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Mak A Saito et al.
Science (New York, N.Y.), 345(6201), 1173-1177 (2014-09-06)
Marine primary productivity is strongly influenced by the scarcity of required nutrients, yet our understanding of these nutrient limitations is informed by experimental observations with sparse geographical coverage and methodological limitations. We developed a quantitative proteomic method to directly assess
J J Jacobs et al.
The Journal of arthroplasty, 29(4), 668-669 (2014-03-25)
Mechanically assisted crevice corrosion (MACC) at metal/metal modular junctions in which at least one of the components is fabricated from cobalt-chromium alloy, has reemerged as a potential clinically significant complication in total hip arthroplasty. The clinical manifestation of MACC may
Jeannette Ø Penny et al.
Acta orthopaedica, 84(2), 130-137 (2013-04-20)
Wear particles from metal-on-metal arthroplasties are under suspicion for adverse effects both locally and systemically, and the DePuy ASR Hip Resurfacing System (RHA) has above-average failure rates. We compared lymphocyte counts in RHA and total hip arthroplasty (THA) and investigated
H I Fal'fushyns'ka et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(3), 52-61 (2013-08-14)
The effect of metal-nanocomposites (Me-NC) of cobalt and zinc (Co- and Zn-NC, correspondingly) synthecized on the basis of vinylpyrrolidone (PS) on the metal-accumulative proteins with antioxidant potential metallothioneins (MT) in crucian carp (Carassius auratus gibelio) was studied. Fish was subjected
Felix A Westerhaus et al.
Nature chemistry, 5(6), 537-543 (2013-05-23)
Molecularly well-defined homogeneous catalysts are known for a wide variety of chemical transformations. The effect of small changes in molecular structure can be studied in detail and used to optimize many processes. However, many industrial processes require heterogeneous catalysts because
R Shukla et al.
The International journal of neuroscience, 116(12), 1391-1402 (2006-12-06)
Evidence from clinical and experimental studies supports the hypothesis of free radical-mediated damage of dopaminergic neurons in the pathology of Parkin's disease (PD). The present study was undertaken to evaluate the role of nitric oxide and oxidative stress in PD.
Shinji Tsuchida et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(8), 975-980 (2014-03-29)
We assessed whether heat shock protein 70 (HSP70) is involved in hypoxia inducible factor 1 alpha (HIF-1α)-dependent anabolic pathways in articular chondrocytes under hypoxic conditions. Primary rabbit chondrocytes were cultured under normoxia (20% oxygen condition) or hypoxia (1% oxygen condition).
Nanda D Paul et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 19(39), 12953-12958 (2013-09-17)
One-pot radicals: Cobalt(III)-carbene radicals, generated by metallo-radical activation of diazo compounds and N-tosylhydrazone sodium salts with cobalt(II) complexes of porphyrins, readily undergo radical addition to carbon monoxide, allowing the catalytic production of ketenes. These ketenes subsequently react with various amines
Tea Romih et al.
The Science of the total environment, 508, 76-84 (2014-12-02)
The aim of this study was to determine whether citric acid adsorbed onto cobalt ferrite (CoFe2O4) nanoparticles (NPs) influences the bioavailability of their constituents Co and Fe. Dissolution of Co and Fe was assessed by two measures: (i) in aqueous
Jari Mokka et al.
Acta orthopaedica, 84(6), 549-554 (2013-11-01)
The clinical findings of adverse reaction to metal debris (ARMD) following large-diameter-head metal-on-metal total hip arthroplasty (LDH MoM THA) may include periarticular fluid collections, soft tissue masses, and gluteal muscle necrosis. The ReCap-M2a-Magnum LDH MoM THA was the most commonly
Nahid Gharib Naseri et al.
Analytical and bioanalytical chemistry, 391(4), 1283-1292 (2008-03-21)
Catalytic adsorptive stripping voltammetry (CAdSV) has been demonstrated at a bismuth film electrode (BiFE) in an injection-moulded electrochemical micro-flow cell. The polystyrene three-electrode flow cell was fabricated with electrodes moulded from a conducting grade of polystyrene containing 40% carbon fibre
D A Loeffler et al.
Journal of neural transmission. Parkinson's disease and dementia section, 9(1), 45-53 (1995-01-01)
Though depletion of CSF homovanillic acid (HVA) concentration has often been regarded as a direct indicator of dopamine (DA) deficiency in Parkinson's Disease (PD), CSF HVA is normal in mildly affected patients. To explore why, we measured DA and its
Marie C Heffern et al.
Current opinion in chemical biology, 17(2), 189-196 (2012-12-29)
Inorganic complexes are versatile platforms for the development of potent and selective pharmaceutical agents. Cobalt possesses a diverse array of properties that can be manipulated to yield promising drug candidates. Investigations into the mechanism of cobalt therapeutic agents can provide
H U Shetty et al.
Clinical chemistry, 42(2), 298-302 (1996-02-01)
Previous studies suggest the presence of increased concentrations of cerebral myo-inositol in Alzheimer disease (AD). To characterize this abnormality further, we quantified myo-inositol and several other polyols in cerebrospinal fluid (CSF) and plasma from 10 AD subjects and 10 healthy
Y Kotake et al.
Journal of neurochemistry, 65(6), 2633-2638 (1995-12-01)
1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ) was detected as a novel endogenous amine in mouse brain and parkinsonian CSF by using the gas chromatography-selected ion-monitoring method. The level of 1BnTIQ was very high in CSF of some parkinsonian patients compared with that of controls
Eric Y Chang et al.
