Showing 1-30 of 461 results for "252859"
Pranav Prasoon et al.
Neuropeptides, 49, 47-54 (2015-01-21)
Somatostatin (SST) and the somatostatin receptor type 2 (sstr2) are expressed in the superficial part (Laminae I-III) of the dorsal horn of the spinal cord. Since the neurons in these laminae also receive nociceptive sensation from the periphery, it was...
Lívia Neves Borgheti-Cardoso et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 74, 103-117 (2015-04-29)
The development of delivery systems able to complex and release siRNA into the cytosol is essential for therapeutic use of siRNA. Among the delivery systems, local delivery has advantages over systemic administration. In this study, we developed and characterized non-viral...
Ângela Sousa et al.
Journal of chromatography. A, 1366, 110-119 (2014-09-30)
Histamine and agmatine amino acid derivatives were immobilized into monolithic disks, in order to combine the specificity and selectivity of the ligand with the high mass transfer and binding capacity offered by monolithic supports, to purify potential plasmid DNA biopharmaceuticals....
Ryosuke Shimizu et al.
Journal of pharmacokinetics and pharmacodynamics, 42(1), 67-77 (2014-11-08)
Second-generation antisense oligonucleotides (ASOs) demonstrate excellent biological stability and in vitro/in vivo potency, and thus are considered to be attractive candidates for drugs to treat various diseases. A pharmacokinetic-pharmacodynamic (PK-PD) model of ASOs is desired for the design of appropriate...
Alfred N Fonteh et al.
PloS one, 10(5), e0125597-e0125597 (2015-05-06)
Sphingolipids are important in many brain functions but their role in Alzheimer's disease (AD) is not completely defined. A major limit is availability of fresh brain tissue with defined AD pathology. The discovery that cerebrospinal fluid (CSF) contains abundant nanoparticles...
Jacob D Brown et al.
Psychopharmacology, 232(4), 673-681 (2014-08-12)
The rewarding effects of physical activity and abused drugs are caused by stimulation of similar brain pathways. Low (LVR) and high (HVR) voluntary running lines were developed by selectively breeding Wistar rats on running distance performance on postnatal days 28-34....
Mary A Forget et al.
PloS one, 9(6), e98623-e98623 (2014-06-04)
Reports demonstrate the role of M-CSF (CSF1) in tumor progression in mouse models as well as the prognostic value of macrophage numbers in breast cancer patients. Recently, a subset of CD14+ monocytes expressing the Tie2 receptor, once thought to be...
Hannah H Lee et al.
Molecular cancer therapeutics, 14(4), 994-1003 (2015-02-20)
The antimicrotubular agent docetaxel is a widely used chemotherapeutic drug for the treatment of multiple solid tumors and is predominantly dependent on hepatic disposition. In this study, we evaluated drug uptake transporters capable of transporting radiolabeled docetaxel. By screening an...
Teus J Weijs et al.
Journal of anatomy, 227(4), 431-439 (2015-09-10)
Pulmonary complications are frequently observed after transthoracic oesophagectomy. These complications may be reduced by sparing the vagus nerve branches to the lung. However, current descriptions of the regional anatomy are insufficient. Therefore, we aimed to provide a highly detailed description...
Rajesh Lakshmanan et al.
Nanomedicine (London, England), 10(23), 3451-3467 (2015-11-27)
The aim of the study is to develop scaffolds that mimic native tissue properties for effective regeneration of the myocardium, which is affected by the gradual thinning of left ventricular tissue after an infarction. Heterogenous nanofibrous scaffolds made of poly(lactide-co-caprolactone)...
Yu Wang et al.
Toxicology and applied pharmacology, 289(1), 1-11 (2015-09-04)
The clinical efficacy of anthracycline anti-neoplastic agents is limited by cardiac and hepatic toxicities. The aim of this study was to assess the hepatoprotective and cardioprotective effects of taurine zinc solid dispersions, which is a newly-synthesized taurine zinc compound, against...
Tanja Kalstrup et al.
Scientific reports, 5, 11866-11866 (2015-07-15)
With the rapid development of a continuously growing selection of unnatural amino acids (UAAs), UAA insertion becomes increasingly popular for investigating proteins. However, it can prove problematic to ensure the homogeneity of the expressed proteins, when homogeneity is compromised by...
Andrea Heinz et al.
Matrix biology : journal of the International Society for Matrix Biology, 38, 12-21 (2014-07-30)
This study aimed to characterize the structures of two elastin-like constructs, one composed of a cross-linked elastin-like polypeptide and the other one of cross-linked tropoelastin, and native aortic elastin. The structures of the insoluble materials and human aortic elastin were...
Young-Seob Lee et al.
Foodborne pathogens and disease, 9(8), 686-691 (2012-08-01)
Tetrandrine (TET) is a bis-benzylisoquinoline alkaloid derived from the radix of Stephania tetrandra S. Moore. TET performs a wide spectrum of biological activities. The radix of S. tetrandrae has been used traditionally in Asia, including Korea, to treat congestive circulatory...
Summer L Gibbs et al.
