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Jia Lu et al.
Toxicology in vitro : an international journal published in association with BIBRA, 27(3), 1007-1017 (2013-02-05)
Zearalenone (ZEN) and its metabolites are commonly found in many food commodities and are known to cause reproductive disorders and genotoxic effects. The major ZEN metabolites are α-zearalenol (α-ZOL) and β-zearalenol (β-ZOL). Although many studies have demonstrated the cytotoxic effects
Hamide Z Senyuva et al.
Journal of AOAC International, 95(6), 1701-1708 (2013-03-05)
A comparison has been made of an LC/MS/MS method using direct analysis of acetonitrile extracts of feed and cereal samples and a method using acetonitrile extraction and subsequent immunoaffinity column (IAC) cleanup. Naturally contaminated samples containing one or more of
Franz Berthiller et al.
Journal of chromatography. A, 1062(2), 209-216 (2005-02-01)
A novel method for the simultaneous determination of the Fusarium mycotoxins nivalenol, deoxynivalenol, fusarenon-X, 3-acetyl-deoxynivalenol, the sum of 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol, diacetoxy-scirpenol, HT-2 toxin, T-2 toxin and zearalenone in maize has been developed using gradient RP-LC with atmospheric pressure chemical
S De Baere et al.
Analytica chimica acta, 756, 37-48 (2012-11-28)
A sensitive and specific method for the quantitative determination of zearalenone (ZEN) and its major metabolites (α-zearalenol (α-ZEL), β-zearalenol (β-ZEL), α-zearalanol (α-ZAL), β-zearalanol (β-ZAL) and zearalanone (ZAN)) in animal plasma using liquid chromatography combined with heated electrospray ionization (h-ESI) tandem
Dojin Ryu et al.
Advances in experimental medicine and biology, 504, 205-216 (2002-04-02)
Zearalenone (ZEN), a common contaminant of all major cereal grains worldwide, is produced by some plant pathogenic molds including Fusarium graminearum and F. culmorum. The biological activity of this mycotoxin is mainly attributed to its estrogenic activity that modulates/disrupts endocrine
A Asci et al.
Minerva pediatrica, 66(6), 571-578 (2014-10-23)
Recently, it was reported that the development of breast tissue and secondary sex characteristics in girls occurred at much younger age and the incidences of premature thelarce (PT) and central idiopathic precocious puberty (ICPP) are increasing. In this context, we
Abdellah Zinedine et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 45(1), 1-18 (2006-10-19)
Zearalenone (ZEA) is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. It is frequently implicated in reproductive disorders of farm animals and occasionally in hyperoestrogenic syndromes in humans. There is evidence that ZEA
Constanze Pietsch et al.
Toxins, 5(1), 184-192 (2013-01-18)
The control of mycotoxins is a global challenge not only in human consumption but also in nutrition of farm animals including aquatic species. Fusarium toxins, such as deoxynivalenol (DON) and zearalenone (ZEN), are common contaminants of animal feed but no
Hyun-Jung Kim et al.
Journal of veterinary science, 13(4), 363-369 (2012-12-29)
In this study, we developed a novel tool for purifying two mycotoxins, aflatoxin B1 (AFB1) and zearalenone (ZEN), in feed. This system utilized monoclonal antibodies (mAbs) against AFB1 and ZEN, and magnetic nanoparticles (MNPs). Among ten MNPs with different diameters
T Kuiper-Goodman et al.
Regulatory toxicology and pharmacology : RTP, 7(3), 253-306 (1987-09-01)
Trans-zearalenone, a resorcylic acid lactone, also known as F-2 toxin, is a nonsteroidal estrogenic mycotoxin produced by numerous species of Fusarium. As a result zearalenone is found in a number of cereal crops and their derived food products. A closely
M Venkataramana et al.
Journal of food science and technology, 51(9), 1920-1928 (2014-09-06)
Fumonisins are one of the most agriculturally significant environmental toxins produced by Fusarium and Aspergillus species that grow on agricultural commodities in the field or during storage. Cereals contaminated with fumonisins causes serious loss to agricultural produce leads to health
Andrea Dall'Erta et al.
Chemical research in toxicology, 26(3), 305-312 (2013-01-26)
Fusarium mycotoxins are secondary metabolites produced by Fusarium spp. in cereals. Among them, deoxynivalenol (DON) and zearalenone (ZEN) are widespread worldwide contaminants of cereal commodities and are ranked as the most important chronic dietary risk factors. Their conjugates, known as
Benedikt Warth et al.
Toxicology letters, 220(1), 88-94 (2013-04-30)
This study reports on the detailed investigation of human deoxynivalenol (DON) and zearalenone (ZEN) in vivo metabolism through the analysis of urine samples obtained from one volunteer following a naturally contaminated diet containing 138μg DON and 10μg ZEN over a
Fen Guo et al.
The Journal of investigative dermatology, 133(6), 1646-1654 (2013-01-24)
Dermal connective tissue is a supportive structure required for skin's barrier function; dysregulated dermal homeostasis results in chronic wounds and fibrotic diseases. The multifunctional cytokine transforming growth factor (TGF) β promotes connective tissue deposition, repair, and fibrosis. TGF-β acts through
Arnau Vidal et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 53, 133-138 (2012-12-04)
The aflatoxins (AFs), deoxynivalenol (DON), ochratoxin A (OTA) and zearalenone (ZEA) are mycotoxins produced by fungal species which can contaminate, alone or simultaneously, cereal-based raw materials. Usually, the higher mycotoxins concentrations in cereals are found in the external layers of
Nurul Aqmar M N Hazalin et al.
