorbed rapidly and
Satoshi Uchiyama et al.
International journal of molecular medicine, 12(6), 949-954 (2003-11-13)
The effect of zinc acexamate in streptozotocin (STZ)-induced diabetic rats was investigated. Rats received a single subcutaneous administration of STZ (6.0 mg/100 g body weight), and the animals were orally administered once daily for 14 days with zinc acexamate (2.5
A Igarashi et al.
General pharmacology, 32(4), 463-469 (1999-05-14)
The effect of zinc acexamate on fracture healing of the femoral-diaphyseal tissues in rats was investigated in vivo. Zinc acexamate (0.3 and 10.0 mg Zn/100 g body weight per day) was orally administered to rats (4 weeks old) surgically fractured
Y H Choi et al.
Xenobiotica; the fate of foreign compounds in biological systems, 40(7), 485-498 (2010-06-04)
1. Zinc acexamate (ZAC) is ionized to zinc and epsilon-acetamidocaproic acid (AACA). Thus, the pharmacokinetics and tissue distribution of zinc and AACA after intravenous (50 mg kg(-1)) and oral (100 mg kg(-1)) administration of ZAC were evaluated in rats. Also
Allergic contact dermatitis to acexamic acid.
Ana Margarida Soares Reis et al.
Contact dermatitis, 58(4), 241-242 (2008-03-21)
Y H Choi et al.
Xenobiotica; the fate of foreign compounds in biological systems, 41(5), 409-415 (2011-01-22)
After both the intravenous and oral administration of zinc acexamate [ZAC; ion-pairing between zinc and ϵ-acetamidocaproic acid (AACA)] and cimetidine together, the areas under the curve (AUCs) of AACA were significantly greater [by 28.2 and 98.9% after the intravenous and
J Hamzah et al.
Acta tropica, 87(3), 345-353 (2003-07-24)
Retinol (vitamin A alcohol) may have a beneficial role in the host response to malaria in humans and previously published data have suggested that it has a direct inhibitory effect on the growth of Plasmodium falciparum in vitro. To further
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