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240486

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Maria Victoria Flores et al.
Biotechnology and bioengineering, 78(7), 795-801 (2002-05-10)
A kinetic model derived from the ping-pong bi-bi reversible mechanism is proposed to described the acylation of glucose by lauric acid in 2-methyl 2-butanol mediated by Candida antarctica lipase at 60 degrees C. The model accounts for the effect of...
Richard Cheng-An Chang et al.
Investigative ophthalmology & visual science, 56(4), 2367-2380 (2015-03-20)
The purpose of this study was to investigate the impact of obesity-induced prediabetes/early diabetes on the retina to provide new evidence on the pathogenesis of type 2 diabetes-associated diabetic retinopathy (DR). A high-fat diet (HFD)-induced obesity mouse model (male C57BL/6J)...
Daniel T Sweet et al.
The Journal of clinical investigation, 125(8), 2995-3007 (2015-07-28)
Fluid shear forces have established roles in blood vascular development and function, but whether such forces similarly influence the low-flow lymphatic system is unknown. It has been difficult to test the contribution of fluid forces in vivo because mechanical or...
General kinetic modeling of the selective hydrogenation of 2-methyl-3-butyn-2-ol over a commercial palladium-based catalyst.
Vernuccio S, et al.
Industrial & Engineering Chemistry Research, 54(46), 11543-11551 (2015)
Roland H Müller et al.
Microbiology (Reading, England), 154(Pt 5), 1414-1421 (2008-05-03)
Growth of Aquincola tertiaricarbonis L108 on the fuel oxygenates methyl tert-butyl ether (MTBE), ethyl tert-butyl ether (ETBE) and tert-amyl methyl ether (TAME), as well as on their main metabolites tert-butyl alcohol (TBA), tert-amyl alcohol (TAA) and 2-hydroxyisobutyrate (2-HIBA) was systematically...
Xuesen Chen et al.
Journal of genetics and genomics = Yi chuan xue bao, 34(2), 171-179 (2007-05-02)
To evaluate genetic relationships using qualitative and/or quantitative differentiation of volatile components in Xinjiang Wild Apple (Malus sieversii (Lebed.) Roem.) and to acquire basic data for the conservation and utilization of the species, aroma components in ripe fruit of M....
R H Hoff et al.
Journal of the American Chemical Society, 123(38), 9338-9344 (2001-09-20)
Kinetic isotope effects and medium effects have been measured for sulfuryl-transfer reactions of the sulfate ester p-nitrophenyl sulfate (pNPS). The results are compared to those from previous studies of phosphoryl transfer, a reaction with mechanistic similarities. The N-15 and the...
Taeyong Kim et al.
Molecules and cells, 37(1), 81-87 (2014-02-21)
Chronic pressure-overload cardiac hypertrophy is associated with an increased risk of morbidity/mortality, largely due to maladaptive remodeling and dilatation that progresses to dilated cardiomyopathy. Alternative splicing is an important biological mechanism that generates proteomic complexity and diversity. The recent development...
Aidong Yuan et al.
PloS one, 10(7), e0133848-e0133848 (2015-07-25)
The axonal cytoskeleton of neurofilament (NF) is a long-lived network of fibrous elements believed to be a stationary structure maintained by a small pool of transported cytoskeletal precursors. Accordingly, it may be predicted that NF content in axons can vary...
A Amberg et al.
Chemical research in toxicology, 12(10), 958-964 (1999-10-20)
tert-Amyl methyl ether (TAME) is intended for use as a gasoline additive to increase oxygen content. Increased oxygen content in gasoline reduces tailpipe emissions of hydrocarbons and carbon monoxide from cars. Due to possible widespread use of TAME, the toxicity...
Feifei Chen et al.
Bioresource technology, 115, 158-163 (2011-12-14)
Sodium chloride salting-in and microwave irradiation were combined to drive thermolysin molecules into mesoporous support to obtain efficiently immobilized enzyme. When the concentration of sodium chloride was 3 M and microwave power was 40 W, 93.2% of the enzyme was...
Jin Ock Kim et al.
PloS one, 10(3), e0122509-e0122509 (2015-03-15)
MicroRNA (miRNA) is an endogenous non-coding RNA species that either inhibits RNA translation or promotes degradation of target mRNAs. miRNAs often regulate cellular signaling by targeting multiple genes within the pathways. In the present study, using Gene Set Analysis, a...
Brian E Schulmeier et al.
Nucleosides, nucleotides & nucleic acids, 25(7), 735-745 (2006-08-11)
The reaction between 2-fluoroadenine (3) and 1,3,5-tri-O-benzyl-1-alpha-D-chloroarabinofuranose (4) with potassium t-amylate was evaluated in various solvents to afford 9-beta-D-(2,3,5-tri-O-benzyl-arabinofuranosyl)-2-fluoroadenine (5) and the corresponding alpha-anomer (6). In addition, 7-beta-D-(2,3,5-tri-O-benzyl-arabinofuranosyl)-2-fluoroadenine (7) and an unusual "bis-fluoroadenine" nucleoside (8) were isolated as byproducts. The...
Jiang-Ning Hu et al.
Journal of agricultural and food chemistry, 56(22), 10988-10993 (2008-11-06)
In the lipase (Novozyme 435)-catalyzed synthesis of ginsenoside Rb1 esters, different acyl donors were found to affect not only the degree of conversion but also the regioselectivity. The reaction of acyl donors with short carbon chain was more effective, showing...
