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M A Caporizzo et al.
Langmuir : the ACS journal of surfaces and colloids, 31(10), 3027-3038 (2015-02-18)
This study systematically investigates how polymer composition changes nanoparticle (NP) grafting and diffusion in solvated random copolymer thin films. By thermal annealing from 135 to 200 °C, thin films with a range of hydrophobicity are generated by varying acrylic acid...
Antonino Tuttolomondo et al.
Clinical biochemistry, 48(1-2), 55-62 (2014-10-05)
Anderson/Fabry disease expresses a wide range of clinical variability in patients that it is possible to explain referring to a genetic variability with numerous mutations described in the literature (more than 600). We report some clinical cases of some members...
Tsong-Long Hwang et al.
Bioorganic & medicinal chemistry, 23(5), 1123-1134 (2015-02-05)
Proteinase 3 (Pr3), and human neutrophil elastase (HNE) are two major neutrophilic serine proteases (NsPs) expressed in neutrophil azurophil granules. Emerging data suggest that excessive release of proteases mediates tissue damage, and therefore prolonged neutrophil accumulation has an important role...
Wataru Nemoto et al.
Neuropharmacology, 99, 221-231 (2015-07-26)
We have previously demonstrated the possibility that angiotensin (Ang) II and its N-terminal metabolite Ang (1-7) act as neurotransmitters and/or neuromodulators in the spinal transmission of nociceptive information. Ang III, which is a C-terminal metabolite of Ang II, can also...
Shoko Morita et al.
Cell and tissue research, 359(3), 865-884 (2015-01-13)
The sensory circumventricular organs (CVOs), which comprise the organum vasculosum of the lamina terminalis (OVLT), the subfornical organ (SFO) and the area postrema (AP), lack a typical blood-brain barrier (BBB) and monitor directly blood-derived information to regulate body fluid homeostasis...
Laura Pietrangelo et al.
Oncotarget, 6(34), 35358-35371 (2015-10-21)
Calcium release units (CRUs) and mitochondria control myoplasmic [Ca2+] levels and ATP production in muscle, respectively. We recently reported that these two organelles are structurally connected by tethers, which promote proximity and proper Ca2+ signaling.Here we show that disposition, ultrastructure...
Simona Codruţa Cobzac et al.
Journal of chromatographic science, 52(9), 1095-1103 (2013-10-29)
The retention behavior for a series of amine neurotransmitters, their precursors, metabolites and structurally related drugs has been investigated in reversed-phase thin-layer chromatography using RP-18, RP-8, RP-2, CN and Diol stationary phases and mixtures of phosphate buffer and methanol as...
Detection of nascent RNA, single-copy DNA and protein localization by immunoFISH in mouse germ cells and preimplantation embryos.
Namekawa SH and Lee JT.
Nature Protocols, 6(3), 270-284 (2011)
Massimiliano Sgroi et al.
Water research, 70, 174-183 (2014-12-22)
Full-scale experiments to evaluate N-nitrosodimethylamine (NDMA) formation and attenuation were performed within an advanced indirect potable reuse (IPR) treatment system, which includes, sequentially: chloramination for membrane fouling control, microfiltration (MF), reverse osmosis (RO), ultraviolet irradiation with hydrogen peroxide (UV/H₂O₂), final...
Yanzhong Yang et al.
Nature communications, 6, 6428-6428 (2015-03-05)
The human genome encodes a family of nine protein arginine methyltransferases (PRMT1-9), whose members can catalyse three distinct types of methylation on arginine residues. Here we identify two spliceosome-associated proteins-SAP145 and SAP49-as PRMT9-binding partners, linking PRMT9 to U2 snRNP maturation....
Miau-Hwa Ko et al.
International journal of molecular sciences, 16(3), 4642-4665 (2015-03-05)
Wallerian degeneration or nerve demyelination, arising from spinal nerve compression, is thought to bring on chronic neuropathic pain. The widely distributed metabotropic glutamate receptor subtype 5 (mGluR5) is involved in modulating nociceptive transmission. The purpose of this study was to...
A Ferrer et al.
Bioresource technology, 132, 115-120 (2013-02-12)
Influence of operational variables in the EFB pulping [acetic acid (60-95%), hydrochloric acid (0.10-0.25%) and time (60-180 min)], on the yield, drainability or beating grade, Kappa number, lignin and viscosity of pulps was studied. By using a factorial design, equations...
Temmei Ito et al.
Biomedical materials (Bristol, England), 10(1), 015025-015025 (2015-03-03)
In order to obtain a hydroxyapatite (HAp)-poly(ethylene glycol) (PEG) composite, tetra amine-terminated PEG was crosslinked using disuccinimidyl tartrate to obtain a PEG hydrogel. Using two kinds of chelators with different stability constants for Ca ion (N-(2-hydroxyethyl) ethylenediamine-N,N',N'-triacetic acid (EDTA-OH, 8.14)...
Anthony Bertucci et al.
Bioorganic & medicinal chemistry letters, 21(2), 710-714 (2011-01-07)
The catalytic activity and the inhibition of a new coral carbonic anhydrase (CA, EC, from the scleractinian coral Stylophora pistillata, STPCA-2, has been investigated. STPCA-2 has high catalytic activity for the physiological reaction being less sensitive to anion and...
Kevin A Kavanagh et al.
Neuropharmacology, 89, 265-273 (2014-10-11)
The neurobiology of methamphetamine (MA) remains largely unknown despite its high abuse liability. The present series of studies explored the role of adenosine receptors on MA reward and reinforcement and identified alterations in the expression of adenosine receptors in dopamine...
