Showing 1-30 of 462 results for "

296082

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Yang Zhang et al.
Dalton transactions (Cambridge, England : 2003), 44(29), 13100-13111 (2015-06-25)
We have recently demonstrated that complexation with (η(6)-arene)Ru(II) fragments confers 4-anilinoquinazoline pharmacophores a higher potential for inducing cellular apoptosis while preserving the highly inhibitory activity of 4-anilinoquinazolines against EGFR and the reactivity of the ruthenium centre to 9-ethylguanine (Chem. Commun....
Ursula J Williams et al.
Dalton transactions (Cambridge, England : 2003), 43(43), 16197-16206 (2014-08-26)
The trivalent compound K[Ce[N(SiHMe2)2]4] was synthesized and oxidized, providing a convenient route to the reported cerium(IV) compound Ce[N(SiHMe2)2]4. Protonolysis reactions of Ce[N(SiHMe2)2]4 with tert-butanol, substituted benzyl alcohols, and 2,6-diphenylphenol yielded the neutral tetravalent compounds Ce(O(t)Bu)4(py)2, Ce2(OCH2C6R5)8(thf)2 (R = Me, F)...
M Ye et al.
Cell death & disease, 5, e1541-e1541 (2014-11-28)
Transient ischemia is a leading cause of cognitive dysfunction. Postischemic ROS generation and an increase in the cytosolic Zn(2+) level ([Zn(2+)]c) are critical in delayed CA1 pyramidal neuronal death, but the underlying mechanisms are not fully understood. Here we investigated...
S Quader et al.
Journal of controlled release : official journal of the Controlled Release Society, 188, 67-77 (2014-06-04)
The ubiquitin-proteasome system is central in the regulation of cellular proteins controlling cell cycle progression and apoptosis, drawing much interest for developing effective targeted cancer therapies. Herein, we developed a novel pH-responsive polymeric-micelle-based carrier system to effectively deliver the proteasome...
Tianran Chen et al.
Physical chemistry chemical physics : PCCP, 17(46), 31278-31286 (2015-11-10)
Methylammonium lead iodide (CH3NH3PbI3) based solar cells have shown impressive power conversion efficiencies of above 20%. However, the microscopic mechanism of the high photovoltaic performance is yet to be fully understood. Particularly, the dynamics of CH3NH3(+) cations and their impact...
Jatinder Kumar et al.
PloS one, 9(6), e98696-e98696 (2014-06-18)
Fourteen saxicolous lichens from trans-Himalayan Ladakh region were identified by morpho-anatomical and chemical characteristics. The n-hexane, methanol and water extracts of the lichens were evaluated for their antioxidant capacities. The lichen extracts showing high antioxidant capacities and rich phenolic content...
Marie Pascaline Rahelivao et al.
Marine drugs, 13(7), 4197-4216 (2015-07-23)
Several species of red algae (Rhodophyta) from the coastal regions of Madagascar have been investigated for their natural products. The most abundant compound was cholesterol (5) in combination with a series of oxidized congeners. The brominated indoles 1-3 along with...
Saleh Sulaiman et al.
Environmental technology, 36(24), 3232-3242 (2015-06-06)
Atorvastatin (ATO), rosuvastatin (RST) and simvastatin (SIM) are commonly used drugs that belong to the statin family (lowering human blood cholesterol levels) and have been detected as contaminants in natural waters. Stability and removal of ATO, RST and SIM from...
Amine Kassouf et al.
Analytica chimica acta, 839, 14-25 (2014-07-30)
Olive oil is one of the most valued sources of fats in the Mediterranean diet. Its storage was generally done using glass or metallic packaging materials. Nowadays, plastic packaging has gained worldwide spread for the storage of olive oil. However...
Sung-Jun Cho et al.
Journal of microbiology (Seoul, Korea), 53(9), 588-591 (2015-08-28)
A Gram-stain-positive, motile, endospore-forming, and strictly aerobic rod-shaped bacterium designated DS80(T) was isolated from an island soil. The strain DS80(T) grew at temperatures between 15 and 40°C (optimum = 30°C) and at pH values ranging from 5.0 to 9.0 (optimum...
Fang Sun et al.
ACS nano, 9(3), 2668-2676 (2015-03-05)
Reliable surface-enhanced Raman scattering (SERS) based biosensing in complex media is impeded by nonspecific protein adsorptions. Because of the near-field effect of SERS, it is challenging to modify SERS-active substrates using conventional nonfouling materials without introducing interference from their SERS...
Rogers E Harry-O'kuru et al.
Journal of agricultural and food chemistry, 63(28), 6422-6429 (2015-07-15)
Renewable resources have evoked a new awakening in both scientific and industrial circles in the past decade. Vegetable oil is one category of renewables that is amenable as a source of new industrial products. Because the source feedstock, seeds, are...
Michael H Abraham et al.
European journal of medicinal chemistry, 43(3), 478-485 (2007-06-05)
Values of in vitro gas to lung partition coefficients, K(lung), of VOCs have been collected from the literature. For 44 VOCs, application of the Abraham solvation equation to log K(lung) yielded a correlation with R(2)=0.968 and S.D.=0.25 log units. Combination...
Divita Mathpal et al.
Current drug delivery, 12(4), 464-471 (2015-03-27)
Invasive pulmonary aspergillosis is a life threatening fungal infection mainly caused by Aspergillus species. Available treatment strategy against pulmonary aspergillosis is having very limited applicability, due to its toxicity and low circulation half-life. Pulmonary drug delivery is one of the...
Konstantinos Grintzalis et al.
