Showing 1-30 of 756 results for "229873"
Yufei Chen et al.
Drug design, development and therapy, 8, 1801-1815 (2014-10-23)
Hydroxychloroquine (HCQ) has been shown to demonstrate anti-inflammatory properties and direct anti-HIV activity. In this study, we describe for the first time the fabrication and in vitro evaluation of two types of intravaginal ring (IVR) devices (a surfaced-modified matrix IVR...
Kyung Min Jeong et al.
Archives of pharmacal research, 38(12), 2143-2152 (2015-11-05)
Deep eutectic solvents (DESs) were investigated as tunable, environmentally benign, yet superior extraction media to enhance the extraction of anthocyanins from grape skin, which is usually discarded as waste. Ten DESs containing choline chloride as hydrogen bond acceptor combined with...
Alessio Innocenti et al.
Bioorganic & medicinal chemistry letters, 15(3), 573-578 (2005-01-25)
A detailed inhibition study of five carbonic anhydrase (CA, EC 4.2.1.1) isozymes with carboxylates including aliphatic (formate, acetate), dicarboxylic (oxalate, malonate), hydroxy/keto acids (l-lactate, l-malate, pyruvate), tricarboxylic (citrate), or aromatic (benzoate, tetrafluorobenzoate) representatives, some of which are important intermediates in...
Meritxell Balmaña et al.
Clinica chimica acta; international journal of clinical chemistry, 442, 56-62 (2015-01-18)
Pancreatic adenocarcinoma (PDAC) usually shows an enhanced expression of sialyl-Lewis X (sLe(x)) and related epitopes. PDAC may secrete some of the proteins carrying such increased sLe(x) determinant into serum, so they could be used as PDAC markers. Previously, we identified...
Gisele H J M Leyten et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(13), 3061-3070 (2015-03-20)
Serum PSA (sPSA) testing has led to the identification of patients with indolent prostate cancer, and inevitably overtreatment has become a concern. Progensa PCA3 urine testing was shown to improve the diagnosis of prostate cancer, but its diagnostic value for...
Sharmistha Samanta Koruri et al.
Archives of microbiology, 197(7), 955-963 (2015-07-15)
The present investigation deals with the optimization of cell growth rate of the candidate probiotic Pediococcus acidilactici in the presence of the specific prebiotic inulin. Three independent variables viz. concentration of inulin, concentration of glucose and pH have been selected...
Gijs den Besten et al.
PloS one, 10(8), e0136364-e0136364 (2015-08-21)
The dietary fiber guar gum has beneficial effects on obesity, hyperglycemia and hypercholesterolemia in both humans and rodents. The major products of colonic fermentation of dietary fiber, the short-chain fatty acids (SCFAs), have been suggested to play an important role....
Lu Liu et al.
Journal of pharmaceutical sciences, 103(7), 1979-1986 (2014-05-17)
We studied the effects of pH and solution additives on freezing-induced perturbations in the tertiary structure of a monoclonal antibody (mAb) by intrinsic tryptophan fluorescence spectroscopy. In general, freezing caused perturbations in the tertiary structure of the mAb, which were...
Kristina Heyne et al.
Cell cycle (Georgetown, Tex.), 14(16), 2619-2633 (2015-06-24)
Humans and primates are long-lived animals with long reproductive phases. One factor that appears to contribute to longevity and fertility in humans, as well as to cancer-free survival, is the transcription factor and tumor suppressor p53, controlled by its main...
Luiz Francisco Rocha e Silva et al.
Antimicrobial agents and chemotherapy, 59(6), 3271-3280 (2015-03-25)
4-Nerolidylcatechol (1) is an abundant antiplasmodial metabolite that is isolated from Piper peltatum roots. O-Acylation or O-alkylation of compound 1 provides derivatives exhibiting improved stability and significant in vitro antiplasmodial activity. The aim of this work was to study the...
Uma K Aryal et al.
PloS one, 10(7), e0130763-e0130763 (2015-07-15)
Protein phosphorylation regulates diverse cellular functions and plays a key role in the early development of plants. To complement and expand upon previous investigations of protein phosphorylation in Arabidopsis seedlings we used an alternative approach that combines protein extraction under...
Yoshihiko Sakaguchi et al.
Research in microbiology, 166(4), 318-325 (2014-08-12)
In Clostridium botulinum, the characteristics of type C and D strains are quite different from other types, and they are classified as group III. They produce C2 binary toxin and C3 exoenzyme in addition to type C and D neurotoxins....
Y Wang et al.
Biomaterials science, 3(7), 1114-1123 (2015-07-07)
In the present study, a series of copolymers (PAMD-Ch) was synthesized by grafting polymeric Plerixafor/AMD3100 (PAMD) with different amounts of cholesterol and the effect of cholesterol modification on siRNA delivery was investigated. PAMD-Ch/siRNA polyplexes exhibited improved colloidal and enzymatic stability...
Gyeong Jin Lee et al.
Macromolecular bioscience, 15(11), 1595-1604 (2015-07-18)
Crosslinked bioreducible polypropylenimine-cystaminebisacrylamides (PPI-CBAs) were synthesized for gene delivery systems. They formed nano-sized polyplexes with high stability even in reducing condition probably due to the re-crosslinking. PPI-CBAs displayed high transfection efficiency comparable to PEI25k in serum condition. However, cytotoxicity increase...
Stephanie A Shumar et al.