The Journal of bone and joint surgery. American volume, 95(22), 2015-2020 (2013-11-22)
Plasma metal ion levels are commonly used in the postoperative follow-up evaluation of patients who have had a metal-on-metal hip arthroplasty. However, the relationship between these levels and clinical and imaging findings is not well known. We evaluated 156 consecutive
Pushya A Potnis et al.
Cellular immunology, 282(1), 53-65 (2013-05-18)
Metal orthopedic implant debris-induced osteolysis of hip bone is a major problem in patients with prosthetic-hips. Although macrophages are the principal targets for implant-wear debris, the receptor(s) and mechanisms underlying these responses are not fully elucidated. We examined whether the
Johannes Levin et al.
Dementia and geriatric cognitive disorders, 29(6), 553-559 (2010-07-08)
Increasing evidence suggests that elevated levels of homocysteine (Hcy) and methylmalonate (MMA) may be involved in the pathogenesis of neurodegenerative diseases. The urine levels of MMA and serum levels of Hcy as well as folic acid and vitamin B(12) were
Wen Zhang et al.
The Analyst, 129(3), 229-234 (2004-02-24)
The fabrication and application of a novel electrochemical detector (ED) with nano crystalline Ce-doped lead dioxide film chemically modified electrode (CME) for liquid chromatography (LC) were described. The Ce-doped PbO(2) film was characterized by X-ray diffractometer (XRD) and scanning tunnel
Valerio Leoni et al.
Journal of lipid research, 46(2), 191-195 (2004-12-04)
In a recent publication [Diestel, A., O. Aktas, D. Hackel, I. Hake, S. Meier, C. S. Raine, R. Nitsch, F. Zipp, and O. Ullrich. 2003. Activation of microglial poly (ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a link between demyelination
Karl Ap Payne et al.
Nature, 517(7535), 513-516 (2014-10-21)
Organohalide chemistry underpins many industrial and agricultural processes, and a large proportion of environmental pollutants are organohalides. Nevertheless, organohalide chemistry is not exclusively of anthropogenic origin, with natural abiotic and biological processes contributing to the global halide cycle. Reductive dehalogenases
Jungho Ryu et al.
Journal of nanoscience and nanotechnology, 13(5), 3422-3426 (2013-07-19)
Spinel structured highly dense NiMn2O4-based (NMO) negative temperature coefficient (NTC) thermistor thick films were fabricated by aerosol-deposition at room temperature. To enhance the thermistor B constant, which represents the temperature sensitivity of the NMO thermistor material, Co and Co-Fe doping
Caroline Ann Lim et al.
Documenta ophthalmologica. Advances in ophthalmology, 130(1), 43-48 (2014-11-09)
The effect of elevated serum cobalt on the human visual system has not yet been established. In light of recent reports of visual problems with elevated cobalt in association with hip prostheses, this review examines the literature for evidence regarding
Andrea L Armstead et al.
Toxicology and applied pharmacology, 278(1), 1-8 (2014-04-22)
Tungsten carbide cobalt (WC-Co) has been recognized as a workplace inhalation hazard in the manufacturing, mining and drilling industries by the National Institute of Occupational Safety and Health. Exposure to WC-Co is known to cause "hard metal lung disease" but
Marlies De Boeck et al.
Mutation research, 533(1-2), 135-152 (2003-12-04)
The purpose of this review is to summarise the data concerning genotoxicity and carcinogenicity of Co and Sb. Both metals have multiple industrial and/or therapeutical applications, depending on the considered species. Cobalt is used for the production of alloys and
Giovanni Forte et al.
Annali dell'Istituto superiore di sanita, 41(2), 189-195 (2005-10-26)
Twenty-six metals and the oxidative status in 71 patients affected by Parkinson's disease and 44 healthy individuals were compared in order to identify potential biomarkers of the disease. In the patients, the following significant imbalances were found (p < or
Anja Rosenow et al.
Biochimica et biophysica acta, 1834(12), 2761-2771 (2013-10-22)
White adipose tissue (WAT) regulates energy metabolism by secretion of proteins with endocrine and paracrine effects. Dysregulation of the secretome of obesity-associated enlarged WAT may lead to obesity-related disorders. This can be caused by hypoxia as a result of poorly
Kazuhiro Yamada
Metal ions in life sciences, 13, 295-320 (2014-01-29)
The primarily function of cobalt in humans is based on its role in cobalamin (Cbl, vitamin B12). Therefore, this chapter will focus on the physiological roles of Cbl and the importance of cobalt in human health. Cbl acts as the
E Sabbioni et al.
The Science of the total environment, 120(1-2), 39-61 (1992-06-09)
The EURO TERVIHT (Trace Element Reference Values in Human Tissues), recently initiated, aims to establish and compare trace metal reference values in inhabitants from the different EC countries. The project anticipates international cooperation of specialized chemical and toxicological laboratories in
Brent L Finley et al.
Journal of toxicology and environmental health. Part B, Critical reviews, 15(8), 493-523 (2012-12-04)
Cobalt (Co) is an essential component of vitamin B(12). As with all metals, at sufficiently high doses, Co may exert detrimental effects on different organ systems, and adverse responses have been observed in animals, patients undergoing Co therapy, and workers
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