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Ciceron Ayala-Orozco et al.
ACS nano, 8(6), 6372-6381 (2014-06-04)
Au nanoparticles with plasmon resonances in the near-infrared (NIR) region of the spectrum efficiently convert light into heat, a property useful for the photothermal ablation of cancerous tumors subsequent to nanoparticle uptake at the tumor site. A critical aspect of
Miranda Sc Wilson et al.
Bio-protocol, 8(15) (2018-08-28)
Inositol phosphates (IPs) comprise a family of ubiquitous eukaryotic signaling molecules. They have been linked to the regulation of a pleiotropy of important cellular activities, but low abundance and detection difficulties have hampered our understanding. Here we present a method
Xiao-Lin Hou et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 962, 20-29 (2014-06-03)
A simple, sensitive and reliable analytical method was developed for the simultaneous determination of 38 veterinary drugs (18 sulfonamides, 11 quinolones and 9 benzimidazoles) and 8 metabolites of benzimidazoles in bovine milk by ultra high performance liquid chromatography-positive electrospray ionization
Zhisheng Zhu et al.
Bioresource technology, 119, 199-207 (2012-06-26)
An efficient pretreatment method using NH(4)OH-H(2)O(2) and ionic liquid (IL) was developed for the recovery of cellulose from sugarcane bagasse (SCB). The regenerated SCB from the combined pretreatment exhibited significantly enhanced enzymatic digestibility with an efficiency of 91.4% after 12h
Yun-Xia Zhu et al.
STAR protocols, 2(3), 100728-100728 (2021-08-20)
Pancreatic islet β cells secrete insulin in a biphasic manner when sensing high blood glucose level. This protocol describes the evaluation of different phases of insulin secretion, as well as basal, glucose-stimulated and total insulin secretion abilities, thereby enabling precise
Wenxing Song et al.
Nanomaterials (Basel, Switzerland), 8(11) (2018-11-08)
Curcumin is a promising anti-cancer drug, but its applications in cancer therapy are limited, due to its poor solubility, short half-life and low bioavailability. In this study, curcumin loaded magnetic alginate/chitosan nanoparticles were fabricated to improve the bioavailability, uptake efficiency
Synthesis and characterization of biocompatible Fe3O4 nanoparticles.
Sun J, et al.
Journal of Biomedical Materials Research Part A, 80(2), 333-341 (2007)
Dilek Battal et al.
Therapeutic drug monitoring, 37(6), 805-811 (2015-05-21)
Mescaline, the primary psychoactive chemical in peyote cactus, has been consumed for thousands of years in ancient religious ceremonies. The US military wanted to determine if mescaline intake was a problem for personnel readiness. Twenty thousand seventeen urine specimens negative
Muhammad Suhaeri et al.
Theranostics, 8(18), 5025-5038 (2018-11-16)
Skin injuries are frequently encountered in daily life, but deep wounds often poorly self-heal and do not recover completely. In this study, we propose a novel skin patch that combines antibiotic, cell-derived extracellular matrix (ECM) and biocompatible polyvinyl alcohol (PVA)
Przemyslaw Mielczarek et al.
Journal of chromatography. A, 1389, 96-103 (2015-03-10)
The metabolic pathways of selegiline (a drug used for the treatment of early-stage Parkinson's disease) were analyzed by electrochemical oxidation with application of the flow electrochemical cell consisting of three electrodes (ROXY™, Antec, the Netherlands). Two types of working electrodes
Noel Kong et al.
Journal of separation science, 37(21), 3015-3023 (2014-08-22)
A sensitive hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry method was developed and validated for the simultaneous detection and quantification of etilefrine and oxilofrine in equine blood plasma and urine. The method is highly sensitive and specific with
Souad Amiar et al.
Cell reports, 30(11), 3778-3792 (2020-03-19)
Apicomplexan parasites are unicellular eukaryotic pathogens that must obtain and combine lipids from both host cell scavenging and de novo synthesis to maintain parasite propagation and survival within their human host. Major questions on the role and regulation of each
Zheng Ser et al.
Analytical biochemistry, 475, 22-28 (2015-01-24)
The successful extraction of metabolites is a critical step in metabolite profiling. By optimizing metabolite extraction, the range and quantitative capacity of metabolomics studies can be improved. We considered eight separate extraction protocols for the preparation of a metabolite extract
Johongir M Muradov et al.
Journal of neurotrauma, 30(10), 840-852 (2013-01-11)
Vasospasm, hemorrhage, and loss of microvessels at the site of contusive or compressive spinal cord injury lead to infarction and initiate secondary degeneration. Here, we used intravenous injection of endothelial-binding lectin followed by histology to show that the number of
Hongxu Lu et al.
Journal of biomedical materials research. Part A, 100(9), 2507-2516 (2012-05-25)
Extracellular matrix (ECM) scaffolds derived from cultured cells have drawn increasing attention for use in tissue engineering. We have developed a method to prepare cultured cell-derived ECM scaffolds by combining three-dimensional cell culture, decellularization, and selective template removal. Cell-ECM-template complexes
Luise Oemisch et al.
