Showing 1-30 of 187 results for "289396"
Ana Maria S Simão et al.
Calcified tissue international, 93(3), 222-232 (2013-08-15)
During endochondral bone formation, chondrocytes and osteoblasts synthesize and mineralize the extracellular matrix through a process that initiates within matrix vesicles (MVs) and ends with bone mineral propagation onto the collagenous scaffold. pH gradients have been identified in the growth...
Hyun Wook Huh et al.
Carbohydrate polymers, 126, 130-140 (2015-05-03)
A biomineralized hydrogel system containing hyaluronic acid (HA) and poloxamer composed of a poly(ethylene oxide)/poly(propylene oxide)/poly(ethylene oxide) (PEO-PPO-PEO) block copolymer was developed as a biomimetic thermo-responsive injectable hydrogel system for bone regeneration. Using HA and poloxamer macromers with polymerizable residues...
Aysel Koç et al.
Journal of biomaterials applications, 29(5), 748-760 (2014-07-27)
Bone tissue is dependent on an efficient blood supply to ensure delivery of nutrients and oxygen. One method to acquire a vascular-engineered bone tissue could be the use of an angiogenic gene-activated scaffold. In the current study, porous chitosan/hydroxyapatite (C/HA)...
Craig J van Dolleweerd et al.
The Journal of infectious diseases, 210(2), 200-208 (2014-02-11)
Rabies post-exposure prophylaxis (PEP) currently comprises administration of rabies vaccine together with rabies immunoglobulin (RIG) of either equine or human origin. In the developing world, RIG preparations are expensive, often in short supply, and of variable efficacy. Therefore, we are...
Jie Deng et al.
Oral oncology, 51(9), 824-831 (2015-07-23)
Concurrent chemoradiation (CCR) therapy is a standard treatment for patients with locally advanced head and neck cancer (HNC). It is well documented that CCR causes profound acute and late toxicities. Xerostomia (the symptom of dry mouth) and hyposalivation (decreased salivary...
Shoji Ohgami et al.
Plant physiology, 168(2), 464-477 (2015-04-30)
Tea plants (Camellia sinensis) store volatile organic compounds (VOCs; monoterpene, aromatic, and aliphatic alcohols) in the leaves in the form of water-soluble diglycosides, primarily as β-primeverosides (6-O-β-D-xylopyranosyl-β-D-glucopyranosides). These VOCs play a critical role in plant defenses and tea aroma quality...
Jing Yao et al.
Journal of controlled release : official journal of the Controlled Release Society, 170(3), 414-420 (2013-06-25)
Anti-herpes simplex virus (HSV) drug acyclovir (ACV) is phosphorylated by the viral thymidine kinase (TK), but not the cellular TK. Phosphorylated ACV inhibits cellular DNA synthesis and kills the infected cells. We hypothesize that ACV monophosphate (ACVP), which is an...
Andrew J Harmata et al.
Clinical orthopaedics and related research, 473(12), 3951-3961 (2015-07-24)
Infectious complications of musculoskeletal trauma are an important factor contributing to patient morbidity. Biofilm-dispersive bone grafts augmented with D-amino acids (D-AAs) prevent biofilm formation in vitro and in vivo, but the effects of D-AAs on osteocompatibility and new bone formation...
Lucas H B Walschot et al.
Acta orthopaedica, 85(6), 600-608 (2014-09-23)
The bone impaction grafting technique restores bone defects in total hip replacement. Porous titanium particles (TiPs) are deformable, like bone particles, and offer better primary stability. We addressed the following questions in this animal study: are impacted TiPs osteoconductive under...
Thomas Chi et al.
PloS one, 10(5), e0124150-e0124150 (2015-05-15)
Ectopic calcification is a driving force for a variety of diseases, including kidney stones and atherosclerosis, but initiating factors remain largely unknown. Given its importance in seemingly divergent disease processes, identifying fundamental principal actors for ectopic calcification may have broad...
C Reilly et al.
Journal of applied microbiology, 117(6), 1798-1809 (2014-09-30)
To test the effect of 0·4% stannous fluoride (SnF2 ) glycerine-based gels on specific portions of the bacterial community in both a clinical observational study and in vitro multispecies plaque-derived (MSPD) biofilm model. Potential changes to specific portions of the...
Lawrence M Kauvar et al.
Antimicrobial agents and chemotherapy, 59(3), 1558-1568 (2014-12-24)
Human cytomegalovirus (HCMV) is the most common infection causing poor outcomes among transplant recipients. Maternal infection and transplacental transmission are major causes of permanent birth defects. Although no active vaccines to prevent HCMV infection have been approved, passive immunization with...
Stefano Scoglio et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 21(7), 992-997 (2014-04-03)
Aphanizomenon flos-aquae (AFA) is a fresh water unicellular blue-green alga that has been traditionally used for over 25 years for its health-enhancing properties. Recent studies have shown the ability of a proprietary AFA extract (Klamin(®)) to improve mood, counteract anxiety...
R Osorio et al.
Journal of dental research, 93(12), 1258-1263 (2014-09-18)
To obtain more durable adhesion to dentin, and to protect collagen fibrils of the dentin matrix from degradation, calcium- and phosphate-releasing particles have been incorporated into the dental adhesive procedure. The aim of the present study was to incorporate zinc-loaded...
Stephan Benke et al.
Nature communications, 6, 6198-6198 (2015-02-06)
Pore-forming toxins are protein assemblies used by many organisms to disrupt the membranes of target cells. They are expressed as soluble monomers that assemble spontaneously into multimeric pores. However, owing to their complexity, the assembly processes have not been resolved...
