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Dj Hausenloy et al.
Heart (British Cardiac Society), 100(7), 544-549 (2014-02-04)
Cyclosporin-A (CsA) has been reported to reduce myocardial infarct size in both the experimental and clinical settings. This protective effect is dependent on its ability to prevent the opening of the mitochondrial permeability transition pore, a critical determinant of cell...
M Roy First et al.
Transplantation, 96(1), 58-64 (2013-04-27)
New-onset diabetes after transplantation (NODAT) occurs commonly. Prior NODAT definitions have been inconsistent. Based on the American Diabetic Association criteria, we propose a new approach to defining NODAT. Analysis of 1416 at-risk transplant recipients was performed. Data from three de...
Jean-François Guichou et al.
Journal of medicinal chemistry, 49(3), 900-910 (2006-02-03)
Cyclophilin A is involved in many cellular processes, including protein folding and intracellular transports. Because cyclophilin A has been shown to interact with HIV-1 gag proteins and to enhance the viral infectivity, nonimmunosuppressive cyclophilin A ligands may represent a new...
Yu-Yan Jia et al.
PloS one, 9(5), e97999-e97999 (2014-05-27)
SIRT1, a class III histone deacetylase, acts as a negative regulator for many transcription factors, and plays protective roles in inflammation and atherosclerosis. Transcription factor nuclear factor of activated T cells (NFAT) has been previously shown to play pro-inflammatory roles...
Carrie Ann Cusack et al.
JAMA dermatology, 151(1), 70-72 (2014-10-23)
Immunosuppressed patients with solid organ transplants have an increased risk for nonmelanoma skin cancer. Vismodegib has been reported to be effective for select locally advanced or metastatic basal cell carcinomas. However, there is no data documenting the use and safety...
Y Gong et al.
The Cochrane database of systematic reviews, (3)(3), CD005526-CD005526 (2007-07-20)
Cyclosporin A has been used for patients with primary biliary cirrhosis, but the therapeutic responses in randomised clinical trials have been heterogeneous. To assess the beneficial and harmful effects of cyclosporin A for patients with primary biliary cirrhosis. Relevant randomised...
Pu Yong Zhang et al.
Journal of medicinal chemistry, 53(14), 5108-5120 (2010-06-22)
A series of novel N-arylalkyl-3,4-diaryl-substituted pyrrole-2,5-diones were synthesized. They exhibited promising P-gp modulating activity in a P-gp overexpressing breast cancer cell line (LCC6MDR). Compound 6 (with three methoxy groups at D-ring) displayed the highest P-gp modulating activity. 6 at 1...
Manthena V S Varma et al.
Journal of medicinal chemistry, 53(3), 1098-1108 (2010-01-15)
Oral bioavailability (F) is a product of fraction absorbed (Fa), fraction escaping gut-wall elimination (Fg), and fraction escaping hepatic elimination (Fh). In this study, using a database comprised of Fa, Fg, Fh, and F values for 309 drugs in humans...
Werner Klinkhammer et al.
Bioorganic & medicinal chemistry, 17(6), 2524-2535 (2009-03-03)
The development of new modulators possessing high efficacy, low toxicity and high selectivity is a pivotal approach to overcoming P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in tumour cells. In this study 39 compounds are presented which have been synthesized and...
Hiroyuki Uchino et al.
Acta neurochirurgica. Supplement, 118, 311-315 (2013-07-24)
Traumatic brain injury and ischemia can result in marked neuronal degeneration and residual impairment of cerebral function. However, no effective pharmacological treatment directed at tissues of the central nervous system (CNS) for acute intervention has been developed. The detailed pathophysiological...
Robert Sidbury et al.
Journal of the American Academy of Dermatology, 71(2), 327-349 (2014-05-13)
Atopic dermatitis is a chronic, pruritic inflammatory dermatosis that affects up to 25% of children and 2% to 3% of adults. This guideline addresses important clinical questions that arise in atopic dermatitis management and care, providing recommendations based on the...
Burçin Yavuz et al.
TheScientificWorldJournal, 2012, 194848-194848 (2012-05-24)
Dry eye syndrome (DES, Keratoconjunctivitis sicca) is a common disorder of the tear film caused by decreased tear production or increased evaporation. Changes in tear composition also promote inflammation on the ocular surface by various mechanisms. Artificial tear drops, tear...
Pakit Vichyanond et al.
Current allergy and asthma reports, 13(3), 308-314 (2013-04-30)
Vernal keratoconjunctivitis is a sight-threatening inflammatory disease of conjunctiva and cornea. It is frequently observed in young children with the onset usually occurring in the first decade of life. Mild cases of VKC tend to remit with nonspecific and supportive...
Christina A Clarke et al.
Journal of the National Cancer Institute, 107(2), doi:10-doi:10 (2015-01-13)
Solid organ transplant recipients have elevated risks of virus-related cancers, in part because of long-term immunosuppression. Merkel cell carcinoma (MCC) is an aggressive skin cancer recently found to have a viral origin, but little is known regarding the occurrence of...
D Iu Andreev et al.
Vestnik khirurgii imeni I. I. Grekova, 172(1), 104-107 (2013-07-03)
The most frequent causes of leg ulcers (90-95%) are chronic venous insufficiency (45-60%), obliterating atherosclerosis of the lower extremity arteries (10-20%), diabetes mellitus (15-25%) and their combinations (10-15%). The leg ulcers, specified as pyoderma gangrenosum, are the rare and severe...