PloS one, 10(6), e0130013-e0130013 (2015-06-09)
Pantothenate kinase-associated neurodegeneration, PKAN, is an inherited disorder characterized by progressive impairment in motor coordination and caused by mutations in PANK2, a human gene that encodes one of four pantothenate kinase (PanK) isoforms. PanK initiates the synthesis of coenzyme A...
J Honorato Júnior et al.
Pesticide biochemistry and physiology, 123, 31-39 (2015-08-13)
Coffee leaf rust (CLR), caused by Hemileia vastatrix, is a major disease affecting coffee production worldwide. In this study, an in-depth analysis of the photosynthetic performance of coffee leaves challenged or not with H. vastatrix and sprayed with either epoxiconazole (EPO)...
Lidong Guo et al.
Journal of the science of food and agriculture, 95(7), 1514-1520 (2014-08-02)
Dietary mineral deficiency, hypertension and diabetes have become serious human health problems. Dietary approaches are increasingly being investigated to address these issues. Identification of food-derived biological peptides has become an important approach to control such diseases. Peptides generated from aquatic...
Rui Xing et al.
Biomedical materials (Bristol, England), 10(5), 055003-055003 (2015-09-12)
Biofilm formation on dental abutment may lead to peri-implant mucositis and subsequent peri-implantitis. These cases are clinically treated with antibiotics such as doxycycline (Doxy). Here we used an electrochemical method of cathodic polarization to coat Doxy onto the outer surface...
Anna L Greenshields et al.
Cancer letters, 357(1), 129-140 (2014-12-03)
Piperine, an alkaloid from black pepper, is reported to have anticancer activities. In this study, we investigated the effect of piperine on the growth and motility of triple-negative breast cancer (TNBC) cells. Piperine inhibited the in vitro growth of TNBC...
Justin P Ludeman et al.
Organic & biomolecular chemistry, 13(7), 2162-2169 (2014-12-24)
Tyrosine sulfation is a widespread post-translational modification that mediates the interactions of secreted and membrane-associated proteins in such varied biological processes as peptide hormone action, adhesion, blood coagulation, complement activation and regulation of leukocyte trafficking. Due to the heterogeneous nature...
Sven Amrhein et al.
Biotechnology and bioengineering, 112(12), 2485-2494 (2015-06-16)
The surface hydrophobicity of a protein is an important factor for its interactions in solution and thus the outcome of its production process. Yet most of the methods are not able to evaluate the influence of these hydrophobic interactions under...
Efrem T Abay et al.
Malaria journal, 14, 8-8 (2015-01-08)
Even though malaria is a completely preventable and treatable disease, it remains a threat to human life and a burden to the global economy due to the emergence of multiple-drug resistant malaria parasites. According to the World Malaria Report 2013...
Zaigham Abbas Rizvi et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(6), 1275-1282 (2014-12-03)
Effect of poly-dispersed acid-functionalized single-walled carbon nanotubes (AF-SWCNTs) was examined on lipid antigen presentation through CD1d pathway on three cell lines, LA4, MHS, and JAWSII used as prototype antigen presenting cells (APCs). CD1d molecule was expressed on 80-90% MHS (prototype...
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Hee Jin Seo et al.
Journal of nanoscience and nanotechnology, 11(11), 10262-10270 (2012-03-15)
A photo-responsive liposome was developed by loading 7-acetoxy coumarin (ATC) in egg phosphatidylcholine (EPC) liposome. ATC was derivetized from 7-hydroxy coumarin using sodium acetate. The ATC-loaded liposomes were prepared by suspending the dry mixture film of ATC/EPC in distilled water...
Misato Kawai et al.
Brain research bulletin, 118, 25-33 (2015-09-06)
Bright light therapy is used as the primary treatment for seasonal affective disorder; however, the mechanisms underlying its antidepressant effect are not fully understood. Previously, we found that C57BL/6J mice exhibit increased depression-like behavior during a short-day condition (SD) and...
Christian Bellehumeur et al.
Journal of virological methods, 222, 182-191 (2015-07-02)
Pan-viral DNA array (PVDA) and high-throughput sequencing (HTS) are useful tools to identify novel viruses of emerging diseases. However, both techniques have difficulties to identify viruses in clinical samples because of the host genomic nucleic acid content (hg/cont). Both propidium...
Arun Kumar et al.
ACS applied materials & interfaces, 7(17), 9211-9227 (2015-04-04)
To minimize cardiotoxicity and to increase the bioavailability of doxorubicin, polymersomes based on redox sensitive amphiphilic triblock copolymer poly(polyethylene glycol methacrylate)-poly(caprolactone)-s-s-poly(caprolactone)-poly(polyethylene glycol methacrylate) (pPEGMA-PCL-ss-PCL-pPEGMA) with disulfide linkage were designed and developed. The polymers were synthesized by ring opening polymerization (ROP)...
David Awotwe Otoo et al.
Journal of pharmaceutical sciences, 103(7), 2042-2052 (2014-05-21)
The aim of the present study was to apply an integrated process analytical technology (PAT) approach to control and monitor the effect of the degree of supercooling on critical process and product parameters of a lyophilization cycle. Two concentrations of...
Mélanie Spilmont et al.
Nutrients, 7(11), 9265-9284 (2015-11-17)
The nutritional benefits of pomegranate have attracted great scientific interest. The pomegranate, including the pomegranate peel, has been used worldwide for many years as a fruit with medicinal activity, mostly antioxidant properties. Among chronic diseases, osteoporosis, which is associated with...

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