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T T H Pham et al.
Biochimie, 107 Pt A, 143-153 (2014-06-22)
Visceral leishmaniasis is a life-threatening disease that affects nearly a million people every year. The emergence of Leishmania strains resistant to existing drugs complicates its treatment. The purpose of this study was to develop a new lipid formulation based on
Daniel T Bowers et al.
ACS nano, 8(12), 12080-12091 (2014-11-27)
Oxygenation in tissue scaffolds continues to be a limiting factor in regenerative medicine despite efforts to induce neovascularization or to use oxygen-generating materials. Unfortunately, many established methods to measure oxygen concentration, such as using electrodes, require mechanical disturbance of the
Seyedeh Hoda Alavizadeh et al.
International journal of pharmaceutics, 473(1-2), 326-333 (2014-07-23)
SPI-077, cisplatin stealth liposome, is the best illustration of poor cisplatin release from liposomes and the subsequent negligible therapeutic activity. For this reason, optimizing drug release kinetics is desirable. In this report, cisplatin was encapsulated in liposomes composed of different
Anna C C Aguiar et al.
Memorias do Instituto Oswaldo Cruz, 110(7), 906-913 (2015-11-13)
Several species of Aspidosperma plants are used to treat diseases in the tropics, including Aspidosperma ramiflorum, which acts against leishmaniasis, an activity that is experimentally confirmed. The species, known as guatambu-yellow, yellow peroba, coffee-peroba and matiambu, grows in the Atlantic
Cecília Durães et al.
International journal of cancer, 135(6), 1343-1355 (2014-03-13)
The most studied genetic susceptibility factors involved in gastric carcinoma (GC) risk are polymorphisms in the inflammation-linked genes interleukin 1 (IL1) B and IL1RN. Despite the evidence pointing to the IL1 region, definite functional variants reproducible across populations of different
Ralph S Grand et al.
Nucleic acids research, 42(20), 12585-12599 (2014-10-25)
Successful progression through the cell cycle requires spatial and temporal regulation of gene transcript levels and the number, positions and condensation levels of chromosomes. Here we present a high resolution survey of genome interactions in Schizosaccharomyces pombe using synchronized cells
S Yamada et al.
Calcified tissue international, 96(4), 347-358 (2014-12-17)
Clinical and experimental studies have reported that phosphate overload plays a central role in the pathogenesis of vascular calcification in chronic kidney disease. However, it remains undetermined whether phosphate induces cellular senescence during vascular calcification. We established a modified uremic
Nathalie Bock et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(2), 366-377 (2014-03-25)
The fabrication of tailored microparticles for delivery of therapeutics is a challenge relying upon a complex interplay between processing parameters and materials properties. The emerging use of electrospraying allows better tailoring of particle morphologies and sizes than current techniques, critical
Jian-Jun Zhang et al.
Cellular & molecular immunology, 11(4), 396-404 (2014-04-15)
Suppressor of cytokine signaling (SOCS) 1 plays a crucial role in the immune response and might contribute to the prognoses of liver failure treated with glucocorticoid. We recruited 47 acute-on-chronic hepatitis B liver failure (ACHBLF) patients receiving glucocorticoid treatment and
Chi Hong Sum et al.
PloS one, 10(11), e0142875-e0142875 (2015-11-13)
In combination with novel linear covalently closed (LCC) DNA minivectors, referred to as DNA ministrings, a gemini surfactant-based synthetic vector for gene delivery has been shown to exhibit enhanced delivery and bioavailability while offering a heightened safety profile. Due to
Pelin Renkoğlu et al.
Pharmaceutical development and technology, 20(3), 380-384 (2014-02-14)
Cocrystals have recently gained importance in the pharmaceutical industry. In this study, olanzapine and carbamazepine cocrystals were synthesized by using nicotinamide as cocrystal forming agent to achieve improvements in the physicochemical characteristics of the active ingredients. An HPLC method was
N Panda et al.
Materials science & engineering. C, Materials for biological applications, 48, 521-532 (2015-01-13)
Biomaterials that stimulate cell attachment and proliferation without any surface modification (e.g. RGD coating) provide potent and cost effective scaffold for regenerative medicine. This study assessed the physico-chemical properties and cell supportive potential of a silk fibroin blend scaffold derived
Chemical, biochemical and toxicological differences between carbon tetrachloride and chloroform. A critical review of recent investigations of these compounds in mammals.
D E Hathway
Arzneimittel-Forschung, 24(2), 173-176 (1974-02-01)
Mridula Dwivedi et al.
Biochimica et biophysica acta, 1838(10), 2716-2727 (2014-05-24)
The tear fluid lipid layer is present at the outermost part of the tear film which lines the ocular surface and functions to maintain the corneal surface moist by retarding evaporation. Instability in the structure of the tear fluid lipid
Leonel Malacrida et al.
Pulmonary pharmacology & therapeutics, 28(2), 122-129 (2014-01-08)
General anesthesia is frequently associated to transient hypoxemia and lung atelectasis. Although volatile anesthetics are safe and widely used, their potential role on anesthesia-induced pulmonary impairment has not been fully explored. In this study, we investigated the effect of volatile
Nina Iszatt et al.
Environment international, 73, 434-439 (2014-09-23)
During 2003-2004, United Utilities water company in North West England introduced enhanced coagulation (EC) to four treatment works to mitigate disinfection by-product (DBP) formation. This enabled examination of the relation between DBPs and birth outcomes whilst reducing socioeconomic confounding. We
Gemma Moiset et al.
