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Koyal Garg et al.
Journal of applied physiology (Bethesda, Md. : 1985), 117(10), 1120-1131 (2014-09-27)
Losartan is a Food and Drug Administration approved antihypertensive medication that is recently emerging as an antifibrotic therapy. Previously, losartan has been successfully used to reduce fibrosis and improve both muscle regeneration and function in several models of recoverable skeletal...
Valérie Jolivel et al.
Acta neuropathologica, 129(2), 279-295 (2014-12-17)
The contribution of microglia to ischemic cortical stroke is of particular therapeutic interest because of the impact on the survival of brain tissue in the ischemic penumbra, a region that is potentially salvable upon a brain infarct. Whether or not...
Ryo Ogawa et al.
Development (Cambridge, England), 142(1), 51-61 (2014-12-07)
Muscle satellite cells are indispensable for muscle regeneration, but the functional diversity of their daughter cells is unknown. Here, we show that many Pax7(+)MyoD(-) cells locate both beneath and outside the basal lamina during myofiber maturation. A large majority of...
Haijing Wang et al.
Journal of chromatographic science, 53(5), 647-654 (2014-09-17)
Determination of volatile organic compounds (VOCs) in crude oil, such as super volatile organic compounds (super VOCs) and simple polycyclic aromatic hydrocarbons (PAHs), is vital for targeting crude oil spill spots. In this study, a static headspace gas chromatography flame...
Yiming Huang et al.
Transplantation, 89(6), 677-685 (2010-01-30)
The role of bone marrow (BM)-derived cells in pancreatic beta-cell regeneration remains unresolved. We examined whether BM-derived cells are recruited to the site of moderate pancreatic injury and contribute to beta-cell regeneration. Low-dose streptozotocin (STZ) treatment was used to induce...
P Krustrup et al.
British journal of sports medicine, 43(11), 825-831 (2008-12-23)
To examine the effects of regular participation in recreational soccer on health profile, 36 healthy untrained Danish men aged 20-43 years were randomised into a soccer group (SO; n = 13), a running group (RU; n = 12) and a...
Kevin P Snyder et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(11), 2517-2525 (2015-04-14)
The stress-related neuropeptide, corticotropin-releasing factor (CRF) regulates the dorsal raphe nucleus-serotonin (DRN-5-HT) system during stress and this may underlie affective and cognitive dysfunctions that characterize stress-related psychiatric disorders. CRF acts on both CRF1 and CRF2 receptor subtypes in the DRN...
Benedikt Galliker et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 15(25), 6161-6168 (2009-05-14)
We have identified two intermediates in the autoxidation of NO*: ONOO*, which was detected by EPR spectroscopy at 295 K and atmospheric pressure in the gas phase, and ONOONO, a red substance produced at 113 K in 2-methylbutane. The red...
Alice W Racca et al.
Human molecular genetics, 24(12), 3348-3358 (2015-03-06)
Distal arthrogryposis is the most common known heritable cause of congenital contractures (e.g. clubfoot) and results from mutations in genes that encode proteins of the contractile complex of skeletal muscle cells. Mutations are most frequently found in MYH3 and are...
Anna K Kopec et al.
The Journal of pharmacology and experimental therapeutics, 351(2), 288-297 (2014-08-21)
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of obesity and metabolic syndrome. Robust coagulation cascade activation is common in obese patients with NAFLD. We identified a critical temporal relationship between thrombin generation and the manifestation of hepatic steatosis...
Li Hu et al.
Stem cells (Dayton, Ohio), 33(8), 2483-2495 (2015-05-27)
Adipogenesis is essential for soft tissue reconstruction following trauma or tumor resection. We demonstrate that CD31(-)/34(+)/146(-) cells, a subpopulation of the stromal vascular fraction (SVF) of human adipose tissue, were robustly adipogenic. Insulin growth factor-1 (IGF1) promoted a lineage bias...
Jürgen Berg et al.
Stem cell reviews, 11(1), 133-149 (2014-08-15)
Adult human adipose-derived mesenchymal stem cells (MSC) have been reported to induce neuroprotective effects in models for Parkinson's disease (PD). However, these effects strongly depend on the most optimal application of the transplant. In the present study we compared monolayer-cultured...
Nicolas Goffart et al.
Neuro-oncology, 17(1), 81-94 (2014-08-03)
Patients with glioblastoma multiforme (GBM) have an overall median survival of 15 months. This catastrophic survival rate is the consequence of systematic relapses that could arise from remaining glioblastoma stem cells (GSCs) left behind after surgery. We previously demonstrated that...
Fernando Eduardo Padovan-Neto et al.
Neuropharmacology, 89, 87-99 (2014-09-10)
It is well known that nitric oxide (NO) interacts with dopamine (DA) within the striatal circuitry. The anti-dyskinetic properties of NO synthase (NOS) inhibitors demonstrate the importance of NO in L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID). Here, we investigated the ability of...
Robert Morhard et al.
IEEE transactions on bio-medical engineering, 67(8), 2337-2348 (2019-12-17)
Ethanol ablation, the injection of ethanol to induce necrosis, was originally used to treat hepatocellular carcinoma, with survival rates comparable to surgery. However, efficacy is limited due to leakage into surrounding tissue. To reduce leakage, we previously reported incorporating ethyl...
Thomas P Ladas et al.
