Showing 1-30 of 117 results for "

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Ulrike Klenke et al.
Endocrinology, 155(5), 1851-1863 (2014-02-26)
Metabolic dysfunctions are often linked to reproductive abnormalities. Adiponectin (ADP), a peripheral hormone secreted by white adipose tissue, is important in energy homeostasis and appetite regulation. GnRH neurons are integral components of the reproductive axis, controlling synthesis, and release of...
Aaron N Reifler et al.
Experimental eye research, 130, 17-28 (2014-12-03)
Intrinsically photosensitive retinal ganglion cells (ipRGCs) are inner retinal photoreceptors that mediate non-image-forming visual functions, e.g. pupillary constriction, regulation of pineal melatonin release, and circadian photoentrainment. Five types of ipRGCs were recently discovered in mouse, but whether they exist in...
Beytul Balci et al.
Journal of agricultural and food chemistry, 57(11), 4888-4894 (2009-05-15)
The ability of the modified electro-Fenton-like (EF-like) process to degrade aqueous solutions of glyphosate, which is the most widely used herbicide in the world, has been assessed with Mn(2+) and other metal ions as catalysts to overcome the problems posed...
Eric M Prager et al.
Neurotoxicology, 44, 335-343 (2014-08-26)
The recent sarin attack in Syria killed 1429 people, including 426 children, and left countless more to deal with the health consequences of the exposure. Prior to the Syrian chemical assault, nerve agent attacks in Japan left many victims suffering...
P L Alferness et al.
Journal of AOAC International, 84(3), 823-846 (2001-06-22)
A collaborative study was conducted to validate a method for the determination of glyphosate and aminomethylphosphonic acid (AMPA) in crops. The analytes are extracted from crops with water, and the crude extracts are then subjected to a cation exchange cleanup....
Hiroko Ikeda et al.
Experimental neurology, 269, 233-241 (2015-05-02)
The role of cannabinoid systems in conditioned fear memory was investigated in streptozotocin (STZ)-induced diabetic mice. The cannabinoid receptor agonist WIN-55,212-2 (1mg/kg, i.p.), when injected into normal mice after conditioning, significantly prolonged the duration of freezing behavior. This effect was...
Vitor Silva Pereira et al.
Psychopharmacology, 232(13), 2263-2273 (2015-01-16)
Systemic treatment with NMDA receptor (NMDAR) antagonists, inhibitors of neuronal nitric oxide synthase (nNOS) or of soluble guanylyl cyclase (sGC), induce antidepressant-like effects in rats. Increased levels of glutamate and nitric oxide (NO) in the medial prefrontal cortex (MPFC) of...
Ting-Hsien Kao et al.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 24(9), 1959-1968 (2014-11-22)
Nerve growth factor (NGF) expression and activity is important in chronic lower back pain but may also act as a pro-catabolic factor in the pathogenesis of intervertebral disc (IVD) degeneration. Lipocalin 2 (Lcn2) expression in IVD was upregulated by NGF...
Chi-Yen Lin et al.
PloS one, 10(4), e0123562-e0123562 (2015-04-22)
Animal cells and cell lines, such as HEK-293 cells, are commonly cultured at 37°C. These cells are often used to express recombinant proteins. Having a higher expression level or a higher protein yield is generally desirable. As we demonstrate in...
Arno E Commandeur et al.
Human reproduction update, 21(5), 593-615 (2015-07-05)
Uterine leiomyomas (fibroids) are highly prevalent benign smooth muscle tumors of the uterus. In the USA, the lifetime risk for women developing uterine leiomyomas is estimated as up to 75%. Except for hysterectomy, most therapies or treatments often provide only...
Han-Jun Wang et al.
American journal of physiology. Heart and circulatory physiology, 308(5), H447-H455 (2014-12-17)
Excitatory amino acids (e.g., glutamate) released by contraction-activated skeletal muscle afferents into the dorsal horn of the spinal cord initiate the central component of the exercise pressor reflex (EPR) in physiological conditions. However, the role of glutamate and glutamate receptors...
Thomas Poiger et al.
Environmental science and pollution research international, 24(2), 1588-1596 (2016-10-28)
Glyphosate is currently one of the most important herbicides worldwide. Its unique properties provide for a wide range of uses in agriculture but also in non-agricultural areas. At the same time, its zwitterionic nature prevents the inclusion in multi-residue analytical...
L F McNair et al.
Journal of developmental origins of health and disease, 6(3), 225-241 (2014-11-05)
Despite huge efforts from public sectors to educate society as to the deleterious physiological consequences of smoking while pregnant, 12-25% of all babies worldwide are born to mothers who smoked during their pregnancies. Chief among the negative legacies bestowed to...
Marco Napoli et al.
Journal of environmental quality, 44(5), 1667-1673 (2015-10-06)
Glyphosate [-(phosphono-methyl)-glycine] is the main herbicide used in the Chianti vineyards. Considering the pollution risk of the water table and that the vineyard tile drain may deliver this pollutant into nearby streams, the objective of the present study was to...
Camila P Almeida-Suhett et al.
Experimental neurology, 273, 11-23 (2015-08-05)
Patients that suffer mild traumatic brain injuries (mTBI) often develop cognitive impairments, including memory and learning deficits. The hippocampus shows a high susceptibility to mTBI-induced damage due to its anatomical localization and has been implicated in cognitive and neurological impairments...