Shunsei Hirohata
Brain and nerve = Shinkei kenkyu no shinpo, 65(11), 1245-1253 (2013-11-10)
The central nervous system involvement in Behcet's disease, usually called neuro-Behcet's disease (NBD), includes acute type and chronic progressive type. Acute NBD is characterized by acute meningoencephalitis with focal lesions, presenting high-intensity areas on T2-weighted images or FLAIR images on...
Ali Monfared et al.
Transplantation, 98(1), 66-71 (2014-07-01)
Hyperhomocysteinemia (hyperHcy) is an important risk factor for atherosclerosis, which is currently a major cause of death in renal transplant patients (RTRs). The aim of this study was to determine the associated factors of hyperHcy in RTRs in northern Iran....
O V Akopova et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(5), 37-49 (2014-02-01)
The effect of Ca(2+)-induced opening of cyclosporine-sensitive pore (mitochondrial permeability transition pore, MPTP) on the oxygen consumption and mitochondrial functional state was studied in the rat liver mitochondria. It was shown that, with the use of glutamate as oxidation substrate...
Peter Forsythe et al.
The Veterinary record, 174 Suppl 2, 13-21 (2014-04-01)
Ciclosporin is a lipophilic cyclic polypeptide with powerful immunosuppressive and immunomodulatory properties that has been used in veterinary medicine for two decades. It is a calcineurin inhibitor whose principal mode of action is to inhibit T cell activation. The drug...
Kathleen M Giacomini et al.
Nature reviews. Drug discovery, 9(3), 215-236 (2010-03-02)
Membrane transporters can be major determinants of the pharmacokinetic, safety and efficacy profiles of drugs. This presents several key questions for drug development, including which transporters are clinically important in drug absorption and disposition, and which in vitro methods are...
Leah Tong et al.
Antimicrobial agents and chemotherapy, 51(10), 3498-3504 (2007-08-01)
Human immunodeficiency virus protease inhibitors (PIs) modestly affect the plasma pharmacokinetics of tenofovir (TFV; -15% to +37% change in exposure) following coadministration with the oral prodrug TFV disoproxil fumarate (TDF) by a previously undefined mechanism. TDF permeation was found to...
Haining He et al.
International journal of radiation biology, 90(10), 897-902 (2014-05-16)
To explore methodological modifications in the detection of DNA damage in sonochemotherapy for cisplatin-resistant human ovarian cancer cells using the comet assays. Chemoresistant cells COC1/DDP were subjected to sonochemotherapy and DNA damage detected with the alkaline and neutral comet assays....
T M Pereira et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 20(6), 651-656 (2006-07-14)
Though used occasionally, systemic therapies in severe childhood psoriasis have not been systematically investigated. Cyclosporin A (CysA) is effective in adults with severe psoriasis but there are no extensive data regarding the efficacy and safety of its use in childhood...
Norris I Hollie et al.
Biochimica et biophysica acta, 1841(6), 888-895 (2013-12-10)
Mice deficient in group 1b phospholipase A2 have decreased plasma lysophosphatidylcholine and increased hepatic oxidation that is inhibited by intraperitoneal lysophosphatidylcholine injection. This study sought to identify a mechanism for lysophosphatidylcholine-mediated inhibition of hepatic oxidative function. Results showed that in...
A Albring et al.
Clinical pharmacology and therapeutics, 96(2), 247-255 (2014-04-05)
Akin to other physiological responses, immune functions can be modified through behavioral conditioning as part of a learned placebo response. However, like every learning process, learned immune responses are subject to extinction. We analyzed the extinction of learned immunosuppression in...
Minjun Chen et al.
Drug discovery today, 16(15-16), 697-703 (2011-06-01)
Drug-induced liver injury (DILI) is a leading cause of drugs failing during clinical trials and being withdrawn from the market. Comparative analysis of drugs based on their DILI potential is an effective approach to discover key DILI mechanisms and risk...
Myfanwy Geyer et al.
Pediatrics, 134(6), e1720-e1726 (2014-11-19)
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome is a monogenic disorder associated with autoimmune destruction of both endocrine and nonendocrine tissues. The classic triad includes candidiasis, hypoparathyroidism, and Addison disease. Up to 25% of patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy...
[70-year-old kidney transplant patient with anorexia and weight loss. Kaposi sarcoma].
E Schulze-Lohoff et al.
Deutsche medizinische Wochenschrift (1946), 138(38), 1885-1886 (2013-09-12)
Pablo Godoy et al.
International journal for parasitology, 45(1), 85-93 (2014-12-09)
Haemonchus contortus is a veterinary nematode that infects small ruminants, causing serious decreases in animal production worldwide. Effective control through anthelmintic treatment has been compromised by the development of resistance to these drugs, including the macrocyclic lactones. The mechanisms of...
Jacqueline S Mourer et al.
Transplantation, 96(1), 49-57 (2013-05-30)
Calcineurin inhibitors (CNIs) have an unfavorable cardiovascular risk profile in renal transplant recipients. The aim of this substudy was to assess the effects of late CNI or mycophenolate mofetil (MMF) withdrawal on ambulatory blood pressure monitoring and carotid intima media...
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