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204439

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Shuying Huo et al.
Dalton transactions (Cambridge, England : 2003), 43(41), 15328-15336 (2014-07-31)
L-Selenomethionine (SeMet), the predominant form of selenium acquired from the diet by humans, has been used as a supplement, and exhibit some important functions like cancer prevention and antioxidative defense. Its interactions with Pt(II) anticancer drugs have been characterized, but...
Susanne Herbst et al.
EMBO molecular medicine, 7(3), 240-258 (2015-02-01)
Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection. Understanding how calcineurin inhibitors impair fungal immunity is a key priority for defining risk of infection. Here, we show that the calcineurin inhibitor tacrolimus impairs clearance of...
Michael S Young et al.
Journal of AOAC International, 97(6), 1737-1741 (2015-01-30)
An SPE-based cleanup protocol was developed for ultra-performance LC (UPLC)/MS/MS determination of residues of the common aminoglycoside antibiotics streptomycin, dihydrostreptomycin, neomycin, and gentamicin in bovine milk, kidney, and muscle. Recoveries for all compounds except neomycin ranged from 80 to 104%...
Eagleson M.
Concise Encyclopedia Chemistry, 887-887 (1994)
Mirjam Ketema et al.
Molecular biology of the cell, 26(13), 2402-2417 (2015-05-15)
Epidermolysis bullosa simplex associated with late-onset muscular dystrophy (EBS-MD) is an autosomal recessive disorder resulting from mutations in the plectin gene. The majority of these mutations occur within the large exon 31 encoding the central rod domain and leave the...
Xinghua Zhu et al.
Experimental cell research, 335(2), 216-223 (2015-05-31)
Enolases are glycolytic enzymes responsible for the ATP-generated conversion of 2-phosphoglycerate to phosphoenolpyruvate. In addition to the glycolytic function, Enolase 1 (ENO1) has been reported up-regulation in several tumor tissues. In this study, we investigated the expression and biologic function...
O Chudomel et al.
Neurochemical research, 40(4), 747-757 (2015-02-04)
Previous studies have shown that the pharmacologic effects of GABAergic drugs and the postsynaptic phasic GABAAergic inhibitory responses in the anterior part of the rat substantia nigra pars reticulata (SNRA) are age- and sex-specific. Here, we investigate whether there are...
Hui Zhang et al.
Biosensors & bioelectronics, 74, 872-877 (2015-08-05)
Salmonella typhimurium and Staphylococcus aureus are most common causes of food-associated disease. A Raman based biosensor was developed for S. typhimurium and S. aureus detection simultaneously. The biosensor was based on nanoparticles enhanced Raman intensity and the specific recognition of...
Songsong Zhu et al.
Cell transplantation, 23(6), 715-727 (2014-04-26)
In cartilage tissue engineering using stem cells, it is important to stimulate proliferation and control the differentiation of stem cells to specific lineages. Here we reported a combined technique for articular cartilage repair, consisting of bone marrow mesenchymal stem cells...
Eef Boets et al.
Nutrients, 7(11), 8916-8929 (2015-11-01)
Short chain fatty acids (SCFA), including acetate, propionate, and butyrate, are produced during bacterial fermentation of undigested carbohydrates in the human colon. In this study, we applied a stable-isotope dilution method to quantify the in vivo colonic production of SCFA...
Anna-Maria Miederer et al.
Nature communications, 6, 6899-6899 (2015-04-22)
Cellular homeostasis relies upon precise regulation of Ca(2+) concentration. Stromal interaction molecule (STIM) proteins regulate store-operated calcium entry (SOCE) by sensing Ca(2+) concentration in the ER and forming oligomers to trigger Ca(2+) entry through plasma membrane-localized Orai1 channels. Here we...
Varvara Tsilia et al.
Foodborne pathogens and disease, 12(11), 904-913 (2015-11-07)
Adhesion of pathogenic bacteria to intestinal mucus, the protective layer of the gastrointestinal epithelium, is often considered a virulence factor. The ability of food-poisoning Bacillus cereus strains to attach to mucus and the factors affecting this interaction have not yet...
Tatjana Orct et al.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 28(4), 701-712 (2015-05-08)
Detoxification of mercury (Hg) with selenium (Se) in the early postnatal period with regard to the expression of metallothionein protein (MT), essential element status, and lipid peroxidation level in tissues has not been studied. Seven-day-old Wistar pups were orally pretreated...
Antoine Guillon et al.
Journal of aerosol medicine and pulmonary drug delivery, 28(4), 290-298 (2015-01-24)
Glycopeptides given intravenously achieve low airway concentrations. Nebulization of teicoplanin may be an efficient way of delivering a high concentration of this antibiotic to the lung. This multistep study assessed the feasibility of teicoplanin nebulization during mechanical ventilation by evaluating:...
Dafni Dimakopoulou-Papazoglou et al.
Food microbiology, 53(Pt B), 76-81 (2015-12-19)
The effect of pH and water activity (aw) on the formation of biofilm by Salmonella enterica ser. Newport, previously identified as a strong biofilm producer, was assessed. Biofilm formation was evaluated in tryptone soy broth at 37 °C and at different...
Gongrui Guo et al.
