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Showing 1-30 of 109 results for "244260" within Papers
Li Wang et al.
Nature communications, 5, 3925-3925 (2014-06-27)
Striatal dopamine (DA) release can be independently triggered not only by action potentials (APs) in dopaminergic axons but also APs in cholinergic interneurons (ChIs). Nicotine causes addiction by modulating DA release, but with paradoxical findings. Here, we investigate how physiologically
Lucy G Chastain et al.
Behavioural brain research, 280, 160-171 (2014-12-03)
Schizophrenia is thought to be caused, at least in part, by dysfunction in striatal dopamine neurotransmission. Both clinical studies and animal research have implicated the dopamine neuromodulator neurotensin (NT) in the pathophysiology of schizophrenia. Utilizing male mice lacking the NT
Raphaël Eddine et al.
Scientific reports, 5, 8184-8184 (2015-02-03)
Midbrain dopamine (DA) neurons are key players in motivation and reward processing. Increased DA release is thought to be central in the initiation of drug addiction. Whereas dopamine neurons are generally considered to be activated by drugs such as nicotine
Yong Wang et al.
Journal of neuroscience research, 92(12), 1733-1745 (2014-07-01)
L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) is the most common complication of standard L-DOPA therapy for Parkinson's disease experienced by most parkinsonian patients. LID is associated with disruption of dopaminergic homeostasis in basal ganglia following L-DOPA administration. Norepinephrine (NE) is another important
Norihiro Tada et al.
Organic & biomolecular chemistry, 8(20), 4701-4704 (2010-08-27)
The direct synthesis of α-bromoketones from alkylarenes by aerobic photooxidation with hydrobromic acid is reported. The key success for this direct oxidative reaction is due to control of bromination with acetic acid and ethanol, which are generated in situ by
Ryuichiro Takeda et al.
Neuroscience letters, 573, 19-23 (2014-05-17)
We previously reported that a unilateral 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease showed allodynia-like withdrawal response to mechanical stimulation of the ipsilateral side of the rat hindpaw. The goal of this study was to investigate the effect of intrastriatal
Chenchen Li et al.
The Journal of physiology, 592(19), 4329-4351 (2014-08-12)
Competing mechanisms of long-term potentiation (LTP) and long-term depression (LTD) in principal neurons of the basolateral amygdala (BLA) are thought to underlie the acquisition and consolidation of fear memories, and their subsequent extinction. However, no study to date has examined
Eric R Swy et al.
Nanoscale, 6(21), 13104-13112 (2014-09-25)
Reports of molecular and cellular imaging using computed tomography (CT) are rapidly increasing. Many of these reports use gold nanoparticles. Bismuth has similar CT contrast properties to gold while being approximately 1000-fold less expensive. Herein we report the design, fabrication
Chelsea A Vadnie et al.
Neuropharmacology, 85, 482-492 (2014-06-15)
Intracerebroventricular administration of neurotensin (NT) suppresses locomotor activity. However, the brain regions that mediate the locomotor depressant effect of NT and receptor subtype-specific mechanisms involved are unclear. Using a brain-penetrating, selective NT receptor type 1 (NTS1) agonist PD149163, we investigated
Noha Attia et al.
Journal of microencapsulation, 31(6), 579-589 (2014-04-29)
Human bone marrow mesenchymal stem cells (hBM-MSCs) show a great promise for the treatment of a variety of diseases. Despite the previous trials to encapsulate hBM-MSCs in alginate-poly-l-lysine-alginate (APA) systems, the various changes that follow immobilisation have not been ascertained
Yong Wang et al.
Synapse (New York, N.Y.), 68(8), 332-343 (2014-03-07)
l-3,4-Dihydroxyphenylalanine (L-DOPA) is the most widely used drug for the treatment of Parkinson's disease. Unfortunately, chronic administration of this dopamine precursor causes L-DOPA-induced dyskinesia (LID), which is a debilitating complication whose pathogenesis remains unclear. In this study, we compared gene
Yasemin Yuksel Durmaz et al.
Macromolecular bioscience, 11(1), 141-150 (2010-10-15)
Hydrophobic- and/or hydrophilic-polymer-grafted PDVB microspheres are synthesized by the combination of hydrobromination and click-chemistry processes. The modified-PDVB microspheres and the intermediates at various stages of synthesis are characterized using GPC, ¹H NMR and FTIR spectroscopy and TGA analysis. Use of
Ahmed Hasbi et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(11), 4806-4820 (2014-07-27)
Although the dopamine D1-D2 receptor heteromer has emerging physiological relevance and a postulated role in different neuropsychiatric disorders, such as drug addiction, depression, and schizophrenia, there is a need for pharmacological tools that selectively target such receptor complexes in order
Production of cellulose nanocrystals using hydrobromic acid and click reactions on their surface.
Sadeghifar H, et al.
J. Mater. Sci., 46(22), 7344-7355 (2011)
Werner Schwalbach et al.
The Journal of chemical physics, 135(19), 194114-194114 (2011-11-25)
A formulation of sixth-order direct perturbation theory (DPT) to treat relativistic effects in quantum-chemical calculations is presented in the framework of derivative theory. Detailed expressions for DPT6 are given at the Hartree-Fock level in terms of the third derivative of
Valentina Mosienko et al.
