Showing 1-30 of 1699 results for "

278475

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Siele Ceuppens et al.
International journal of environmental research and public health, 12(8), 10171-10197 (2015-08-27)
Fresh herbs such as basil constitute an important food commodity worldwide. Basil provides considerable culinary and health benefits, but has also been implicated in foodborne illnesses. The naturally occurring bacterial community on basil leaves is currently unknown, so the epiphytic...
Juan Pablo Tosar et al.
Nucleic acids research, 43(11), 5601-5616 (2015-05-06)
Intercellular communication can be mediated by extracellular small regulatory RNAs (sRNAs). Circulating sRNAs are being intensively studied for their promising use as minimally invasive disease biomarkers. To date, most attention is centered on exosomes and microRNAs as the vectors and...
Erik Selander et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(20), 6395-6400 (2015-04-29)
Interactions among microscopic planktonic organisms underpin the functioning of open ocean ecosystems. With few exceptions, these organisms lack advanced eyes and thus rely largely on chemical sensing to perceive their surroundings. However, few of the signaling molecules involved in interactions...
J W Keele et al.
Journal of animal science, 93(3), 956-964 (2015-05-29)
Bovine respiratory disease complex (BRDC) is the most expensive disease in beef cattle in the United States costing the industry at least US$1 billion annually. Bovine respiratory disease complex causes damage to lung tissue resulting in persistent lung lesions observable...
Seyed Mohammad Kalantari et al.
Journal of the mechanical behavior of biomedical materials, 48, 183-191 (2015-05-09)
Porous scaffolds of Ti-6Al-4V were produced by mixing of this alloy with different amount of magnesium (Mg) powders. The mixtures were compacted in steel die by applying uniaxial pressure of 500 MPa before sintering the compacts in sealed quartz tubes...
Christina Kober et al.
Journal of translational medicine, 13, 216-216 (2015-07-08)
Oncolytic virotherapy is a novel approach for the treatment of glioblastoma multiforme (GBM) which is still a fatal disease. Pathologic features of GBM are characterized by the infiltration with microglia/macrophages and a strong interaction between immune- and glioma cells. The...
Xiao-Dong Cheng et al.
Talanta, 141, 8-14 (2015-05-13)
The present study described the preparation and application of zwitterionic stationary phases (ACS) with controllable ratio of positively charged tertiary amine groups and negatively charged carboxyl groups. Various parameters, including water content, pH values and ionic strength of the mobile...
Susana Machado et al.
BioMed research international, 2014, 703253-703253 (2014-08-26)
Recent success in the treatment of congenital blindness demonstrates the potential of ocular gene therapy as a therapeutic approach. The eye is a good target due to its small size, minimal diffusion of therapeutic agent to the systemic circulation, and...
Hongbin Liu et al.
Journal of pharmaceutical and biomedical analysis, 109, 142-149 (2015-03-17)
RP-HPLC has been demonstrated as a powerful tool to study antibody free thiol and disulfide variants. Recently, the introduction of UHPLC columns with wide pore size (300Å) and small particle size (1.7μm) offered the opportunity to further improve the separation...
Paniz Sheikholeslami et al.
Experimental eye research, 137, 18-31 (2015-06-06)
The potential of hydrophobically-modified poly(vinyl pyrrolidone) as a shear-responsive, self-associative hydrogel for ophthalmic applications is demonstrated. Hydrophobic modification was achieved via random copolymerization of N-vinylpyrrolidone with N-vinylformamide, the latter of which can be hydrolyzed to expose a desired degree of...
Afshin Beheshti et al.
Oncotarget, 6(34), 35419-35432 (2015-10-27)
The concept of age-dependent host control of cancer development raises the natural question of how these effects manifest across the host tissue/organ types with which a tumor interacts, one important component of which is the aging immune system. To investigate...
Priscilla Rocío-Bautista et al.
Talanta, 139, 13-20 (2015-04-18)
Three metal-organic frameworks (MOFs), specifically HKUST-1, MOF-5, and MIL-53(Al), have been synthetized, characterized, studied and compared in a vortex-assisted dispersive micro-solid-phase extraction (VA-D-µ-SPE) procedure in combination with high-performance liquid chromatography (HPLC) with diode-array detection (DAD) for determining seven parabens in...
Marten A Hoeksema et al.
EMBO molecular medicine, 6(9), 1124-1132 (2014-07-11)
Macrophages are key immune cells found in atherosclerotic plaques and critically shape atherosclerotic disease development. Targeting the functional repertoire of macrophages may hold novel approaches for future atherosclerosis management. Here, we describe a previously unrecognized role of the epigenomic enzyme...
Huanan Li et al.
ACS applied materials & interfaces, 7(29), 15855-15865 (2015-07-04)
A series of pullulan-doxorubicin conjugates (Pu-DOXs) were investigated for effectively delivering DOX to nuclei of hepatic carcinoma cells in subcutaneous tumor model. These Pu-DOXs were prepared by conjugating DOX onto pullulan molecule via pH-responsive hydrazone bond using spacers with different...
Marilena E Dasenaki et al.
Journal of agricultural and food chemistry, 63(18), 4493-4508 (2015-04-01)
A wide-scope screening methodology has been developed for the identification of veterinary drugs and pharmaceuticals in fish tissue and milk using ultrahigh-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC-QTOF MS). The method was validated using a qualitative approach at two...
