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Kazumasu Sasaki et al.
British journal of pharmacology, 172(2), 654-667 (2014-06-11)
μ Opioid receptor knockout (MOP-KO) mice display several behavioural differences from wild-type (WT) littermates including differential responses to nociceptive stimuli. Brain structural changes have been tied to behavioural alterations noted in transgenic mice with targeting of different genes. Hence, we
Antonis Kourtidis et al.
PloS one, 10(6), e0129964-e0129964 (2015-06-13)
Altered protein expression and phosphorylation are common events during malignant transformation. These perturbations have been widely explored in the context of E-cadherin cell-cell adhesion complexes, which are central in the maintenance of the normal epithelial phenotype. A major component of
Yasuhito Funahashi et al.
The Journal of urology, 192(6), 1864-1870 (2014-07-06)
Rebamipide is used as a topical therapeutic agent for various organs. We examined the healing effects of intravesical rebamipide on damaged urothelium in a rat model of chemically induced cystitis. Hydrochloride was injected in the bladder of female Sprague Dawley®
Mohamad H Darwish et al.
Molecular medicine reports, 11(2), 1462-1468 (2014-11-06)
Neuroblastoma (NB) is a rare pediatric disease in Lebanon for which poor prognosis remains a major challenge. Genetic polymorphism of genes coding for drug‑metabolizing enzymes may influence the response of a patient to chemotherapy. This study investigates a possible association
Marina G Pintado-Herrera et al.
Analytica chimica acta, 851, 1-13 (2014-12-03)
This work presents the development, optimization and validation of a multi-residue method for the simultaneous determination of 102 contaminants, including fragrances, UV filters, repellents, endocrine disruptors, biocides, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and several types of pesticides in
Lisa Terranova et al.
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 18(4), 338-345 (2015-04-23)
Among biomaterials used for filling bone defects, beta-tricalcium phosphate (β-TCP) is suitable in non-bearing bones, particularly in dental implantology, oral and maxillofacial surgery. When β-TCP granules are placed in a bone defect, they occupy the void 3D volume. Little is
Xuan Gui et al.
Fitoterapia, 95, 51-57 (2014-03-13)
Illicium lanceolatum is a traditional Chinese medicine (TCM) for treating inflammatory diseases. Anti-inflammatory activities of I. lanceolatum stems and leaves were tested using ear edema models induced by dimethyl benzene in mice. Bioassay-guided fractionation of the ethanol extract of I.
Anna H Le et al.
PloS one, 9(8), e106013-e106013 (2014-08-26)
Angiogenesis, the formation of new blood vessels, is important for the survival of ovarian transplants and the restoration of ovarian functions. Without angiogenesis, transplanted ovarian tissue becomes more susceptible to tissue damage and necrosis. Administration of analgesics for pain management
Ana García-Sacristán et al.
Nucleic acids research, 43(1), 565-580 (2014-12-17)
The 5' untranslated region of hepatitis C virus (HCV) genomic RNA contains an internal ribosome entry site (IRES) element, composed of domains II-IV, which is required for cap-independent translation initiation. Little information on the 3D structure of the whole functional
Yang Xu et al.
Behavioural brain research, 286, 1-10 (2015-02-28)
BRD7 is a bromodomain-containing protein (BCP), and recent evidence implicates the role of BCPs in the initiation and development of neurodevelopmental disorders. However, few studies have investigated the biological functions of BRD7 in the central nervous system. In our study
Christopher J C Whitehouse et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 17(24), 6862-6868 (2011-04-28)
The oxidation of o-xylene by P450(BM3) from Bacillus megaterium yields, in addition to the products formed by microsomal P450s, two metabolites containing an NIH-shifted methyl group, one of which lacks the aromatic character of the substrate. The failure of the
Yu-Ting Wu et al.
Scientific reports, 5, 9718-9718 (2015-04-14)
It is desirable to obtain unlimited supplies of endothelial cells for research and therapeutics. However, current methods of deriving endothelial cells from humans suffer from issues, such as limited supplies, contamination from animal substances, and lengthy/complicated procedures. In this article
Jennifer R Hay et al.
Journal of neuropathology and experimental neurology, 74(12), 1147-1157 (2015-11-18)
Traumatic brain injury (TBI) is a risk factor for dementia. Mixed neurodegenerative pathologies have been described in late survivors of TBI, but the mechanisms driving post-TBI neurodegeneration remain elusive. Increasingly, blood-brain barrier (BBB) disruption has been recognized in a range
Paul J Mintz et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(8), 2515-2520 (2015-02-13)
In response to an urgent need for improved diagnostic and predictive serum biomarkers for management of metastatic prostate cancer, we used phage display fingerprinting to analyze sequentially acquired serum samples from a patient with advancing prostate cancer. We identified a
T Biron-Shental et al.
Placenta, 36(2), 199-203 (2014-12-17)
The intrauterine environment, including the placenta, is influenced by a variety of factors, among which is diabetes during pregnancy. These factors can affect lifetime morbidity. Senescence is a state of cellular metabolic arrest, known to be correlated with age-related diseases
Domokos Gerö et al.
