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295531

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Jianbin Zhang et al.
AAPS PharmSciTech, 15(3), 731-740 (2014-02-21)
The objective of this study is to investigate the effect of lipolysis on the release of poorly water-soluble drug from SMEDDS in the perspective of drug core/shell location. For this purpose, four SMEDDS formulations with various core/shell properties were developed...
Martina Baliova et al.
Biochemical and biophysical research communications, 454(1), 25-29 (2014-10-12)
A ubiquitous feature of neurotransmitter transporters is the presence of short C-terminal PDZ binding motifs acting as important trafficking elements. Depending on their very C-terminal sequences, PDZ binding motifs are usually divided into at least three groups; however this classification...
Ilaria Solano et al.
Physical chemistry chemical physics : PCCP, 17(43), 28774-28781 (2015-10-09)
For the first time, to our knowledge, spectroscopic ellipsometry (SE) has been combined with state-of-the-art AFM differential height measurements conducted after shaving nano-lithography of ultrathin, soft-matter films for thickness determination. We investigated self-assembled monolayers of SH-(CH2)11-EGn-OH molecules on gold, where...
Shubin Liu
The journal of physical chemistry. A, 117(5), 962-965 (2013-01-19)
Bond rotations are common and important in molecular studies such as drug design and enzymatic reactions. Steric hindrance and hyperconjugation are often borrowed to justify the origin of bond rotation barriers. However, there exists no consensus, even for as simple...
A R Sarika et al.
Applied biochemistry and biotechnology, 167(5), 1280-1289 (2012-05-05)
The bacteriocins of lactic acid bacteria have considerable potential for biopreservation. The Lactococcus lactis strain PSY2 (GenBank account no. JF703669) isolated from the surface of marine perch Perca flavescens produced antibacterial activity against pathogenic and spoilage-causing Gram-positive and Gram-negative bacteria...
Taeko Mizutani et al.
Experimental dermatology, 23 Suppl 1, 23-26 (2014-09-23)
It is well known that the Camellia japonica leaf exhibits antioxidant activity because of its high content of polyphenolic compounds. Thus, the extract prepared from mature leaves of C. japonica (CJML) has been widely used as an anti-ageing material in foods...
Gui-Mei Han et al.
Talanta, 147, 207-212 (2015-11-26)
We report a simple one-step hydrothermal method for the synthesis of hydrophilic luminescent upconversion nanoparticles (UCNPs) using malonic acid as the stabilizer and functional agent. Using this method, two UCNPs with different colors of upconversion luminescence were synthesized. The surface...
Zhao-dong Du et al.
Molecular vision, 21, 523-531 (2015-05-23)
To determine whether protein tyrosine phosphatase 1B (PTP1B) is expressed in rat retinal pigment epithelium (RPE) cells, to evaluate whether inhibition of PTP1B contributes to initiation of RPE cells into an active state, and to investigate the signaling pathways involved...
Feng Zhu et al.
ACS nano, 9(3), 2948-2959 (2015-02-11)
Organometallic halide perovskites CH3NH3PbX3 (X = I, Br, Cl) have quickly become one of the most promising semiconductors for solar cells, with photovoltaics made of these materials reaching power conversion efficiencies of near 20%. Improving our ability to harness the...
Emi Takamitsu et al.
Analytical biochemistry, 464, 83-93 (2014-07-22)
To establish a non-radioactive, cell-free detection system for protein N-myristoylation, metabolic labeling in a cell-free protein synthesis system using bioorthogonal myristic acid analogues was performed. After Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) with a biotin tag, the tagged proteins were separated by...
Nadja Mannowetz et al.
PloS one, 7(7), e41030-e41030 (2012-08-23)
To reach the egg in the ampulla, sperm have to travel along the female genital tract, thereby being dependent on external energy sources and substances to maintain and raise the flagellar beat. The vaginal fluid is rich in lactate, whereas...
Malik M Keshwani et al.
The Biochemical journal, 466(2), 311-322 (2014-12-23)
The alternative splicing of human genes is dependent on SR proteins, a family of essential splicing factors whose name derives from a signature C-terminal domain rich in arginine-serine dipeptide repeats (RS domains). Although the SRPKs (SR-specific protein kinases) phosphorylate these...
Wei Wan et al.
Biochimica et biophysica acta, 1844(6), 1059-1070 (2014-03-19)
The genetic incorporation of the 22nd proteinogenic amino acid, pyrrolysine (Pyl) at amber codon is achieved by the action of pyrrolysyl-tRNA synthetase (PylRS) together with its cognate tRNA(Pyl). Unlike most aminoacyl-tRNA synthetases, PylRS displays high substrate side chain promiscuity, low...
P Stanic et al.
European journal of obstetrics, gynecology, and reproductive biology, 91(1), 65-70 (2000-05-19)
To evaluate the influence of cryopreservation medium and freezing-thawing techniques on human sperm motility and morphology. 63 semen samples were obtained from 39 donors to the artificial insemination programme. Possible effects of the sperm dilution with cryomedium on the motility...
J F A Valente et al.
Analytical biochemistry, 459, 61-69 (2014-05-28)
The p53 tumor suppressor gene has been widely explored for gene therapy as an alternative to the common treatments. Recently, the supercoiled conformation of a p53-encoding plasmid proved to be more efficient in cell transfection and protein expression than the...
Leandro R Soria et al.
