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Thomas Zander et al.
Molecules (Basel, Switzerland), 25(17) (2020-09-02)
Hyaluronan is an essential physiological bio macromolecule with different functions. One prominent area is the synovial fluid which exhibits remarkable lubrication properties. However, the synovial fluid is a multi-component system where different macromolecules interact in a synergetic fashion. Within this...
Ursula Sommer et al.
Molecules (Basel, Switzerland), 25(15) (2020-07-31)
The biocompatibility of a cast porous and with a calcium titanate reaction layer functionalized titanium alloy (Ti-6Al-7Nb) was tested by means of cell culture, and a small (rat) and large animal (sheep) model. The uncoated titanium material served as a...
Xi Chen et al.
Current biology : CB, 30(8), 1477-1490 (2020-03-21)
How septin architecture is remodeled from an hourglass to a double ring during cytokinesis in fungal and animal cells remains unknown. Here, we show that during the hourglass-to-double-ring transition in budding yeast, septins acquire a "zonal architecture" in which paired...
Eva Pigna et al.
EBioMedicine, 40, 717-732 (2019-02-05)
Histone deacetylase 4 (HDAC4) has been proposed as a target for Amyotrophic Lateral Sclerosis (ALS) because it mediates nerve-skeletal muscle interaction and since its expression in skeletal muscle correlates with the severity of the disease. However, our recent studies on...
Ruitao Su et al.
Science advances, 6(41) (2020-10-11)
Microfluidic devices fabricated via soft lithography have demonstrated compelling applications such as lab-on-a-chip diagnostics, DNA microarrays, and cell-based assays. These technologies could be further developed by directly integrating microfluidics with electronic sensors and curvilinear substrates as well as improved automation...
Shalini Iyer et al.
PeerJ, 6, e5815-e5815 (2018-10-26)
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two late onset neurodegenerative diseases, have been shown to share overlapping cellular pathologies and genetic origins. Studies suggest that a hexanucleotide repeat expansion in the first intron of the C9orf72 gene is...
J Y Hilary Wong et al.
Learning & memory (Cold Spring Harbor, N.Y.), 28(2), 53-71 (2021-01-17)
Discrimination of sensory signals is essential for an organism to form and retrieve memories of relevance in a given behavioral context. Sensory representations are modified dynamically by changes in behavioral state, facilitating context-dependent selection of behavior, through signals carried by...
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