Showing 1-30 of 1137 results for "

270997

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Mahmoud Alebouyeh et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 975, 40-44 (2014-12-02)
A simple and rapid high-performance liquid chromatographic method with spectrophotometric detection was developed for the determination of lamivudine in human plasma. Sample preparation was accomplished through protein precipitation with acetonitrile followed by aqueous phase separation using dichloromethane. Lamivudine and the...
Suhair Sunoqrot et al.
Journal of controlled release : official journal of the Controlled Release Society, 191, 115-122 (2014-05-20)
Nanoparticle (NP)-based drug delivery platforms have received a great deal of attention over the past two decades for their potential in targeted cancer therapies. Despite the promises, passive targeting approaches utilizing relatively larger NPs (typically 50-200nm in diameter) allow for...
Fátima Brandão et al.
Metallomics : integrated biometal science, 7(9), 1352-1363 (2015-06-19)
Clarification of the mechanisms of mercury (Hg) toxicity in fish remains challenging. An innovative approach to this clarification is the combined assessment of metabolomic shifts, alterations in the antioxidant system and the risk of oxidative damage, and Hg bioaccumulation. This...
Tatiana Cucu et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(9), 1406-1415 (2015-07-28)
Sucrose esters (E 473) are emulsifiers used in foods to improve different technological properties. They should conform to the specifications laid down in Commission Regulation No. 231/2012 and be used at amounts not exceeding the maximal ones set by Commission...
Saer Samanipour et al.
Journal of chromatography. A, 1375, 123-139 (2014-12-17)
Comprehensive two-dimensional gas chromatography (GC×GC) is used widely to separate and measure organic chemicals in complex mixtures. However, approaches to quantify analytes in real, complex samples have not been critically assessed. We quantified 7 PAHs in a certified diesel fuel...
Giulia Gigliobianco et al.
Journal of biomaterials applications, 30(1), 50-60 (2015-02-06)
Tissue-engineered constructs often fail due to poor integration with the patient's tissues. Specifically, they fail to be neovascularised, leading to the death and loss of the implanted tissues. Thus, there is a need to produce angiogenic materials to improve tissue...
C Neveu et al.
British journal of pharmacology, 171(19), 4425-4439 (2014-06-11)
The neuropeptide 26RFa and its cognate receptor GPR103 are involved in the control of food intake and bone mineralization. Here, we have tested, experimentally, the predicted ligand-receptor interactions by site-directed mutagenesis of GPR103 and designed point-substituted 26RFa analogues. Using the...
Xi Zhan et al.
Pharmaceutical research, 32(7), 2280-2291 (2015-01-17)
A key step of delivering extracellular agents to its intracellular target is to escape from endosomal/lysosomal compartments, while minimizing the release of digestive enzymes that may compromise cellular functions. In this study, we examined the intracellular distribution of both fluorecent...
Xi Zhang et al.
Small (Weinheim an der Bergstrasse, Germany), 11(45), 6091-6096 (2015-10-20)
A one-step method to produce ≈12 nm hydrodynamic diameter water-soluble CdSe/ZnS quantum dots (QDs), as well as CdS/ZnS, ZnSe/ZnMnS/ZnS, AgInS2 /ZnS, and CuInS2 /ZnS QDs, by ligand exchange with a near-monolayer of organosilane caps is reported. The method cross-links the...
Peter Chhour et al.
ACS nano, 8(9), 9143-9153 (2014-09-05)
Nanoparticles of complex architectures can have unique properties. Self-assembly of spherical nanocrystals is a high yielding route to such systems. In this study, we report the self-assembly of a polymer and nanocrystals into aggregates, where the location of the nanocrystals...
T Leisinger et al.
Biodegradation, 5(3-4), 237-248 (1994-12-01)
Dichloromethane (DCM) is efficiently utilized as a carbon and energy source by aerobic, Gram-negative, facultative methylotrophic bacteria. It also serves as a sole carbon and energy source for a nitrate-respiring Hyphomicrobium sp. and for a strictly anaerobic co-culture of a...
Rajaian Pushpabai Rajesh et al.
Anticancer research, 35(1), 283-293 (2015-01-01)
Marine invertebrates called ascidians are prolific producers of bioactive substances. The ascidian Eudistoma viride, distributed along the Southeast coast of India, was investigated for its in vitro cytotoxic activity against human cervical carcinoma (HeLa) cells by the MTT assay. The...
Kelly Munro et al.
Journal of chromatography. A, 1396, 34-44 (2015-04-22)
The modelling and prediction of reversed-phase chromatographic retention time (tR) under gradient elution conditions for 166 pharmaceuticals in wastewater extracts is presented using artificial neural networks for the first time. Radial basis function, multilayer perceptron and generalised regression neural networks...
Paul R S Baker et al.
Journal of lipid research, 55(11), 2432-2442 (2014-09-17)
Phospholipids serve as central structural components in cellular membranes and as potent mediators in numerous signaling pathways. There are six main classes of naturally occurring phospholipids distinguished by their distinct polar head groups that contain many unique molecular species with...
Lilu Guo et al.
Antioxidants & redox signaling, 22(18), 1633-1645 (2015-03-10)
Increased lipid peroxidation occurs in many conditions associated with inflammation. Because lipid peroxidation produces lipid aldehydes that can induce inflammatory responses through unknown mechanisms, elucidating these mechanisms may lead to development of better treatments for inflammatory diseases. We recently demonstrated...
Shantanu S Chandratre et al.