Journal of structural biology, 192(3), 418-425 (2015-10-04)
Spt5 (NusG in bacteria) is the only RNA polymerase-associated factor known to be conserved in all three domains of life. In archaea and eukaryotes, Spt5 associates with Spt4, an elongation factor that is absent in bacteria, to form a functional...
Henriette Franz et al.
Oncotarget, 6(7), 4773-4789 (2015-03-10)
The histone code reader Spindlin1 (SPIN1) has been implicated in tumorigenesis and tumor growth, but the underlying molecular mechanisms remain poorly understood. Here, we show that reducing SPIN1 levels strongly impairs proliferation and increases apoptosis of liposarcoma cells in vitro...
Sebastian Wieland et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(27), 9946-9956 (2015-07-15)
Animals are facing a complex sensory world in which only few stimuli are relevant to guide behavior. Value has to be assigned to relevant stimuli such as odors to select them over concurring information. Phasic dopamine is involved in the...
Christina Lamparter et al.
Toxicological sciences : an official journal of the Society of Toxicology, 141(1), 59-67 (2014-06-11)
Exposure to the anticonvulsant drug valproic acid (VPA) is associated with an increased risk of congenital malformations. Although the mechanisms contributing to its teratogenicity are poorly understood, VPA has been shown to induce DNA double strand breaks (DSB) and to...
Barbara McKenzie et al.
International journal of pharmaceutics, 490(1-2), 1-8 (2015-05-20)
A modified hen's egg chorioallantoic membrane (HET-CAM) test has been developed, combining ImageJ analysis with Adobe(®) Photoshop(®). The irritation potential of an ophthalmic medicine can be quantified using this method, by monitoring damage to blood vessels. The evaluation of cysteamine...
Abida Siddiqa et al.
Viruses, 6(7), 2762-2777 (2014-07-19)
Cervical cancer is the third most common cause of cancer-related death in women worldwide. Infection with high-risk human papillomavirus (HPV) is established as the cause of cervical carcinoma, therefore, high risk HPV detection may have prognostic significance for the women...
Jessica Bellec et al.
Current gene therapy, 15(5), 447-459 (2015-08-13)
Polarized airway epithelial cell cultures modelling Cystic Fibrosis Transmembrane conductance Regulator (CFTR) defect are crucial for CF and biomedical research. RNA interference has proven its value to generate knockdown models for various pathologies. More recently, genome editing using CRISPR-Cas9 artificial...
Tadanobu Takahashi et al.
PloS one, 10(12), e0144038-e0144038 (2015-12-03)
Mumps viruses show diverse cytopathic effects (CPEs) of infected cells and viral plaque formation (no CPE or no plaque formation in some cases) depending on the viral strain, highlighting the difficulty in mumps laboratory studies. In our previous study, a...
Praveen Kumar Agarwal et al.
Bioresource technology, 192, 90-96 (2015-05-30)
The aim of the study was to increase production of (R)-PAC by altering carboligation activity of Pdc in Saccharomyces cerevisiae. Pdc1 activity was modified by over-expression as well as changing the rate of decarboxylation and carboligation by site specific mutation...
Min-Sik Lee et al.
Nature communications, 6, 7769-7769 (2015-07-18)
The activity of the phosphatase and tensin homologue (PTEN) is known to be suppressed via post-translational modification. However, the mechanism and physiological significance by which post-translational modifications lead to PTEN suppression remain unclear. Here we demonstrate that PTEN destabilization is...
Marcello Clerici et al.
Nature communications, 5, 5399-5399 (2014-11-19)
Ubiquitin-specific protease USP4 is emerging as an important regulator of cellular pathways, including the TGF-β response, NF-κB signalling and splicing, with possible roles in cancer. Here we show that USP4 has its catalytic triad arranged in a productive conformation. Nevertheless...
Alexander G J Skorput et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(31), 10977-10988 (2015-08-08)
Gestational exposure to ethanol has been reported to alter the disposition of tangentially migrating GABAergic cortical interneurons, but much remains to be elucidated. Here we first established the migration of interneurons as a proximal target of ethanol by limiting ethanol...
Avnika A Ruparelia et al.
Acta neuropathologica, 128(6), 821-833 (2014-10-03)
Mutations in the co-chaperone Bcl2-associated athanogene 3 (BAG3) can cause myofibrillar myopathy (MFM), a childhood-onset progressive muscle disease, characterized by the formation of protein aggregates and myofibrillar disintegration. In contrast to other MFM-causing proteins, BAG3 has no direct structural role...
Fumihiro Ito et al.
MicrobiologyOpen, 3(6), 922-936 (2014-10-11)
Molecular chaperones function in various important physiological processes. Null mutants of genes for the molecular chaperone ClpB (Hsp104), and those that encode J-domain proteins (DnaJ, CbpA, and DjlA), which may act as Hsp40 co-chaperones of DnaK (Hsp70), were constructed from...
K M Winter et al.
Vox sanguinis, 109(3), 231-238 (2015-05-09)
Red cells frozen with glycerol may require gamma-irradiation after thawing and deglycerolization for transfusion to at-risk patients. Both freezing and irradiation are known to cause red cell damage. However, the effect of irradiation on the quality of deglycerolized red cells...
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