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201-201-8

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Kristen P Zeligs et al.
Frontiers in oncology, 10, 805-805 (2020-07-09)
Purpose: Despite high initial response rates with cytoreductive surgery, conventional chemotherapy and the incorporation of biologic agents, ovarian cancer patients often relapse and die from their disease. New approaches are needed to improve patient outcomes. This study was designed to...
Milan M Patel et al.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 109(5), 739-743 (2010-03-30)
It is well established that fibrous dysplasia (FD) is caused by mutations of the Arg(201) codon of the GNAS gene. However, the role of GNAS mutation in the pathogenesis of cement-osseous dysplasias (COD) and cemento-ossifying fibromas (COF) is not fully...
Denis Ravel et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(4), 1258-1265 (2008-02-19)
There is a clear clinical need for cytotoxic drugs with a lower systemic toxicity. DTS-201 (CPI-0004Na) is a peptidic prodrug of doxorubicin that shows an improved therapeutic index in experimental models. The purpose of the current study was to complete...
Kana Nakata et al.
Cytoskeleton (Hoboken, N.J.), 69(4), 221-234 (2012-02-14)
Primary cilia are organelles that extend from the cell surface. More than 600 proteins have been identified in cilia, but ciliary targeting mechanisms are poorly understood. Nephronophthisis (NPHP) is an autosomal recessive cystic kidney disease with 11 responsible genes (NPHP1-11)...
M Koppán et al.
The Prostate, 38(2), 151-158 (1999-02-11)
Receptors for luteinizing hormone-releasing hormone (LH-RH) found in prostate cancers might be used for targeting of chemotherapeutic agents. Doxorubicin derivative 2-pyrrolinodoxorubicin (AN-201) can be linked to carrier analog [D-Lys6]LH-RH to form the targeted cytotoxic analog of LH-RH, AN-207. We evaluated...
Yoshimitsu Fukushima et al.
Annals of nuclear medicine, 22(5), 363-369 (2008-07-05)
Earlier studies suggested that elevated cardiac troponin T (cTnT) might be useful for detecting less severe types of myocardial injury (i.e., non-ST segment elevation myocardial infarction). The objective of this study is to elucidate the usefulness of (201)thallous chloride ((201)TlCl)...
Yasushi Akutsu et al.
Japanese heart journal, 45(5), 739-748 (2004-11-24)
We investigated simultaneously the correlations between dobutamine-induced contractile reserve (CC), thallium-201 reverse redistribution (RR) and a mismatch between perfusion and metabolism (MM) to the magnitude of functional recovery. In 32 patients with coronary angioplasty early after infarction, echocardiography was performed...
Hideki Otsuka et al.
The journal of medical investigation : JMI, 56(3-4), 136-141 (2009-09-19)
We report the findings of Thallium-201 chloride ((201)TlCl) scintigraphy and consider how to use this technique to evaluate the character of soft tissue lesions. We enrolled 91 consecutive patients (45 males and 46 females, age range 8-91-years-old). Nineteen patients were...
H Çaksen et al.
Genetic counseling (Geneva, Switzerland), 20(3), 255-260 (2009-10-27)
Rubinstein-Taybi syndrome (RTS) is a rare syndrome with a frequency of approximately 1 in 125,000 affected newborns, which is characterized by mental retardation, growth retardation, a particular dysmorphology and, in a subset of cases, immunodeficiency. RTS is typically caused by...
Zhongwei Xin et al.
OncoTargets and therapy, 11, 4125-4136 (2018-07-28)
The mucin 1 (MUC1) heterodimeric protein (N-terminal subunit and C-terminal subunit) is aberrantly overexpressed in esophageal squamous cell carcinoma (ESCC) and has been linked to poor outcomes in this disease. The detailed mechanism(s), however, remains unclear. In this article, we...
Marianne Arnestad et al.
Circulation, 115(3), 361-367 (2007-01-11)
The hypothesis that some cases of sudden infant death syndrome (SIDS) could be caused by long-QT syndrome (LQTS) has been supported by molecular studies. However, there are inadequate data regarding the true prevalence of mutations in arrhythmia-susceptibility genes among SIDS...
Giselle Fernandes Taboada et al.
Pituitary, 12(3), 165-169 (2008-07-22)
The purpose of the present study is to evaluate the prevalence of the gsp oncogene in Brazilian patients harboring somatotropinomas and non-functioning pituitary adenomas (NFPA). Patients and methods Deoxyribonucleic acid was extracted from 54 somatotropinomas and 14 NFPA. Exons 8...
Maciej Czachorowski et al.
Biochemistry, 48(35), 8422-8434 (2009-07-23)
The mammalian Slc11a1 and Slc11a2 proteins define a large family of secondary metal transporters. Slc11a1 and Slc11a2 function as pH-dependent divalent cation transporters that play a critical role in host defenses against infections and in Fe2+ homeostasis, respectively. The position...
Yared Tekabe et al.
JACC. Cardiovascular imaging, 5(1), 59-67 (2012-01-14)
The aim of this study was to image expression of receptor for advanced glycation end products (RAGE) in a mouse model of myocardial reperfusion injury. RAGE and its ligands are implicated in the pathogenesis of ischemia/reperfusion injury and infarction. We...
Seung Eun Lee et al.
Human pathology, 43(8), 1234-1242 (2012-01-17)
GNAS mutations have been implicated in the development of fibrous dysplasia and multiple endocrinopathies of the Albright-McCune syndrome. To investigate the diagnostic utility of GNAS mutations in patients with fibrous dysplasia, we performed mutational analyses of histologically confirmed fibrous dysplasia...