Molecular imaging, 14 (2015-03-31)
Hematoxylin-eosin (H&E) staining of tissue has been the mainstay of pathology for more than a century. However, the learning curve for H&E tissue interpretation is long, whereas intra- and interobserver variability remain high. Computer-assisted image analysis of H&E sections holds...
Linette Castillo-Pichardo et al.
Translational oncology, 7(5), 546-555 (2014-11-13)
Metastatic disease still lacks effective treatments, and remains the primary cause of cancer mortality. Therefore, there is a critical need to develop better strategies to inhibit metastatic cancer. The Rho family GTPase Rac is an ideal target for anti-metastatic cancer...
Van B Lu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(20), 8021-8034 (2015-05-23)
Under physiological conditions, the voltage-gated sodium channel Nav1.8 is expressed almost exclusively in primary sensory neurons. The mechanism restricting Nav1.8 expression is not entirely clear, but we have previously described a 3.7 kb fragment of the Scn10a promoter capable of...
Claudia A Benavente et al.
Oncotarget, 5(20), 9594-9608 (2014-10-23)
The retinoblastoma (Rb) family of proteins are key regulators of cell cycle exit during development and their deregulation is associated with cancer. Rb is critical for normal retinal development and germline mutations lead to retinoblastoma making retinae an attractive system...
Klaus Eyer et al.
Pharmaceutical research, 31(12), 3415-3425 (2014-06-15)
The membrane protein P-glycoprotein (P-gp) plays key roles in the oral bioavailability of drugs, their blood brain barrier passage as well as in multidrug resistance. For new drug candidates it is mandatory to study their interaction with P-gp, according to...
Florian Labarrade et al.
Journal of cosmetic dermatology, 14(3), 191-203 (2015-07-17)
The chromosomal passenger complex (CPC) is an assembly made of four interacting proteins: survivin, borealin, INCENP, and aurora kinase B. CPC is the key regulatory complex responsible for the correct development of cellular mitosis, accompanying each step of the chromosomal...
Sachiko Kitamoto et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 129-136 (2015-07-28)
The in vivo rodent alkaline comet assay (comet assay) is a promising technique to evaluate DNA damage in vivo. However, there is no agreement on a method to evaluate DNA damage in organs where cytotoxicity is observed. As a part...
Brandon T Gufford et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(9), 1353-1359 (2015-06-14)
Women at high risk of developing breast cancer are prescribed selective estrogen response modulators, including raloxifene, as chemoprevention. Patients often seek complementary and alternative treatment modalities, including herbal products, to supplement prescribed medications. Milk thistle preparations, including silibinin and silymarin...
Sachiko Kitamoto et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 137-143 (2015-07-28)
As a part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiative international validation study of the in vivo alkaline comet assay (comet assay), we examined DNA damage in the liver, stomach, and bone marrow of rats dosed...
L R Jaidev et al.
Materials science & engineering. C, Materials for biological applications, 47, 40-47 (2014-12-11)
Pancreatic cancer is the fourth leading cancer with 85% mortality rate in USA alone and it is prevalent in many other developed and developing countries. Clinically, gemcitabine is prescribed as the first line chemotherapeutic drug for pancreatic cancer treatment. Gemcitabine-loaded...
S Höstman et al.
Acta anaesthesiologica Scandinavica, 57(1), 63-70 (2012-11-22)
Ventilation with low tidal volumes reduces mortality in acute respiratory distress syndrome. A further reduction of tidal volumes might be beneficial, and it is known that apneic oxygenation (no tidal volumes) with arteriovenous CO(2) removal can keep acid-base balance and...
M Vergara-Barberán et al.
Food chemistry, 169, 28-33 (2014-09-23)
The improvement of protein extraction from olive leaves using an enzyme-assisted protocol has been investigated. Using a cellulase enzyme (Celluclast® 1.5L), different parameters that affect the extraction process, such as the influence and amount of organic solvent, enzyme amount, pH...
Seog Won Chang et al.
The plant pathology journal, 30(4), 384-396 (2014-12-17)
Vegetative compatibility groups (VCGs) are determined for many fungi to test for the ability of fungal isolates to undergo heterokaryon formation. In several fungal plant pathogens, isolates belonging to a VCG have been shown to share significantly higher genetic similarity...
Axel Luviano et al.
Oncology letters, 7(5), 1651-1656 (2014-04-26)
In the search for novel chemotherapeutic agents for cancer treatment, capsaicin has been shown to inhibit proliferation and induce apoptosis in various types of cancer cell line, including leukaemia cell lines. The capsaicin analogues, rinvanil and phenylacetylrinvanil (PhAR), share a...
Anne Bernhardt et al.
Medical mycology, 53(2), 132-144 (2015-01-01)
In a retrospective study, we investigated 52 formalin-fixed, paraffin-embedded (FFPE) samples from cats with histologically confirmed cutaneous and subcutaneous mycoses to determine if the pathogens could be identified by molecular methods. Aim of the study was to obtain a deep...
Anna Miodek et al.
Sensors (Basel, Switzerland), 15(10), 25015-25032 (2015-10-02)
An aptasensor with enhanced anti-fouling properties has been developed. As a case study, the aptasensor was designed with specificity for human thrombin. The sensing platform was developed on screen printed electrodes and is composed of a self-assembled monolayer made from...

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