Weihong Qu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 990, 15-22 (2015-04-05)
Column chromatography has been widely used as a scalable purification strategy for recombinant adeno-associated virus (rAAV) vectors. The rAAV1, 2, 4, 5, 6, 8 and 9 serotypes could be separated using affinity resins, ion exchange resins or other types of...
Dariusz Wawro et al.
International journal of molecular sciences, 12(11), 7286-7300 (2011-12-17)
This paper describes a method for preparing chitosan fibers modified with hydroxyapatite (HAp), tricalcium phosphate (β-TCP), and HAp/β-TCP nanoparticles. Fiber-grade chitosan derived from the northern shrimp (Pandalus borealis) and nanoparticles of tricalcium phosphate (β-TCP) and hydroxyapatite (HAp) suspended in a...
Muriel Babey et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(6), 1064-1076 (2014-12-17)
The primary goal of this study was to determine whether the IGF1R in mature osteoblasts and osteocytes was required for the catabolic actions of continuous parathyroid hormone (cPTH). Igf1r was deleted from male and female FVN/B mice by breeding with...
Yoshitaka Ogita et al.
The Journal of biological chemistry, 290(33), 20245-20256 (2015-07-08)
The Ras family of small GTPases function in a wide variety of biological processes as "molecular switches" by cycling between inactive GDP-bound and active GTP-bound forms. Di-Ras1 and Di-Ras2 were originally identified as small GTPases forming a distinct subgroup of...
Hydroxyapatite and hydroxyapatite-based ceramics.
Orlovskii VP, et al.
Inorganic Materials, 38(10), 973-984 (2002)
F Munarin et al.
International journal of biological macromolecules, 72, 199-209 (2014-08-12)
Pectin-based biocomposite hydrogels were produced by internal gelation, using different hydroxyapatite (HA) powders from commercial source or synthesized by the wet chemical method. HA possesses the double functionality of cross-linking agent and inorganic reinforcement. The mineralogical composition, grain size, specific...
A I Espirito Santo et al.
Biochemical and biophysical research communications, 464(4), 1145-1150 (2015-07-26)
The treatment of autoimmune disorders has been revolutionised by the introduction of biologics such as anti-tumour necrosis factor (anti-TNF). Although in rheumatoid arthritis patients a bone sparing effect of anti-TNF has been shown, the mechanism is not fully understood. Anti-TNF...
Julien Ramier et al.
Journal of materials science. Materials in medicine, 25(6), 1563-1575 (2014-03-04)
Electrospinning coupled with electrospraying provides a straightforward and robust route toward promising electrospun biocomposite scaffolds for bone tissue engineering. In this comparative investigation, four types of poly(3-hydroxybutyrate) (PHB)-based nanofibrous scaffolds were produced by electrospinning a PHB solution, a PHB/gelatin (GEL)...
David Pastorino et al.
Acta biomaterialia, 28, 205-214 (2015-09-20)
Characterization of the intricate pore structure of calcium phosphate cements is a key step to successfully link the structural properties of these synthetic bone grafts with their most relevant properties, such as in vitro or in vivo behaviour, drug loading...
Giulia Pavani et al.
Blood, 124(7), 1157-1165 (2014-06-25)
Recombinant activated human factor VII (rhFVIIa) is an established hemostatic agent in hemophilia, but its mechanism of action remains unclear. Although tissue factor (TF) is its natural receptor, rhFVIIa also interacts with the endothelial protein C receptor (EPCR) through its...
Ruixue Yin et al.
Materials science & engineering. C, Materials for biological applications, 46, 239-245 (2014-12-11)
In this work, hydroxyapatite (HA) was first dispersed into cyclic acetal unit based monomers (EHD), and then EHD/HA composites were obtained by in-situ photopolymerization. FTIR and XRD analyses were used to successfully confirm the chemical composition of this composite. Real-time...
Shih-Yeh Lin et al.
Biotechnology and bioengineering, 112(10), 2005-2015 (2015-05-23)
Enterovirus 71 (EV71) is responsible for the outbreaks of hand-foot-and-mouth disease in the Asia-Pacific region. To produce the virus-like particle (VLP) vaccine, we previously constructed recombinant baculoviruses to co-express EV71 P1 polypeptide and 3CD protease using the Bac-to-Bac(®) vector system....
Takaya Kurokawa et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(8), 1218-1225 (2015-05-17)
Diltiazem, a calcium channel blocker, is mainly metabolized via demethylation or deacetylation in humans. Diltiazem demethylation is catalyzed by cytochrome P450 2D6 and 3A4. Although it was previously reported that the area under the curve ratio of deacetyldiltiazem to diltiazem...
Yoshikuni Goto et al.
Journal of biochemistry, 157(6), 439-449 (2015-01-13)
In this study, we examined the role of aminopeptidases with reference to endoplasmic reticulum aminopeptidase 1 (ERAP1) in nitric oxide (NO) synthesis employing murine macrophage cell line RAW264.7 cells activated by lipopolysaccharide (LPS) and interferon (IFN)-γ and LPS-activated peritoneal macrophages...
Niladri Nath Panda et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(5), 971-982 (2014-09-02)
This study evaluated the mechanical properties and osteogenic potential of a silk fibroin scaffold prepared from a 70:30 blend of Eri (Philosamia ricini) and Tasar (Antheraea mylitta) silk, respectively (ET scaffolds). An electrospinning process was used to prepare uniformly blended...

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