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Zeyou Wang et al.
Oncotarget, 6(5), 3147-3164 (2015-01-22)
MicroRNA-381 (miR-381) is a highly expressed onco-miRNA that is involved in malignant progression and has been suggested to be a good target for glioblastoma multiforme (GBM) therapy. In this study, we employed two-dimensional fluorescence differential gel electrophoresis (2-D DIGE) and
Maria de la Paz Celorio-Mancera et al.
Insect biochemistry and molecular biology, 61, 34-45 (2015-05-03)
More than half of the proteome from mandibular glands in caterpillars is represented by chemosensory proteins. Based on sequence similarity, these proteins are putative transporters of ligands to gustatory receptors in sensory organs of insects. We sought to determine whether
Zhijing Tan et al.
Journal of proteome research, 14(4), 1968-1978 (2015-03-04)
Glycosylation has significant effects on protein function and cell metastasis, which are important in cancer progression. It is of great interest to identify site-specific glycosylation in search of potential cancer biomarkers. However, the abundance of glycopeptides is low compared to
Mari Akiyama
Analytical and bioanalytical chemistry, 406(24), 5805-5813 (2014-04-04)
Inspection of patient-derived cells used in transplantation is non-invasive. Therefore, proteomics analysis using supernatants of cells cultured before transplantation is informative. In order to investigate the cell niche of bovine periosteal cells, supernatants of these cultured cells were subjected to
Devendar Anumandla et al.
Organic letters, 16(19), 5112-5115 (2014-09-13)
Diamination of alkenes and dienes has found widespread use in the synthesis of biologically active target molecules. Although the 1,2-diamination of alkenes has been comprehensively explored, versatile methods that install higher order 1,n-diamine moieties (e.g., n = 3-5) are not
Marta Veses-Garcia et al.
Applied and environmental microbiology, 81(23), 8118-8125 (2015-09-20)
Shiga-toxigenic bacteriophages are converting lambdoid phages that impart the ability to produce Shiga toxin to their hosts. Little is known about the function of most of the genes carried by these phages or the impact that lysogeny has on the
Keiichi Akasaka et al.
American journal of physiology. Lung cellular and molecular physiology, 308(2), L105-L117 (2014-11-16)
Whole-lung lavage (WLL) remains the standard therapy for pulmonary alveolar proteinosis (PAP), a process in which accumulated surfactants are washed out of the lung with 0.5-2.0 l of saline aliquots for 10-30 wash cycles. The method has been established empirically.
T R Miller et al.
Annals of internal medicine, 89(1), 47-50 (1978-07-01)
A prospective analysis of the value of urinary diagnostic indices in ascertaining the cause of acute renal failure was undertaken. Our results show that in the setting of acute oliguria a diagnosis of potentially reversible prerenal azotemia is likely with
Yi-Ren Chen et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 69, 150-162 (2014-04-23)
The direct modulation of Antrodia cinnamomea (AC) on the prominent role of liver fibrosis-hepatic stellate cells (HSCs) in situ remains unclear. Firstly, the administration of A. cinnamomea mycelial extract (ACME) could improve liver morphology and histological changes including collagen formation
Dan Shen et al.
The New phytologist, 204(3), 577-594 (2014-08-19)
Verticillium longisporum, a soil-borne pathogenic fungus, causes vascular disease in oilseed rape (Brassica napus). We proposed that plant microRNAs (miRNAs) are involved in the plant-V. longisporum interaction. To identify oilseed rape miRNAs, we deep-sequenced two small RNA libraries made from
Ilaria Fiorentino et al.
Experimental cell research, 330(2), 240-247 (2014-09-24)
Nanoparticle (NPs) delivery systems in vivo promises to overcome many obstacles associated with the administration of drugs, vaccines, plasmid DNA and RNA materials, making the study of their cellular uptake a central issue in nanomedicine. The uptake of NPs may
Sylwia Głowniak et al.
Molecules (Basel, Switzerland), 26(7) (2021-04-04)
Highly porous activated carbons were synthesized via the mechanochemical salt-templating method using both sustainable precursors and sustainable chemical activators. Tannic acid is a polyphenolic compound derived from biomass, which, together with urea, can serve as a low-cost, environmentally friendly precursor
Tony Ly et al.
eLife, 4 (2015-01-03)
Previously, we analyzed protein abundance changes across a 'minimally perturbed' cell cycle by using centrifugal elutriation to differentially enrich distinct cell cycle phases in human NB4 cells (Ly et al., 2014). In this study, we compare data from elutriated cells
Christopher T Esapa et al.
PloS one, 10(4), e0122650-e0122650 (2015-04-11)
Ectopic calcification (EC), which is the pathological deposition of calcium and phosphate in extra-skeletal tissues, may be associated with hypercalcaemic and hyperphosphataemic disorders, or it may occur in the absence of metabolic abnormalities. In addition, EC may be inherited as
Judit Cubedo et al.
Translational research : the journal of laboratory and clinical medicine, 164(3), 209-222 (2014-04-09)
High-density lipoprotein (HDL) functionality, which is closely associated with its composition and transport capabilities, determines its role in atheroprotection. During acute phase processes, HDL seems to lose its anti-inflammatory and cytoprotective properties. In this study, we hypothesized that after an
Marcin M Grzybowski et al.