Alvaro Goyanes et al.
Drug development and industrial pharmacy, 41(3), 362-368 (2013-11-28)
In this study, a new co-processed excipient composed of microcrystalline cellulose (MCC), sorbitol, chitosan and Eudragit® E, easily obtained by wet massing, to increase the dissolution rate of active ingredients of low water solubility from pellets prepared by extrusion-spheronization is...
ShuoHao Huang et al.
Plant physiology and biochemistry : PPB, 85, 9-13 (2014-11-15)
Vitamin B6 (VB6) comprises six interconvertible pyridine compounds (vitamers), among which pyridoxal 5'-phosphate (PLP) is a coenzyme involved in a high diversity of biochemical reactions. In plants, PLP is de novo synthesized, and pyridoxine (PN) is usually maintained as the...
Eduardo Parra et al.
Oncology reports, 33(1), 413-418 (2014-10-30)
Inhibition of basal Jun kinase (JNK) activity by small interfering RNAs (siRNAs) enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells. Although the JNK pathway has been extensively studied in recent years, little is known concerning the signaling...
Wei-Wei Zhao et al.
Journal of chromatography. A, 1370, 121-128 (2014-12-03)
Metal-organic frameworks (MOFs) have great potential for applications in chromatography due to their highly tailorable porous structures and unique properties. In this work, the stable MOF UiO-66 was evaluated as both a normal-phase (NP-) and a reverse-phase (RP-) stationary phase...
Sumitra Miriyala et al.
The international journal of biochemistry & cell biology, 68, 70-77 (2015-09-01)
Impaired cardiovascular function during acute myocardial infarction (MI) is partly associated with recruitment of activated polymorphonuclear neutrophils. The protective role of arjunolic acid (AA; 2,3,23-trihydroxy olean-12-en-28-oic acid) is studied in the modulation of neutrophil functions in vitro by measuring the...
Kazumasu Sasaki et al.
British journal of pharmacology, 172(2), 654-667 (2014-06-11)
μ Opioid receptor knockout (MOP-KO) mice display several behavioural differences from wild-type (WT) littermates including differential responses to nociceptive stimuli. Brain structural changes have been tied to behavioural alterations noted in transgenic mice with targeting of different genes. Hence, we...
Filippa Fleetwood et al.
Scientific reports, 4, 7518-7518 (2014-12-18)
Angiogenesis plays an important role in cancer and ophthalmic disorders such as age-related macular degeneration and diabetic retinopathy. The vascular endothelial growth factor (VEGF) family and corresponding receptors are regulators of angiogenesis and have been much investigated as therapeutic targets....
Mina Sharbatoghli et al.
Cell journal, 17(3), 547-553 (2015-10-16)
Melatonin, the chief secretory product of the pineal gland, regulates dynamic physiological adaptations that occur in seasonally breeding mammals as a response to changes in daylight hours. Because of the presence of melatonin in semen and the mem- brane melatonin...
Smita Jaiswal et al.
Experimental biology and medicine (Maywood, N.J.), 240(1), 67-78 (2014-08-16)
The development of small animal models that elicit human immune responses to dengue virus (DENV) is important since prior immunity is a major risk factor for developing severe dengue disease. This study evaluated anti-DENV human antibody (hAb) responses generated from...
Hao Xu et al.
Stem cells and development, 24(22), 2723-2732 (2015-07-15)
Excitatory commissural V3 interneurons (INs) of the ventral spinal cord have been shown to balance locomotor rhythm regularity and robustness in vivo. Unfortunately, due to the scarcity of these cells in the spinal cord, in vitro studies of dissociated V3...
Katerina Naumoska et al.
Journal of chromatography. A, 1381, 229-238 (2015-01-20)
Three TLC methods were used for an initial screening of some common plant triterpenoids and phytosterols in cuticular wax extracts of different vegetables (zucchini, eggplant, tomato, red pepper, mangold, spinach, lettuce, white-colored radicchio di Castelfranco, raddichio Leonardo, white cabbage, red...
Agnes Csiszar et al.
Breast cancer research : BCR, 16(5), 433-433 (2014-09-13)
Interleukin-like epithelial-to-mesenchymal transition inducer (ILEI) is an essential cytokine in tumor progression that is upregulated in several cancers, and its altered subcellular localization is a predictor of poor survival in human breast cancer. However, the regulation of ILEI activity and...
M A García-Sevillano et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 75-84 (2015-02-11)
Although mercury (Hg) is an important environmental and occupational pollutant, its toxicological effects, especially in serum and red blood cells (RBCs), have been scarcely studied. A toxicometabolomics workflow based on high resolution mass spectrometry approaches has been applied to investigate...
Chih-Lun Cheng et al.
Journal of biomedical science, 22, 103-103 (2015-11-18)
Highly desaturated n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are synthesized by desaturases and elongase. They exert hepatoprotective effects to prevent alcoholic fatty liver syndrome or cholestatic liver injury. However, it is unclear...
Ian S Westley et al.
Therapeutic drug monitoring, 37(6), 821-826 (2015-03-17)
The polymorphic nature of cytochrome P450 2D6 has made therapeutic drug monitoring of the anti-anginal agent perhexiline a compulsory step in reducing adverse events associated with plasma concentrations above the therapeutic range (0.15-0.60 mg/L). The aim of this study was...
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