Showing 1-30 of 1699 results for "278475"
Sara Tomei et al.
Molecular oncology, 9(1), 93-104 (2014-09-02)
The existence of a dichotomy between immunologically active and quiescent tumor phenotypes has been recently recognized in several types of cancer. The activation of a Th1 type of immune signature has been shown to confer better prognosis and likelihood to...
Bikramjit Ghosh et al.
Marine biotechnology (New York, N.Y.), 17(6), 841-853 (2015-09-28)
This study examined the feasibility of alginate microcapsules manufactured using a low-impact technology and reagents to protect orally delivered immunogens for use as immunoprophylactics for fish. Physical characteristics and protein release kinetics of the microcapsules were examined at different pH...
Daniel A Enquobahrie et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(7), 904-910 (2015-02-14)
Repeat pregnancies with different perinatal outcomes minimize underlying maternal genetic diversity and provide unique opportunities to investigate nongenetic risk factors and epigenetic mechanisms of pregnancy complications. We investigated gestational diabetes mellitus (GDM)-related differential DNA methylation in early pregnancy peripheral blood...
Shewit Kalayou et al.
Cell biology and toxicology, 30(6), 361-376 (2014-11-25)
The mycotoxin alternariol (AOH) is an important contaminant of fruits and cereal products. The current study sought to address the effect of a non-toxic AOH concentration on the proteome of the steroidogenic H295R cell model. Quantitative proteomics based on stable...
Anna Della Corte et al.
Talanta, 140, 52-61 (2015-06-07)
The abundance of lipids in plants is influenced by genotype and phenotype. Despite being a very important class of plant metabolites, knowledge of grape lipids is still very limited to date, with the exception of those located in seeds. Few...
Pamela Brunswick et al.
Journal of chromatography. A, 1405, 49-71 (2015-06-16)
A rapid and sensitive liquid chromatography quadrupole time of flight method has been established for the determination of total naphthenic acid concentrations in aqueous samples. This is the first methodology that has been adopted for routine, high resolution, high throughput...
Marika Massaro et al.
PloS one, 10(6), e0129652-e0129652 (2015-06-27)
High intakes of n-3 fatty acids exert anti-inflammatory effects and cardiovascular protection, but the underlying molecular basis is incompletely defined. By genome-wide analysis we searched for novel effects of docosahexaenoic acid (DHA) on gene expression and pathways in human vascular...
X Liu et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 123(5), 308-316 (2015-05-20)
Plant polyphenols, such as hydrolysable tannins, are present in the human diet and known to exhibit anti-diabetic and anti-obesity activity. We previously reported that the representative hydrolysable tannin compound α-penta-galloyl-glucose (α-PGG) is a small molecule insulin mimetic that, like insulin...
Sajjad Karim et al.
CNS & neurological disorders drug targets, 13(8), 1334-1345 (2014-10-28)
Non-communicable chronic diseases have been apparently established as threat to human health, and are currently the world's main killer. Cardiovascular diseases (CVD), cancer, diabetes and neurodegenerative diseases are collectively amounting to more than 60% of non-communicable disease burden across world....
Xiao-Yao Song et al.
International journal of molecular sciences, 16(6), 13490-13506 (2015-06-16)
Atrazine (2-chloro-4-ethytlamino-6-isopropylamine-1,3,5-triazine; ATR) is widely used as a broad-spectrum herbicide. Animal studies have demonstrated that ATR exposure can cause cell death in dopaminergic neurons. The molecular mechanisms underlying ATR-induced neuronal cell death, however, are unknown. In this study, we investigated...
Chun-Hao Huang et al.
The Journal of nutritional biochemistry, 26(8), 808-817 (2015-05-06)
The beneficial effects of garlic (Allium sativum) consumption in treating human diseases have been reported worldwide over a long period of human history. The strong antioxidant effect of garlic extract (GE) has also recently been claimed to prevent cancer, thrombus...
Jiahao Guo et al.
Physical chemistry chemical physics : PCCP, 17(43), 28985-28992 (2015-10-13)
Exploiting an alternative of the Pt-based counter-electrode materials for the triiodide reduction reaction has become a major interest in the fundamental research of dye-sensitized solar cells. Transition-metal selenides have recently been demonstrated as promising non-precious metal electrocatalysts for the triiodide...
Jiang-Shan Lian et al.
Hepatobiliary & pancreatic diseases international : HBPD INT, 14(4), 413-421 (2015-08-11)
Because of the diversity of the clinical and laboratory manifestations, the diagnosis of autoimmune liver disease (AILD) remains a challenge in clinical practice. The value of metabolomics has been studied in the diagnosis of many diseases. The present study aimed...
Nicolas C Nalpas et al.
Scientific reports, 5, 13629-13629 (2015-09-09)
Mycobacterium bovis, the agent of bovine tuberculosis, causes an estimated $3 billion annual losses to global agriculture due, in part, to the limitations of current diagnostics. Development of next-generation diagnostics requires a greater understanding of the interaction between the pathogen...
Cristina Vilanova et al.
Scientific reports, 5, 17163-17163 (2015-11-26)
Microbial communities are ubiquitous in both natural and artificial environments. However, microbial diversity is usually reduced under strong selection pressures, such as those present in habitats rich in recalcitrant or toxic compounds displaying antimicrobial properties. Caffeine is a natural alkaloid...
Michal Holčapek et al.
