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Yufei Wang et al.
Analytical and bioanalytical chemistry, 411(11), 2363-2371 (2019-02-28)
Measurement of serum progesterone is important in determining ovarian function. Most progesterone measurements are performed with immunoassays and results are often variable. Standardization of the measurements requires a reliable reference method. An isotope dilution liquid chromatography tandem mass spectrometry (ID-LC/MS/MS)...
Rachel J Smith et al.
The European journal of neuroscience, 30(3), 493-503 (2009-08-07)
The orexin/hypocretin system has recently been implicated in reward-processing and addiction. We examined the involvement of the orexin system in cue-induced reinstatement of extinguished cocaine-seeking by administering the orexin 1 receptor antagonist SB-334867 (SB) or the orexin 2 receptor antagonist...
Yu-Ling Lian et al.
Molecular medicine reports, 16(2), 1920-1926 (2017-06-20)
Pain is the most pronounced complaint of women with endometriosis, however the underlying mechanism is still poorly understood. In the present study, the authors evaluate the effect of transient receptor potential vanilloid type 1 (TRPV1) of dorsal root ganglia (DRG)...
Magdalena Koziczak-Holbro et al.
The Journal of pharmacology and experimental therapeutics, 369(2), 188-199 (2019-03-02)
The anabolic effects of β2-adrenoceptor (β2-AR) agonists on skeletal muscle have been demonstrated in various species. However, the clinical use of β2-AR agonists for skeletal muscle wasting conditions has been limited by their undesired cardiovascular effects. Here, we describe the...
Zhong Wang et al.
Mediators of inflammation, 2011, 848309-848309 (2011-03-16)
Our previous study concerning brain trauma has shown that progesterone could regulate toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) signaling pathway in the brain, which also has been proved to play important roles in early brain injury (EBI)...
Laura M Breshears et al.
PloS one, 11(7), e0158969-e0158969 (2016-07-16)
Secreted factors of Staphylococcus aureus can activate host signaling from the epidermal growth factor receptor (EGFR). The superantigen toxic shock syndrome toxin-1 (TSST-1) contributes to mucosal cytokine production through a disintegrin and metalloproteinase (ADAM)-mediated shedding of EGFR ligands and subsequent...
2-Hydroxypropyl-?-cyclodextrin (HP-?-CD): a toxicology review.
Gould S & Scott RC.
Food And Chemical Toxicology, 43(10), 1451-1459 (2005)
The influence of polyvinylpyrrolidone on naproxen complexation with hydroxypropyl- β -cyclodextrin
Mura P, et al.
European Journal of Pharmaceutical Sciences, 13(2), 187-194 (2001)
Dmitri R Davydov et al.
Biochemistry, 47(43), 11348-11359 (2008-10-04)
To establish a direct method for monitoring substrate binding in cytochrome P450eryF applicable at elevated hydrostatic pressures, we introduce a laser dye Fluorol-7GA (F7GA) as a novel fluorescent ligand. The high intensity of fluorescence and the reasonable resolution of the...
Dobrin Draganov et al.
NPJ breast cancer, 7(1), 22-22 (2021-03-04)
We show that treatment with the FDA-approved anti-parasitic drug ivermectin induces immunogenic cancer cell death (ICD) and robust T cell infiltration into breast tumors. As an allosteric modulator of the ATP/P2X4/P2X7 axis which operates in both cancer and immune cells...
D E Rusyniak et al.
Neuroscience, 154(4), 1619-1626 (2008-06-07)
When given in a warm environment MDMA (3,4-methylenedioxymethamphetamine, ecstasy) causes hyperthermia by increasing interscapular brown adipose tissue (iBAT) heat production and decreasing heat loss via cutaneous vasoconstriction. When given in a cold environment, however, MDMA causes hypothermia by an unknown...
The fabrication of hollow spherical copper sulfide nanoparticle assemblies with 2-hydroxypropyl- β -cyclodextrin as a template under sonication
Xu J-Z, et al.
Ultrasonics Sonochemistry, 13(5), 451-454 (2006)
Jagdishbhai L Italia et al.
PloS one, 6(10), e25744-e25744 (2011-10-15)
Despite advances in the treatment, the morbidity and mortality rate associated with invasive aspergillosis remains unacceptably high (70-90%) in immunocompromised patients. Amphotericin B (AMB), a polyene antibiotic with broad spectrum antifungal activity appears to be a choice of treatment but...
Shuhua Chen et al.
PloS one, 6(8), e24293-e24293 (2011-09-16)
Previously, we demonstrated that allopregnanolone (APα) promoted proliferation of rodent and human neural progenitor cells in vitro. Further, we demonstrated that APα promoted neurogenesis in the hippocampal subgranular zone (SGZ) and reversed learning and memory deficits in the male triple...
Hyung Jun Choi et al.
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 17(3), 400-408 (2019-07-30)
This study aimed to investigate the long-term effects of aripiprazole treatment during adolescence on behavior, cognitive function, and dopamine D2 receptor (D2R) expression in adult rats. Adolescent male Sprague-Dawley rats were injected intraperitoneally with aripiprazole, risperidone, or vehicle control for...
Development and pharmacological evaluation of ropivacaine-2-hydroxypropyl- β -cyclodextrin inclusion complex
de Araujo DR, et al.
European Journal of Pharmaceutical Sciences, 33(1), 60-71 (2008)
Leiming Wang et al.
Science advances, 6(18), eaaz8031-eaaz8031 (2020-06-05)
The orphan nuclear receptor COUP-TFII is expressed at a low level in adult tissues, but its expression is increased and shown to promote progression of multiple diseases, including prostate cancer, heart failure, and muscular dystrophy. Suppression of COUP-TFII slows disease...