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Tzer-Min Kuo et al.
Journal of cellular physiology, 234(8), 13984-13993 (2019-01-10)
Areca nut has been evaluated as a group I carcinogen to humans. However, the exact compounds of areca nut causing oral cancer remain unproven. Previous findings from our lab revealed that arecoline N-oxide (ANO), a metabolite of arecoline, exhibits an...
Jiao Wu et al.
Journal of plant research, 132(4), 531-540 (2019-05-28)
Areca nuts (seeds of Areca catechu L.) are a traditional and popular masticatory in India, Bangladesh, Malaysia, certain parts of China, and some other countries. Four related pyridine alkaloids (arecoline, arecaidine, guvacoline, and guvacine) are considered being the main functional...
Yu-Lin Chen et al.
Cancers, 12(1) (2019-12-28)
We established the NHRI-HN1 cell line from a mouse tongue tumor induced by 4-nitroquinoline 1-oxide (4-NQO)/arecoline, with further selection for cell stemness via in vitro sphere culture, to evaluate potential immunotherapies for oral squamous cell carcinoma (OSCC) in East and...
Annals of Tropical Medicine and Parasitology, 58, 119-131 (1964)
A Dakkak et al.
Acta tropica, 165, 26-32 (2016-07-21)
This study was undertaken in the Province of Sidi Kacem in northwest Morocco between April 2010 and March 2011. The main objective of the study was to determine the prevalence of Echinococcus granulosus (Eg) infection in owned dogs. This province...
Mafaz Ullah et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 43(10), 761-769 (2014-04-26)
Oral submucous fibrosis is a pre-malignant fibrotic condition caused by areca nut use and involves reduced mucosal vascularity. Arecoline is the principal areca nut alkaloid and is cytotoxic for epithelium and fibroblasts. Endothelial cell cycle arrest is reported on exposure...
Romi Dasgupta et al.
Archives of physiology and biochemistry, 124(5), 436-441 (2017-12-28)
Betel nut of Areca catechu is chewed by millions of people for increased capacity to work and stress reduction, but it contains arecoline that causes hypothyroidism. The aim is to investigate the role of arecoline on thyroid activity in cold...
Arecoline Increases Glycolysis and Modulates pH Regulator Expression in HA22T/VGH Hepatoma Cells, Leading to Increase of Intracellular Ca
Hsiao-Ling Cheng et al.
Journal of Cancer, 8(16), 3173-3182 (2017-11-22)
Gail Winger et al.
Behavioural pharmacology, 31(4), 359-367 (2020-01-11)
This study aimed to use central and peripheral assays to compare the effects of the muscarinic antagonist scopolamine with those of a novel muscarinic antagonist, L-687,306 [(3R,4R)-3-(3-cyclopropyl-1,2,4,oxadiazol[5-yl]-1-azabicyclo[2.2.1]heptane. Groups of rats were trained to discriminate the stimulus effects of the muscarinic...
Shajedul Islam et al.
Clinical epigenetics, 12(1), 12-12 (2020-01-15)
DNA hypermethylation of tumor suppressor genes is observed in precancerous lesions and oral cancer of individuals with the habits of betel quid (BQ) chewing. SIRT1 has been identified as playing a role in the maintenance of epithelial integrity, and its...
Sarah L Withey et al.
The Journal of pharmacology and experimental therapeutics, 366(2), 397-409 (2018-05-23)
Evidence suggests that the α4β2, but not the α7, subtype of the nicotinic acetylcholine receptor (nAChR) plays a key role in mediating the behavioral effects of nicotine and related drugs. However, the importance of other nAChR subtypes remains unclear. The...
Liqun Gu et al.
Toxicology, 419, 32-39 (2019-03-27)
Arecoline, the major active ingredient of the betel nut, is involved in the pathogenesis of oral submucous fibrosis. However, the underlying mechanism of this pathogenesis remains unclear. In this study, we found that arecoline suppresses the cell proliferation of the...