Analytical and bioanalytical chemistry, 407(17), 5033-5043 (2015-02-20)
A new continuous comprehensive two-dimensional liquid chromatography-electrospray ionization mass spectrometry method has been developed for the lipidomic characterization of complex biological samples. The reversed-phase ultra-high-performance liquid chromatography with a C18 column (150 mm × 1 mm, 1.7 μm) used in the first...
Davy Baudelet et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 986-987, 35-43 (2015-02-24)
The P2X receptors are seven-transmembrane domain G protein-coupled receptors and the 7 subtypes of P2X receptors identified in humans, and named P2X1 to P2X7, are channel receptors whose endogenous ligand is ATP. New antagonists of the P2X7 receptor were developed...
Mark Jesus M Magbanua et al.
Breast cancer research : BCR, 17, 73-73 (2015-05-30)
The molecular biology involving neoadjuvant chemotherapy (NAC) response is poorly understood. To elucidate the impact of NAC on the breast cancer transcriptome and its association with clinical outcome, we analyzed gene expression data derived from serial tumor samples of patients...
Davy Baudelet et al.
Journal of chromatography. A, 1363, 257-269 (2014-07-21)
Analytical enantioseparation of three pyroglutamide derivatives with pharmacological activity against the purinergic receptor P2X7, was run in both high-performance liquid chromatography and supercritical fluid chromatography. Four polysaccharide based chiral stationary phases, namely amylose and cellulose tris (3,5-dimethylphenylcarbamate), amylose tris ((S)-α-methylbenzylcarbamate)...
Nóra Grecsó et al.
Biomedical chromatography : BMC, 29(5), 788-796 (2014-10-24)
The stereoisomers of 1,2,3,4-tetrahydroisoquinoline amino alcohol analogues and derivatives thereof were separated in normal-phase mode on chiral stationary phases based on preprepared silica coated with cellulose tris-(3,5-dimethylphenyl carbamate), cellulose tris-(3-chloro-4-methylphenyl carbamate), cellulose tris-(4-methylbenzoate) or cellulose tris-(4-chloro-3-methylphenyl carbamate). On all the...
Taylor C Rose et al.
Development genes and evolution, 225(4), 235-251 (2015-07-15)
The postembryonic development and caste differentiation patterns of lower termites have been described multiple times in a variety of different species. However, most of these studies focused on gross ontogeny, without carefully describing the maturation of any particular organ or...
L Meme et al.
International journal of immunopathology and pharmacology, 27(3), 437-444 (2014-10-04)
Since raloxifene, a drug used in osteoporosis therapy, inhibits osteoclast, but not osteoblast functions, it has been suggested to improve recovery during implant surgery. The present paper describes an effective method to link raloxifene, through a covalent bond, to a...
Jone Garate et al.
Analytical and bioanalytical chemistry, 407(16), 4697-4708 (2015-04-24)
Imaging mass spectrometry is becoming a reference technique in the field of lipidomics, due to its ability to map the distribution of hundreds of species in a single run, along a tissue section. The next frontier is now achieving increasing...
Danielle L Peters et al.
BMC genomics, 16, 664-664 (2015-09-04)
A rapid worldwide increase in the number of human infections caused by the extremely antibiotic resistant bacterium Stenotrophomonas maltophilia is prompting alarm. One potential treatment solution to the current antibiotic resistance dilemma is "phage therapy", the clinical application of bacteriophages...
Alexander H Mo et al.
Nanoscale, 7(2), 771-775 (2014-11-29)
Colloidal particles with two or more different surface properties (Janus particles) are of interest in catalysis, biological imaging, and drug delivery. Eccentric nanoparticles are a type of Janus particle consisting of a shell that envelops the majority of a core...
Yihua Chen et al.
Nature communications, 10(1), 1112-1112 (2019-03-09)
Further minimizing the defect state density in the semiconducting absorber is vital to boost the power conversion efficiency of solar cells approaching Shockley-Queisser limit. However, it lacks a general strategy to control the precursor chemistry for defects density reduction in...
Halina Abramczyk et al.
The Analyst, 140(7), 2224-2235 (2015-03-03)
We have studied live non-malignant (MCF10A), mildly malignant (MCF7) and malignant (MDA-MB-231) breast cancer cells and human breast cancer tissue. We demonstrate the first application of Raman imaging and spectroscopy in diagnosing the role of lipid droplets in cell line...
Lara Patriquin et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 10(9), 1311-1318 (2015-07-23)
Early detection of lung cancer in high-risk individuals reduces mortality. Low-dose spiral computed tomography (LDCT) is the current standard but suffers from an exceedingly high false-positive rate (>96%) leading to unnecessary and potentially dangerous procedures. We, therefore, set out to...
Zhaohui Wang et al.
ACS nano, 9(7), 7563-7571 (2015-06-18)
We demonstrate that surface modified nanocellulose fibers (NCFs) can be used as substrates to synthesize supercapacitor electrodes with the highest full electrode-normalized gravimetric (127 F g(-1)) and volumetric (122 F cm(-3)) capacitances at high current densities (300 mA cm(-2) ≈...
Navid Bizmark et al.
Langmuir : the ACS journal of surfaces and colloids, 31(34), 9282-9289 (2015-08-05)
Nanoparticle attachment at a fluid interface is a process that often takes place concurrently with nanoparticle aggregation in the bulk of the suspension. Here we investigate systematically the coupling of these processes with reference to the adsorption of aqueous suspensions...

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