Boriana Zaharieva et al.
International journal of cancer, 117(6), 952-956 (2005-06-30)
Alterations of chromosome 8, preferentially deletions of 8p and gains of 8q, belong to the most frequent cytogenetic changes in bladder cancer. CMYC on 8q24 is a candidate oncogene in this region. Little is known about the clinical significance of...
Xiaoyun Chen et al.
Molecular vision, 26, 517-529 (2020-08-21)
Interleukin-6 (IL-6) is elevated in intraocular fluid from eyes with proliferative vitreoretinopathy (PVR), but the exact role of the cytokine is still unclear. We investigated the function and mechanism of IL-6 in retinal pigment epithelium (RPE) cell biology in vitro...
Mickael-F El Hachmane et al.
The Journal of biological chemistry, 289(3), 1388-1401 (2013-12-07)
TASK3 two-pore domain potassium (K2P) channels are responsible for native leak K channels in many cell types which regulate cell resting membrane potential and excitability. In addition, TASK3 channels contribute to the regulation of cellular potassium homeostasis. Because TASK3 channels...
Victoria Mendoza et al.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 15(1), 28-32 (2005-02-11)
The frequency of activating mutations of the GSPalpha gene as the etiology of GH-secreting pituitary adenomas has been the subject of important ethnogenetic variability. Whereas up to 40% of Caucasian patients with acromegaly have tumors which harbor these somatic mutations...
Haruhiko Osawa et al.
Clinical endocrinology, 69(1), 36-44 (2007-11-27)
The c-Jun N-terminal kinase 1 (JNK1, mitogen-activated kinase 8; MAPK8) phosphorylates insulin receptor substrate-1 (IRS-1) at serine 307, which induces insulin resistance. MAPK8 activity is increased in obese insulin-resistant mice, whereas mapk8 (-/-) mice show decreased adiposity and improved insulin...
R N Fontaine et al.
Biochemistry, 30(28), 7008-7014 (1991-07-16)
The gene encoding the rat pancreatic cholesterol esterase has been isolated and characterized. Analysis of overlapping genomic clones showed that the cholesterol esterase gene spans approximately 8 kb, containing 11 exons interrupted by 10 introns. The exons ranged in size...
A Ogura et al.
Nephron, 68(2), 239-244 (1994-01-01)
The clinical course of murine hereditary nephrotic syndrome (ICGN strain) was determined by examining 201 animals under different conditions. In the early stage, significant hypoproteinemia and hypoalbuminemia developed (p < 0.001) in parallel with a progressive rise in urinary protein...
Bihui Zhong et al.
Hepatology (Baltimore, Md.), 50(2), 546-554 (2009-07-09)
Keratins (K) 8 and 18 variants predispose carriers to the development of end-stage liver disease and patients with chronic hepatitis C to disease progression. Hepatocytes express K8/K18, whereas biliary epithelia express K8/K18/K19. K8-null mice, which are predisposed to liver injury...
C J Kozlosky et al.
Oncogene, 10(2), 299-306 (1995-01-19)
Hek is a member of the eph subfamily of receptor tyrosine kinases whose members include elk, hek2, sek, eph and eck among others. Using a soluble form of hek consisting of the extracellular region of the receptor fused to the...
H Endeman et al.
The European respiratory journal, 37(6), 1431-1438 (2010-10-05)
The role of individual cytokines and polymorphisms in pneumonia has been described, but the relationship between different cytokines and polymorphisms in relation to causative microorganisms, antibiotics, corticosteroids and clinical course has not. This study questions the relationship between cytokines, polymorphisms...
D Xing et al.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 17(6), 377-380 (2000-12-09)
To examine the association between Ser326Cys polymorphism in hOGG1 gene, which is involved in the repair of 8-hydroxyguanine in damaged DNA, and investigate the risk of squamous cell carcinoma of the esophagus in Chinese. Ser326Cys polymorphism in hOGG1 gene was...
Yong Wang et al.
Zhonghua yi xue za zhi, 85(48), 3396-3400 (2006-01-18)
To investigate the distribution of (tttta) n microsatellite polymorphism in the promoter of CYP11a gene in Chinese women with polycystic ovary syndrome (PCOS) and the relationship between such polymorphism and PCOS. Peripheral blood samples were obtained from 201 women with...
J Boruwa et al.
Bioorganic & medicinal chemistry letters, 14(13), 3571-3574 (2004-06-05)
The absolute stereochemistry of the new antifungal and antibacterial antibiotic produced by Streptomyces sp.201 has been established by achieving the total synthesis of the product. A series of analogues have also been synthesized by changing the side chain and their...
B M Connelly et al.
The journal of physical chemistry. A, 116(24), 6180-6187 (2012-04-19)
Laboratory studies are described that suggest reactive uptake of glyoxal on particulate containing HNO(3) could contribute to the formation of secondary organic aerosol (SOA) in the upper troposphere (UT). Using a Knudsen cell flow reactor, glyoxal is observed to react...
M B Bass et al.
Proteins, 13(1), 26-37 (1992-05-01)
While cytochrome P-450cam catalyzes the hydroxylation of camphor to 5-exo-hydroxycamphor with 100% stereospecificity, norcamphor is hydroxylated by this enzyme yielding 45% 5-exo-, 47% 6-exo-, and 8% 3-exo-hydroxynorcamphor (Atkins, W.M., Sligar, S.G., J. Am. Chem. Soc. 109:3754-3760, 1987). The present study...
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