Showing 1-28 of 28 results for "


M Rahman et al.
Journal of applied toxicology : JAT, 14(1), 43-46 (1994-01-01)
The effect of isoflurane on the anaerobic metabolism of halothane to chlorodifluoroethene (CDE) and chlorotrifluoroethane (CTE) was studied with microsomes of guinea pig liver by gas chromatography. The reaction mixture used to measure the end products of anaerobic metabolism consisted...
M J Diaz et al.
Biochemical pharmacology, 46(6), 1076-1080 (1993-09-14)
Male Wistar albino rats were treated for a 7 day period with equimolar doses of the trimer and tetramer oligomers of chlorotrifluoroethylene (CTFE), resulting in significant hepatomegaly for both compounds. In addition, both trimer and tetramer significantly induced the peroxisomal...
D R Dohn et al.
Biochemistry, 24(19), 5137-5143 (1985-09-10)
Chlorotrifluoroethene, a potent nephrotoxin, is a substrate for the glutathione S-transferases present in the cytosolic and microsomal fractions of rat liver. The glutathione conjugate formed by both subcellular fractions has been identified as S-(2-chloro-1,1,2-trifluoroethyl)glutathione by 1H and 19F NMR and...
N J DelRaso et al.
Toxicology letters, 59(1-3), 41-49 (1991-12-01)
The toxicity of polychlorotrifluoroethylene oil (3.1 oil) hydraulic fluid is believed to be related to the conversion of neutral chlorotrifluoroethylene (CTFE) oligomers to their corresponding halogenated fatty acids. Male Fischer-344 rats were orally gavaged (1.25 g/kg/d) with two batch formulated...
C D Hassall et al.
Chemico-biological interactions, 49(3), 283-297 (1984-05-01)
The nephrotoxicity of chlorotrifluoroethylene ( CTFE ) was examined using isolated rabbit renal tubules suspensions. Exposure of the tubules to CTFE resulted in consumption of CTFE , formation of a glutathione conjugate and inhibition of active organic acid transport. Synthetic...
P J Boogaard et al.
Biochemical pharmacology, 39(8), 1335-1345 (1990-04-15)
The aim of this study was to set up an in vitro system to study nephrotoxicity of xenobiotics which allows exposure at low concentrations for long periods (1-5 days). A very pure preparation of isolated proximal tubular cells (PTC) from...
J C Lin et al.
Journal of biomaterials science. Polymer edition, 11(7), 701-714 (2000-09-30)
It is believed that the interactions between the biological environment and biomaterial surface are the key factors influencing its biocompatibility. Therefore, plasma processing, which can vary the surface properties without altering the bulk properties, has been considered as one of...
I Hayakawa et al.
The International journal of prosthodontics, 10(1), 44-48 (1997-01-01)
This study examined the intraoral changes of the elastic properties and roughness of a tissue conditioner after treatment with a fluorinated copolymer coating agent developed by the authors. The surface of the conditioner was treated with the agent on half...
Chengcheng Zeng et al.
Polymers, 11(8) (2019-08-08)
The mechanical properties of composites are highly dependent on the interfacial interaction. In the present work, inspired by marine mussel, the adhesion between energetic crystals of 1,3,5-triamino-2,4,6-trinitrobenzene (TATB) and polymer binders was improved. Three types of linear polymeric agents of...
S J Hargus et al.
Biochemistry, 30(3), 717-721 (1991-01-22)
The stereochemistry of S-(2-chloro-1,1,2-trifluoroethyl)glutathione formation was studied in rat liver cytosol, microsomes, N-ethylmaleimide-treated microsomes, 9000g supernatant fractions, purified rat liver microsomal glutathione S-transferase, and isolated rat hepatocytes. The absolute configuration of the chiral center generated by the addition of glutathione...
J N Commandeur et al.
Biochemical pharmacology, 42(1), 31-38 (1991-06-21)
The relationship between the relative nephrotoxicity of the mercapturic acids (NAc) of the fluorinated ethylenes tetrafluoroethylene (TFE), chlorotrifluoroethylene (CTFE), 1,1-dichloro-2,2-difluoroethylene (DCDFE) and 1,1-dibromo-2,2-difluoroethylene (DBDFE), and the biotransformation by activating (N-deacetylase and beta-lyase) and inactivating (N-acetyltransferase) enzymes was studied in the...
J L Plummer et al.
Anaesthesia and intensive care, 12(4), 293-295 (1984-11-01)
The volatile halothane metabolites, 2-chloro-1,1,1,-trifluoroethane and 2-chloro-1,1-difluoroethylene, were identified in the exhaled breath of ten children during halothane anaesthesia. Although there was considerable variation among children in the concentration and time-course of metabolite exhalation, exhaled concentrations of these metabolites were...
G L Kennedy
Critical reviews in toxicology, 21(2), 149-170 (1990-01-01)
Fluorine-containing monomers form the basis for production of a large number of commercially important polymers. Most of the polymerization occurs as gas-phase reactions, hence the hazards associated with the monomers arises primarily from inhalation. The chemicals covered in this review...
Alvaro Mata et al.
IEEE transactions on nanobioscience, 2(4), 287-294 (2004-09-21)
The present study investigated whether osteoblasts could attach to a culture substratum through a surface texture-dependent mechanism. Four test groups were used: (A) untextured, and three texture groups with maximum feature sizes of (B) <0.5 microm, (C) 2 microm, and...
E Tanaka et al.