Journal of the American Chemical Society, 136(46), 16167-16175 (2014-10-16)
Disaccharides are well-known for their membrane protective ability. Interaction between sugars and multicomponent membranes, however, remains largely unexplored. Here, we combine molecular dynamics simulations and fluorescence microscopy to study the effect of mono- and disaccharides on membranes that phase separate
Andrey G Pradko et al.
Steroids, 97, 78-86 (2014-09-10)
Starting from (22R,23R)-2α,3α,22,23,26-pentahydroxy-5α-cholestan-6-one 26-hemisuccinate, conjugates of 28-norcastasterone with horse radish peroxidase and bovine serum albumin were prepared. The latter conjugate was injected into rabbits; produced polyclonal antibodies were used to quantitate 6-keto-brassinosteroids. The newly developed analytical system was used in
Gülengül Duman et al.
Journal of liposome research, 24(4), 259-269 (2014-04-15)
The moisture-imparting effect of sodium hyaluronate (Na-HA) was investigated in liposome, gel and lipogelosome topical formulations. Sixteen liposome formulations were prepared with or without Na-HA (45 kDa) using various ratios of dimyristoylphosphatidylcholine, 1,2-dimyristoyl-sn-glycero-3-phosphatidylglycerol, dipalmitoylphosphatidylcholine and phospholipon 100H. The liposomes were
Hua Ren et al.
Biochemical and biophysical research communications, 457(4), 572-577 (2015-01-21)
In the past decade, monoclonal antibodies (mAbs) have revolutionized the treatment of non-Hodgkin lymphomas (NHLs). Although Fc-dependent mechanisms of mAb-mediated tumor clearance have been extensively studied, the ability of mAbs to directly evoke programmed cell death (PCD) and the underlying
Wendy A Kellner et al.
Genome research, 25(11), 1600-1609 (2015-08-16)
CpG islands (CGIs) are associated with over half of human gene promoters and are characterized by a unique chromatin environment and high levels of bidirectional transcriptional activity relative to surrounding genomic regions, suggesting that RNA polymerase (Pol II) progression past
Mengyuan Kan et al.
Experimental biology and medicine (Maywood, N.J.), 240(2), 230-234 (2014-10-12)
Age-related macular degeneration (AMD) is a late-onset, neurodegenerative disease. Genes related to lipid metabolism are important in AMD pathogenesis. Recently, a variant rs2075650 located in lipid metabolism-related locus APOE/TOMM40 was identified to be associated with advanced AMD and early AMD
M Salimi et al.
Cell proliferation, 47(2), 172-179 (2014-01-29)
To evaluate anti-proliferative as well as apoptotic activities of compounds identified in chloroform extract of Juglans regia leaves, on human breast and oral cancer cell lines (MCF-7 and BHY). Column chromatography, MTT assay, flowcytometry and western blotting have all been
Mayssa H Mokalled et al.
Developmental biology, 406(2), 109-116 (2015-09-20)
Myocardin-Related Transcription Factors A and B (MRTF-A and MRTF-B) are highly homologous proteins that function as powerful coactivators of serum response factor (SRF), a ubiquitously expressed transcription factor essential for cardiac development. The SRF/MRTF complex binds to CArG boxes found
Fangkun Ning et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(12), 5349-5360 (2014-09-17)
The short palate, lung and nasal epithelial clone 1 (SPLUNC1) protein is a member of the palate, lung, and nasal epithelium clone (PLUNC) family, also known as bactericidal/permeability-increasing (BPI) fold-containing protein, family A, member 1 (BPIFA1). SPLUNC1 is an abundant
J S V Bharat et al.
The journal of contemporary dental practice, 13(6), 850-855 (2013-02-14)
This study is to evaluate the role of 1:1 v/v 30% trichloromethane and monomer solvent in enhancing the durability of bonding between cross-linked acrylic teeth and different heatcured denture bases with or without mechanical preparations made on ridge lap portion
Li Jiao et al.
Digestive diseases and sciences, 60(12), 3590-3602 (2015-07-18)
Inflammatory bowel disease results from a combination of dysfunction of intestinal epithelial barrier and dysregulation of mucosal immune system. iPLA2β has multiple homeostatic functions and shown to play a role in membrane remodeling, cell proliferation, monocyte chemotaxis, and apoptosis. The
Berta Cillero-Pastor et al.
Analytical and bioanalytical chemistry, 407(8), 2213-2222 (2014-12-17)
The remodeling of the synovial membrane, which normally lubricates the joints by producing synovial fluid, is one of the most characteristic events in the pathology of osteoarthritis (OA). The heterogeneity and spatial distribution of proteins in the synovial membrane are
Maidina Tuohetahuntila et al.
Biochimica et biophysica acta, 1851(2), 220-230 (2014-12-17)
Hepatic stellate cell (HSC) activation is a critical step in the development of chronic liver disease. We previously observed that the levels of triacylglycerol (TAG) species containing long polyunsaturated fatty acids (PUFAs) are increased in in vitro activated HSCs. Here
Messaouda Khallef et al.
Cytotechnology, 67(2), 207-213 (2013-12-24)
Genotoxic effects of bromoform and chloroform, disinfection by-products of the chlorination of drinking water, were examined by using mitotic index (MI), mitotic phase, chromosome aberrations (CAs) and comet assay on root meristematic cells of Allium cepa. Different concentrations of bromoform
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