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Katsuyoshi Ando et al.
Inflammatory bowel diseases, 21(7), 1541-1552 (2015-04-23)
The role of hnRNP A1 in the onset of intestinal inflammation remains unclear. This study investigated the function of hnRNP A1 in mice enteritis models. C57Bl6/J mice were intraperitoneally injected with anti-CD3 antibodies to develop enteritis. In the DSS-induced colitis
Xiangdi Yu et al.
Pharmacology, 95(5-6), 293-299 (2015-05-30)
Neuropathic pain is a well-known type of chronic pain caused by damage to the nervous system. Until recently, researchers have found that increased generation of reactive oxygen species (ROS) contributes to the development of exaggerated pain hypersensitivity during neuropathic pain.
C Egloff et al.
Osteoarthritis and cartilage, 22(11), 1886-1893 (2014-08-12)
Interactions between mechanical and non-mechanical independent risk factors for the onset and progression of Osteoarthritis (OA) are poorly understood. Therefore, the goal of the present study was to investigate the in vivo effects of muscle weakness, joint inflammation and the combination
Janneke Hilderink et al.
Journal of cellular and molecular medicine, 19(8), 1836-1846 (2015-03-18)
Clinical islet transplantation is a promising treatment for patients with type 1 diabetes. However, pancreatic islets vary in size and shape affecting their survival and function after transplantation because of mass transport limitations. To reduce diffusion restrictions and improve islet
Cássia Valério Romanini et al.
Journal of neuroscience research, 93(8), 1240-1249 (2015-02-24)
4-Hydroxy-3-methoxy-acetophenone (apocynin) is a naturally occurring methoxy-substitute catechol that is isolated from the roots of Apocynin cannabinum (Canadian hemp) and Picrorhiza kurroa (Scrophulariaceae). It has been previously shown to have antioxidant and neuroprotective properties in several models of neurodegenerative disease
Christopher M Peters et al.
Anesthesiology, 122(4), 895-907 (2015-01-13)
Chronic postsurgical pain, a significant public health problem, occurs in 10 to 50% of patients undergoing major surgery. Acute pain induces endogenous analgesia termed conditioned pain modulation (CPM), and the strength of CPM preoperatively predicts the likelihood of chronic postsurgical
Wino J Wijnen et al.
PloS one, 9(5), e96290-e96290 (2014-05-03)
MicroRNAs (miRNAs) regulate many aspects of cellular function and their deregulation has been implicated in heart disease. MiRNA-30c is differentially expressed in the heart during the progression towards heart failure and in vitro studies hint to its importance in cellular
Karla M Rodriguez et al.
Behavioral and brain functions : BBF, 11(1), 34-34 (2015-11-06)
Fibroblast growth factors (FGFs) are crucial signaling molecules that direct the development of the vertebrate brain. FGF8 gene signaling in particular, may be important for the development of the hypothalamus-pituitary-adrenal (HPA)-axis. Indeed, newborn Fgf8 hypomorphic mice harbor a major reduction
Su Mei Wu et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 187, 202-213 (2015-05-31)
The present study seeks to detect oxidative damage and to compare anti-oxidative responses among liver, gills and brain of adult zebrafish that were cooled from 28 °C (control) to 12 °C (treatment) for 0-24 h. The lipid peroxidation of liver
Hui Yu et al.
Experimental and therapeutic medicine, 9(5), 1631-1638 (2015-07-03)
The host response to spinal cord injury (SCI) can lead to an ischemic environment that can induce cell death. Therapeutic interventions using neurotrophic factors have focused on the prevention of such reactions in order to reduce this cell death. Vascular
Miyoun Yoo et al.
Research in microbiology, 162(7), 724-728 (2011-05-18)
Hydroxylation of the non-growth substrate biphenyl by recombinant o-xylene dioxygenases from Rhodococcus sp. strain DK17 was studied through bioconversion experiments. The metabolites from the biphenyl hydroxylation by each enzyme were identified and quantified by gas chromatography-mass spectrometry. The L266F mutant
Paolo Miccoli et al.
Surgery, 156(6), 1550-1557 (2014-12-03)
Cell adhesion molecules, represented by the immunoglobulin family and selectins, play an important role in the progression of cancer. A correlation between selectins and tumor aggressiveness has been demonstrated in several reports. Eighty-eight patients (mean age, 41.0 ± 14 years)
Reza Hosseinzadeh et al.
PloS one, 9(7), e102992-e102992 (2014-07-30)
Nanocrystalline mixed metal oxides (MMO) of various metal cations were synthesized and were used for coating a piece of copper wire as a new high sensitive solid phase micro extraction (SPME) fiber in extraction and determination of BTEX compounds from
Melannie J Bachman et al.
Environmental toxicology and chemistry, 34(9), 1989-1995 (2015-04-22)
Elevated levels of persistent organic pollutants (POPs) have been reported in tropical Pacific Island cetaceans and their environment. In addition, recent health concerns in cetacean populations have warranted investigation into potential physiological effects from POP exposure for this region. Cytochrome
Laura Brohée et al.
Oncotarget, 6(13), 11264-11280 (2015-04-03)
Lipogenesis inhibition was reported to induce apoptosis and repress proliferation of cancer cells while barely affecting normal cells. Lipins exhibit dual function as enzymes catalyzing the dephosphorylation of phosphatidic acid to diacylglycerol and as co-transcriptional regulators. Thus, they are able
Ramla Gary et al.
