Showing 1-30 of 136 results for "226904"
Ning Chen et al.
Cytotechnology, 66(6), 945-966 (2013-12-03)
Optimization of cell culture processes can benefit from the systematic analysis of experimental data and their organization in mathematical models, which can be used to decipher the effect of individual process variables on multiple outputs of interest. Towards this goal...
Edouard Godineau et al.
Organic letters, 8(21), 4871-4874 (2006-10-06)
[reaction: see text] A formal [2+2+2] process has been devised that allows the stereocontrolled formation of ring-fused piperidines from allylsilanes possessing an oxime moiety. The cascade involves an intermolecular radical addition of an alpha-iodoacetate onto an allylsilane double bond, which...
Herong Cui et al.
Molecules (Basel, Switzerland), 24(11) (2019-06-04)
Curcuma zedoaria (dry stenophora of Curcuma phaeocaulis Val., Curcuma kwangsiensis S. G. Lee et C. F. Liang, or Curcuma wenyujin Y. H. Chen et C.Ling) is a representative herb with clinical effects on liver diseases after being vinegar-processed. The crude...
Shilo Rosenwasser et al.
The Plant cell, 26(6), 2689-2707 (2014-06-13)
Marine viruses are major ecological and evolutionary drivers of microbial food webs regulating the fate of carbon in the ocean. We combined transcriptomic and metabolomic analyses to explore the cellular pathways mediating the interaction between the bloom-forming coccolithophore Emiliania huxleyi...
Coriness Piñeyro-Ruiz et al.
Frontiers in pediatrics, 8, 202-202 (2020-05-12)
Background & Objective: Hypospadias, characterized by the displacement of the opening of the urethra at any point in the medial-ventral side of the penis, is classified upon severity as mild (Type I) and severe (Type II and Type III) hypospadias....
K M Sharif et al.
Biomedical chromatography : BMC, 29(12), 1826-1833 (2015-06-03)
Multivariate analysis of thin-layer chromatography (TLC) images was modeled to predict antioxidant activity of Pereskia bleo leaves and to identify the contributing compounds of the activity. TLC was developed in optimized mobile phase using the 'PRISMA' optimization method and the...
Kalaiselvi Senthil et al.
PloS one, 10(4), e0123360-e0123360 (2015-04-16)
Free radical scavenging activity (FRSA), total phenolic content (TPC), and total flavonoid content (TFC) of in vitro cultured and field grown Withania somnifera (Ashwagandha) roots were investigated. Withanolides analysis and comprehensive metabolic profiling between 100% methanol extracts of in vitro...
G Cabrera et al.
Journal of cellular biochemistry, 112(8), 2189-2199 (2011-04-12)
Trypanosoma cruzi, a parasitic protozoan, is the etiological agent of Chagas disease, an endemic and neglected pathology in Latin America. It presents a life cycle that involves a hematophagous insect and man as well as domestic and wild mammals. The...
April M Luke et al.
Mutation research, 694(1-2), 65-71 (2010-09-21)
Single strand breaks (SSBs) are one of the most frequent DNA lesions caused by endogenous and exogenous agents. The most utilized alkaline-based assays for SSB detection frequently give false positive results due to the presence of alkali-labile sites that are...
Helga Pankoke et al.
Journal of insect physiology, 82, 99-108 (2015-08-27)
Iridoid glycosides are plant defence compounds with potentially detrimental effects on non-adapted herbivores. Some plant species possess β-glucosidases that hydrolyse iridoid glycosides and thereby release protein-denaturing aglycones. To test the hypothesis that iridoid glycosides and plant β-glucosidases form a dual...
David P Enot et al.
Cell cycle (Georgetown, Tex.), 14(15), 2399-2407 (2015-06-23)
Recently, we reported that saturated and unsaturated fatty acids trigger autophagy through distinct signal transduction pathways. Saturated fatty acids like palmitate (PA) induce autophagic responses that rely on phosphatidylinositol 3-kinase, catalytic subunit type 3 (PIK3C3, best known as VPS34) and...
Letian Shan et al.
Molecular bioSystems, 10(11), 2965-2973 (2014-08-22)
Lumbar disc herniation (LDH) is a commonly occurring disease, threatening human health and life quality. Lack of a gold standard of diagnosis has hindered the efficiency and efficacy of clinical therapy against LDH. Traditional Chinese medicine (TCM) has provided an...
Tetrahedron Letters, 47, 6045-6045 (2006)
Matthew C Sinton et al.
iScience, 24(1), 101931-101931 (2021-01-08)
Nonalcoholic fatty liver disease (NAFLD) is currently the most prevalent form of liver disease worldwide. This term encompasses a spectrum of pathologies, from benign hepatic steatosis to non-alcoholic steatohepatitis, which have, to date, been challenging to model in the laboratory...
Sílvia Petronilho et al.
Molecules (Basel, Switzerland), 25(2) (2020-01-16)
Wine aroma is the result of complex interactions between volatile compounds and non-volatile ones and individual perception phenomenon. In this work, an aroma network approach, that links volatile composition (chromatographic data) with its corresponding aroma descriptors was used to explain...
Suganthagunthalam Dhakshinamoorthy et al.