Anti-cancer drugs, 24(8), 852-861 (2013-06-15)
There is growing interest in the discovery of bioactive metabolites from endophytes as an alternative source of therapeutics. Identification of their therapeutic targets is essential in understanding the underlying mechanisms and enhancing the resultant therapeutic effects. As such, bioactive compounds
Feng Gao et al.
Mutation research, 755(1), 6-10 (2013-05-07)
Mycotoxins are considered to be significant contaminants of food and animal feed. Zearalenone (ZEA) is a hepatotoxic mycotoxin with estrogenic and anabolic activity found in cereal grains worldwide. ZEA affects hematological and immunological parameters in humans and rodents. The compound
Yuquan Xu et al.
Applied and environmental microbiology, 79(6), 2038-2047 (2013-01-22)
10,11-Dehydrocurvularin is a prevalent fungal phytotoxin with heat shock response and immune-modulatory activities. It features a dihydroxyphenylacetic acid lactone polyketide framework with structural similarities to resorcylic acid lactones like radicicol or zearalenone. A genomic locus was identified from the dehydrocurvularin
Ling-Hong Meng et al.
Journal of natural products, 76(11), 2145-2149 (2013-11-08)
Sumalarins A-C (1-3), the new and rare examples of sulfur-containing curvularin derivatives, along with three known analogues (4-6), were isolated and identified from the cytotoxic extract of Penicillium sumatrense MA-92, a fungus obtained from the rhizosphere of the mangrove Lumnitzera
Direct determination of the estrogenic compounds 8-prenylnaringenin, zearalenone, ?- and ?-zearalenol in beer by liquid chromatography-mass spectrometry.
Maragou NC, et al.
Journal of Chromatography A, 1202(1), 47-57 (2008)
J Böhm
Archiv fur Tierernahrung, 42(2), 95-111 (1992-01-01)
Mycotoxins are metabolic products of mycotoxins which have various chemical structures and show various toxic effects. Deoxynivalenol (vomitoxin) is an important economic factor in pig production due to growth depression and suppression of the immune system. Previous studies have shown
A Vulić et al.
Journal of analytical toxicology, 43(2), 126-133 (2018-10-09)
Metabolic transformation of zearalenone (ZEA), a mycotoxin which can contaminate both food and feed, results in the formation of five metabolites, one of them being zeranol (α-ZAL), which can be abused in farm animals as a growth promoter. To the
M R Armando et al.
International journal of food microbiology, 161(3), 182-188 (2013-01-22)
The effect of Saccharomyces cerevisiae RC008 and RC016 strains, previously selected based on their aflatoxin B₁ mycotoxin binding ability and beneficial properties, against Aspergillus carbonarius and Fusarium graminearum under different interacting environmental conditions was evaluated. In vitro studies on the
Csilla Krifaton et al.
Journal of hazardous materials, 244-245, 429-435 (2013-01-01)
The aim of this study was to screen microbes for their zearalenone degrading potential and to select microbes whose activities do not create toxic or endocrine disrupting metabolites. Bioluminescent bioreporters (Saccharomyces cerevisiae BLYES and BLYR) were successfully used to monitor
Zearalenone and zeranol: potential residue problems in livestock.
S F Sundlof et al.
Veterinary and human toxicology, 28(3), 242-250 (1986-06-01)
E Jakimiuk et al.
Polish journal of veterinary sciences, 12(1), 149-158 (2009-05-23)
Among large husbandry animals, swine are the most predisposed to zearalenone (ZEA) intoxication, mainly because cereal is an important component of their diet. Studies performed so far (in vivo, in vitro) suggest that ZEA and its metabolites, which may appear
Simultaneous determination of trichothecene mycotoxins and zearalenone in cereals by gas chromatography-mass spectrometry.
Tanaka T, et al.
Journal of Chromatography A, 882(1-2), 23-28 (2000)
U Tiemann et al.
Food additives and contaminants, 24(3), 306-314 (2007-03-17)
This review summarizes the toxicological data on the effects of the mycotoxins zearalenone (ZON), its metabolites, and deoxynivalenol (DON) on different parameters relating to reproductive and non-reproductive organs in female pigs. In vivo, 22 mg ZON kg(-1) in the diet
Miner Luo et al.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 29(7), 729-733 (2013-07-11)
To prepare the monoclonal antibody against zearalenone (ZEN) toxin and preliminarily establish the colloidal gold immunochromatographic detection method for ZEN. The artificial antigen ZEN-BSA and ZEN-OVA were prepared by active ester method. Mice were immunized with ZEN-OVA and monoclonal antibodies
M Gajecki
Polish journal of veterinary sciences, 5(2), 117-122 (2002-08-23)
The main arguments, discussed by different international organizations, which confirm the significance of problems connected with the presence of zearalenone in animal feed materials and their influence on the safety of food materials are shown in this review article. The
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