Biomedical optics express, 6(12), 4738-4748 (2015-12-30)
Immunofluorescence is a biological technique that allows displaying the localization of the target molecule through a fluorescent microscope. We used a combination of gold nanoparticles and the fluorescein isothiocianate, FITC, as optical contrast agents for laser scanning confocal microscopy imaging
Elvan Bakar et al.
Environmental toxicology, 30(12), 1406-1415 (2014-06-17)
We aimed to investigate of protective role of proanthocyanidin (PA) and vitamin E (vit E) against to toxic effect of formaldehyde (FA). Twenty-eight Wistar albino rats were divided into four groups: control group, rats treated with FA intraperitoneal (i.p.) (10
Kathryn Futrega et al.
Biomaterials, 62, 1-12 (2015-05-27)
Microwell platforms are frequently described for the efficient and uniform manufacture of 3-dimensional (3D) multicellular microtissues. Multiple partial or complete medium exchanges can displace microtissues from discrete microwells, and this can result in either the loss of microtissues from culture
James P Bernot et al.
The Journal of parasitology, 101(2), 167-181 (2014-12-17)
This paper aims to resolve the dual composition of the triakid shark-hosted tetraphyllidean genus Calliobothrium--an issue that has been recognized for over a decade. As it stands, this genus includes a number of large species with laciniate proglottids, most of
M L Alves da Silva et al.
Journal of tissue engineering and regenerative medicine, 9(6), 714-723 (2013-10-25)
Paracrine signalling from chondrocytes has been reported to increase the synthesis and expression of cartilage extracellular matrix (ECM) by stem cells. The use of conditioned medium obtained from chondrocytes for stimulating stem cells chondrogenic differentiation may be a very interesting
Ajlan Al Zaki et al.
Journal of biomedical nanotechnology, 11(10), 1836-1846 (2015-10-28)
Long-circulating gold nanoparticles (AuNPs) have garnered a great deal of interest as both imaging and therapeutic agents. However, their protracted elimination and long-term persistence within many organ systems remains a concern for clinical translation. To improve the excretion of long-circulating
Shuying Yu et al.
Molecular genetics and genomics : MGG, 290(4), 1277-1285 (2015-01-15)
The myosin essential light chain (ELC) is a structure component of the actomyosin cross-bridge, however, the functions in the central nervous system (CNS) development and regeneration remain poorly understood. Planarian Dugesia japonica has revealed fundamental mechanisms and unique aspects of
Jing Lu et al.
Molecular medicine reports, 12(2), 2668-2676 (2015-05-09)
Neuropilin 1 (NRP1), a receptor of vascular endothelial growth factor (VEGF), promotes angiogenesis, tumor growth, tumor invasion and metastasis. However, the function of NRP1 in melanoma progression, as well as the effect of NRP1 expression on the prognosis of patients
Christian Dullin et al.
Journal of synchrotron radiation, 22(4), 1106-1111 (2015-07-03)
Lung imaging in mouse disease models is crucial for the assessment of the severity of airway disease but remains challenging due to the small size and the high porosity of the organ. Synchrotron inline free-propagation phase-contrast computed tomography (CT) with
Henriette Jülke et al.
Cell transplantation, 24(6), 1111-1125 (2013-12-18)
The purpose of this study was to evaluate the use of three different superparamagnetic iron oxide (SPIO) particles for labeling of ovine and equine bone marrow (BM)-derived multipotent stromal cells (MSCs) in vitro. MSCs were obtained from five adult sheep
Martin Steinberger et al.
Pflugers Archiv : European journal of physiology, 467(9), 1965-1974 (2014-11-15)
Duchenne muscular dystrophy (DMD) is a human genetic disease characterized by fibrosis and severe muscle weakness. Currently, there is no effective treatment available to prevent progressive fibrosis in skeletal muscles. The serum- and glucocorticoid-inducible kinase SGK1 regulates a variety of
Aisha Sultana et al.
Translational oncology, 0 (2014-05-17)
Importance of androgen receptor (AR) as an independent prognostic marker in Pakistani women with breast cancer (BCa) remains unexplored. Our aim was to identify the expression and potential prognostic value of AR, its upstream regulator (pAkt) and target gene (pPTEN)
Weijun Xuan et al.
Journal of biophotonics, 8(6), 502-511 (2014-09-10)
Transcranial low-level laser (light) therapy (LLLT) is a new non-invasive approach to treating a range of brain disorders including traumatic brain injury (TBI). We (and others) have shown that applying near-infrared light to the head of animals that have suffered
Adrienne L Watson et al.
Oncotarget, 5(6), 1502-1514 (2014-04-01)
Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas that occur spontaneously, or from benign plexiform neurofibromas, in the context of the genetic disorder Neurofibromatosis Type 1 (NF1). The current standard treatment includes surgical resection, high-dose chemotherapy, and/or radiation.
Jaemin Kim et al.
Nature communications, 5, 5747-5747 (2014-12-10)
Sensory receptors in human skin transmit a wealth of tactile and thermal signals from external environments to the brain. Despite advances in our understanding of mechano- and thermosensation, replication of these unique sensory characteristics in artificial skin and prosthetics remains
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