Yoon Ju Cho et al.
Laboratory animal research, 27(3), 197-203 (2011-10-15)
Tribromoethanol (2,2,2-tribromoethanol, TBE) is a popular injectable anesthetic agent used in mice in Korea. Our goal was to assess the risks associated with side effects (lesions) in the abdominal cavity, especially at high doses. To understand the underlying pathophysiological changes...
?-tert-alkylation of ketones: 2-tert-pentylcyclopentanone
Organic Syntheses, 62, 95-95 (1984)
C Lorentz et al.
Biotechnology letters, 32(12), 1955-1960 (2010-09-03)
Chlorogenic acid (5-caffeoyl quinic acid (CQA)) extracted from Hydrangea macrophylla (44%, w/w) with 98% purity, was acylated with palmitic acid by Novozym 435 to yield mono-acylated CQA. Acylation of CQA was achieved in 2-methyl-2-butanol at 60°C, and yielded two mono-acylated...
Hanadie Yousef et al.
Nature medicine, 25(6), 988-1000 (2019-05-16)
An aged circulatory environment can activate microglia, reduce neural precursor cell activity and impair cognition in mice. We hypothesized that brain endothelial cells (BECs) mediate at least some of these effects. We observe that BECs in the aged mouse hippocampus...
S Raza et al.
Protein science : a publication of the Protein Society, 10(2), 329-338 (2001-03-27)
A major problem in predicting the enantioselectivity of an enzyme toward substrate molecules is that even high selectivity toward one substrate enantiomer over the other corresponds to a very small difference in free energy. However, total free energies in enzyme-substrate...
Tomohiro Terai et al.
Digestive diseases and sciences, 59(7), 1415-1427 (2014-01-24)
Trinitrobenzenesulfonic acid (TNBS)-induced colitis is one of the most widely used experimental colitis models. However, there is no standard procedure for inducing colitis by TNBS because it is difficult to achieve a uniform distribution of colitis. We have developed a...
Rhodium?Catalyzed Regioselective C7?Functionalization of N?Pivaloylindoles.
Xu L, et al.
Angewandte Chemie (International Edition in English), 55(1), 321-325 (2016)
E Castillo et al.
Journal of biotechnology, 102(3), 251-259 (2003-05-06)
A solvent engineering strategy was applied to the lipase-catalyzed synthesis of xylitol-oleic acid monoesters. The different esterification degrees for this polyhydroxylated molecule were examined in different organic solvent mixtures. In this context, conditions for high selectivity towards monooleoyl xylitol synthesis...
I Moench et al.
Journal of molecular and cellular cardiology, 72, 374-383 (2014-05-03)
We have recently shown that in mouse ventricular myocytes, t-tubules can be quickly and tightly sealed during the resolution of hyposmotic shock of physiologically relevant magnitude. Sealing of t-tubules is associated with trapping extracellular solution inside the myocytes but the...
Lu Li et al.
Enzyme and microbial technology, 69, 46-53 (2015-02-03)
Sugar esters of fatty acids have many applications as biocompatible and biodegradable emulsifiers, which are determined by their degrees of esterification (DE). Direct esterification of fructose with lauric acid in organic media used commercial immobilized Candida antarctica lipase B (CALB)...
A S Collins et al.
Toxicological sciences : an official journal of the Society of Toxicology, 49(1), 15-28 (1999-06-15)
The oxygenate tert-amyl methyl ether (TAME) is a gasoline fuel additive used to reduce carbon monoxide in automobile emissions. To evaluate the relative health risk of TAME as a gasoline additive, information is needed on its pharmacokinetics and toxicity. The...
Susan C J Sumner et al.
Journal of applied toxicology : JAT, 23(6), 427-436 (2003-11-25)
Tertiary amyl methyl ether (TAME) is a gasoline fuel additive used to reduce emissions. Understanding the metabolism and distribution of TAME is needed to assess potential human health issues. The effect of dose level, duration of exposure and route of...
M P Bousquet et al.
Biotechnology and bioengineering, 63(6), 730-736 (1999-07-09)
Unsaturated fatty acid alpha-butylglucoside esters were prepared by enzymatic esterification of alpha-butylglucoside in nonaqueous media. Conditions were firstly optimized using oleic acid as acyl group. Synthesis was possible in several solvents but the presence of water co-product in the medium...
David Van Mater et al.
Cancer research, 75(3), 605-614 (2014-12-17)
Some patients with soft-tissue sarcoma (STS) report a history of injury at the site of their tumor. Although this phenomenon is widely reported, there are relatively few experimental systems that have directly assessed the role of injury in sarcoma formation....
T W Swyer et al.
Perfusion, 29(6), 539-543 (2014-05-08)
Currently there are no medications that can be administered to help deliver more oxygen to the myocardial region experiencing abnormal perfusion. The purpose of this study was to look at the nanoparticle dodecafluoropentane in an emulsion as an oxygen carrier....
Joseph A Laszlo et al.
Journal of liposome research, 24(4), 304-312 (2014-03-22)
The acylglycerides of lipoic and dihydrolipoic acids may serve as slow-release sources for cutaneous delivery of these antioxidants when formulated in a liposomal vehicle. Testing was conducted to determine the storage stability of lipoyl glycerides in phospholipid-based liposomes. Lipoyl glycerides...
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