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30270

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Humaira Gowher et al.
Cancer biology & therapy, 3(11), 1062-1068 (2004-11-13)
Hypermethylation of tumor suppressor genes caused by aberrant activity of DNA methyltransferases is an important mechanism that contributes to cancer. The reaction mechanism of DNA methyltransferases, which includes formation of a covalent intermediate between the enzyme and the target base
Jason D Barbour et al.
Current HIV/AIDS reports, 2(1), 29-34 (2005-08-11)
The development of clinical symptoms, and clinical progression among persons infected with HIV-1 is the manifestation of the effects of the pathogenic viral life cycle of HIV-1. Individual variants of HIV-1 vary widely in features that determine viral fitness and
Barbara A Fox et al.
Infection and immunity, 83(5), 2148-2155 (2015-03-18)
Live attenuated vaccine strains, such as type I nonreplicating uracil auxotroph mutants, are highly effective in eliciting lifelong immunity to virulent acute infection by Toxoplasma gondii. However, it is currently unknown whether vaccine-elicited immunity can provide protection against acute infection
Björn F Koel et al.
Journal of virology, 89(7), 3763-3775 (2015-01-23)
The majority of currently circulating influenza A(H1N1) viruses are antigenically similar to the virus that caused the 2009 influenza pandemic. However, antigenic variants are expected to emerge as population immunity increases. Amino acid substitutions in the hemagglutinin protein can result
Lizhen Qiao et al.
Journal of chromatography. A, 1360, 240-247 (2014-08-19)
Glucaminium-based ionic liquids are a new class of recently developed ionic liquids and prepared by functionalizing the amine group of N-methyl-d-glucamine, which renders them good hydrophilicity due to the presence of the glucose structure and charged quaternary ammonium group. In
Szu-Ying Hung et al.
Analytica chimica acta, 857, 64-70 (2015-01-22)
This study describes the development of a simple, enzyme-free, label-free, sensitive, and selective system for detecting adenosine based on the use of Tween 20-stabilized gold nanoparticles (Tween 20-AuNPs) as an efficient fluorescence quencher for boron dipyrromethene-conjugated adenosine 5'-triphosphate (BODIPY-ATP) and
N O Davidson et al.
Current opinion in lipidology, 6(2), 70-74 (1995-04-01)
A site-specific cytidine deamination (cytidine to uridine) in nuclear apolipoprotein B messenger RNA creates a translational stop codon that produces apolipoprotein B48. This process is mediated by an enzyme composed of distinct subunits, including apolipoprotein B messenger RNA editing enzyme
Elena Di Daniel et al.
BMC cell biology, 10, 54-54 (2009-07-18)
The phosphoinositide (PIns) signalling pathway regulates a series of neuronal processes, such as neurotransmitter release, that are thought to be altered in mood disorders. Furthermore, mood-stabilising drugs have been shown to inhibit key enzymes that regulate PIns production and alter
Renaud Mahieux et al.
The Journal of general virology, 86(Pt 9), 2489-2494 (2005-08-16)
In the absence of the human immunodeficiency virus type 1 (HIV-1) Vif protein, the host-cell cytidine deaminases APOBEC3F and -3G are co-packaged along with virion RNA. Upon infection of target cells, nascent single-stranded DNA can be edited extensively, invariably giving
Enzymatic conversion of cytidine to lysidine in anticodon of bacterial isoleucyl-tRNA--an alternative way of RNA editing.
Henri Grosjean et al.
Trends in biochemical sciences, 29(4), 165-168 (2004-05-06)
Barbara Tavazzi et al.
Clinical biochemistry, 38(11), 997-1008 (2005-09-06)
To set up a novel simple, sensitive, and reliable ion-pairing HPLC method for the synchronous separation of several purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis and screening of inborn errors of metabolism (IEM). The separation
Yang Zhou et al.
Nucleic acids research, 41(11), 5669-5678 (2013-04-23)
The conserved pre-mRNA retention and splicing (RES) complex, which in yeast consists of Bud13p, Snu17p and Pml1p, is thought to promote nuclear retention of unspliced pre-mRNAs and enhance splicing of a subset of transcripts. Here, we find that the absence
Sheng Guo et al.
Food chemistry, 167, 468-474 (2014-08-26)
Jujube (Ziziphus jujuba) fruit is widely consumed as food and traditional Chinese medicine in Asian countries due to its potential effects for human health. To facilitate selection of the maturity stage providing optimum health benefits, jujube fruits were analysed at
Yuanyuan Chen et al.
PloS one, 8(3), e60503-e60503 (2013-04-02)
During hippocampal development, the Cornus Ammonis (CA) and the dentate gyrus (DG) undergo waves of neurogenesis and neuronal migration and maturation independently. This stage is widely known to be vulnerable to environmental stresses, but its underlying mechanism is unclear. Alcohol
Sang Hee Lee et al.
Rapid communications in mass spectrometry : RCM, 18(9), 973-977 (2004-04-30)
Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases. However, during the last decade, the analytical methods for nucleosides by gas chromatography/mass spectrometry (GC/MS) and high-performance liquid chromatography (HPLC) with single-parameter detectors like electron-capture detection (ECD) have not
Aravind Goud G Patil et al.
