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Haiyang Zhang et al.
The journal of physical chemistry. B, 114(14), 4876-4883 (2010-03-20)
Puerarin and daidzin, two major isoflavonoids of Radix puerariae , are widely adopted in traditional Chinese medicine. Foundational aspects related to separating the two compounds are essential to develop a more economical purification process. Inclusion models of the two compounds
Dae-Hyoung Yoo et al.
International journal of food sciences and nutrition, 66(8), 912-918 (2015-07-15)
Biological activities of soybean saponins are dependent on their metabolism by gut microbiota, which generate absorbable bioactive metabolites. Therefore, to enhance the pharmacological effect of soybean, we fermented defatted soybean powder (SP) with Lactobacillus pentosus var. plantarum C29 and measured
Lena Jankowiak et al.
Food chemistry, 160, 371-378 (2014-05-07)
We here report on the use of water as a 'green' extraction solvent for the isolation of isoflavones from okara, a by-product of soymilk production. At a low liquid-to-solid ratio of 20 to 1 and 20 °C, 47% of the
Yan Yan et al.
Journal of pharmaceutical and biomedical analysis, 95, 76-84 (2014-03-19)
A liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method was developed and validated for simultaneous determination of seven constituents including puerarin, daidzin, daidzein, paeoniflorin, albiflorin, liquiritin and liquiritigenin in rat plasma using schisandrin as the internal standard (IS). The plasma samples
Lun-Cheng Kuo et al.
Applied microbiology and biotechnology, 94(5), 1181-1188 (2012-02-22)
In order to produce isoflavone aglycosides effectively, a process of isoflavone hydrolysis by Bacillus subtilis natto NTU-18 (BCRC 80390) was established. This process integrates the three stages for the production of isoflavone aglycosides in one single fermenter, including the growth
Vamsidhar Yerramsetty et al.
The Journal of nutrition, 144(5), 631-637 (2014-03-22)
Despite considerable interest in the physiologic effects of isoflavones, the in vivo bioavailability of the most common isoflavone forms, malonylglucoside conjugates, has not been determined. Differences in the bioavailability of malonylglucosides compared with the nonconjugated β-glucoside forms may explain the
MinHee Park et al.
Journal of food science, 77(1), C128-C134 (2011-12-21)
Isoflavone profiles of a fermented soy food, cheonggukjang, were modified using almond powder. Isoflavones were analyzed by high performance liquid chromatography (HPLC) with an ultraviolet detector. Malonyl derivatives of isoflavones decreased and aglycones of isoflavones increased in samples with almond
Ka H Wong et al.
Journal of ethnopharmacology, 164, 53-63 (2015-01-07)
Puerariae Lobatae Radix (PLR) and Puerariae Thomsonii Radix (PTR) are traditional Chinese medicines used for the treatment of diabetes and cardiovascular diseases. These two herbs are used interchangeably in clinical practice, even though they possess significantly different chemical profiles. In
Conrad Theil et al.
Archives of gynecology and obstetrics, 284(2), 459-465 (2010-09-08)
Phytooestrogens are known to cause anti-cancer effects on mamma carcinoma cells. In this study, the effects of the lignan secoisolariciresinol and the isoflavone glycosides and aglycones genistein, genistin, daidzein and daidzin were tested on MCF-7 and BT20 cells in vitro.
Yanqing Zang et al.
Bioscience, biotechnology, and biochemistry, 79(1), 117-123 (2014-09-12)
We investigated the effects of a mixture of daidzin and glycitin, which are the glycoside-form isoflavones of daidzein and glycitein, respectively, on body weight, lipid levels, diabetic markers, and metabolism in a high-fat diet (HF) fed C57BL/6J mice for 92 days.
Si Young Cho et al.
Journal of medicinal food, 13(5), 1061-1068 (2010-09-11)
Chitooligosaccharides (COS), a kind of oligosaccharide made from chitin or chitosan, have been used a popular remedy for hangovers. In this study we investigated the in vitro effect of COS lactate salt on ethanol-induced cytotoxicity and the in vivo effect
Benyakan Pongkitwitoon et al.
Planta medica, 76(8), 831-836 (2009-12-25)
Pueraria candollei (White Kwao Khuer) is a medicinal plant containing puerarin, daidzin, genistin, daidzein, and genistein as major isoflavonoids used for its rejuvenating and estrogenic effects. In order to analyze these compounds, a single enzyme-linked immunosorbent assay (ELISA) for total
Ting Zhang et al.
PloS one, 7(1), e30259-e30259 (2012-01-26)
New therapeutic tools and molecular targets are needed for treatment of Japanese encephalitis virus (JEV) infections. JEV requires an α-1 translational frameshift to synthesize the NS1' protein required for viral neuroinvasiveness. Several flavonoids have been shown to possess antiviral activity
Rafael Bolaños et al.
Menopause (New York, N.Y.), 17(3), 660-666 (2010-05-14)
The incidence of vasomotor crises during the climacterium varies in women across different populations, and phytoestrogen consumption seems to play an important role in this problem. The aim of this study was to determine whether intervention with soy (dietary, extract
Aliya Ahmad et al.
Pharmaceutical biology, 53(5), 758-766 (2015-03-11)
Soybean and its fermented products are the most common source of isoflavones in human food. The present study quantifies the major glycosides and aglycones in soybean and its fermented product tempeh isoflavone extracts. The comparision of antioxidant effects and BACE1
Barbara S Lang et al.