Drug metabolism and disposition: the biological fate of chemicals, 23(1), 48-54 (1995-01-01)
Chlorotrifluoroethene is nephrotoxic in rats, and glutathione S-transferase-catalyzed S-(2-chloro-1,1,2-trifluorethyl)glutathione (CTFG) formation is the initial step in its bioactivation. CTFG biosynthesis and the activities of cytosolic and microsomal glutathione S-transferases were measured in rat and human hepatocytes and in human hepatoma-derived...
N J DelRaso et al.
The Journal of membrane biology, 149(1), 33-40 (1996-01-01)
GABA-activated Cl- current was expressed in Xenopus oocytes after injecting cRNA that had been transcribed in vitro from complementary DNA (cDNA) coding for a single GABA rho i-subunit cloned from human retina. The expressed current was insensitive to 100 microM...
Tetsuya Yamamoto et al.
Organic letters, 14(13), 3454-3457 (2012-06-14)
The palladium-catalyzed cross-coupling of chlorotrifluoroethylene and arylboronic acids proceeds in the presence of a base and H(2)O to provide α,β,β-trifluorostyrene derivatives in satisfactory yields.
Stereochemistry of the microsomal glutathione S-transferase-catalyzed addition of glutathione to chlorotrifluoroethene in isolated rat hepatocytes.
S J Hargus et al.
Advances in experimental medicine and biology, 283, 289-293 (1991-01-01)
C S Godin et al.
Fundamental and applied toxicology : official journal of the Society of Toxicology, 18(4), 557-569 (1992-05-01)
Perfluoro-n-decanoic acid (PFDA) is a perfluorinated fatty acid that produces hepatomegaly and increased peroxisomal beta-oxidation when administered to rodents. Chlorotrifluoroethylene (CTFE) trimer acid and CTFE tetramer acid are metabolites of the six- and eight-carbon oligomers of CTFE, respectively. They are...
N J DelRaso et al.
Fundamental and applied toxicology : official journal of the Society of Toxicology, 17(3), 550-562 (1991-10-01)
Polychlorotrifluoroethylene (3.1 oil) is a nonflammable hydraulic fluid composed of chlorotrifluoroethylene (CTFE) oligomers of different carbon chain lengths (C5 to C9), primarily six (trimer) and eight (tetramer) carbons. Four test groups of Fischer 344 rats (16 rats/group) were orally gavaged...
Georges Morel et al.
Journal of applied toxicology : JAT, 25(2), 153-165 (2005-03-04)
The role of cytochrome P450 activity in the nephrotoxicity of chlorotrifluoroethylene (CTFE) and 1,1-dichloro-2,2-difluoroethylene (DCDFE) was investigated in the male rat. Hepatic cytochrome P450 1A1 and principally P450 2B1/2 were induced by beta-naphthoflavone and phenobarbital, respectively. Nephrotoxicity was evaluated by...
N J DelRaso
Toxicology letters, 68(1-2), 91-99 (1993-05-01)
This report will give a general overview of some of the in vitro methodologies used in toxicity testing. The use of computer-based structure-activity relationships and cell culture testing systems can provide valuable toxicological data for hazard and risk assessments. In...
Yang Liu et al.
Nature materials, 19(11), 1169-1174 (2020-07-01)
Relaxor ferroelectrics exhibit outstanding dielectric, electromechanical and electrocaloric properties, and are the materials of choice for acoustic sensors, solid-state coolers, transducers and actuators1-4. Despite more than five decades of intensive study, relaxor ferroelectrics remain one of the least understood material...
Seung-Cheol Jee et al.
International journal of molecular sciences, 21(23) (2020-12-06)
Cudrania tricuspidata has diverse biological activities, such as antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. This study investigated the protective effects of C. tricuspidata fruit extracts (CTFE) against scopolamine (SCO)-induced neuron impairment. The neuroprotective effects of CTFE on SCO-induced memory dysfunction...
E A Dietz et al.
American Industrial Hygiene Association journal, 45(6), 382-385 (1984-06-01)
Two new methods for sampling and analysis of chlorotrifluoroethylene (CTFE) exceeding 1 ppm (4.8 mg/m3) time-weighted-average concentrations were developed and compared. The first involved collecting air in bags followed by gas chromatographic (GC) analysis of sample aliquots using flame ionization...
D R Dohn et al.
The Journal of pharmacology and experimental therapeutics, 235(3), 851-857 (1985-12-01)
The glutathione and cysteine conjugates of the nephrotoxin chlorotrifluoroethene, S-(2-chloro-1,1,2-trifluoroethyl)glutathione (CTFG) and S-(2-chloro-1,1,2-trifluoroethyl)cysteine (CTFC), are potent nephrotoxins in male rats. Morphological changes in the kidneys were observed 1.5 hr after giving 100 mumol/kg of CTFG (i.v.), and severe damage to...
J W Harris et al.
Chemical research in toxicology, 5(1), 34-41 (1992-01-01)
Several haloalkenes are selective nephrotoxins. The bioactivation of nephrotoxic haloalkenes involves hepatic glutathione S-conjugate formation, peptidase-catalyzed metabolism of the glutathione S-conjugates to the corresponding cysteine S-conjugates, uptake of cysteine S-conjugates by the kidneys, and renal cysteine conjugate beta-lyase-catalyzed beta-elimination of...
Xiang-Zhong Chen et al.
Macromolecular rapid communications, 32(1), 94-99 (2011-03-25)
Greatly enhanced energy density in poly(vinylidene fluoride-chlorotrifluoroethylene) [P(VDF-CTFE)] is realized through interface effects induced by a photo cross-linking method. Being different from nanocomposites with lowered dielectric strength, the cross-linked P(VDF-CTFE)s possess a high breakdown field as well as remarkably elevated...