Molecular bioSystems, 11(9), 2406-2416 (2015-07-16)
Altered metabolism is increasingly acknowledged as an important aspect of cancer, and thus serves as a potentially fertile area for the identification of therapeutic targets or leads. Our recent work using transcriptional data to predict metabolite levels in cancer cells...
Udi Jumhawan et al.
Journal of bioscience and bioengineering, 120(5), 555-561 (2015-04-29)
Development of authenticity screening for Asian palm civet coffee, the world-renowned priciest coffee, was previously reported using metabolite profiling through gas chromatography/mass spectrometry (GC/MS). However, a major drawback of this approach is the high cost of the instrument and maintenance....
Michitaka Kohashi et al.
Journal of Crohn's & colitis, 8(9), 1010-1021 (2014-03-04)
To improve the clinical course of ulcerative colitis (UC), more accurate serum diagnostic and assessment methods are required. We used serum metabolomics to develop diagnostic and assessment methods for UC. Sera from UC patients, Crohn's disease (CD) patients, and healthy...
Zhi-xue Cheng et al.
Fish & shellfish immunology, 40(2), 524-530 (2014-08-15)
Streptococcus iniae infection has emerged as a serious fish health and economic problem in the global aquaculture operations. Current antibiotic options are few and possess severe practical limitations and potential adverse environmental impacts. The major factor contributing to the large...
Shenghong Ma et al.
Oncotarget, 6(11), 8606-8620 (2015-04-01)
Cancer-associated isocitrate dehydrogenase (IDH) 1 and 2 mutations gain a new activity of reducing α-KG to produce D-2-hydroxyglutarate (D-2-HG), which is proposed to function as an oncometabolite by inhibiting α-KG dependent dioxygenases. We investigated the function of D-2-HG in tumorigenesis...
Shuming Yang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 901, 25-33 (2012-06-30)
Methoxyamine (MX) is the first DNA base-excision-repair (BER) inhibitor evaluated in humans. This work described the development and validation of an LC-MS/MS method for quantitative determination of MX in human plasma. In this method, MX and its stable isotope methoxyl-d(3)-amine...
Dong Ho Suh et al.
Journal of agricultural and food chemistry, 62(34), 8764-8771 (2014-08-08)
Metabolite profiling of red and white pitayas (Hylocereus polyrhizus and Hylocereus undatus) was performed using gas chromatography-time-of-flight-mass spectrometry and ultraperformance liquid chromatography-quadrupole-time-of-flight-mass spectrometry with multivariate analysis. Different species and parts of pitayas (red peel, RP; white peel, WP; red flesh...
Xinyi Zhou et al.
Talanta, 147, 82-89 (2015-11-26)
Male infertility has become an important public health problem worldwide. Nowadays the diagnosis of male infertility frequently depends on the results of semen quality or requires more invasive surgical intervention. Therefore, it is necessary to develop a novel approach for...
Takahiro Yamauchi et al.
Molecular pharmacology, 74(1), 82-91 (2008-04-24)
The cytotoxicity of the monofunctional alkylator temozolomide (TMZ) is mediated by mismatch repair (MMR) triggered by O(6)-alkylguanine, whereas MMR protects cells against bifunctional alkylators, including carmustine (BCNU). Therefore, TMZ may be cytotoxic to BCNU-resistant cancer cells because MMR affects sensitivity...
Eva M Goellner et al.
Cancer research, 71(6), 2308-2317 (2011-03-17)
Glioblastoma multiforme (GBM) is a devastating brain tumor with poor prognosis and low median survival time. Standard treatment includes radiation and chemotherapy with the DNA alkylating agent temozolomide (TMZ). However, a large percentage of tumors are resistant to the cytotoxic...
Ángel Sánchez-Illana et al.
Scientific reports, 7(1), 17039-17039 (2017-12-08)
Therapeutic hypothermia (TH) initiated within 6 h from birth is the most effective therapeutic approach for moderate to severe hypoxic-ischemic encephalopathy (HIE). However, underlying mechanisms and effects on the human metabolism are not yet fully understood. This work aims at studying...
Joong Kyong Ahn et al.
PloS one, 10(8), e0135856-e0135856 (2015-08-14)
Behcet's disease (BD) with arthritis is often confused with seronegative arthritis (SNA) because of shared clinical symptoms and the lack of definitive biomarkers for BD. To investigate possible metabolic patterns and potential biomarkers of BD with arthritis, metabolomic profiling of...
Bo Peng et al.
Fish & shellfish immunology, 45(2), 869-876 (2015-06-10)
Edwardsiella tarda causes fish disease and great economic loss. However, metabolic strategy against the pathogen remains unexplored. In the present study, GC-MS based metabolomics was used to investigate the metabolic profile from tilapias infected by sublethal dose of E. tarda. The...
Moa Andresen Bergström et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(10), 1823-1832 (2011-07-08)
In the present work, the characterization of the biotransformation and bioactivation pathways of the cannabinoid receptor 1 antagonist rimonabant (Acomplia) is described. Rimonabant was approved in Europe in 2006 for the treatment of obesity but was withdrawn in 2008 because...
Chang-wen Wu et al.
FEMS microbiology letters, 362(8), fnv040-fnv040 (2015-03-13)
PcPAF is a novel antifungal protein identified by our recent study, which is produced by a fungal strain Penicillium citrinum W1 isolated from a south-west Indian Ocean sediment sample. The present study identified glycine as a potential metabolite which increased...

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