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Martina Abrigo et al.
ACS applied materials & interfaces, 7(14), 7644-7652 (2015-03-24)
Electrospun materials have been widely investigated in the past few decades as candidates for tissue engineering applications. However, there is little available data on the mechanisms of interaction of bacteria with electrospun wound dressings of different morphology and surface chemistry....
Jian-Yuan Lee et al.
Scientific reports, 5, 16808-16808 (2015-11-26)
The efficiency of forward osmosis (FO) process is generally limited by the internal concentration polarization (ICP) of solutes inside its porous substrate. In this study, mesoporous silica gel (SG) with nominal pore size ranging from 4-30 nm was used as fillers...
HyeongJin Lee et al.
Journal of colloid and interface science, 430, 315-325 (2014-06-30)
Biomedical scaffolds have been widely investigated because they are essential for support and promotion of cell adhesion, proliferation and differentiation in three-dimensional (3D) structures. An ideal scaffold should be highly porous to enable efficient nutrient and oxygen transfer and have...
Stewart R Dods et al.
Journal of chromatography. A, 1376, 74-83 (2014-12-30)
Protein separation is an integral step in biopharmaceutical manufacture with diffusion-limited packed bed chromatography remaining the default choice for industry. Rapid bind-elute separation using convective mass transfer media offers advantages in productivity by operating at high flowrates. Electrospun nanofibre adsorbents...
Shigeo Hayashi et al.
Journal of enzyme inhibition and medicinal chemistry, 29(6), 846-867 (2014-02-13)
Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatment of inflammatory diseases/syndromes; however, traditional NSAIDs exhibit serious side-effects such as gastrointestinal damage...
Yang Li et al.
Macromolecular bioscience, 15(1), 52-62 (2014-12-06)
To address the downside of conventional photo-patterning which can alter the chemical composition of protein scaffolds, we developed a non-covalent photo-patterning strategy for gelatin (denatured collagen) hydrogels that utilizes UV activated triple helical hybridization of caged collagen mimetic peptide (caged...
Sandeep Goyal et al.
Journal of lipid research, 55(9), 1933-1943 (2014-07-16)
Cytochrome P450 (P450 or CYP) 46A1 is expressed in brain and has been characterized by its ability to oxidize cholesterol to 24S-hydroxycholesterol. In addition, the same enzyme is known to further oxidize 24S-hydroxycholesterol to the 24,25- and 24,27-dihydroxy products, as...
Ciğdem Gölgelioğlu et al.
Electrophoresis, 34(2), 331-342 (2012-11-20)
A simple porogen containing only DMF and aqueous buffer was used for synthesis of monolithic stationary media for CEC). Butyl methacrylate (BMA)-based capillary monoliths were obtained using proposed porogen together with acrylic/methacrylic cross-linking agents with different alkyl chain lengths. For...
Emma-Dune Leriche et al.
Molecules (Basel, Switzerland), 19(12), 20731-20750 (2014-12-17)
Highly branched polyamidoamine (PAMAM) dendrimers presenting biological activities have been envisaged as non-viral gene delivery vectors. They are known to associate with nucleic acid (DNA) in non-covalent complexes via electrostatic interactions. Although their transfection efficiency has been proved, PAMAMs present...
Kazunori Shimomura et al.
Tissue engineering. Part A, 21(13-14), 2066-2075 (2015-03-31)
Radial tears of the meniscus represent one of the most common injuries of the knee, and result in loss of biomechanical meniscal function. However, there have been no established, effective treatments for radial meniscal tears. Nanofibrous materials produced by electrospinning...
Abhijit Achyut Gurjarpadhye et al.
Tissue engineering. Part C, Methods, 21(7), 758-766 (2014-12-30)
Lumen endothelialization of bioengineered vascular scaffolds is essential to maintain small-diameter graft patency and prevent thrombosis postimplantation. Unfortunately, nondestructive imaging methods to visualize this dynamic process are lacking, thus slowing development and clinical translation of these potential tissue-engineering approaches. To...
Fengchun Zhao et al.
Analytical and bioanalytical chemistry, 407(30), 8959-8970 (2015-10-03)
To develop a broad-specificity immunoassay for organophosphorus pesticides (OPs), a broad-specificity monoclonal antibody (MAb) for OPs against a generic hapten, O,O-diethyl O-(3-carboxyphenyl) phosphorothioate with the carboxy group in the meta position of the benzene ring, was produced. Eight haptens were...
Yu-Chih Chiang et al.
ACS nano, 8(12), 12502-12513 (2014-12-09)
The loss of overlying enamel or cementum exposes dentinal tubules and increases the risk of several dental diseases, such as dentin hypersensitivity (causing sharp pain and anxiety), caries, and pulp inflammation. This paper presents a fast-reacting, more reliable and biocompatible...
P Abdul Rasheed et al.
The Analyst, 140(8), 2713-2718 (2015-02-19)
Single stranded DNA fragments were conjugated onto gold nanoparticles leading to the formation of gold nanoparticle clusters upon hybridization with complementary strands. These clusters were successfully implemented for signal amplification in an electrochemical DNA sensor based on a graphene substrate....
Urara Hasegawa et al.
Macromolecular bioscience, 15(11), 1512-1522 (2015-06-24)
Prodrug micelles carrying 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione (ADT-OH), a compound possessing chemopreventive properties, are prepared from amphiphilic block copolymers linking ADT-OH via an ester bond using glycine (PAM-PGlyADT) and isoleucine linkers (PAM-PIleADT). The release of ADT-OH from the PAM-PIleADT micelles is much slower...
Ciro Menale et al.
