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Marta Grabowska et al.
Histology and histopathology, 30(9), 1089-1100 (2015-03-17)
Analysis of the impact of immunosuppressants on apoptosis and PCNA in the rat ventral prostate. The studies were performed on 48 male Wistar rats. The animals were divided into a control group and 7 experimental groups. For 6 months, the
Yutaka Kimura et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(5), 759-768 (2014-03-08)
We established a luciferase reporter assay system, the Multi-ImmunoTox Assay (MITA), to evaluate the effects on key predictivein vitro components of the human immune system. The system is composed of 3 stable reporter cell lines transfected with 3 luciferase genes
Abigail M Dalzell et al.
Toxicology letters, 235(3), 189-198 (2015-04-14)
ABC transporters play an important role in the disposition of avermectins in several animal species. In this study the interactions of three key avermectins, abamectin, emamectin and ivermectin, with human and mouse homologues of MDR1 (ABCB1/Abcb1a) and MRP (ABCC/Abcc), transporters
Manisha Sahay et al.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 24(5), 897-902 (2013-09-14)
To determine the role of the oral glucose tolerance test in the early detection of new-onset diabetes after transplantation (NODAT) and to compare the various risk factors and insulin kinetics in the transplant patients, we studied 41 live-related renal allograft
Angela C Webster et al.
BMJ (Clinical research ed.), 331(7520), 810-810 (2005-09-15)
To compare the positive and negative effects of tacrolimus and ciclosporin as initial treatment for renal transplant recipients. Systematic review. Reports of comparative randomised trials of tacrolimus and ciclosporin identified by searches of Medline, Embase, the Cochrane Register of Controlled
Xiaoling Puyang et al.
Antimicrobial agents and chemotherapy, 54(5), 1981-1987 (2010-02-24)
The current standard of care for hepatitis C virus (HCV) infection, pegylated alpha interferon in combination with ribavirin, has a limited response rate and adverse side effects. Drugs targeting viral proteins are in clinical development, but they suffer from the
Efficacy and safety of tocilizumab combined with cyclosporine A in a patient with rheumatoid arthritis and concomitant chronic hepatitis C virus infection.
Chiara Giannitti et al.
Clinical and experimental rheumatology, 31(5), 816-816 (2013-09-12)
Sami Akbulut et al.
The Journal of surgical research, 193(2), 658-666 (2014-10-05)
To investigate the potential protective antioxidant role of ursodeoxycholic acid (UDCA), melatonin, and allopurinol treatment in cyclosporine (CsA)-induced hepatotoxicity. Hepatotoxicity was established in Sprague-Dawley rats by daily administration of CsA. Treatment groups were additionally administered UDCA, melatonin, or allopurinol treatments.
Yibo Zhuang et al.
American journal of physiology. Renal physiology, 308(8), F857-F866 (2015-02-20)
Proteinuria is involved in the development of tubular lesions and in the progressive loss of renal function in chronic kidney diseases via uncertain mechanisms. Growing evidence suggests a pathogenic role of mitochondrial dysfunction in chronic kidney diseases. Therefore, the present
Abigail A Lamikanra et al.
PloS one, 10(3), e0119836-e0119836 (2015-03-18)
The role of infection in erythropoietic dysfunction is poorly understood. In children with P. falciparum malaria, the by-product of hemoglobin digestion in infected red cells (hemozoin) is associated with the severity of anemia which is independent of circulating levels of
Kentaro Yano et al.
Journal of pharmaceutical sciences, 104(9), 2789-2794 (2014-12-30)
P-glycoprotein (P-gp) regulates absorption of many drugs in the gastrointestinal tract and their accumulation in tumor tissues, but the basis of substrate recognition by P-gp remains unclear. Bitter-tasting phenylthiocarbamide, which stimulates taste receptor 2 member 38 (T2R38), increases P-gp activity
Azza A K El-Sheikh et al.
Translational research : the journal of laboratory and clinical medicine, 164(1), 46-56 (2014-02-04)
Mycophenolic acid (MPA) is an immunosuppressant used in transplant rejection, often in combination with cyclosporine (CsA) and tacrolimus (Tac). The drug is cleared predominantly via the kidneys, and 95% of the administered dose appears in urine as 7-hydroxy mycophenolic acid
Closing the pore on reperfusion injury: myocardial protection with cyclosporine.
Jochen D Muehlschlegel
Anesthesiology, 121(2), 212-213 (2014-06-05)
Tsukasa Ugajin et al.
Molecular immunology, 66(2), 180-188 (2015-03-25)
Zinc (Zn) is an essential nutrient, and Zn deficiency causes immunodeficiency and skin disorders. Basophils express FcɛRI on their surface and release multiple mediators after receptor cross-linking, including large amounts of IL-4. However, the mechanisms involved in the FcɛRI-mediated regulation
Concurrent administration of darbepoetin alfa, cyclosporine A, and prednisolone is useful for T cell large granular lymphocyte leukemia associated with myelodysplastic syndrome complicated by Coombs-negative hemolytic anemia.