Molecular medicine (Cambridge, Mass.), 20, 313-328 (2014-05-21)
Poly(ADP-ribose) polymerase-1 (PARP-1) activation is a hallmark of oxidative stress-induced cellular injury that can lead to energetic failure and necrotic cell death via depleting the cellular nicotinamide adenine dinucleotide (NAD(+)) and ATP pools. Pharmacological PARP-1 inhibition or genetic PARP-1 deficiency
P Calis et al.
European journal of obstetrics, gynecology, and reproductive biology, 185, 126-130 (2015-01-13)
To evaluate the effect of ischemia-reperfusion on follicle count and viability of follicles in a rat model with adnexal torsion. A total of 24 female adult Wistar albino rats were included in the study. In the first laparotomy, right ovaries
Lalit Batra et al.
PLoS neglected tropical diseases, 8(12), e3322-e3322 (2014-12-05)
No ideal vaccine exists to control plague, a deadly dangerous disease caused by Yersinia pestis. In this context, we cloned, expressed and purified recombinant F1, LcrV antigens of Y. pestis and heat shock protein70 (HSP70) domain II of M. tuberculosis
Waleed M Renno et al.
Journal of neurotrauma, 32(3), 170-184 (2014-07-16)
Our previous studies have established that (-)-epigallocatechin-3-gallate (EGCG) has both neuroprotective and -regenerative capacity after sciatic nerve injury. Moreover, this improvement was evident on the behavioral level. The aim of this study was to investigate the central effects of ECGC
Shao-Yu Peng et al.
Taiwanese journal of obstetrics & gynecology, 53(2), 151-157 (2014-07-16)
Liver fibrosis results from the wound healing response to chronic liver damage. Advanced liver fibrosis results in cirrhosis and liver failure, and liver transplantation is often the only option for effective therapy; however, the shortage of available donor livers limits
José Alexandre da Rocha Curvelo et al.
Archives of oral biology, 59(9), 928-937 (2014-06-08)
The aim of this study was to evaluate the effect of SLPI on the growth and biological processes of Candida albicans. Two C. albicans strains were used in this study, a clinical isolate resistant to fluconazole (PRI) and a reference
Jun Wang et al.
International journal of clinical and experimental medicine, 8(8), 12774-12782 (2015-11-10)
It is recognized that Fibroblast Growth Factor 4 (FGF-4) could not only increase the proliferation of bone marrow mesenchymal stem cells (BMSCs), but also induce BMSCs into hepatocyte-like cells in vitro. However, the role of FGF4 played in liver regeneration
Owain W Howell et al.
Neuropathology and applied neurobiology, 41(6), 798-813 (2014-11-26)
Multiple sclerosis (MS) is a progressive inflammatory neurological disease affecting myelin, neurons and glia. Demyelination and neurodegeneration of cortical grey matter contribute to a more severe disease, and inflammation of the forebrain meninges associates with pathology of the underlying neocortical
Nathaly Espitia Pinzon et al.
PloS one, 9(6), e100574-e100574 (2014-06-25)
Infiltration of leukocytes is a major pathological event in white matter lesion formation in the brain of multiple sclerosis (MS) patients. In grey matter lesions, less infiltration of these cells occur, but microglial activation is present. Thus far, the interaction
Stephen F Murphy et al.
PloS one, 10(5), e0125623-e0125623 (2015-05-02)
Chronic pelvic pain syndrome (CPPS) is the most common form of prostatitis, accounting for 90-95% of all diagnoses. It is a complex multi-symptom syndrome with unknown etiology and limited effective treatments. Previous investigations highlight roles for inflammatory mediators in disease
Jimmy F P Berbée et al.
Nature communications, 6, 6356-6356 (2015-03-11)
Brown adipose tissue (BAT) combusts high amounts of fatty acids, thereby lowering plasma triglyceride levels and reducing obesity. However, the precise role of BAT in plasma cholesterol metabolism and atherosclerosis development remains unclear. Here we show that BAT activation by
Yue Liu et al.
Diagnostic pathology, 9, 180-180 (2014-12-17)
The tumor suppressor protein p16(INK4a) has been extensively studied in many tumors with very different results, ranging from its loss to its clear overexpression, which may be associated with degree of tumor differentiation and prognosis. However, its expression remains unclear
Alán Alpár et al.
Nature communications, 5, 4421-4421 (2014-07-18)
Local environmental cues are indispensable for axonal growth and guidance during brain circuit formation. Here, we combine genetic and pharmacological tools, as well as systems neuroanatomy in human fetuses and mouse models, to study the role of endocannabinoid and Slit/Robo
Kyuichi Kadota et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 10(9), 1301-1310 (2015-08-21)
We previously reported the prognostic significance of the lung adenocarcinoma immune microenvironment. In this study, we preformed comprehensive analysis of immune markers and their associations with prognosis in patients with lung squamous cell carcinoma. We reviewed surgically resected, solitary lung
Heloisa R Cadorim et al.
Talanta, 146, 203-208 (2015-12-24)
An analytical method for the determination of sulfur, as the tin mono-sulfide (SnS) molecule, in crude oil using high-resolution continuum source graphite furnace molecular absorption spectrometry (HR-CS GF MAS) has been developed. The molecular absorbance of the SnS has been
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