Pharmaceutical research, 32(2), 362-374 (2014-08-06)
Combined treatment based on cisplatin-loaded Poly(D,L-lactic-co-glicolic)acid (PLGA) nanoparticles (NP-C) plus the NSAID piroxicam was used as novel treatment for mesothelioma to reduce side effects related to cisplatin toxicity. PLGA nanoparticles were prepared by double emulsion solvent evaporation method. Particle size...
Slavko Klobčar et al.
Biomedical chromatography : BMC, 29(12), 1901-1906 (2015-05-27)
The isolation of four oxidative degradation products of atorvastatin using preparative high-performance liquid chromatography applying at least two chromatographic steps is known from the literature. In this paper it is shown that the same four impurities could be isolated from...
Xiaoqin Xiong et al.
Scientific reports, 5, 9254-9254 (2015-03-26)
A flexible membrane consisting of MoS2/carbon nanofibers has been fabricated by a simple electrospinning method. MoS2 nanosheets are uniformly encapsulated in the inter-connected carbon nanofibers with diameters of ~150 nm. When evaluated as a binder-free electrode for sodium-ion batteries, the as-obtained...
X Y Chen et al.
Poultry science, 94(11), 2597-2603 (2015-10-11)
Cold stress triggers an anti-oxidative response in animals regulated by Nrf2 (nuclear factor 2-like, NFE2L2) binding to deoxyribonucleic acid-regulatory sequences near stress-responsive genes. To identify chicken Nrf2-regulated genes, 3 genetically related experimental groups (EG) with 40 Huainan partridge chickens in...
Chiara Testa et al.
Journal of medicinal chemistry, 57(22), 9424-9434 (2014-10-28)
Side chain-to-side chain cyclizations represent a strategy to select a family of bioactive conformations by reducing the entropy and enhancing the stabilization of functional ligand-induced receptor conformations. This structural manipulation contributes to increased target specificity, enhanced biological potency, improved pharmacokinetic...
Cristina Dumitriu et al.
Materials science & engineering. C, Materials for biological applications, 45, 56-63 (2014-12-11)
Various TiO2 nanofibers on Ti surface have been fabricated via electrospinning and calcination. Due to different elaboration conditions the electrospun fibers have different surface feature morphologies, characterized by scanning electronic microscopy, surface roughness, and contact angle measurements. The results have...
E Mázl Chánová et al.
Physiological research, 64 Suppl 1, S61-S73 (2015-10-09)
In this study, we investigate the preparation of surface pattern of functional groups on poly(lactide) (PLA) surfaces through the controlled deposition of core-shell self-assemblies based on functionalized PLA-b-PEO amphiphilic block copolymers from selective solvents. Through grafting RGDS peptide onto the...
Marta C Hatzell et al.
Environmental science & technology, 48(23), 14041-14048 (2014-11-05)
The amount of salinity-gradient energy that can be obtained through capacitive mixing based on double layer expansion depends on the extent the electric double layer (EDL) is altered in a low salt concentration (LC) electrolyte (e.g., river water). We show...
Fábio Faria-Oliveira et al.
BMC microbiology, 15, 271-271 (2015-11-27)
Saccharomyces cerevisiae multicellular communities are sustained by a scaffolding extracellular matrix, which provides spatial organization, and nutrient and water availability, and ensures group survival. According to this tissue-like biology, the yeast extracellular matrix (yECM) is analogous to the higher Eukaryotes...
Xuepei Zhang et al.
Journal of chromatography. A, 1359, 84-90 (2014-07-30)
A new approach for proteome-wide profiling drug binding proteins by using monolithic capillary affinity chromatography in combination with HPLC-MS/MS is reported. Two immunosuppresive drugs, namely FK506 and cyclosporin A, were utilized as the experimental models for proof-of-concept. The monolithic capillary...
Arvind H Jadhav et al.
Journal of nanoscience and nanotechnology, 15(10), 7988-7996 (2016-01-05)
Electro-spun fabricated TiO2 nanofibers were prepared by simple electro-spinning method, in subsequent step silver (Ag) was deposited using precipitation method and obtained Ag-TiO2 composite nanofibers. The properties and morphology of these prepared composite nanofibers were characterized by XRD, SEM, EDX...
Cui Wang et al.
Environmental pollution (Barking, Essex : 1987), 190, 133-138 (2014-04-22)
Occupational and experimental studies have revealed the organs most affected by dimethylformamide (DMF) are liver and gastrointestinal tract. However, few studies have focused on the potential effect of outdoor pollution of DMF. This study examined the health risk of hospitalization...
Diana Guzman-Villanueva et al.
International journal of pharmaceutics, 473(1-2), 579-590 (2014-07-27)
The RNA interference (RNAi) constitutes a conservative mechanism in eukaryotic cells that induces silencing of target genes. In mammalians, the RNAi is triggered by siRNA (small interfering RNA) molecules. Due to its potential in silencing specific genes, the siRNA has...
Yanlin Lv et al.
Analytica chimica acta, 839, 74-82 (2014-07-30)
A new type of fluorescent probe capable of detecting Ag(+) and Hg(2+) in two independent channels was developed in the present work. Specifically, in CH3CN-MOPS mixed solvents with CH3CN/MOPS ratio (v/v) of 15/85, this type of probe fluoresced weakly, and...
Chengyun Wang et al.
Experimental eye research, 129, 74-82 (2014-12-03)
Dexamethasone is a glucocorticoid that is widely used in the ophthalmic arena. The recent FDA approved dexamethasone implant can provide a three month efficacy but with high rate of drug related cataract and high intraocular pressure (IOP). It seems that...