Showing 1-30 of 72 results for "220507"
Sanja Matić et al.
Journal of biochemical and molecular toxicology, 26(8), 322-330 (2012-07-11)
The in vivo sex-linked recessive lethal test was carried out in Drosophila melanogaster to investigate whether or not five substituted 4-hydroxy-2H-chromen-2-ones can modulate the genotoxicity of the well-established mutagenic agent ethyl methanesulfonate (EMS). For this purpose, 3 days old Canton...
Annamalai Muthusamy et al.
International journal of radiation biology, 90(12), 1229-1239 (2014-05-17)
The purpose of the investigation was to induce somaclonal variations by gamma rays (GR), ethylmethane sulphonate (EMS) and sodium azide (SA) during in vitro organogenesis of cotton. The shoot tip explants were irradiated with 5-50 Gray (Gy) GR (Cobalt 60)...
Cheryl A Hobbs et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 172-181 (2015-07-28)
As a part of an international validation of the in vivo rat alkaline comet assay (comet assay) initiated by the Japanese Center for the Validation of Alternative Methods (JaCVAM) we examined six chemicals for potential to induce DNA damage: 2-acetylaminofluorene...
Interspecific comparison of ethyl methanesulfonate-induced mutation rates in relation to genome size.
A P Schalet
Mutation research, 49(3), 313-340 (1978-03-01)
Hui Chen et al.
PloS one, 8(1), e55252-e55252 (2013-02-06)
Small RNA-mediated gene silencing pathways play important roles in the regulation of development, genome stability and various stress responses in many eukaryotes. Recently, a new type of small interfering RNAs (qiRNAs) approximately 20-21 nucleotides long in Neurospora crassa have been...
Laura Vicedo Jacociunas et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(12), 1131-1134 (2013-07-09)
Cynara scolymus L., popularly known as artichoke, has been widely used in traditional medicine as an herbal medicament for therapeutic purposes. The study aimed at assessing the protective activity of Cynara scolymus leaf extract (LE) against DNA lesions induced by...
Barbara Stachowiak
Polish journal of microbiology, 62(1), 67-72 (2013-07-09)
Astaxanthin is a xanthophill pigment with commercial application in the aquaculture, pharmaceutical, food and cosmetic industries. The red yeast Xanthophyllomyces dendrorhous is one of the most promising microorganisms for its industrial production. However, astaxanthin content in wild yeast strains is...
Elmar Gocke et al.
Toxicology letters, 190(3), 254-265 (2009-10-28)
In order to assess the risk of patients being exposed to an anti-AIDS medication contaminated with EMS we have performed in depth genotoxicity, general toxicity and DMPK investigations. The results of these studies are reported in the accompanying papers of...
Pinar Erkekoglu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 72, 98-110 (2014-07-12)
Most common alkylanilines in the environment are 2,6-dimethylaniline (2,6-DMA), 3,5-dimethylaniline (3,5-DMA), and 3-ethylaniline (3-EA). 3,5-Dimethylaminophenol (3,5-DMAP), a metabolite of 3,5-DMA, is of particular interest, as it is potentially genotoxic. Supplementation with organic or inorganic forms of selenium (Se) may reduce...
Xavier Sainsily et al.
Biochemical pharmacology, 86(11), 1584-1593 (2013-10-03)
Urotensin-II (UII), a cyclic undecapeptide, selectively binds the urotensin-II receptor (UT receptor), a G protein-coupled receptor (GPCR) involved in cardiovascular effects and associated with numerous pathophysiological conditions including hypertension, atherosclerosis, heart failure, pulmonary hypertension and others. In order to identify...
Pingyu Wang et al.
SpringerPlus, 3, 201-201 (2014-05-09)
Geranylgeranyl reductase (CHL P) catalyzes the reduction of geranylgeranyl diphosphate to phytyl diphosphate, and provides phytol for both Chlorophyll (Chl) and tocopherol synthesis. In this study, we isolated a yellow-green leaf mutant, 502ys, in rice (Oryza sativa). The mutant exhibited...
Leiying Zheng et al.
Plant physiology, 168(3), 1000-1012 (2015-05-24)
Sugars not only serve as energy and cellular carbon skeleton but also function as signaling molecules regulating growth and development in plants. Understanding the molecular mechanisms in sugar signaling pathways will provide more information for improving plant growth and development....
Leon F Stankowski et al.
Mutagenesis, 30(3), 335-342 (2015-05-03)
As part of the international Pig-a validation trials, we examined the induction of Pig-a mutant reticulocytes and red blood cells (RET(CD59-) and RBC(CD59-), respectively) in peripheral blood of male Sprague Dawley(®) rats treated with urethane (25, 100 and 250mg/kg/day) or...
Philip E Boulais et al.
Biochemical pharmacology, 85(4), 541-550 (2012-12-12)
The chemokine SDF-1 (CXCL12) selectively binds to CXCR4, a member of the G protein-coupled receptor (GPCR) superfamily. In this study, we used the substituted-cysteine accessibility method (SCAM) to identify specific residues of the fourth transmembrane domain (TM4) that contribute to...
Nidhi Rawat et al.
BMC plant biology, 12, 205-205 (2012-11-09)
Triticum monococcum L., an A genome diploid einkorn wheat, was the first domesticated crop. As a diploid, it is attractive genetic model for the study of gene structure and function of wheat-specific traits. Diploid wheat is currently not amenable to...