Neuropharmacology, 85, 73-80 (2014-05-28)
Polymorphisms in the TPH2 gene coding for the serotonin synthesizing enzyme in the brain are considered as risk factors associated with depression and anxiety in humans. However, whether a certain variation in the TPH2 gene leads to decreased brain serotonin
Samuel W Cramer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(14), 5664-5679 (2015-04-10)
The Ca(2+) channelopathies caused by mutations of the CACNA1A gene that encodes the pore-forming subunit of the human Cav2.1 (P/Q-type) voltage-gated Ca(2+) channel include episodic ataxia type 2 (EA2). Although, in EA2 the emphasis has been on cerebellar dysfunction, patients
A 39-year-old male slaughterhouse worker with recurrent fever, cough, and shortness of breath.
Tashfeen Mahmood et al.
Chest, 144(6), 1959-1963 (2013-12-04)
Tangui Maurice
Behavioural brain research, 296, 270-278 (2015-09-20)
Drugs activating the sigma-1 (σ1) chaperone protein are anti-amnesic and neuroprotective in neurodegenerative pathologies like Alzheimer's disease (AD). Since these so-called σ1 receptor (σ1R) agonists modulate cholinergic and glutamatergic systems in a variety of physiological responses, we addressed their putative
K Sangeetha et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 79(5), 884-888 (2011-05-24)
L-arginine hydrochloride monohydrate and L-arginine hydrobromide monohydrate single crystals are irradiated by 100 MeV Ag8+ swift heavy ions. The residual gases liberated from the irradiated samples are monitored as a function of ion fluence using quadrupole mass analyzer. The C2H3+
Andreia Teixeira-Castro et al.
Brain : a journal of neurology, 138(Pt 11), 3221-3237 (2015-09-17)
Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph disease. We identified citalopram, a selective serotonin
Dalila Mango et al.
Experimental neurology, 261, 733-743 (2014-09-01)
γ-Aminobutyric acid A receptor (GABAAR)-mediated postsynaptic currents were recorded in brain slices from substantia nigra pars reticulate neurons. The selective adenosine A1 receptor (A1R) antagonist, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), increased the frequency, but not the amplitude of spontaneous inhibitory post-synaptic currents (IPSCs)
Yuri Choi et al.
ACS nano, 8(11), 11377-11385 (2014-10-18)
Hybrid nanoparticles composed of multiple components can offer unique opportunities for understanding the nanoscale mechanism and advanced material applications. Here, we report the synthesis of heterodimeric silver-carbon dot nanoparticles (Ag-CD NPs) where the Ag NP is grown on the surface
Kellianne J Richardson et al.
The Journal of pharmacology and experimental therapeutics, 352(1), 156-165 (2014-11-05)
Nitrous oxide (N2O) gas is a widely used anesthetic adjunct in dentistry and medicine that is also commonly abused. Studies have shown that N2O alters the function of the N-methyl-d-aspartate (NMDA), GABAA, opioid, and serotonin receptors among others. However, the
Xuesheng Zhang et al.
Environmental toxicology and pharmacology, 38(3), 881-890 (2014-12-03)
In the present study, the toxic effects of the oral exposure of 2-hydroxylated dioxin (2-HODD) in ICR male mice were examined. The mice were administered different doses (0.2, 2.0 and 20.0mg/kg) of 2-HODD. After 14 days of exposure, the oxidative
M Julia García-Fuster et al.
Neuropharmacology, 89, 204-214 (2014-10-07)
FADD is a crucial adaptor of death receptors that can engage apoptosis or survival actions (e.g. neuroplasticity) through its phosphorylated form (p-FADD). Although FADD was shown to participate in receptor mechanisms related to drugs of abuse, little is known on
Yaohui Tang et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(7), 1138-1147 (2014-04-10)
Neural stem cells (NSCs) show therapeutic potential for ischemia in young-adult animals. However, the effect of aging on NSC therapy is largely unknown. In this work, NSCs were transplanted into aged (24-month-old) and young-adult (3-month-old) rats at 1 day after
Guinevere A Giffin et al.
The journal of physical chemistry. B, 113(49), 15914-15920 (2009-11-13)
The NH(2)(+) stretching modes of secondary amine salts have been previously studied, but the band assignments are inconsistent between the various studies. This paper assigns characteristic NH(2)(+) group frequencies between approximately 2500 and 2400 cm(-1). Crystal structures of four diamine
Hayden T Ravert et al.
Journal of labelled compounds & radiopharmaceuticals, 57(12), 695-698 (2014-10-21)
The 4-[(18)F]-fluorobenzyltriphenylphosphonium cation was synthesized by a series of microwave reactions from no carrier added [(18)F]-fluoride. The microwave procedure reduced the quantity of reagents used and synthesis time when compared with the original synthesis. In addition, problematic solid phase extraction
Kechun Yang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(48), 15888-15897 (2014-11-28)
Although evidence suggests that DA modulates hippocampal function, the mechanisms underlying that dopaminergic modulation are largely unknown. Using perforated-patch electrophysiological techniques to maintain the intracellular milieu, we investigated how the activation of D1-type DA receptors regulates spike timing-dependent plasticity (STDP)
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