The Journal of biological chemistry, 288(16), 11252-11262 (2013-03-07)
Approximately one third of the world population is infected with Mycobacterium tuberculosis, the causative agent of tuberculosis. A better understanding of the pathogen biology is crucial to develop new tools/strategies to tackle its spread and treatment. In the host macrophages
[Molecular basis for tRNA(Ile) agmatinylation essential for AUA codon decoding].
Tomoyuki Numata
Seikagaku. The Journal of Japanese Biochemical Society, 84(12), 1004-1008 (2013-01-29)
Hendrik Huthoff et al.
Virology, 334(2), 147-153 (2005-03-23)
The human apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G, or hA3G) protein, provides cells with an intracellular antiretroviral activity that is associated with the hypermutation of viral DNA through cytidine deamination. Indeed, hA3G belongs to a family of vertebrate
Joana Rocha-Pereira et al.
Journal of virology, 87(21), 11798-11805 (2013-08-30)
Human noroviruses are a major cause of food-borne illness, accountable for 50% of all-etiologies outbreaks of acute gastroenteritis (in both developing and developed countries). There is no vaccine or antiviral drug for the prophylaxis or treatment of norovirus-induced gastroenteritis. We
Valeria Godoy et al.
Journal of hepatology, 61(6), 1337-1343 (2014-07-19)
Both hepatocytes and cholangiocytes release ATP into the bile, where it acts as a potent autocrine/paracrine stimulus that activates biliary secretory mechanisms. ATP is known to be metabolized into multiple breakdown products, ultimately yielding adenosine. However, the elements implicated in
Naveenan Navaratnam et al.
International journal of hematology, 83(3), 195-200 (2006-05-25)
Enzymes that deaminate cytidine to uridine play an important role in a variety of pathways from bacteria to man. Ancestral members of this family were able to deaminate cytidine only in a mononucleotide or nucleoside context. Recently, a family of
Bärbel Schröfelbauer et al.
Journal of virology, 79(17), 10978-10987 (2005-08-17)
The human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr has previously been shown to bind to the cellular uracil DNA glycosylase UNG. We show here that the binding of Vpr to UNG and to the related enzyme SMUG induces
Eva Tyteca et al.
Journal of chromatography. A, 1368, 125-131 (2014-12-03)
In this study, the separation of twelve nucleobases and nucleosides was optimized via chromatogram simulation (i.e., prediction of individual retention times and estimation of the peak widths) with the use of an empirical (reversed-phase) non-linear model proposed by Neue and
Ana Judith Perisé-Barrios et al.
AIDS (London, England), 28(16), 2365-2374 (2014-08-28)
Patients infected by the HIV type 1 (HIV-1) frequently show a general deregulation of immune system. A direct influence of HIV-1 particles on B-cell activation, proliferation and B-cell phenotype alterations has been recently described. Moreover, expression of activation-induced cytidinedeaminase (AID)
Tomislav Horvat et al.
PloS one, 8(1), e54672-e54672 (2013-01-22)
Glycans are essential regulators of protein function and are now in the focus of research in many physiological and pathophysiological processes. There are numerous modes of regulating their biosynthesis, including epigenetic mechanisms implicated in the expression of glyco-genes. Since N-glycans
Koji Hayakawa et al.
The Journal of biological chemistry, 288(24), 17099-17110 (2013-04-30)
The orexin system plays a central role in the integration of sleep/wake and feeding behaviors in a broad spectrum of neural-metabolic physiology. Orexin-A and orexin-B are produced by the cleavage of prepro-orexin, which is encoded on the Hcrt gene. To
Yu Wang et al.
European journal of pediatrics, 173(9), 1233-1244 (2014-04-17)
It has been hypothesized that dysregulation of brain-expressed genes is the major predisposing underlying mechanism for autism. This dysregulation may be mediated by differential methylation of CpG sites within gene promoters, which could be candidate biomarkers and used for early
Paul J Pockros
Clinics in liver disease, 17(1), 105-110 (2012-11-28)
Nucleoside/nucleotide analogue polymerase inhibitors (NPIs) are analogues of natural substrates that bind the active site of NS5B and terminate viral RNA chain generation and generally provide a high genetic barrier to resistance and are effective in all genotypes. NPIs such
C Arimany-Nardi et al.
British journal of pharmacology, 171(16), 3868-3880 (2014-05-02)
Inhibitors of DNA methyltransferases (DNMTs), such as azacytidine, decitabine and zebularine, are used for the epigenetic treatment of cancer. Their action may depend upon their translocation across the plasma membrane. The aim of this study was to identify transporter proteins
Fan Shen et al.
The Journal of clinical endocrinology and metabolism, 100(1), E148-E154 (2014-10-11)
N(6)-methyladenosine (m(6)A) modification plays a fundamental role in the epigenetic regulation of the mammalian transcriptome. m(6)A can be demethylated by fat mass- and obesity-associated (FTO) protein and α-ketoglutarate-dependent dioxygenase alkB homolog 5 (ALKBH5) protein. However, the importance of m(6)A alteration
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