Experimental neurology, 269, 120-132 (2015-04-12)
Low frequency electrical stimulation (LFS) can reduce neural excitability and suppress seizures in animals and patients with epilepsy. However the therapeutic outcome could benefit from the determination of the cell types involved in seizure suppression. We used optogenetic techniques to...
Matthew B Veldman et al.
Molecular neurodegeneration, 10, 67-67 (2015-12-10)
Although the genetic cause for Huntington's disease (HD) has been known for over 20 years, the mechanisms that cause the neurotoxicity and behavioral symptoms of this disease are not well understood. One hypothesis is that N-terminal fragments of the HTT protein...
Pascal Stuelsatz et al.
Developmental biology, 397(1), 31-44 (2014-09-23)
Extraocular muscles (EOMs) are highly specialized skeletal muscles that originate from the head mesoderm and control eye movements. EOMs are uniquely spared in Duchenne muscular dystrophy and animal models of dystrophin deficiency. Specific traits of myogenic progenitors may be determinants...
Yuan Tang et al.
Nanomedicine : nanotechnology, biology, and medicine, 10(8), 1711-1718 (2014-06-19)
Rebuilding of infarcted myocardium by mesenchymal stem cells (MSCs) has not been successful because of poor cell survival due in part to insufficient blood supply after myocardial infarction (MI). We hypothesize that targeted delivery of vascular endothelial growth factor (VEGF)...
Weiwei Tao et al.
The Journal of biological chemistry, 290(33), 20086-20097 (2015-06-27)
Elevated circulating free fatty acid levels are important contributors to insulin resistance in the muscle and liver, but the underlying mechanisms require further elucidation. Here, we show that geranylgeranyl diphosphate synthase 1 (GGPPS), which is a branch point enzyme in...
Mandi M Murph et al.
Bioorganic & medicinal chemistry, 23(17), 5999-6013 (2015-07-21)
Autotaxin (ATX) is an enzyme discovered in the conditioned medium of cultured melanoma cells and identified as a protein that strongly stimulates motility. This unique ectonucleotide pyrophosphatase and phosphodiesterase facilitates the removal of a choline headgroup from lysophosphatidylcholine (LPC) to...
Anthony C Johnson et al.
Neuropharmacology, 93, 116-123 (2015-02-07)
Previously we demonstrated that exposure of the central nucleus of the amygdala (CeA) to elevated corticosterone (CORT) induces nociceptive behaviors that are reversed by glucocorticoid and/or mineralocorticoid (GR/MR) receptor antagonism. Here we test the hypothesis that in a cholesterol (CHOL)-implanted...
Sara A Olenich et al.
The Journal of physiology, 592(15), 3325-3338 (2014-06-22)
Temporal expression of positive and negative angiogenic factors in response to detraining is poorly understood. We report the protein expression of anti-angiogenic peptides (thrombospondin-1, TSP-1; and endostatin) as well as pro-angiogenic factors (vascular endothelial growth factor, VEGF; matrix metalloproteinases-2 and...
Mingxing Wang et al.
International journal of nanomedicine, 10, 5635-5646 (2015-09-15)
In this study, we investigated a series of cationic polyelectrolytes (PEs) with different size and composition for their potential to improve delivery of an antisense phosphorodiamidate morpholino oligomer (PMO) both in vitro and in vivo. The results showed that the...
Aitak Farzi et al.
Brain, behavior, and immunity, 44, 106-120 (2014-09-15)
Toll-like receptors (TLRs) and nuclear-binding domain (NOD)-like receptors (NLRs) are sensors of bacterial cell wall components to trigger an immune response. The TLR4 agonist lipopolysaccharide (LPS) is a strong immune activator leading to sickness and depressed mood. NOD agonists are...
Dorottya Czövek et al.
Respiratory research, 15, 81-81 (2014-08-15)
Hyperoxia exposure leads to the development of lung injury and bronchial hyperreactivity (BHR) via involvement of nitric oxide (NO) pathway. We aimed at characterizing whether the stimulation of the NO pathway by sildenafil or vasoactive intestinal peptide (VIP) is able...
Chang Seok Lee et al.
The Journal of biological chemistry, 289(37), 25556-25570 (2014-07-24)
Rapamycin at high doses (2-10 mg/kg body weight) inhibits mammalian target of rapamycin complex 1 (mTORC1) and protein synthesis in mice. In contrast, low doses of rapamycin (10 μg/kg) increase mTORC1 activity and protein synthesis in skeletal muscle. Similar changes...
Heidi Tran et al.
The European journal of neuroscience, 41(1), 55-68 (2014-11-19)
The striatum is the key input nucleus of the basal ganglia, and is implicated in motor control and learning. Despite the importance of striatal circuits, the mechanisms associated with their development are not well established. Previously, Ten-m3, a member of...
Georg F Weber et al.
The Journal of experimental medicine, 211(6), 1243-1256 (2014-05-14)
Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine, but the immunophysiological processes that confer either protection or morbidity are not completely understood. We show that in response to lung infection, B1a B...
Chengcao Sun et al.
Journal of applied physiology (Bethesda, Md. : 1985), 118(2), 224-237 (2015-01-17)
Sulforaphane (SFN), one of the most important isothiocyanates in the human diet, is known to have chemo-preventive and antioxidant activities in different tissues via activation of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as...