FEBS letters, 588(9), 1686-1691 (2014-03-20)
We recently reported that hepatocyte mitochondrial aquaporin-8 (mtAQP8) channels facilitate the uptake of ammonia and its metabolism into urea. Here we studied the effect of bacterial lipopolysaccharides (LPS) on ammonia-derived ureagenesis. In LPS-treated rats, hepatic mtAQP8 protein expression and diffusional...
Yiming Li et al.
Analytical chemistry, 86(14), 6850-6857 (2014-06-18)
We describe the characterization of degradation products responsible for color change in near UV-visible light-irradiated and heat-stressed monoclonal antibody (mAb) drug product in liquid formulation. The treated samples were characterized using reversed-phase HPLC and size-exclusion HPLC with absorption spectroscopy. Both...
C J L Silwood et al.
Journal of dental research, 81(6), 422-427 (2002-07-05)
We have explored the ability of high-resolution NMR techniques to (1) index salivary biomolecules and (2) provide valuable data regarding intra- and inter-subject variability in the concentrations of a series of components readily determinable by this technique (organic acids and...
Yeshwant Singh et al.
Asian Pacific journal of tropical medicine, 8(8), 630-635 (2015-09-01)
To determine the potential drug-drug interactions between anti-malarial candidate 97/78 and anti-tubercular drug rifabutin in-vivo in rats followed by in-vitro investigation of the underlying mechanisms of drug interaction. Single oral dose study was conducted in male and female rats at...
Alejandro Cruz et al.
Molecules (Basel, Switzerland), 17(9), 10178-10191 (2012-08-28)
Symmetric and non-symmetric 2-(N-H, N-methyl, N-ethylenyl and N-aryl)guanidinebenzothiazoles were synthesized from the reaction of ammonia, methylamine, pyrrolidine and aniline with dimethyl benzo[d]thiazol-2-yl-carbonodithioimidate as intermediate. The products were characterized by ¹H-, ¹³C-NMR spectroscopy and three of them by X-ray diffraction analysis....
Xudong Guo et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 16(8), 1727-1732 (2015-04-09)
A multifunctional magnesium oxide (MgO) layer was successfully introduced into perovskite solar cells (PSCs) to enhance their performance. MgO was coated onto the surface of mesoporous TiO(2) by the decomposition of magnesium acetate and, therefore, could block contact between the...
Ali Nematollahzadeh et al.
Journal of chromatography. A, 1345, 154-163 (2014-05-03)
In the present work, we report a novel method for the reinforcement of hierarchically structured molecularly imprinted polymer (MIP) for the separation of human serum albumin (HSA) and immunoglobulin G (IgG) proteins under pressure driven flow conditions. The template proteins...
Lukas Jud et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(29), 10400-10407 (2015-06-16)
The 2'-trifluoromethylthio (2'-SCF3 ) modification endows ribonucleic acids with exceptional properties and has attracted considerable interest as a reporter group for NMR spectroscopic applications. However, only modified pyrimidine nucleosides have been generated so far. Here, the syntheses of 2'-SCF3 adenosine...
Michaela Frybortova et al.
Journal of inorganic biochemistry, 126, 46-54 (2013-06-19)
In order to shed light on the mechanism that underlies activity of bifunctional mononuclear Pt(II) analogs of transplatin we examined in the present work a DNA binding mode of the analog of transplatin, namely trans-[Pt(CH3NH2)2Cl2], in which NH3 groups were...
Chih-Jen Cheng et al.
American journal of physiology. Renal physiology, 308(5), F437-F443 (2014-12-06)
SPAK [STE20 (sterile 20)/SPS1-related proline/alanine-rich kinase] kinase consists of a full-length (FL-) and an alternatively spliced kidney-specific (KS-) isoform. SPAK regulates the NaCl cotransporter (NCC) in the distal convoluted tubule (DCT). The relative abundance and role of FL- vs. KS-SPAK...
Mohammad Mahdi Tavakoli et al.
ACS nano, 9(10), 10287-10295 (2015-08-19)
Flexible thin film solar cells have attracted a great deal of attention as mobile power sources and key components for building-integrated photovoltaics, due to their light weight and flexible features in addition to compatibility with low-cost roll-to-roll fabrication processes. Among...
Claudia Lautert et al.
SpringerPlus, 3, 506-506 (2014-10-04)
The contamination of consumer food and animal feed with toxigenic fungi has resulted in economic losses worldwide in animal industries. Mycotoxins are highly biologically reactive secondary metabolites and can inhibit protein synthesis and cell multiplication. Considering the cytotoxicity of mycotoxins...
April D Lewoczko et al.
Physical chemistry chemical physics : PCCP, 15(13), 4707-4714 (2013-02-21)
Using density functional theory calculations, we report on the adsorption of methylamine on gold and compare its adsorption to a selection of alkylamines, methanol and methanethiol. On the (111) surface, the amines, thiol and alcohol bind in the ontop site...
Gopa Dhar et al.
Biochemistry, 54(4), 1132-1143 (2015-01-08)
Curcumin, derived from rhizomes of the Curcuma longa plant, is known to possess a wide range of medicinal properties. We have examined the interaction of curcumin with actin and determined their binding and thermodynamic parameters using isothermal titration calorimetry. Curcumin...
Oliver Wahl et al.
Journal of pharmaceutical and biomedical analysis, 114, 254-264 (2015-06-21)
The modern bisphosphonate drug ibandronate sodium, a challenging candidate for impurity profiling, was analyzed using high performance liquid chromatography (HPLC) combined with corona charged aerosol detection (CAD). Separation was achieved on a mixed mode column combining hydrophobic C18 and strong...
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