Avik Roy et al.
PloS one, 9(7), e101883-e101883 (2014-07-10)
Increase of the density of dendritic spines and enhancement of synaptic transmission through ionotropic glutamate receptors are important events, leading to synaptic plasticity and eventually hippocampus-dependent spatial learning and memory formation. Here we have undertaken an innovative approach to upregulate...
Xiaomei Yang et al.
The Science of the total environment, 512-513, 406-414 (2015-02-04)
Repeated applications of glyphosate may contaminate the soil and water and threaten their quality both within the environmental system and beyond it through water erosion related processes and leaching. In this study, we focused on the transport of glyphosate and...
Shani Stern et al.
PloS one, 10(7), e0132577-e0132577 (2015-07-18)
Excitation of neurons by an externally induced electric field is a long standing question that has recently attracted attention due to its relevance in novel clinical intervention systems for the brain. Here we use patterned quasi one-dimensional neuronal cultures from...
Sherri Lee Jones et al.
Behavioural brain research, 291, 118-129 (2015-05-27)
Repeated administration of 10 μg of estradiol benzoate (EB) every 4 days to the ovariectomized (OVX) rat induces a behavioral sensitization of sexual behaviors. Repeated copulation or the receipt of vaginocervical stimulation (VCS) attenuates the sensitization of appetitive sexual behaviors...
Hong Xu et al.
Journal of neurophysiology, 113(4), 1165-1174 (2014-11-28)
The caudal nucleus of the solitary tract (NTS) serves as the site of the first synapse for visceral sensory inputs to the central nervous system. The NTS sends functional projections to multiple brain nuclei, with gastric-related projections primarily targeting the...
Ketamine for depression: evidence, challenges and promise.
Carlos A Zarate et al.
World psychiatry : official journal of the World Psychiatric Association (WPA), 14(3), 348-350 (2015-09-27)
Cai Li et al.
Neuropharmacology, 95, 154-167 (2015-03-23)
M-type (Kv7) K(+) channels, encoded by KCNQ2-KCNQ5 genes, play a pivotal role in controlling neuronal excitability. However, precisely how neuronal activity regulates Kv7 channel translocation has not yet been fully defined. Here we reported activity-dependent changes in Kv7 channel subunits...
M J Shaw et al.
Journal of chromatography. A, 876(1-2), 127-133 (2000-05-24)
High-performance chelation ion chromatography (HPCIC), involving a chelating silica substrate bonded with aminomethylphosphonic acid, has been developed as a novel technique for the quantitative determination of beryllium in complex matrices. An isocratic separation method, using an eluent containing 1 M...
Peter B Schwarz et al.
The Journal of physiology, 592(16), 3597-3609 (2014-05-27)
Noradrenergic neurotransmission in the brainstem is closely coupled to changes in muscle activity across the sleep-wake cycle, and noradrenaline is considered to be a key excitatory neuromodulator that reinforces the arousal-related stimulus on motoneurons to drive movement. However, it is...
Chunyan Hou et al.
Journal of proteome research, 9(8), 4093-4101 (2010-06-24)
A novel kind of immobilized metal affinity chromatography (IMAC) column based on organic-inorganic hybrid silica monolith has been developed. The monolithic support was prepared in a 250 microm i.d. capillary by the sol-gel method with tetraethoxysilane (TEOS) and 3-aminopropyltriethoxysilane (APTES)...
Hannah C Bygd et al.
Biomaterials, 56, 187-197 (2015-05-03)
Macrophage reprogramming has long been the focus of research in disease therapeutics and biomaterial implantation. With different chemical and physical properties of materials playing a role in macrophage polarization, it is important to investigate and categorize the activation effects of...
David M Dorris et al.
Journal of neurophysiology, 113(3), 720-729 (2014-11-08)
Sex differences in neuron electrophysiological properties were traditionally associated with brain regions directly involved in reproduction in adult, postpubertal animals. There is growing acknowledgement that sex differences can exist in other developmental periods and brain regions as well. This includes...
Valentina Ferretti et al.
Brain structure & function, 220(5), 2653-2661 (2014-06-20)
The function of AMPA receptors phosphorylation in synaptic plasticity has been dissected in many in vitro models but its role and dynamics on experience-dependent plasticity are still unclear. Here we studied the effects of AMPA receptor manipulations in the ventral...
Fabrizia Cesca et al.
The Journal of biological chemistry, 290(29), 18045-18055 (2015-06-04)
Kidins220 (kinase D-interacting substrate of 220 kDa)/ankyrin repeat-rich membrane spanning (ARMS) acts as a signaling platform at the plasma membrane and is implicated in a multitude of neuronal functions, including the control of neuronal activity. Here, we used the Kidins220(-/-)...
A S F Araújo et al.
Chemosphere, 52(5), 799-804 (2003-05-22)
Glyphosate [N-(phosphonomethyl)-glycine] is a broad-spectrum, non-selective, post-emergence herbicide that is widely used in agricultural. We studied, in vitro, changes in the microbial activity of typical Hapludult and Hapludox Brazilian soils, with and without applied glyphosate. Glyphosate was applied at a...