Journal of medical microbiology, 64(10), 1201-1207 (2015-08-06)
Toxoplasmosis is one of the most common parasitic diseases worldwide and it poses a serious challenge regarding prevention, diagnosis and therapy. The commonly used diagnostic methods are mostly based on the detection of specific antibodies in sera. Since they are
Yi-Ching Hsueh et al.
Biological chemistry, 396(9-10), 1151-1162 (2015-03-18)
Lipopolysaccharides (LPS) are central components of the outer membrane and consist of Lipid A, the core polysaccharide, and the O-antigen. The synthesis of LPS is initiated at the cytosolic face of the cytoplasmic membrane. The subsequent transport to and across
A Marechal et al.
Journal of chromatography. A, 1365, 140-147 (2014-09-25)
This paper presents a photografting process of monolithic silica capillary columns based on the ene-thiol click chemistry. This study is performed on a "generic" vinyl-functionalized silica monolith (Hmin 6±1μm). The photoclick reaction is investigated using different thiol monomers (octadecanethiol, cysteine
R A Wevers et al.
Clinical chemistry, 41(5), 744-751 (1995-05-01)
This study describes a standardized method for recording single-pulse 1H-nuclear magnetic resonance (1H-NMR) spectra from cerebrospinal fluid (CSF). Quantitative data for alanine, valine, threonine, and lactic acid correlated well with data obtained with conventional techniques. The pH of the samples
Yogananda Maspolim et al.
Chemosphere, 140, 54-62 (2014-08-07)
This study compared reactor performance and the respective microbial community dynamics in the conventional single-stage and 2-phase anaerobic digestion (AD) systems, treating municipal sludge to generate methane. The 2-phase system's COD and VS reduction, and methane production could be maintained
Emmely E Treffers et al.
Proteomics, 15(13), 2267-2280 (2015-03-13)
Chikungunya virus (CHIKV) is an arthropod-borne reemerging human pathogen that generally causes a severe persisting arthritis. Since 2005, the virus has infected millions of people during outbreaks in Africa, Indian Ocean Islands, Asia, and South/Central America. Many steps of the
Emiko Yanokura et al.
Systematic and applied microbiology, 38(5), 305-314 (2015-05-27)
The species Bifidobacterium longum is currently divided into three subspecies, B. longum subsp. longum, B. longum subsp. infantis and B. longum subsp. suis. This classification was based on an assessment of accumulated information on the species' phenotypic and genotypic features.
Kristine Y DeLeon-Pennell et al.
Journal of molecular and cellular cardiology, 76, 218-226 (2014-09-23)
Periodontal disease (PD) strongly correlates with increased mortality post-myocardial infarction (MI); however, the underlying mechanisms are unknown. Matrix metalloproteinase (MMP)-9 levels directly correlate with dysfunction and remodeling of the left ventricle (LV) post-MI. Post-MI, MMP-9 is produced by leukocytes and
Tomohiro Yokota et al.
PloS one, 9(4), e94895-e94895 (2014-04-17)
Ductus arteriosus (DA) closure follows constriction and remodeling of the entire vessel wall. Patent ductus arteriosus occurs when the DA does not close after birth, and this condition is currently treated using cyclooxygenase inhibitors. However, the efficacy of cyclooxygenase inhibitors
Saleh Yazdani et al.
Disease models & mechanisms, 8(8), 919-930 (2015-06-03)
Proteinuria is an important cause of tubulointerstitial damage. Anti-proteinuric interventions are not always successful, and residual proteinuria often leads to renal failure. This indicates the need for additional treatment modalities by targeting the harmful downstream consequences of proteinuria. We previously
Hai-Guang Xin et al.
Molecular and cellular biochemistry, 392(1-2), 117-124 (2014-03-22)
In hypertensive animals and patients, oxidative stress represents the primary risk factor for progression of renal disease. Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic antioxidant
Giora van Straten et al.
PloS one, 9(6), e100077-e100077 (2014-06-20)
The detoxification of ammonia occurs mainly through conversion of ammonia to urea in the liver via the urea cycle and glutamine synthesis. Congenital portosystemic shunts (CPSS) in dogs cause hyperammonemia eventually leading to hepatic encephalopathy. In this study, the gene
Mi Young Noh et al.
Developmental biology, 399(2), 315-324 (2015-01-24)
Yellow protein (dopachrome conversion enzyme, DCE) is involved in the melanin biosynthetic pathway that significantly accelerates pigmentation reactions in insects. Recent studies have suggested that the insect yellow genes represent a rapidly evolving gene family generating functionally diverse paralogs, but
Afonso P Basto et al.
Molecular immunology, 64(1), 36-45 (2014-12-04)
The use of immunogenic formulations targeting pattern recognition receptors towards modulation of immune responses is a promising strategy to develop better vaccines against infectious and malignant diseases. Molecules targeting TLR2 offer interesting properties that are relevant for vaccine development, including
The challenge of complexity and arginine metabolism.
Francesco Saverio Dioguardi
The American journal of clinical nutrition, 98(2), 507-508 (2013-07-23)
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