AAPS PharmSciTech, 16(1), 98-107 (2014-09-06)
The relapse of cancer after first line therapy with anticancer agents is a common occurrence. This recurrence is believed to be due to the presence of a subpopulation of cells called cancer stem cells in the tumor. Therefore, a combination...
Katerina Naumoska et al.
Journal of chromatography. A, 1381, 229-238 (2015-01-20)
Three TLC methods were used for an initial screening of some common plant triterpenoids and phytosterols in cuticular wax extracts of different vegetables (zucchini, eggplant, tomato, red pepper, mangold, spinach, lettuce, white-colored radicchio di Castelfranco, raddichio Leonardo, white cabbage, red...
M Soledade C Pedras et al.
Bioorganic & medicinal chemistry letters, 23(2), 484-487 (2012-12-13)
The phytoalexin cyclobrassinin is a plant defense that has additional importance since it inhibits brassinin hydrolase, a phytoalexin detoxifying enzyme produced by the plant pathogen Alternaria brassicicola. Hence, the 1,3-thiazino[6,5-b]indole scaffold of cyclobrassinin has great application as a lead structure...
Iu V Plekhanova et al.
Prikladnaia biokhimiia i mikrobiologiia, 49(2), 203-208 (2013-06-26)
Cells of dichloromethane (DChM) bacteria-destructors were immobilized by sorption on different types of membranes, which were fixed on the measuring surface of a pH-sensitive field transistor. The presence of DChM in the medium (0.6-8.8 mM) led to a change in...
Wolfgang Dohle et al.
ChemMedChem, 9(2), 350-370 (2014-01-18)
The syntheses and antiproliferative activities of novel substituted tetrahydroisoquinoline derivatives and their sulfamates are discussed. Biasing of conformational populations through substitution on the tetrahydroisoquinoline core at C1 and C3 has a profound effect on the antiproliferative activity against various cancer...
Abdulrahman M Elbagory et al.
Steroids, 101, 110-115 (2015-06-23)
The chemical study on the total extract of the zoanthid Palythoa tuberculosa, collected from the Red Sea, resulted in the isolation of seven polyhydroxylated sterols (1-7), six of which, palysterols A-F (2-7), are new. Their chemical structures were elucidated on...
Nisrina Ramadhani et al.
International journal of pharmaceutics, 475(1-2), 514-522 (2014-09-15)
The oral route of administration is the most common and preferred route of drug delivery due to its ease of administration, cost-effectiveness and flexibility in design. However, limited aqueous solubility of the active pharmaceutical ingredient can result in poor bioavailability...
Xing Huang et al.
Nature communications, 6, 7408-7408 (2015-06-16)
Currently, studies on organic two-dimensional (2D) materials with special optic-electronic properties are attracting great research interest. However, 2D organic systems possessing promising electrical transport properties are still rare. Here a highly crystalline thin film of a copper coordination polymer, Cu-BHT...
Kailin Deng et al.
Journal of agricultural and food chemistry, 63(12), 3161-3167 (2015-03-13)
Carcinogenic nitropolycyclic aromatic hydrocarbons (nitro-PAHs) are ubiquitous in the ambient environment. They are emitted predominantly from internal combustion engines and by reacting polycyclic aromatic hydrocarbons with nitrogen oxide. The emerging evidence that nitro-PAHs are taken up by plants and bioaccumulatd...
Paula Solar et al.
Journal of nanobiotechnology, 13, 14-14 (2015-04-18)
Advances in nanostructure materials are leading to novel strategies for drug delivery and targeting, contrast media for magnetic resonance imaging (MRI), agents for hyperthermia and nanocarriers. Superparamagnetic iron oxide nanoparticles (SPIONs) are useful for all of these applications, and in...
Xavier Rovira et al.
ChemMedChem, 9(12), 2685-2698 (2014-09-10)
The active conformation of a family of metabotropic glutamate receptor subtype 4 (mGlu4 ) positive allosteric modulators (PAMs) with the cyclohexane 1,2-dicarboxylic scaffold present in cis-2-(3,5-dichlorophenylcarbamoyl)cyclohexanecarboxylic acid (VU0155041) was investigated by testing structurally similar six-membered ring compounds that have a...
Barbara J Fuhrman et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 23(12), 2649-2657 (2014-12-05)
Interindividual differences in estrogen metabolism may partially account for differences in risks of estrogen-responsive cancers. We conducted a proof-of-performance study to assess the reproducibility of a LC/MS-MS method for measurement of 15 serum estrogens and metabolites (all 15 termed EM)...
Rishikesh Kumar et al.
Drug delivery, 22(3), 383-388 (2014-03-08)
Drug delivery systems are a promising technology to increase poor solubility and bioavailability of compounds. Therefore we have developed PLGA-PEG encapsulated amphotericin B nanoparticles (NPs) drug delivery technology to increase the solubility of amphotericin B and target the macrophage of...
E Pérez et al.
Materials science & engineering. C, Materials for biological applications, 55, 218-226 (2015-06-29)
The need to enhance charge capacity in neural stimulation-electrodes is promoting the formation of new materials and coatings. Among all the possible types of graphene, pristine graphene prepared by graphite electrochemical exfoliation, is used in this work to form a...
V Mistretta et al.
Acta clinica Belgica, 69(1), 53-61 (2014-03-19)
Azole antifungals are a group of fungistatic agents that can be administered orally or parenterally. The determination of the concentrations of these antifungals (miconazole, fluconazole, ketoconazole, posaconazole, voriconazole, itraconazole, and its major active metabolite, hydroxy-itraconazole) in serum can be useful...