Applied and environmental microbiology, 80(18), 5561-5571 (2014-07-09)
We show here that oxidative stress is involved in both sclerotial differentiation (SD) and aflatoxin B1 biosynthesis in Aspergillus flavus. Specifically, we observed that (i) oxidative stress regulates SD, as implied by its inhibition by antioxidant modulators of reactive oxygen...
Hamed Abedini Najafabadi et al.
Bioresource technology, 193, 90-96 (2015-06-29)
In this research, direct conversion of wet algal biomass into biodiesel using supercritical methanol was studied. In this process, microalgal lipids simultaneously was extracted and converted to biodiesel under high pressure and temperature conditions without using any catalyst. Several experiments...
Hee Youn Choi et al.
Pharmacogenetics and genomics, 25(12), 595-608 (2015-09-15)
The effects of various polymorphisms in cytochrome P450 (CYP) enzyme and transporter genes on the pharmacokinetics (PK) of simvastatin were evaluated in healthy Korean men. Plasma concentration data for simvastatin and simvastatin acid were pooled from four phase I studies...
Katharina Böck et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(14), 5548-5560 (2015-02-25)
Pd-mediated Negishi cross-coupling reactions were studied by a combination of kinetic measurements, electrospray-ionization (ESI) mass spectrometry, (31)P NMR and UV/Vis spectroscopy. The kinetic measurements point to a rate-determining oxidative addition. Surprisingly, this step seems to involve not only the Pd catalyst...
Youn Gee Seo et al.
Archives of pharmacal research, 38(2), 223-228 (2014-08-20)
The purpose of this study was to develop a novel tacrolimus-loaded solid self-emulsifying drug delivery system (SEDDS) using Labrafac as an oil phase. The ternary phase diagram was plotted with Labrafac, Labrasol and Lauroglycol used as an oil, surfactant and...
Gabriel F Ballester-Lozano et al.
The British journal of nutrition, 114(5), 713-726 (2015-07-30)
Seven isoproteic and isolipidic semi-purified diets were formulated to assess specific nutrient deficiencies in sulphur amino acids (SAA), n-3 long-chain PUFA (n-3 LC-PUFA), phospholipids (PL), P, minerals (Min) and vitamins (Vit). The control diet (CTRL) contained these essential nutrients in...
Janne Hakkarainen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(9), 3806-3816 (2015-05-29)
Hydroxysteroid (17β)-dehydrogenase type 1 (HSD17B1) catalyzes the conversion of low active 17-ketosteroids, androstenedione (A-dione) and estrone (E1) to highly active 17-hydroxysteroids, testosterone (T) and E2, respectively. In this study, the importance of HSD17B1 in ovarian estrogen production was determined using...
Eagleson M.
Concise Encyclopedia Chemistry, 471-471 (1994)
Hajer Trabelsi et al.
Journal of the science of food and agriculture, 95(10), 2028-2032 (2014-09-13)
The search for other sources of vegetable oils by the exploitation and the enhancement of other oil plants will be needed to meet the demands of the international market. This study aims to determine the triacylglycerol (TAG) molecular species and...
L Horev et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 29(4), 761-766 (2014-09-02)
Preservatives are important and frequent skin sensitizers, found in a wide range of products for personal and occupational use. According to the European legislation, some cosmetic ingredients are restricted in terms of quantity and a detailed list of ingredients must...
Yannick Lecompte et al.
Journal of pharmaceutical and biomedical analysis, 96, 127-134 (2014-04-20)
Methoxyisoflavone (5-methyl-7-methoxyisoflavone) is a synthetic isoflavone used by bodybuilders for its ergogenic properties. A recent study demonstrated that methoxyisoflavone metabolites can induce false-positive results in urinary immunoassay screening tests for cannabinoids, and only one metabolite has been identified. To improve...
Magda Aniołowska et al.
Journal of the American Oil Chemists' Society, 92(11-12), 1621-1631 (2015-12-08)
The aim of the study was to determine the effect of oil degradation on the content of glycidyl esters (GEs) in oils used for the frying of French fries. As frying media, refined oils such as rapeseed, palm, palm olein...
Marta Guembe-García et al.
Polymers, 12(6) (2020-06-04)
We anchored a colourimetric probe, comprising a complex containing copper (Cu(II)) and a dye, to a polymer matrix obtaining film-shaped chemosensors with induced selectivity toward glycine. This sensory material is exploited in the selectivity detection of glycine in complex mixtures...
Andrei Ponta et al.
Journal of drug targeting, 22(7), 619-628 (2014-04-29)
Nanoparticles are widely used as drug carriers for controlled, tumor-targeted delivery of various anticancer agents that have biopharmaceutical limitations such as water solubility and tissue permeability. Growing evidence suggests that nanoparticles not only reduce toxic side effects of anticancer drugs...
Neeraj Prabhakar et al.
Nanoscale, 7(23), 10410-10420 (2015-05-23)
Recently reported photoluminescent nanographene oxides (nGOs), i.e. nanographene oxidised with a sulfuric/nitric acid mixture (SNOx method), have tuneable photoluminescence and are scalable, simple and fast to produce optical probes. This material belongs to the vast class of photoluminescent carbon nanostructures...
Fernando Sánchez-Patán et al.
Food chemistry, 183, 273-282 (2015-04-13)
In this study, we have assessed the phenolic metabolism of a cranberry extract by microbiota obtained from the ascending colon and descending colon compartments of a dynamic gastrointestinal simulator (SHIME). For comparison, parallel fermentations with a grape seed extract were...