Journal of chromatography. A, 1370, 17-24 (2014-12-03)
Many studies in pharmacology, toxicology and environmental science require a method for determining the freely dissolved concentration of a target substance. A recently developed tool for this purpose is equilibrium passive sampling with polymeric materials. However, this method has rarely
Holly D Cox et al.
Drug testing and analysis, 7(1), 31-38 (2014-09-12)
AOD9604 is a peptide consisting of the C-terminal fragment of human growth hormone from amino acids 177-191 with an additional tyrosine residue at the N-terminus of the peptide. It is reported to mimic the lipolytic properties of growth hormone without
Theresa A Isbell et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 65-71 (2015-01-16)
The determination of morphine and its isobaric metabolites morphine-3-beta-d-glucuronide (M3G) and morphine-6-beta-d-glucuronide (M6G) is useful for therapeutic drug monitoring and forensic identification of drug use. In particular, capillary electrophoresis with mass spectrometry (CE-MS) represents an attractive tool for opioid analysis.
Bo Shen et al.
Cell, 182(1), 59-72 (2020-06-04)
Early detection and effective treatment of severe COVID-19 patients remain major challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID-19 and 53 control individuals. We then trained a machine learning model using proteomic and metabolomic measurements
Joo Hyung Kim et al.
Scientific reports, 5, 16123-16123 (2015-11-04)
One long-standing goal in the emerging field of flexible and transparent electronic devices is to meet the demand of key markets, such as enhanced output performance for metal oxide semiconductor thin film transistors (TFTs) prepared by a solution process. While
Alexandre Janel et al.
Stem cells and development, 23(24), 2972-2982 (2014-07-24)
The systematic localization of chronic lymphocytic leukemia (CLL) B-cells in the bone marrow (BM), together with the ex vivo protective effect of stromal cells on their spontaneous apoptosis, both indicate a specific role of the BM microenvironment. In vivo, the
Miranda G M Kok et al.
Talanta, 132, 1-7 (2014-12-06)
In order to assess the utility of a recently developed capillary electrophoresis-mass spectrometry (CE-MS) method for the study of anionic metabolites in urine, a comparison was made with hydrophilic interaction chromatography-MS (HILIC-MS) using negative electrospray ionization. After optimization of the
Angela Rodayan et al.
The Science of the total environment, 487, 731-739 (2014-04-15)
In this study the levels of 19 drugs of abuse were estimated throughout a wastewater treatment plant using polar organic chemical integrative samplers (POCIS), 24h composite samples and grab samples. Overall removal efficiencies and removals in between each treatment unit
Manish M Khandagale et al.
Journal of chromatography. A, 1356, 180-187 (2014-07-09)
The solvent dependency of the detection response is a major limitation of corona-charged aerosol detection (C-CAD). The present study empirically investigates the utility of temperature and flow-rate gradients to overcome solvent gradient limitations of C-CAD. In preliminary flow-injection investigations, it
Rui Liang et al.
Scientific reports, 5, 8078-8078 (2015-01-30)
Oxidative stress and apoptosis are involved in Ochratoxin A (OTA)-induced renal cytotoxicity. Apoptosis signal-regulating kinase 1 (ASK1) is a Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK, MAP3K) family member that plays an important role in oxidative stress-induced cell apoptosis. In this
Junlong Tian et al.
Scientific reports, 5, 8025-8025 (2015-01-27)
A carbon-matrix nickel composite magnetoplasmonic film with a 3D sub-micron periodic triangular roof-type antireflection structure (SPTAS) was fabricated via a simple and promising method that combines chemosynthesis with biomimetic techniques. The Troides helena (Linnaeus) forewing (T_FW) was chosen as the
Siddhartha Sankar Boxi et al.
Dalton transactions (Cambridge, England : 2003), 44(47), 20464-20474 (2015-11-07)
Arsenic poisoning from drinking water has been an important global issue in recent years. Because of the high level toxicity of arsenic to human health, an easy, inexpensive, low level and highly selective detection technique is of great importance to
F Munarin et al.
International journal of biological macromolecules, 72, 199-209 (2014-08-12)
Pectin-based biocomposite hydrogels were produced by internal gelation, using different hydroxyapatite (HA) powders from commercial source or synthesized by the wet chemical method. HA possesses the double functionality of cross-linking agent and inorganic reinforcement. The mineralogical composition, grain size, specific
Wenxing Song et al.
International journal of pharmaceutics, 555, 322-336 (2018-11-19)
The lack of efficient and cost-effective methods for gene delivery has significantly hindered the applications of gene therapy. In this paper, a simple one step and cost effective salting-out method has been explored to fabricate silk-PEI nanoparticles (SPPs) and magnetic-silk/PEI
Xavier Arqué et al.
Nature communications, 10(1), 2826-2826 (2019-06-30)
Bio-catalytic micro- and nanomotors self-propel by the enzymatic conversion of substrates into products. Despite the advances in the field, the fundamental aspects underlying enzyme-powered self-propulsion have rarely been studied. In this work, we select four enzymes (urease, acetylcholinesterase, glucose oxidase
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