Sandhya Sukumaran et al.
Ecotoxicology and environmental safety, 91, 110-116 (2013-02-19)
The impact of chronic genotoxicity to natural populations is always questioned due to their reproductive surplus. We used a comet assay to quantify primary DNA damage after exposure to a reference mutagen ethyl methane sulfonate in two species of crustacean...
Zhenyan Yan et al.
Plant physiology, 150(2), 710-721 (2009-04-28)
GLYCOGEN SYNTHASE KINASE3 (GSK3) is a highly conserved serine/threonine kinase involved in a variety of developmental signaling processes. The Arabidopsis (Arabidopsis thaliana) genome encodes 10 GSK3-like kinases that are clustered into four groups. Forward genetic screens have so far uncovered...
A R Kraynak et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 77-86 (2015-07-28)
As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM) initiative international validation study of the in vivo rat alkaline comet assay (comet assay), we examined the ability of the assay to determine the genotoxicity of 2-acetylaminofluorene...
Thomas Kaever et al.
Journal of virology, 88(19), 11339-11355 (2014-07-18)
Vaccinia virus (VACV) L1 is an important target for viral neutralization and has been included in multicomponent DNA or protein vaccines against orthopoxviruses. To further understand the protective mechanism of the anti-L1 antibodies, we generated five murine anti-L1 monoclonal antibodies...
Laura Vicedo Jacociunas et al.
Journal of medicinal food, 15(10), 873-878 (2012-08-16)
Cynara scolymus L. (Asteraceae), popularly known as artichoke, has been widely used in herbal medicine for the treatment of hepatic diseases. The genotoxicity of C. scolymus L. leaf extract (LE) and the ability to modulate the genetic toxicity of the...
Sandhya Sukumaran et al.
Mutation research, 757(1), 8-14 (2013-07-23)
There is considerable evidence that genetic damage in organisms occurs in the environment as a result of exposure to genotoxins and ionising radiation, but we have limited understanding of the extent to which this results in adverse consequences at a...
Martina Galdíková et al.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 50(10), 698-707 (2015-08-15)
The potential genotoxic effect of thiacloprid formulation on bovine peripheral lymphocytes was evaluated using the comet assay and the cytogenetic endpoints: chromosome aberrations (CAs), sister chromatid exchanges (SCEs) and micronuclei (MNi). Whole blood cultures were treated with the insecticide at...
Milan Mladenović et al.
Biochemical pharmacology, 86(9), 1376-1396 (2013-08-27)
Considering the controversial results concerning the antimutagenicity of some phenolic compounds recorded in the literature, the antigenotoxic effects of four selected phenolic compounds, myricetin, quercetin, rutin, and rosmarinic acid, against DNA damage induced by alkylation with ethyl methanesulfonate (EMS), were...
Navot Galpaz et al.
Archives of biochemistry and biophysics, 539(2), 117-125 (2013-08-27)
In order to broaden the available genetic variation of melon, we developed an ethyl methanesulfonate mutation library in an orange-flesh 'Charentais' type melon line that accumulates β-carotene. One mutagenized M2 family segregated for a novel recessive trait, a yellow-orange fruit...
Carol Beevers et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 165-171 (2015-07-28)
As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiative international validation study of the in vivo rat alkaline comet assay (comet assay), we examined sodium arsenite, thioacetamide, and diethanolamine. Using the JaCVAM approved study protocol version...
Taku Sasaki et al.
Genetics, 192(4), 1271-1280 (2012-10-02)
The dms4 (defective in meristem silencing 4) mutant of Arabidopsis thaliana is unique in having defects in both RNA-directed DNA methylation (RdDM) and plant development. DMS4 is an evolutionarily conserved, putative transcription factor of the Iwr1 (interacts with RNA polymerase...
Leilei Tang et al.
Environmental and molecular mutagenesis, 55(1), 15-23 (2013-11-26)
Mutagenic and clastogenic effects of some DNA damaging agents such as methyl methanesulfonate (MMS) and ethyl methanesulfonate (EMS) have been demonstrated to exhibit a nonlinear or even "thresholded" dose-response in vitro and in vivo. DNA repair seems to be mainly...
Tera C Levin et al.
eLife, 3 (2014-10-10)
The origin of animal multicellularity may be reconstructed by comparing animals with one of their closest living relatives, the choanoflagellate Salpingoeca rosetta. Just as animals develop from a single cell-the zygote-multicellular rosettes of S. rosetta develop from a founding cell....
Günter Speit et al.
Mutagenesis, 27(6), 743-747 (2012-08-08)
The cytokinesis-block micronucleus assay (CBMN assay) with cultured human lymphocytes is a well-established assay in genotoxicity testing and human biomonitoring. For both approaches, human lymphocytes are stimulated by phytohaemagglutinin (PHA) and cultured for about 72 h; 44 h after PHA...
Barbara Härtel et al.
Plant molecular biology, 81(4-5), 337-346 (2013-01-05)
A forwards genetic screen of a chemically mutated plant population identified mitochondrial RNA editing factor 10 (MEF10) in Arabidopsis thaliana. MEF10 is a trans-factor required specifically for the C to U editing of site nad2-842. The MEF10 protein is characterized...

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