Determination and pharmacokinetic studies of arecoline in dog plasma by liquid chromatography-tandem mass spectrometry.
Li B
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 15;969, 12-18 (2014)
Osamu Uehara et al.
Oncology letters, 14(1), 1186-1192 (2017-07-12)
Betel quid chewing is implicated in the high prevalence of oral cancer in Southeast Asian countries. One of the major components of betel quid is arecoline. In the present study, in order to characterize the association between chronic arecoline stimulation...
Ji Eun Kim et al.
PloS one, 14(4), e0215205-e0215205 (2019-04-13)
Although constipation has been researched in various neurological disorders, including Parkinson's disease (PD) and spinal cord injury (SCI), the pathological mechanism of this symptom has not been investigated in Alzheimer's disease (AD) associated with loss of nerve cells in the...
Bing Li et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 969, 12-18 (2014-08-21)
A rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of arecoline concentration in dog plasma. Plasma sample was prepared by protein precipitation using n-hexane (containing 1% isoamyl alcohol) with β-pinene as...
Vipin Jain et al.
Journal of agricultural and food chemistry, 65(9), 1977-1983 (2017-02-14)
Chewing of areca nut in different forms such as betel quid or commercially produced pan masala and gutkha is common practice in the Indian subcontinent and many parts of Asia and is associated with a variety of negative health outcomes...
Romi Dasgupta et al.
Archives of physiology and biochemistry, 123(2), 105-111 (2016-12-27)
Millions of people consume betel nut for increased capacity of work. It contains arecoline which is highly toxic and has several untoward side effects on endocrine functions. In this article, the role of arecoline on thyroid function under metabolic stress...
Mark Spensley et al.
G3 (Bethesda, Md.), 8(9), 2941-2952 (2018-08-01)
Many drugs act very rapidly - they can turn on or off their targets within minutes in a whole animal. What are the acute effects of drug treatment and how does an animal respond to these? We developed a simple...
Yi-Ping Huang et al.
Clinical and experimental pharmacology & physiology, 44(8), 880-887 (2017-04-30)
Activation of peroxisome proliferator-activated receptor alpha (PPARα) has been reported to disrupt tumour metabolism and to promote anticancer activity through interfering with the Warburg effect. This study is to investigate whether Warburg effect-related proteins also could be identified in oral...
Barkha Shakya et al.
Toxicology mechanisms and methods, 29(3), 187-202 (2018-10-16)
In the present study geraniol at the final concentration of 10, 20, 30, and 40 µM was mixed in the diet along with 80 µM of arecoline and the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ) Bg9 were allowed to feed...
Sid Ahmed Labed et al.
Immunity, 48(5), 963-978 (2018-05-17)
Regulated antimicrobial peptide expression in the intestinal epithelium is key to defense against infection and to microbiota homeostasis. Understanding the mechanisms that regulate such expression is necessary for understanding immune homeostasis and inflammatory disease and for developing safe and effective...
Indraneel Saha et al.
Archives of physiology and biochemistry, 126(1), 7-16 (2018-08-28)
Arecoline is known to cause endocrine dysfunction. In the current article role of arecoline on pineal-testis activity was investigated in hypothyroid rats induced by propylthiouracil (PTU). PTU treatment caused thyroid dysfunction ultrastructurally with a fall in T3 and T4 levels...
Zhizhong Xu et al.
Neuroreport, 30(2), 134-138 (2018-12-21)
Cerebral demyelination is possibly one of the main pathological factors involved in the development of schizophrenia. Our previous studies have showed that Areca catechu nut extract could ameliorate cognitive decline by facilitating myelination processes in the frontal cortex in a...
Peng-Yang Hsu et al.
Oncotarget, 8(55), 93712-93728 (2017-12-08)
Cordyceps militaris (CM) and its active ingredient cordycepin have been reported to inhibit tumor growth, but the mechanisms are not fully understood. This study used a mouse model for oral cancer and a cell line, 4NAOC-1 derived from the model...