Andrew Woolston et al.
Oncotarget, 6(23), 19483-19499 (2015-07-15)
Lung adenocarcinoma possesses distinct patterns of EGFR/KRAS mutations between East Asian and Western, male and female patients. However, beyond the well-known EGFR/KRAS distinction, gender and ethnic specific molecular aberrations and their effects on prognosis remain largely unexplored. Association modules capture...
Weiyi Huang et al.
Oncology reports, 34(3), 1510-1516 (2015-07-17)
NIN/RPN12 binding protein 1 (NOB1p) encoded by NOB1 has been found to be an essential factor in 26S proteasome biogenesis which participates in protein degradation. However, the functions of NOB1 in non-small cell lung cancer cells are largely unknown. In...
Fee Bengsch et al.
Cell cycle (Georgetown, Tex.), 14(10), 1540-1547 (2015-03-19)
Oncogene-induced senescence (OIS) is an important tumor suppression mechanism preventing uncontrolled proliferation in response to aberrant oncogenic signaling. The profound functional and morphological remodelling of the senescent cell involves extensive changes. In particular, alterations in protein ubiquitination during senescence have...
Davide Pacitti et al.
PloS one, 10(5), e0127041-e0127041 (2015-05-16)
Selenium (Se) is an essential oligonutrient, as a component of several Se-containing proteins (selenoproteins), which exert important biological functions within an organism. In livestock, Se-enriched products have been proposed as dietary supplements to be included into functional feeds for animal...
M Sela et al.
Cell death & disease, 6, e1728-e1728 (2015-04-17)
Mesenchymal stromal cells (MSCs) are multipotent and can be derived from different adult tissues including fat. Our repeated attempts to produce long-term proliferative cultures of rat abdominal adipose stem cells (aASCs) under normal oxygen concentration (21%) were unsuccessful. We set...
Takeaki Nagamine et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 997, 187-193 (2015-06-30)
In order to clarify the mechanism of fucoidan transport, we developed the chromatographic determination method. A size-exclusion chromatography (SEC) method for the determination of Okinawa-fucoidan using Develosil 300 Diol-5 (60×8.0mm I.D., 30nm pore-diameter) with the eluent containing 1% non-ionic detergent...
Boe S Sorensen et al.
Cancer, 120(24), 3896-3901 (2014-08-12)
The feasibility of monitoring epidermal growth factor receptor (EGFR) mutations in plasma DNA from patients with advanced non-small cell lung cancer (NSCLC) during treatment with erlotinib and its relation to disease progression was investigated. The amount of EGFR-mutant DNA was...
Daniel Matatagui et al.
Sensors (Basel, Switzerland), 14(7), 12658-12669 (2014-07-17)
The following paper examines a time-efficient method for detecting biological warfare agents (BWAs). The method is based on a system of a Love-wave immunosensor combined with a microfluidic chip which detects BWA samples in a dynamic mode. In this way...
Jérémy Carlier et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 70-77 (2014-12-23)
Hypoglycin A (HGA) is the toxic principle in ackee (Blighia sapida Koenig), a nutritious and readily available fruit which is a staple of the Jamaican working-class and rural population. The aril of the unripe fruit has high concentrations of HGA...
Zhike Chen et al.
The Journal of steroid biochemistry and molecular biology, 149, 118-127 (2015-02-17)
Resistance to endocrine therapies in hormone receptor (HR)-positive breast cancer is a significant clinical problem for a considerable number of patients. The oncogenic transcription factor c-MYC (hereafter referred to as MYC), which regulates glutamine metabolism in cancer cells, has been...
Yongguang Tu et al.
Nanoscale, 7(48), 20539-20546 (2015-11-21)
A compact TiO(2) layer is crucial to achieve high-efficiency perovskite solar cells. In this study, we developed a facile, low-cost and efficient method to fabricate a pinhole-free and ultrathin blocking layer based on highly crystallized TiO(2) quantum dots (QDs) with...
Lucas A Salas et al.
Epigenetics, 10(7), 650-661 (2015-06-04)
Trihalomethanes (THM) are undesired disinfection byproducts (DBPs) formed during water treatment. Mice exposed to DBPs showed global DNA hypomethylation and c-myc and c-jun gene-specific hypomethylation, while evidence of epigenetic effects in humans is scarce. We explored the association between lifetime...
Anthony Delalande et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(7), 1735-1744 (2015-06-07)
Tendon injury is a major musculoskeletal disorder with a high public health impact. We propose a non-viral based strategy of gene therapy for the treatment of tendon injuries using histidylated vectors. Gene delivery of fibromodulin, a proteoglycan involved in collagen...
Shrikant A Survase et al.
Journal of industrial microbiology & biotechnology, 40(2), 209-215 (2012-11-28)
The study was focused on developing a continuous method to produce an alcohol mixture suitable to be used as a gasoline supplement. The immobilized column reactor with wood pulp fibers was successfully used for the continuous production of butanol and...
Jeong-Woo Seo et al.
Biochemistry, 53(49), 7854-7865 (2014-11-19)
Lactimidomycin (LTM, 1) and iso-migrastatin (iso-MGS, 2) belong to the glutarimide-containing polyketide family of natural products. We previously cloned and characterized the mgs biosynthetic gene cluster from Streptomyces platensis NRRL 18993. The iso-MGS biosynthetic machinery featured an acyltransferase (AT)-less type...