Showing 1-7 of 7 results for " "
M A Argiriadi et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(19), 10637-10642 (1999-09-15)
The crystal structure of recombinant murine liver cytosolic epoxide hydrolase (EC has been determined at 2.8-A resolution. The binding of a nanomolar affinity inhibitor confirms the active site location in the C-terminal domain; this domain is similar to that...
S D Lyman et al.
The Journal of biological chemistry, 255(18), 8650-8654 (1980-09-25)
Hepatic microsomal epoxide hydrolase activity (EC, assayed using styrene oxide as the substrate, has a pH optimum of 9.5 from C57BL/6J mice and a pH optimum of 8.7 from DBA/2J mice. In cross and back-cross matings between C57BL/6J and...
A Sevanian et al.
Biochimica et biophysica acta, 614(2), 489-500 (1980-08-07)
The activity of rat lung epoxide hydrolase (epoxide hydrolase, EC was studied using two lipid epoxides which can be isolated from lung tissue. These epoxides displayed different Km,app and hydration rates. Methyl cis-9,10-epoxystearate was hydrated 20-times more rapidly than...
P Wang et al.
Biochemistry, 21(23), 5769-5776 (1982-11-09)
Epoxide hydrolase (EC was purified to electrophoretic homogeneity from human liver cytosol by using hydrolytic activity toward trans-8-ethylstyrene 7,8-oxide (TESO) as an assay. The overall purification was 400-fold. The purified enzyme has an apparent monomeric molecular weight of 58...
J K Hartsfield et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 11(10), 915-918 (2000-09-26)
Heat lability of the mouse hepatic microsomal epoxide hydrolase 1 enzyme-specific activity (EC is greater for the A/J than the C57BL/6J strain. Analysis of the microsomal epoxide hydrolase 1 cDNA coding sequences shows the C57BL/6J and A/J strains to...
Lisa T Elfström et al.
Biochemistry, 45(1), 205-212 (2006-01-04)
The catalytic mechanism of epoxide hydrolase (EC involves acid-assisted ring opening of the oxirane during the alkylation half-reaction of hydrolysis. Two tyrosyl residues in the active site of epoxide hydrolases have been shown to contribute to the catalysis of...
P A Bell et al.
The Journal of biological chemistry, 268(19), 14011-14017 (1993-07-05)
The cDNA containing the complete coding region for rat microsomal epoxide hydrolase (EC was cloned into the expression/secretion vector pIN-III-OmpA3 and expressed in Escherichia coli strain TG1. Recombinant epoxide hydrolase was found to represent 4-9% of total bacterial protein...

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