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Ying-Ping Deng et al.
Experimental neurology, 269, 213-223 (2015-04-12)
Hypomyelination is the major cause of neurodevelopmental deficits that are associated with perinatal white matter injury. Chondroitin sulfate proteoglycans (CSPGs) are known to exert inhibitory effects on the migration and differentiation of oligodendrocytes (OLs). However, few studies describe the roles
Lei Han et al.
ACS applied materials & interfaces, 7(26), 14463-14470 (2015-06-16)
As substitutes for natural peroxidases, most nanomaterial-based enzyme mimetics (nanozymes) have unique properties such as high stability, low-cost, large surface area, and high catalytic activity. However, they usually work in acidic conditions and thus impede their real applications. In this
Lili Huang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(49), 16309-16319 (2014-12-05)
The hypothalamic NPY system plays an important role in regulating food intake and energy expenditure. Different biological actions of NPY are assigned to NPY receptor subtypes. Recent studies demonstrated a close relationship between food intake and growth hormone (GH) secretion;
Amit Vaish et al.
Chemical communications (Cambridge, England), 49(26), 2685-2687 (2013-02-26)
We have developed a method based on self-assembly of thiols on Au substrates to immobilize membrane proteins at interfaces. Using water soluble nitrilotriacetic acid (NTA)-terminated oligo(ethylene glycol) thiols, a histidine-tagged G protein-coupled membrane receptor (GPCR) was captured in a defined
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds
Maria Desemparats Saenz-de-Juano et al.
PloS one, 10(4), e0125157-e0125157 (2015-04-29)
Very limited information on the post-implantatory effects of vitrification has been published till now. We observed in a previous study that the vitrification procedure for the cryopreservation of embryos introduced transcriptomic and proteomic modifications in the rabbit foetal placenta at
Baozhang Li et al.
Sensors (Basel, Switzerland), 14(6), 9889-9899 (2014-06-06)
We have developed a highly sensitive flexible pressure sensor based on a piezopolymer and silver nanowires (AgNWs) composite. The composite nanofiber webs are made by electrospinning mixed solutions of poly(inylidene fluoride) (PVDF) and Ag NWs in a cosolvent mixture of
Wen Jen Lin et al.
Carbohydrate polymers, 120, 7-14 (2015-02-11)
The aim of this study was to develop hepatocyte-targeting non-viral polymeric nono-carriers for gene delivery. Chitosan was selected as the main polymer. An asialoglycoprotein receptor recognized sugar, galactose, was introduced. The methoxy poly(ethylene glycol) (mPEG) or short chain poly(ethylene glycol)
Filipa Pires et al.
Biochimica et biophysica acta, 1850(6), 1158-1168 (2015-02-11)
The use of conjugated polymers allows versatile interactions between cells and flexible processable materials, while providing a platform for electrical stimulation, which is particularly relevant when targeting differentiation of neural stem cells and further application for therapy or drug screening.
Micky Fu Xiang Lee et al.
Journal of chromatography. A, 1394, 71-80 (2015-04-04)
A thermo-responsive random copolymer, POEGMA (poly(oligoethylene glycol) methacrylate) grafted on cationized agarose adsorbent was used for size selective protein adsorption. The effects of OEGMA300 ((oligoethylene glycol) methyl ether methacrylate, Mn=300g/mol) content and temperature on the adsorption of bovine serum albumin
K Bhattacharya et al.
Dalton transactions (Cambridge, England : 2003), 44(19), 9221-9229 (2015-04-25)
Research on energy storage devices has created a niche owing to the ever increasing demand for alternative energy production and its efficient utilisation. Here, a novel composite of Fe3O4 nanospheres and carbon quantum dots (C-dots) have been synthesized by a
Inas H Hafez et al.
Scientific reports, 4, 6295-6295 (2014-09-16)
Cost reduction and improved durability are the two major targets for accelerating the commercialization of polymer electrolyte membrane fuel cells (PEFCs). To achieve these goals, the development of a novel method to fabricate platinum (Pt)-based electrocatalysts with a high mass
Mohamed R Berber et al.
Scientific reports, 5, 16711-16711 (2015-11-26)
Driven by the demand for the commercialization of fuel cell (FC) technology, we describe the design and fabrication of a highly durable FC electrocatalyst based on double-polymer-coated carbon nanotubes for use in polymer electrolyte membrane fuel cells. The fabricated electrocatalyst
Rifat J Hussain et al.
Physiology & behavior, 138, 113-117 (2014-12-03)
Our laboratory has previously shown that antidepressants regulate glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC). To determine if PFC GR are involved in antidepressant effects on behavior or hypothalamic-pituitary-adrenocortical (HPA) axis activity, we treated floxed GR male mice
Suzanne M D'Addio et al.
Molecular pharmaceutics, 12(5), 1554-1563 (2015-03-27)
Tuberculosis (TB) remains a major global health concern, and new therapies are needed to overcome the problems associated with dosing frequency, patient compliance, and drug resistance. To reduce side effects associated with systemic drug distribution and improve drug concentration at
Venkata N K B Adusumalli et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 16(11), 2312-2316 (2015-06-16)
An intense single-band blue emission at λ=450 nm is observed from Tm(3+) ions through Ce(3+) sensitization, for the first time, in colloidal Ce(3+) /Tm(3+) -doped NaYF4 nanocrystals. The intense Tm(3+) emission through broad-band excitation is advantageous for developing luminescent nanocomposites
Luis Miguel Azofra et al.