The Journal of biological chemistry, 287(45), 38124-38134 (2012-09-19)
Aldehyde dehydrogenase-2 (ALDH2) catalyzes the bioactivation of nitroglycerin (glyceryl trinitrate, GTN) in blood vessels, resulting in vasodilation by nitric oxide (NO) or a related species. Because the mechanism of this reaction is still unclear we determined the three-dimensional structures of
Jia-Hui Li et al.
Alcohol (Fayetteville, N.Y.), 56, 21-28 (2016-11-07)
Numerous studies demonstrate that reactive aldehydes are highly toxic and aldehyde dehydrogenase 2 (ALDH2)-mediated detoxification of reactive aldehydes is thought as an endogenous protective mechanism against reactive aldehydes-induced cell injury. This study aims to explore whether lipoic acid, a potential
Martine Kienzle Hagen et al.
Canadian journal of physiology and pharmacology, 90(8), 1095-1103 (2012-07-20)
This study analyzed and compared the content of isoflavones in 2 soy products, the effectiveness of isoflavones as antioxidants, in vitro, and demonstrated the antioxidant effect of a soy diet in rats with myocardial infarction (MI). Isoflavone content was analyzed
Haiyang Zhang et al.
The journal of physical chemistry. B, 116(12), 3880-3889 (2012-03-02)
Beta-cyclodextrin (β-CD) is an ideal candidate for a host molecule, and it is used as such in drug delivery and separation technology. The structural behavior of free β-CD and host-guest complexes of β-CD with two isoflavonoid isomers (puerarin and daidzin)
Xin Dong et al.
Food chemistry, 135(3), 1643-1652 (2012-09-08)
Previous laboratory and animal studies reported that soy isoflavones were major bioactive compounds in soy to exert chemoprotection of prostate cancer. However, these studies cannot reflect the realistic effects that soy may induce through diets, and little is known about
Lizhen Qiao et al.
Journal of chromatography. A, 1396, 62-71 (2015-04-22)
Two tricationic ionic liquids were prepared and then bonded onto the surface of supporting silica materials through "thiol-ene" click chemistry as new stationary phases for high-performance liquid chromatography. The obtained columns of tricationic ionic liquids were evaluated respectively in the
Wei Zhong et al.
Journal of hepatology, 62(6), 1375-1381 (2014-12-30)
Effective therapies for alcoholic liver disease are currently unavailable. The present study tested the efficacy of Alda-1, a specific aldehyde dehydrogenase 2 (ALDH2) activator, in treating alcoholic liver disease. Male C57BL/6J mice were exposed to alcohol for a time-course study
Sen Zhang et al.
Biotechnology and applied biochemistry, 62(2), 255-259 (2014-06-13)
To achieve efficient production of succinyldaidzin and succinylgenistin, resting cells of a solvent-stable strain Bacillus licheniformis ZSP01 were used to react with pure isoflavones or soybean flour extract in a reaction medium with 10% dimethyl sulfoxide. Strikingly, 0.8 mM daidzein
Chenxi Zhao et al.
Phytochemical analysis : PCA, 22(6), 503-508 (2011-04-16)
Isoflavones are main bioactive components of Pueraria lobata (Willd.) Ohwi. Puerarin has been used as the marker compound in herb quality evaluation in the Chinese Pharmacopoiea. However, it is also important to include the other isoflavones present in the herb
Hai-Dong Guo et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 8-15 (2015-01-02)
Puerarin is the major isoflavone of Puerariae Lobatae Radix. A method for large scale purification of puerarin was developed through resins adsorption and acid hydrolysis. The adsorption properties of six macroporous resins (D101, S-8, H103, X-5, HPD600, AB-8) were compared
Carey E Gleason et al.
Journal of Alzheimer's disease : JAD, 47(4), 1009-1019 (2015-09-25)
In a previous trial, treatment with soy isoflavones was associated with improved nonverbal memory, construction abilities, verbal fluency, and speeded dexterity compared to treatment with placebo in cognitively healthy older adults. The current trial aimed to examine the potential cognitive
Li Yang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(20), 1773-1780 (2011-05-24)
A novel method using column chromatography on oligo-β-cyclodextrin-Sepharose HP for the preparation of high purity daidzin from crude soybean samples was proposed in this work. The isoflavone of daidzin in sample A and B was purified under the optimum mobile
Soo-Jin Yeom et al.
Journal of agricultural and food chemistry, 60(6), 1535-1541 (2012-01-19)
The recombinant β-glucosidase from the hyperthermophilic archaeon Pyrococcus furiosus was purified with a specific activity of 330 U/mg for genistin by His-trap chromatography. The specific activity of the purified enzyme followed the order genistin > daidzin > glycitin> malonyl glycitin
Jennifer H Ahn-Jarvis et al.
Cancer prevention research (Philadelphia, Pa.), 8(11), 1045-1054 (2015-08-16)
Epidemiologic associations suggest that populations consuming substantial amounts of dietary soy exhibit a lower risk of prostate cancer. A 20-week randomized, phase II, crossover trial was conducted in 32 men with asymptomatic prostate cancer. The crossover involved 8 weeks each
Ji-Cheng Chen et al.
Food chemistry, 186, 256-264 (2015-05-16)
Soy germ rich in isoflavones has attracted much attention for health-promoting characteristics. An effective approach via Monascus aged vinegar soaking was adopted to enhance the aglycone amount. The profiles and interconversion of soy germ isoflavones via Monascus aged vinegar soaking
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