Tetsumi Yoshida et al.
Annals of hematology, 93(11), 1937-1939 (2014-04-24)
Anne Pick et al.
Bioorganic & medicinal chemistry, 16(17), 8224-8236 (2008-08-06)
At the end of the last century tariquidar (XR9576) was synthesized, pharmacologically investigated, and classified as a promising 3rd generation P-glycoprotein (P-gp) modulator. Following the discovery of BCRP in 1998 an increasing number of substances were studied in relation to
Wim F P M Van den Hof et al.
Toxicology, 324, 18-26 (2014-07-23)
The liver is responsible for drug metabolism and drug-induced hepatotoxicity is the most frequent reason for drug withdrawal, indicating that better pre-clinical toxicity tests are needed. In order to bypass animal models for toxicity screening, we exposed primary mouse hepatocytes
Jhon A Ochoa-Alvarez et al.
Oncotarget, 6(11), 9045-9060 (2015-04-01)
Podoplanin (PDPN) is a unique transmembrane receptor that promotes tumor cell motility. Indeed, PDPN may serve as a chemotherapeutic target for primary and metastatic cancer cells, particularly oral squamous cell carcinoma (OSCC) cells that cause most oral cancers. Here, we
Oded Ovadia et al.
Bioorganic & medicinal chemistry, 18(2), 580-589 (2010-01-09)
A peptide-peptoid hybrid (peptomer) library was designed and synthesized, based on the sequence Phe-d-Phe-Arg-Trp-Gly. This sequence was previously found to specifically activate the melanocortin-4-receptor (MC4R) which participates in regulation of energy homeostasis and appetite. The library of peptomers included a
Shengjun Nie et al.
PloS one, 10(3), e0119853-e0119853 (2015-03-27)
Plant mitochondria constitute a major source of ROS and are proposed to act as signaling organelles in the orchestration of defense response. At present, the signals generated and then integrated by mitochondria are still limited. Here, fluorescence techniques were used
Immunosuppression for membranous nephropathy.
Zhenjie Chen et al.
Lancet (London, England), 381(9884), 2162-2163 (2013-06-26)
Konrad Meissner et al.
Anesthesiology, 121(6), 1281-1291 (2014-07-30)
Interindividual variability and drug interaction studies suggest that blood-brain barrier drug transporters mediate human methadone brain biodistribution. In vitro and animal studies suggest that methadone is a substrate for the efflux transporter P-glycoprotein, and that P-glycoprotein-mediated transport influences brain access
Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were
Wolfgang Arns et al.
Clinical nephrology, 79(6), 421-431 (2013-04-25)
In a 6-month prospective, openlabel, multicenter study, 128 de novo kidney transplant patients receiving cyclosporine (CsA) and steroids were randomized to an intensified regimen of enteric-coated mycophenolate sodium (EC-MPS) or to a standard EC-MPS regimen to Week 6 posttransplant, after
Mir-Jamal Hosseini et al.
Cell biochemistry and biophysics, 70(1), 367-381 (2014-04-03)
Oxidative damage has been implicated in disorders associated with abnormal copper metabolism and also Cu(2+) overloading states. Besides, mitochondria are one of the most important targets for Cu(2+), an essential redox transition metal, induced hepatotoxicity. In this study, we aimed
Lihong Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(48), 19023-19028 (2007-11-21)
Autophagy is a lysosome-dependent cellular catabolic mechanism mediating the turnover of intracellular organelles and long-lived proteins. Reduction of autophagy activity has been shown to lead to the accumulation of misfolded proteins in neurons and may be involved in chronic neurodegenerative
André Hoerning et al.
Transplantation, 99(1), 210-219 (2014-08-08)
Immunosuppressive therapy with mammalian target of rapamycin inhibitors (mTORi) requires maintenance of an effective inhibition of the alloimmune response, whereas reducing drug-related nephrotoxicity. Therapeutic monitoring is based on mTORi trough levels, which do not necessarily reflect biologic effects on the
Jennifer A Faralli et al.
Biochimica et biophysica acta, 1833(12), 3306-3313 (2013-10-09)
The purpose of this study was to determine how dexamethasone (DEX) regulates the expression and activity of αvβ3 integrin. FACS analysis showed that DEX treatment induced expression of an activated αvβ3 integrin. Its expression remained high as long as DEX
Yang Zhou et al.
Antonie van Leeuwenhoek, 108(1), 163-171 (2015-05-20)
Mycobacterium bovis is the causative agent of tuberculosis in cattle. Infection of macrophages with M. bovis leads to the activation of the "nucleotide binding and oligomerization, leucine-rich repeat and pyrin domains-containing protein 3" (NLRP3) and "absent in melanoma 2" (AIM2)
Mauro Galeazzi et al.
Annals of the New York Academy of Sciences, 1110, 544-549 (2007-10-04)
Because of the relatively high prevalence of both hepatitis C virus (HCV) infection and autoimmune disorders (ADs), it is not rare to encounter in daily clinical practice patients with ADs also carrying HCV. Corticosteroids and/or immunosuppressant drugs are needed to
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