Physical chemistry chemical physics : PCCP, 15(33), 14026-14036 (2013-07-19)
The mechanism of the S(N)2 model glycosylation reaction between ethanol, 1,2-ethanediol and methoxymethanol has been studied theoretically at the B3LYP/6-311+G(d,p) computational level. Three different types of reactions have been explored: (i) the exchange of hydroxyl groups between these model systems;
Zhen Liu et al.
Biomaterials, 56, 206-218 (2015-05-03)
Since understanding the healthy status of gastrointestinal tract (GI tract) is of vital importance, clinical implementation for GI tract-related disease have attracted much more attention along with the rapid development of modern medicine. Here, a multifunctional theranostic system combining X-rays/CT/photothermal/photoacoustic
Anais Berthelot-Ricou et al.
Fertility and sterility, 100(3), 882-888 (2013-06-13)
To assess the genotoxicity of three oocyte vitrification protocols. Murine assay. Biogenotoxicology research laboratory. CD1 female mice. Three mouse oocyte groups were exposed to three commercialized human oocyte vitrification protocols. Protocols 1 and 2 contained dimethyl sulfoxide and ethylene glycol
Suk Ho Bhang et al.
Biomaterials, 55, 33-43 (2015-05-03)
At high concentrations, manganese (Mn) promotes cellular neurodevelopment but causes toxicity. Here, we report that Mn ion at high concentrations can be delivered to pheochromocytoma 12 (PC12) cells using gold nanoparticles (AuNPs) to enhance cellular neurodevelopment without toxicity. Mn(2+) release
Diana Adliene et al.
Radiation protection dosimetry, 165(1-4), 406-409 (2015-03-31)
Evaluation of the new lead-free optically transparent nanocomposites is provided in this paper along with the introduction to their fabrication technologies and the results of investigation of their X-ray attenuating and optical properties before and after their exposure to high
Huile Gao et al.
Molecular pharmaceutics, 11(8), 2755-2763 (2014-07-02)
Gliomas are hard to treat because of the two barriers involved: the blood-brain barrier and blood-tumor barrier. In this study, a dual-targeting ligand, angiopep-2, and an activatable cell-penetrating peptide (ACP) were functionalized onto nanoparticles for glioma-targeting delivery. The ACP was
Chunfeng Wang et al.
Materials science & engineering. C, Materials for biological applications, 45, 261-269 (2014-12-11)
Lipase from Candida rugosa (CRL) was chemically and physically immobilized onto four types of rod-shaped mesoporous silica (RSMS). RSMS prepared using surfactant P123 and poly(ethylene glycol) as co-templates was functionalized with (3-aminopropyl)triethoxysilane (APTES) to obtain P-RSMS by post-synthesis grafting. Tetraethoxysilane
Dmitry Shvartsman et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(7), 1243-1253 (2014-04-29)
Tissue reinnervation following trauma, disease, or transplantation often presents a significant challenge. Here, we show that the delivery of vascular endothelial growth factor (VEGF) from alginate hydrogels ameliorates loss of skeletal muscle innervation after ischemic injury by promoting both maintenance
Suresh Gadde et al.
Advanced healthcare materials, 3(9), 1448-1456 (2014-03-25)
Liver X receptors (LXRs) attenuate inflammation by modulating the expression of key inflammatory genes, making LXRs and their ligands particularly attractive candidates for therapeutic intervention in cardiovascular, metabolic, and/or inflammatory diseases. Herein, enhanced proresolving activity of polymeric nanoparticles (NPs) containing
Sandra Flessau et al.
Physical chemistry chemical physics : PCCP, 16(22), 10444-10455 (2014-05-03)
The optical properties of single colloidal semiconductor nanoparticles (NPs) are considerably influenced by the direct environment of the NPs. Here, the influence of different liquid and solid glycol matrices on CdSe-based NPs is investigated. Since the fluorescence of individual NPs
Zhijun Tai et al.
ChemSusChem, 6(4), 652-658 (2013-03-06)
Following our previous report on the selective transformation of cellulose to ethylene glycol (EG) over a binary catalyst composed of tungstic acid and Ru/C, we herein report a new low-cost but more effective binary catalyst by using Raney nickel in
Tomoki Nishikawa et al.
Organic & biomolecular chemistry, 13(47), 11426-11431 (2015-10-08)
Among l- and d-oligopeptides with multiple pyrenes as pendants, the dipeptides with two and three pyrenes showed blue-coloured circularly polarised luminescence as high as |gem|≈ (0.86-1.1) × 10(-2) at around 450 nm, reflecting from exciton couplets of twisted pyrenes.
James A Kruse
Critical care clinics, 28(4), 661-711 (2012-09-25)
Accidental or intentional ingestion of substances containing methanol and ethylene glycol can result in death, and some survivors are left with blindness, renal dysfunction, and chronic brain injury. However, even in large ingestions, a favorable outcome is possible if the
Hongje Jang et al.
Advanced healthcare materials, 4(12), 1833-1840 (2015-06-19)
Herein, hybrid nanocomposite of praseodymium doped TiO2 nanocrystals and graphene oxide nanosheets are prepared by facile hydrothermal treatment. As-synthesized Pr-TiO2 /NGO hybrid nanocomposite exhibits enhanced photocatalytic activity under visible light irradiation by the intact graphene oxide and doped lanthanide mediated
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